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| 1 | Integrative Chinese and western medicine on atherosclerosis of coronary heart disease: what are the new control strategies?显示文摘How to control and prevent atherosclerosis(AS) remains a global issue that needs to be deeply discussed. The innovation concept of AS and coronary heart disease(CHD) in western medicine provides a good opportunity to develop the traditional Chinese medicine etiology and new control strategies accordingly. This article reviewed and refined the updated control strategies of AS of CHD integrated Chinese and western medicine based on the innovation concept and therapeutic guideline of AS and CHD during the last 10 years. | Yue Liu Yuerong Jiang Jingchun Zhang Dazhuo Shi | 2014 | Chinese Science Bulletin2014，59，11： | 4 |
| 2 | Prediction and systematic study of protein-protein interaction networks of Leptospira interrogans显示文摘Leptospira interrogans serovar Lai is a pathogenic bacterium that causes a spirochetal zoonosis in humans and some animals. With its complete genome sequence available, it is possible to analyze protein-protein interactions from a whole- genome standpoint. Here we combine four recently developed computational approaches (gene fusion method, gene neighbor method, phylogenetic profiles method, and operon method) to predict protein-pro- tein interaction networks of Leptospira interrogans strain Lai. Through comprehensive analysis on in- teractions among proteins of motility and chemotaxis system, signal transduction, lipopolysaccaride bio- synthesis and a series of proteins related to adhesion and invasion, we provided information for further studying on its pathogenic mechanism. In addition, we also assigned 203 previously uncharacterized proteins with possible functions based on the known functions of its interacting partners. This work is helpful for further investigating L. interrogans strain Lai. | SUN Jingchun XU Jinlin CAO Jianping LIU Qi GUO Xiaokui SHI Tieliu LI Yixue | 2006 | Chinese Science Bulletin2006，51，11： | 3 |
| 3 | Analysis and application of large-scale protein-protein interaction data sets显示文摘Protein-protein interactions play key roles in cells. Lots of experimental approaches and in silico methods have been developed to identify and predict large-scale pro- tein-protein interactions. However, compared with the tradi- tionally experimental results, the high-throughput pro- tein-protein interaction data often contain the false positives in high probability. In order to fully utilize the large-scale data, it is necessary to develop bioinformatic methods for systematically evaluating those data in order to further im- prove the data reliability and mine biological information. This review summarizes the methodologies of analysis and application of high-throughput protein-protein interaction data, including the evaluation methods, the relationship be- tween protein-protein interaction data and other protein biological information, and their applications in biological study. In addition, this paper also suggests some interesting topics on mining high-throughput protein-protein interaction data. | SUN Jingchun XU Jinlin LI Yixue SHI Tieliu | 2005 | Chinese Science Bulletin2005，50，20： | 2 |
| 4 | Integrated metabolomics analysis of the effect of PPARδ agonist GW501516 on catabolism of BCAAs and carboxylic acids in diabetic mice显示文摘The peroxisome proliferator-activated receptor(PPARδ)agonists are reported to improve insulin sensitivity,reduce glucose levels,and alleviate dysfunctional lipid metabolism in animal models of type 2 diabetes mellitus.However,the underlying mechanisms remain incompletely understood.Metabolism plays an essential role in the biological system.Monitoring of metabolic changes in response to disease conditions or drug treatment is critical for better understanding of the pathophysiological mechanisms.In this study,metabolic profiling analysis by gas chromatography-mass spectrometry integrated with targeted analysis by liquid chro matography-mass spectrometry was carried out in plasma samples of db/db diabetic mice after six-week treatment of PPARδagonist GW501516.GW501516 treatment significantly altered levels of metabolites,such as branched-chain amino acids(BCAAs),BCAA metabolites(3-hydroxyisobutyric