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| 1 | A stringent dual control system overseeing transcription and activity of the Cre recombinase for the liver-specific conditional gene knock-out mouse model显示文摘Liver cancer is one of the most threatening diseases in Chinese population. Just like in other tissues, tumor initiation and development in liver involve multiple steps of genetic and epigenetic alterations with several unknown details. However, unlike in other tissues, a tis-sue specific inducible Cre recombinase system that allows temporal and spatial deletion of a target DNA fragment is still not available for in vivo functional gene annotation in hepatocytes. In our pursuit to establish such a mouse model, we designed a dual inducible Cre transgene system and tested it in cultured cells. By combining a CCAAT/enhancer binding protein β (C/EBP β) promoter derived Tet-off expression system and the estrogen receptor (ER) mediated functional control, we show a desirable profile of both hepatocyte-specificity and regulability of the Cre expression in a series of critical assessments in the cell culture system, which provides confidence in continua-tion of our ongoing pursuit in mouse. | Yu Wu Yinghua He Hongyu Zhang Xinlan Dai Xiaoyu Zhou Jun Gu Guan Wang Jingde Zhu | 2008 | Journal of Genetics and Genomics2008，35，7： | 3 |
| 2 | The microbial metallogeny of weathering crust REE deposits in South China显示文摘VERY little is known about the roles of microorganisms in the metallogeny of weathering crust REE deposits, although there has been much literature on REE behavior in weathering conditions. The present note deals with the microorganisms in 4 weathering profiles of an REE deposit and their roles in migration and accumulation of REE in weathering conditions. 1 Cultivation and identification of microorganisms Under strict sterilization, samples were collected from various parts of 4 weathering profiles of granites in a weathering crust REE deposit in South China. The samples were then cultivated for microorganisms with ordinary agars as culture media and then the cultivated microorganisms were dyed and identifiedunder a microscope. The sampled positions and cultivated numbers of microbial colonies are shown | CHEN Binghui~(1,2), WANG Zhimei~3, HUANG Limei~3, WU Fuhai~3, CHEN Jingde~2 and XU Wenlie~2 1. Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Department of Earth Sciences, Zhongshan University, Guangzhou 510275, China 3. Guangdong Pharmaceutical College, Guangzhou 510244, China | 1999 | Chinese Science Bulletin1999，44，S2： | 3 |
| 3 | Memantine combined with environmental enrichment improves spatial memory and alleviates Alzheimer's disease-like pathology in senescence-accelerated prone-8(SAMP8) mice显示文摘Memantine is a N-methyl-D-aspartate(NMDA) receptor antagonist approved for the treatment of moderate to severe Alzheimer's disease(AD).Environmental enrichment(EE) has shown significant beneficial effects on functional improvement in AD.In this study,we sought to determine whether combining these two distinct therapies would yield greater benefit than either drug used alone.We investigated the effect of memantine combined with EE on spatial learning and memory and AD-like pathology in a widely used AD model,the senescence-accelerated prone mice(SAMP8).The SAMP8 mice were randomly assigned to enriched housing(EH) or standard housing(SH),where either memantine(20 mg/kg) or saline was given by gastric lavage once daily continuously for eight weeks.Our results showed that,when provided separately,memantine and EE significantly improved spatial learning and memory by shortening escape latencies and increasing the frequency of entrance into the target quadrant.When combined,memantine and EE showed additive effect on learning and memory as evidenced by significant shorter escape latencies and higher frequency of target entrance than either drug alone.Consistent with the behavior results,pathological studies showed that both memantine and EE significantly reduced hippocampal CA1 neurofibrilliary tangles(NFTs) as well as amyloid beta precursor protein(APP) levels.Combining both therapies synergistically lessened NFTs and APP expression compared to either drug alone in SAMP8 mice,indicating that the combination of memantine with EE could offer a novel and efficient therapeutic strategy for the treatment of AD. | Jingde Dong Mi Zhou Xiaoqiang Wu Mingyang Du Xiaoshan Wang | 2012 | The Journal of Biomedical Research2012，26，6： | 2 |
