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| 1 | Brain dynamic mechanisms on the visual attention scale with Chinese characters cues显示文摘The temporal dynamics in brain evoked by the scale of visual attention with the cues of Chinese characters were studied by recording event-related potentials (ERPs). With the fixed orientation of visual attention, 14 healthy young participants performed a search task in which the search array was preceded by Chinese characters cues, '大, 中, 小' (large, medium, small). 128 channels scalp ERPs were recorded to study the role of visual attention scale played in the visual spatial attention. The results showed that there was no significant difference in the ERP components evoked by the three Chinese characters cues except the in-feroposterior N2 latency. The targets evoked P2, N2 amplitudes and latency have significant differences with the different cues of large, middle and small, while P1 and N1 components had no significant difference. The results suggested that the processing of scale of visual attention was mainly concerned with P2, N2 components, while the P1, N1 components were mainly related with | GAO Wenbin WEI Jinghan PENG Xiaohu WEI Xing LUO Yuejia | 2002 | Chinese Science Bulletin2002，47，19： | 8 |
| 2 | Quantitative determination of diterpenoid alkaloid Fuziline by hydrophilic interaction liquid chromatography (HILIC)–electrospray ionization mass spectrometry and its application to pharmacokinetic study in rats显示文摘 | Jianguo Sun Fengyi Zhang Ying Peng Jinghan Liu Yunxi Zhong Guangji Wang | 2013 | Journal of Chromatography B2013，，： | 1 |
| 3 | Significant histological changes are not rare in indeterminate‐phase chronic hepatitis B patients with hepatitis B e antigen‐negative and normal alanine aminotransferase levels显示文摘Background&Objectives:The degree of liver injury in indeterminate chronic hepatitis B(CHB)infection patients with Hepatitis B e antigen(HBeAg)‐negative and persistently normal alanine aminotransferase(PNALT)levels is yet unclear.Therefore,we aimed to assess liver histological changes in such patients by liver biopsy and explore possible predictors.Methods:Overall,711 HBeAg‐negative CHB patients with PNALT levels who underwent liver biopsy from January 2017 to June 2022 were included in this retrospective study.The relationships between histological changes and predictors were assessed by smooth curve fitting and multivariate logistic regression analysis models.Data were also analyzed using American Association for the Study of Liver Disease(AASLD)modified alanine aminotransferase(ALT)criteria.Results:The proportion of significant histological changes in the indeterminate phase was higher than that in the inactive phase(53.97%vs.41.33%).The adjusted odds ratios(aORs)of significant necroinflammation and histological changes for the indeterminate phase were 2.05 and 1.43,respectively,when compared with the inactive phase by multivariate logistic regression analyses.Significant histological changes in the‐phase were positively associated with age,ALT,Aspartate aminotransferase(AST),Hepatitis B surface antigen(HBsAg),and Hepatitis B virus(HBV)DNA levels but negatively correlated with platelet(PLT)levels.HBV DNA≥5 log10 U/L and PLT<200�109/L were independent predictive factors for assessing histological changes in indeterminate‐phase patients.Similar analysis findings were obtained using the two sets of modified ALT criteria.Conclusions:Significant histological changes are not rare in indeterminatephase CHB patients and are higher than in the inactive phase,regardless of the ALT criteria.Histological investigation is strongly suggested for intermediate stage patients with HBV DNA>5 log10 U/L or PLT<200�109/L and antiviral therapy should be considered for such patients. | Deliang Huang Guangde Zhou Jinghan Peng Qinxian Cai Guojun Li Hong Yu Zhibing Zhu Yuanyuan Chen Huiyi Lai Jinyan Jiang Hong Yu Jun Chen | 2023 | iLABMED2023，1，3： | 0 |
| 4 | 土星主要卫星天体测量定标试验显示文摘在地面望远镜观测土星主要卫星的精确定位中,目前普遍采用CCD成像技术。为了测量视场中暗卫星的位置,常采用4颗主要卫星(土卫三-土卫六)进行定标。鉴于技术的进步,目前CCD视场正在逐步增加,如何精确定标图像值得研究。利用2010年1月20日在云南天文台1 m望远镜上观测的不同取向的105幅CCD图像进行了试验研究。采用了美国喷气推进实验室土星主要卫星历表和美国海军天文台的UCAC4恒星星表进行计算,相对于不同的参考对象进行定标。结果表明,采用4颗主要卫星进行定标并测量离卫星较近的观测对象时具有较好的测量准确度和内部精度。测量离定标星较远的卫星时,这种定标方法具有较大的不确定性。采用6颗主要卫星(土卫三-土卫八)进行定标,所有卫星的测量结果具有更好的外部和内部符合。即便如此,采用四常数模型和六常数模型定标的结果都不是令人满意,这揭示CCD视场存在明显的扭曲效应。如果采用视场中的恒星定标,卫星的外部符合和内部精度明显变差,这说明UCAC4恒星参考星表也不是理想的定标用参考星表。 | Jinghan Peng 王娜 | 2017 | 天文研究与技术2017，14，3： | 0 |
| 5 | Time of Liver Function Abnormal Identification on Prediction of the Risk of Anti-tuberculosis-induced Liver Injury显示文摘Background and Aims:Anti-tuberculosis(anti-TB)druginduced liver injury(AT-DILI)is the most common side effect in patients who received anti-TB therapy.AT-DILI management includes monitoring liver function until symptoms arise in patients without high-risk factors for liver damage.The present study aimed to investigate the effect of liver function test(LFT)abnormal identification on the risk of DILI,including liver failure and anti-TB drug resistance in patients without high-risk factors.Methods:A total of 399 patients without high-risk factors for liver damage at baseline and who experienced LFT abnormal during the 6 months of first-line anti-TB treatment were enrolled.The Roussel Uclaf Causal Relationship Assessment Method(RUCAM,2016)was applied in suspected DILI.The correlations between the time of LFT abnormal identification and DILI,liver failure,and anti-TB drug resistance were analyzed by smooth curve fitting and multivariable logistic regression models.Results:Among all study patients,131 met the criteria for DILI with a mean RUCAM causality score of 8.86±0.63.26/131 and 105/131 were in the probable grading and highly probable grading,respectively.The time of abnormal LFT identification was an independent predictor of DILI,liver failure,and anti-TB drug resistance in the crude model and after adjusting for other risk patient factors.The time of abnormal LFT identification was positively correlated with DILI,liver failure,and anti-TB drug resistance.The late identification group(>8 weeks)had the highest risk of DILI,followed by liver failure compared with the other two groups.Conclusions:The time to identification of LFT was positively correlated with DILI,liver failure,and anti-TB drug resistance.The risk of DILI and liver failure was significantly increased in the late identification group with abnormal LFT identified after 8 weeks compared with 4 and 8 weeks.Early monitoring of LFT is recommended for patients without the high-risk factor of DILI after anti-TB treatment is initiated. | Deliang Huang Jinghan Peng Lin Lei Yuanyuan Chen Zhibing Zhu Qingxian Cai Yongcong Deng Jun Chen | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 0 |
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