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您的检索式：作者名="Nathan Tam"
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| 1 | Machine learning predictions of irradiation embrittlement in reactor pressure vessel steels显示文摘Irradiation increases the yield stress and embrittles light water reactor(LWR)pressure vessel steels.In this study,we demonstrate some of the potential benefits and risks of using machine learning models to predict irradiation hardening extrapolated to low flux,high fluence,extended life conditions.The machine learning training data included the Irradiation Variable for lower flux irradiations up to an intermediate fluence,plus the Belgian Reactor 2 and Advanced Test Reactor 1 for very high flux irradiations,up to very high fluence.Notably,the machine learning model predictions for the high fluence,intermediate flux Advanced Test Reactor 2 irradiations are superior to extrapolations of existing hardening models.The successful extrapolations showed that machine learning models are capable of capturing key intermediate flux effects at high fluence.Similar approaches,applied to expanded databases,could be used to predict hardening in LWRs under life-extension conditions. | Yu-chen Liu Henry Wu Tam Mayeshiba Benjamin Afflerbach Ryan Jacobs Josh Perry Jerit George Josh Cordell Jinyu Xia Hao Yuan Aren Lorenson Haotian Wu Matthew Parker Fenil Doshi Alexander Politowicz Linda Xiao Dane Morgan Peter Wells Nathan Almirall Takuya Yamamoto G.Robert Odette | 2022 | npj Computational Materials2022，，1： | 0 |
| 2 | Transgenerational bone toxicity in F3 medaka (Oryzias latipes) induced by ancestral benzo[a]pyrene exposure: Cellular and transcriptomic insights显示文摘Benzo[a]pyrene(BaP),a ubiquitous pollutant,raises environmental health concerns due to induction of bone toxicity in the unexposed offspring.Exposure of F0 ancestor medaka(Oryzias latipes)to 1μg/L BaP for 21 days causes reduced vertebral bone thickness in the unexposed F3 male offspring.To reveal the inherited modifications,osteoblast(OB)abundance and molecular signaling pathways of transgenerational BaP-induced bone thinning were assessed.Histomorphometric analysis showed a reduction in OB abundance.Analyses of the miRNA and mRNA transcriptomes revealed the dysregulation of Wnt signaling(frzb/ola-miR-1–3p,sfrp5/ola-miR-96–5p/miR-455–5p)and bone morphogenetic protein(Bmp)signaling(bmp3/ola-miR-96–5p/miR-181b-5p/miR-199a-5p/miR-205–5p/miR-455–5p).Both pathways are major indicators of impaired bone formation,while the altered Rank signaling in osteoclasts(c-fos/miR-205–5p)suggests a potentially augmented bone resorption.Interestingly,a typical BaP-responsive pathway,the Nrf2-mediated oxidative stress response(gst/ola-miR-181b-5p/miR-199a-5p/miR-205),was also affected.Moreover,mRNA levels of epigenetic modification enzymes(e.g.,hdac6,hdac7,kdm5b)were found dysregulated.The findings indicated that epigenetic factors(e.g.,miRNAs,histone modifications)may directly regulate the expression of genes associated with transgenerational BaP bone toxicity and warrants further studies.The identified candidate genes and miRNAs may serve as potential biomarkers for BaP-induced bone disease and as indicators of historic exposures in wild fish for conservation purposes. | Jiezhang Mo Miles Teng Wan DorisWai-Ting Au Jingchun Shi Nathan Tam Xian Qin Napo K.M.Cheung Keng Po Lai Christoph Winkler Richard Yuen-Chong Kong Frauke Seemann | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
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