| 4 | ZIF-7@carbon composites as multifunctional interlayer for rapid and durable Li-S performance显示文摘The notorious'shuttle effect'of polysulfide during charge-discharge process induces grievous capacity fading,while the sluggish polysulfide conversion kinetics significantly hinders the development of practically viable lithium-sulfur(Li-S)batteries.In this study,a novel ZIF-7@carbon composite with ZIF-7 sheets vertically rooted on carbon cloth was developed as multifunctional interlayer to address these issues.The composite shows directional layered structure with outstanding compactness,and thus can provide massive active sites for accelerated redox reactions.The pore channels are perpendicular to the square surface,resulting in extremely high utilization of one-dimensional channels.Therefore,this structure can not only maintain the structural stability during the charge-discharge process by providing enough space for volume expansion,but also contribute to efficient exposure and utilization of active sites for the physical/chemical adsorption and catalytic conversion of polysulfide.As a result,Li-S batteries with the as-developed interlayer deliver a considerable areal capacity of 4.75 mAh cm^(-2) at an elevated sulfur loading of 5.5 mg cm^(-2),and an impressive cyclability with an extremely low capacity-fading rate of merely 0.04%per cycle over 500 cycles at 1 C. | Xingbo Wang Yan Zhao Feichao Wu Shuming Liu Zisheng Zhang Zhaoyang Tan Xiaohang Du Jingde Li | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 5 | An orderly arranged dual-role MIL-53(Al)nanorods array rooted on carbon nanotube film for long-life and stable lithium-sulfur batteries显示文摘It is of great value to synchronously resolve the critical issues of the polysulfide shuttle and dendrite growth in lithium-sulfur(Li-S)batteries.Herein,a bifunctional Al-based Material of Institute Lavoisier-53(MIL-53(Al))/carbon nanotube(MIL-53/CNT)composite is reported for this matter,which was constructed by growing an ordered MIL-53(Al)nanorods array on the CNT film.For the sulfur cathode,the proposed structure serves as a multifunctional interlayer to block polysulfides and accelerate their catalytic conversion,thus efficaciously inhibiting the shuttle effect.Meanwhile,when applied as the anode host material(Li@MIL-53/CNT),the flexible CNT film serves as a self-standing framework to accommodate Li metal and alleviate the volume expansion,while the uniform ion channels built by the MIL-53(Al)nanorods array along with the abundant oxygen groups can homogenize Li ion diffusion,enabling a steady Li plating/stripping behavior and limiting the dendrite growth.Not surprisingly,Li-S full battery with MIL-53/CNT interlayer and Li@MIL-53/CNT anode delivers an appreciable specific capacity of 735 mAh·g^(–1)and excellent cycle durability at 5 C,presenting a limited capacity decay of 0.03%per cycle in 500 cycles.Besides,an impressive cycle stability and rate capability are also achieved at high-sulfur loading and lean electrolyte conditions. | Feichao Wu Quanqing Li Gaofeng Jin Yuhong Luo Xiaohang Du Jingde Li Zisheng Zhang | 2023 | Nano Research2023，16，2： | 1 |
| 6 | Prediction of prognosis in gallbladder carcinoma by CD147 and MMP-2 immunohistochemistry显示文摘 | Wei Wu Rongbing Wang Hui Liu Jie Peng Damao Huang Bo Li Jingde Ruan | 2009 | Medical Oncology2009，，2： | 1 |
| 7 | Engineering zirconium-based metal-organic framework-801 films on carbon cloth as shuttle-inhibiting interlayers for lithium-sulfur batteries显示文摘Lithium-sulfur batteries have been regarded as the next-generation rechargeable batteries due to their high theoretical energy density and specific capacity.Nevertheless,the shuttle effect of lithium polysulfides has hindered the development of lithium-sulfur batteries.Herein,a novel zirconium-based metal-organic framework-801 film on carbon cloth was developed as a versatile interlayer for lithium-sulfur batteries.This interlayer has a hierarchical porous structure,suitable for the immobilization of lithium polysulfides and accommodating volume expansion on cycling.Moreover,the MOF-801 material is capable of strongly adsorbing lithium polysulfides and promoting their catalytic conversion,which can be enhanced by the abundant active sites provided by the continuous structure of the MOF-801 films.Based on the above advantages,the lithium-sulfur battery,with the proposed interlayer,delivers an initial discharge capacity of 927 mAh·g^(-1) at 1 C with an extremely low decay rate of 0.04%over 500 cycles.Additionally,a high area capacity of 4.3 mAh·cm^(-2) can be achieved under increased S loading. | Gaofeng Jin Jiale Zhang Baoying Dang Feichao Wu Jingde Li | 2022 | Frontiers of Chemical Science and Engineering2022，16，4： | 0 |
| 8 | Comparison of Rice Yield and Evaluation Methods for Drought Resistance under Drought Stress in the Whole Growth Period and Flowering Period显示文摘[Objectives]This study was conducted to improve the drought resistance of rice and cultivate new varieties of drought-tolerant rice to effectively alleviate the reduction in rice yield caused by drought.[Methods]Twenty two indica and japonica rice varieties were tested to compare the yield differences under drought stress in the whole growth period and under drought stress in the flowering period.[Results]Drought stress in the whole growth period and flowering period significantly reduced rice yield,as well as the number of filled grains per plant,the number of filled grains per panicle and grain weight per plant.To evaluate the drought tolerance of rice varieties,relative yield could be used as the index under both drought stresses in the whole growth period and the flowering period.[Conclusions]This study provides a theoretical reference for drought-tolerant rice breeding and screening. | Qian ZHU Wuyun FANG Yiru LI Yueming YI Cunli GONG Jingde WU Shimei WANG | 2022 | Agricultural Biotechnology2022，11，3： | 0 |