acid and 3-hydroxyisovaleric acid),long-chain fatty acids,uric acid and ketone bodies(3-hydroxybutyric acid and 2-hydroxybutyric acid)which are all associated with the impaired systemic insulin sensitivity.The pre sent results indicate the beneficial effect of PPARδagonist in alleviating insulin resistance of diabetic mice by favorably modulating metabolic profile,thus providing valuable information in understanding the therapeutic potential of PPARδagonists in correcting metabolic dysfunction in diabetes. | Li Xiang Juan Nie Li Wang Yu Wang Jingchun Shi Juntong Wei Chi-Wai Lau Zongwei Cai Yu Huang | 2021 | Chinese Chemical Letters2021，32，7： | 1 |
| 5 | Refined phylogenetic profiles method for predicting protein-protein interactions显示文摘 | Jingchun Sun Jinlin Xu Zhen Liu Qi Liu Aimin Zhao Tieliu Shi Yixue Li | 2005 | Bioinformatics2005，21，16： | 1 |
| 6 | Transgenerational bone toxicity in F3 medaka (Oryzias latipes) induced by ancestral benzo[a]pyrene exposure: Cellular and transcriptomic insights显示文摘Benzo[a]pyrene(BaP),a ubiquitous pollutant,raises environmental health concerns due to induction of bone toxicity in the unexposed offspring.Exposure of F0 ancestor medaka(Oryzias latipes)to 1μg/L BaP for 21 days causes reduced vertebral bone thickness in the unexposed F3 male offspring.To reveal the inherited modifications,osteoblast(OB)abundance and molecular signaling pathways of transgenerational BaP-induced bone thinning were assessed.Histomorphometric analysis showed a reduction in OB abundance.Analyses of the miRNA and mRNA transcriptomes revealed the dysregulation of Wnt signaling(frzb/ola-miR-1–3p,sfrp5/ola-miR-96–5p/miR-455–5p)and bone morphogenetic protein(Bmp)signaling(bmp3/ola-miR-96–5p/miR-181b-5p/miR-199a-5p/miR-205–5p/miR-455–5p).Both pathways are major indicators of impaired bone formation,while the altered Rank signaling in osteoclasts(c-fos/miR-205–5p)suggests a potentially augmented bone resorption.Interestingly,a typical BaP-responsive pathway,the Nrf2-mediated oxidative stress response(gst/ola-miR-181b-5p/miR-199a-5p/miR-205),was also affected.Moreover,mRNA levels of epigenetic modification enzymes(e.g.,hdac6,hdac7,kdm5b)were found dysregulated.The findings indicated that epigenetic factors(e.g.,miRNAs,histone modifications)may directly regulate the expression of genes associated with transgenerational BaP bone toxicity and warrants further studies.The identified candidate genes and miRNAs may serve as potential biomarkers for BaP-induced bone disease and as indicators of historic exposures in wild fish for conservation purposes. | Jiezhang Mo Miles Teng Wan DorisWai-Ting Au Jingchun Shi Nathan Tam Xian Qin Napo K.M.Cheung Keng Po Lai Christoph Winkler Richard Yuen-Chong Kong Frauke Seemann | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
| 7 | Underwater Diver Image Enhancement via Dual-Guided Filtering显示文摘The scattering and absorption of light propagating underwater cause the underwater images to present lowcontrast,color deviation,and loss of details,which in turn make human posture recognition challenging.To address these issues,this study introduced the dual-guided filtering technique and developed an underwater diver image improvement method.First,the color distortion of the underwater diver image was solved using white balance technology to obtain a color-corrected image.Second,dual-guided filtering was applied to the white balanced image to correct the distorted color and enhance its details.Four feature weight maps of the two images were then calculated,and two normalizedweightmapswere constructed formulti-scale fusion using normalization.To better preserve the obtained image details,the fusion image was histogram-stretched to obtain the final enhanced result.The experimental results validated that this method has improved the accuracy of underwater human posture recognition. | Jingchun Zhou Taian Shi Weishi Zhang Weishen Chu | 2022 | Computer Modeling in Engineering & Sciences2022，，5： | 0 |
| 8 | The Protocol of Ultrasonic Backscatter Measurements of Musculoskeletal Properties显示文摘This study aims to introduce the protocol for ultrasonic backscatter measurements of musculoskeletal properties based on a novel ultrasonic backscatter bone diagnostic(UBBD)instrument.Dual-energy X-ray absorptiometry(DXA)can be adopted to measure bone mineral density(BMD)in the hip,spine,legs and the whole body.The muscle and fat mass in the legs and the whole body can be also calculated by DXA body composition analysis.Based on the proposed protocol for backscatter measurements by UBBD,ultrasonic backscatter signals can be measured in vivo,deriving three backscatter parameters[apparent integral backscatter(AIB),backscatter signal peak amplitude(BSPA)and the corresponding arrival time(BSPT)].AIB may provide important diagnostic information about bone properties.BSPA and BSPT may be important indicators of muscle and fat properties.The standardized backscatter measurement protocol of the UBBD instrument may have the potential to evaluate musculoskeletal characteristics,providing help for promoting the application of the backscatter technique in the clinical diagnosis of musculoskeletal disorders(MSDs),such as osteoporosis and muscular atrophy. | Dongsheng Bi Lingwei Shi Boyi Li Ying Li Chengcheng Liu Lawrence HLe Jingchun Luo Sijia Wang Dean Ta | 2024 | Phenomics2024，4，1： | 0 |
| 9 | Protocol for Brain Magnetic Resonance Imaging and Extraction of Imaging‑Derived Phenotypes from the China Phenobank Project显示文摘Imaging-derived phenotypes(IDPs)have been increasingly used in population-based cohort studies in recent years.As widely reported,magnetic resonance imaging(MRI)is an important imaging modality for assessing the anatomical structure and function of the brain with high resolution and excellent soft-tissue contrast.The purpose of this article was to describe the imaging protocol of the brain MRI in the China Phenobank Project(CHPP).Each participant underwent a 30-min brain MRI scan as part of a 2-h whole-body imaging protocol in CHPP.The brain imaging sequences included T1-magnetization that prepared rapid gradient echo,T2 fuid-attenuated inversion-recovery,magnetic resonance angiography,difusion MRI,and resting-state functional MRI.The detailed descriptions of image acquisition,interpretation,and post-processing were provided in this article.The measured IDPs included volumes of brain subregions,cerebral vessel geometrical parameters,microstructural tracts,and function connectivity metrics. | Chengyan Wang Zhang Shi Yan Li Xueqin Xia Xutong Kuang Shufang Qian Le Xue Lizhen Lan Yudan Wu Na Zhang Ji Tao Xumei Hu Wenzhao Cao Naying He Yike Guo Weibo Chen Jun Zhang Jingchun Luo He Wang Mei Tian | 2023 | Phenomics2023，3，6： | 0 |
| 10 | Theoretical and technical progress in exploration practice of the deep-water large oil fields, Santos Basin, Brazil显示文摘The history and results of petroleum exploration in the Santos Basin, Brazil are reviewed. The regularity of hydrocarbon enrichment and the key exploration technologies are summarized and analyzed using the seismic, gravity, magnetic and drilling data. It is proposed that the Santos Basin had a structural pattern of two uplifts and three depressions and the Aram-Uirapuru uplift belt controlled the hydrocarbon accumulation. It is believed that the main hydrocarbon source kitchen in the rift period controlled the hydrocarbon-enriched zones, paleo-structures controlled the scale and quality of lacustrine carbonate reservoirs, and continuous thick salt rocks controlled the hydrocarbon formation and preservation. The process and mechanism of reservoirs being transformed by CO_(2)charging were revealed. Five key exploration technologies were developed,including the variable-velocity mapping for layer-controlled facies-controlled pre-salt structures, the prediction of lacustrine carbonate reservoirs, the prediction of intrusive/effusive rock distribution, the detection of hydrocarbons in lacustrine carbonates, and the logging identification of supercritical CO_(2)fluid. These theoretical recognitions and exploration technologies have contributed to the discovery of deep-water super-large reservoirs under CNODC projects in Brazil, and will guide the further exploration of deep-water large reservoirs in the Santos Basin and other similar regions. | HE Wenyuan SHI Buqing FAN Guozhang WANG Wangquan WANG Hongping WANG Jingchun ZUO Guoping WANG Chaofeng YANG Liu | 2023 | Petroleum Exploration and Development2023，50，2： | 0 |
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