| 9 | Localization of epileptic foci in Children with childhood absence epilepsy by magnetoencephalography combined with synthetic aperture magnetometry显示文摘This present study was aimed to investigate the localizable diagnostic value of magnetoencephalography (MEG) combined with synthetic aperture magnetometry (SAM) in childhood absence epilepsy (CAE).Thirteen CAE patients underwent MEG detection at resting state and after hyperventilation,and then the epileptic foci were located by SAM.In the thirteen CAE patients,epileptic foci were found in five cases (38.5%),and they were all located in the bilateral frontal lobe,suggesting that the frontal lobe in some CAE patients may serve as the epileptic foci.Our findings indicate that MEG combined with SAM could be of diagnostic value in localizing the epileptic foci in certain CAE patients. | Xiuxiu Hu Jingde Dong XiaoshanWang Ting Wu Lu Yang Xiaopeng Lu | 2011 | The Journal of Biomedical Research2011，25，4： | 0 |
| 10 | Breeding of a Water-saving Drought-resistant Two-line Hybrid Rice Variety Wanliangyou 1008显示文摘Drought is one of the important factors limiting rice production,and the application of new water-saving rice varieties is urgently needed in rice production.Wanliangyou 1008 bred by Institute of Rice Research,Anhui Academy of Agricultural Sciences is a new two line hybrid rice variety with some good traits,including high drought resistance,high yield and good disease resistance.Wanlingyou 1008 was obtained by crossing drought-resistant high-quality restorer line DJ1008 and disease-resistant two-line sterile line Wan 25S.In this paper,the breeding process,characteristics and seed production technology of the variety were described in detail. | Shimei WANG Yueming YI Wuyun FANG Qian ZHU Cunli GONG Jingde WU Liansong YANG | 2022 | Agricultural Biotechnology2022，11，2： | 0 |
| 11 | Baseline susceptibility of Helicoverpa armigera,Plutella xylostella,and Spodoptera frugiperda to the meta-diamide insecticide broflanilide显示文摘Broflanilide is a novel meta-diamide insecticide that acts as a y-aminobutyric acid-gated chloride channel allosteric modulator.With its unique mode of action,broflanilide has no known cross-resistance with existing insecticides and is expected to be an effective tool for the management of insecticide resistance.Establishing the base-line susceptibility to this insecticide is an essential step for developing and implementing effective resistance management strategies.Here we evaluated the baseline susceptibil-ity to broflanilide for 3 cosmopolitan lepidopteran pest species,Helicoverpa armigera,Plutella xylostella,and Spodoptera frugiperda.Broflanilide exhibited high activity against populations sampled in the major distribution range of these pests in China,with median lethal concentrations(LCso)ranging between 0.209 and 0.684,0.076 and 0.336,and 0.075 and 0.219 mg/L for H.armigera,P xylostella,and S.frugiperda,respectively.Among-population variability in susceptibility to broflanilide was moderate for H.armigera(3.3-fold),P xylostella(4.4-fold),and S.frugiperda(2.9-fold).The recommended diagnostic concentrations for H.armigera,P xylostella,and S.frugiperda were 8,4,and 2 mg/L,re-spectively.Little or no cross-resistance to broflanilide was detected in 3 diamide-resistant strains of P xylostella and 1 spinosyns-resistant strain of S.frugiperda.Our results provide critical information for the development of effective resistance management programs to sustain efficacy of broflanilide against these key lepidopteran pests. | Xingliang Wang Tailong Shi Ping Tang Shengnan Liu Bofeng Hou Dong Jiang Jingde Lu Yihua Yang Yves Carriere Yidong Wu | 2023 | Insect Science2023，30，4： | 0 |
| 12 | Continuous amino-functionalized University of Oslo 66 membranes as efficacious polysulfide barriers for lithium−sulfur batteries显示文摘The shuttle effect of soluble polysulfides is a serious problem impeding the development of lithium−sulfur batteries.Herein,continuous amino-functionalized University of Oslo 66 membranes supported on carbon nanotube films are proposed as ion-permselective interlayers that overcome these issues and show outstanding suppression of the polysulfide shuttle effect.The proposed membrane material has appropriately sized pores,and can act as ionic sieves and serve as barriers to polysulfides transport while allowing the passage of lithium ions during electrochemical cycles,thereby validly preventing the shuttling of polysulfides.Moreover,a fast catalytic conversion of polysulfides is also achieved with the asdeveloped interlayer.Therefore,lithium−sulfur batteries with this interlayer show a desirable initial capacity of 999.21 mAh·g^(-1)at 1 C and a durable cyclic stability with a decay rate of only 0.04%per cycle over 300 cycles.Moreover,a high area capacity of 4.82 mAh·cm^(-2)is also obtained even under increased sulfur loading(5.12 mg·cm^(-2))and a lean-electrolyte condition(E/S=4.8μL·mg^(-1)). | Bowen Du Yuhong Luo Feichao Wu Guihua Liu Jingde Li Wei Xue | 2023 | Frontiers of Chemical Science and Engineering2023，17，2： | 0 |
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