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| 1 | Power Grid Islands Service Restoration Based on Cloud Computing显示文摘提出了一种基于云计算思想的电网恢复重构方法,利用网络中大量的分布式计算资源加速求取孤岛间网络恢复重构的最优解。利用电力系统分层分布式体系结构将含有多个微网的复杂配电网络视为不同的子云计算区,每个子云计算区根据自身情况将重构的服务请求分解为多个可独立处理的计算块并提交分布的计算节点进行并行处理和结果取优。相关联子云计算区之间可通信以协调不同区域间的负荷转供,最终实现故障恢复重构的目标。算例分析结果验证了该方法的有效性。 | ZHANG Hao HE Jinghan YIN Hang BO Zhiqian B Kirby | 2011 | 中国电机工程学报2011，31，34： | 14 |
| 2 | Fuzzy Synthetic Evaluation of Water Quality of Naoli River Using Parameter Correlation Analysis显示文摘In order to improve the effectiveness of Fuzzy Synthetic Evaluation (FSE) models, a Parameter Correlation Analysis (PCA) was introduced into the FSE and a case study was carried out in the Naoli River in the Sanjiang Plain, Northeast China. The basic principle of the PCA is that the pairs of parameters which are highly correlated and linear with each other would contribute the same information to an assessment and one of them should be eliminated. The method of the PCA is that a correlation relationship among candidate parameters is examined before the FSE. If there is an apparent nonlinear or curvilinear relationship between two parameters, then both will be retained; if the correlation is significant (p<0.01), and the scatter plot suggests a linear relationship, then one of them will be deleted. However, which one will be deleted? For solving this problem, a sensitivity test was conducted and the higher sensitivity parameters remained. The results indicate that the original data should be preprocessed through the PCA for redundancy and variability. The study shows that introducing the PCA into the FSE can simplify the FSE calculation process greatly, while the results have not been changed much. | WANG Jianhua LU Xianguo TIAN Jinghan JIANG Ming | 2008 | Chinese Geographical Science2008，18，4： | 14 |
| 3 | Active injection protection scheme for flexible HVDC grids based on amplitude of input impedance显示文摘High-voltage direct current(HVDC)grids require fast and reliable protection of the DC lines.The performance of traditional protection schemes is easily impaired by the limitations of the boundary condition and nonlinearity from the control of converters.One of the key technologies for flexible HVDC grids is the half-bridge modular multilevel converter(HB-MMC).Considering the high controllability of HB-MMC,this study proposes an active injection protection scheme to improve the reliability and sensitivity of the HVDC grid protection.The HB-MMC is used to inject a sinusoidal characteristic signal,at the specified frequency,into the DC lines.Then,the voltage and current at the specified frequency are extracted using the Prony algorithm to calculate the input impedance,which is used for the identification of internal and external faults.The active injection protection scheme was simulated for various cases in the simulation software Power Systems Computer Aided Design.The simulation results indicate that the proposed protection scheme is highly reliable and can overcome transition resistance. | Jinghan He Keao Chen Meng Li Yong Tang Ming Nie | 2021 | Global Energy Interconnection2021，4，6： | 11 |
| 4 | Tumor-associated macrophages in liver cancer:From mechanisms to therapy显示文摘Multidimensional analyses have demonstrated the presence of a unique tumor microenvironment(TME)in liver cancer.Tumor-associated macrophages(TAMs)are among the most abundant immune cells infiltrating the TME and are present at all stages of liver cancer progression,and targeting TAMs has become one of the most favored immunotherapy strategies.In addition,macrophages and liver cancer cells have distinct origins.At the early stage of liver cancer,macrophages can provide a niche for the maintenance of liver cancer stem cells.In contrast,cancer stem cells(CSCs)or poorly differentiated tumor cells are key factors modulating macrophage activation.In the present review,we first propose the origin connection between precursor macrophages and liver cancer cells.Macrophages undergo dynamic phenotypic transition during carcinogenesis.In this course of such transition,it is critical to determine the appropriate timing for therapy and block specific markers to suppress protumoral TAMs.The present review provides a more detailed discussion of transition trends of such surface markers than previous reviews.Complex crosstalk occurs between TAMs and liver cancer cells.TAMs play indispensable roles in tumor progression,angiogenesis,and autophagy due to their heterogeneity and robust plasticity.In addition,macrophages in the TME interact with other immune cells by directing cell-to-cell contact or secreting various effector molecules.Similarly,tumor cells combined with other immune cells can drive macrophage recruitment and polarization.Despite the latest achievements and the advancements in treatment strategies following TAMs studies,comprehensive discussions on the communication between macrophages and cancer cells or immune cells in liver cancer are currently lacking.In this review,we discussed the interactions between TAMs and liver cancer cells(from cell origin to maturation),the latest therapeutic strategies(including chimeric antigen receptor macrophages),and critical clinical trials for hepatocellular carcinoma(HCC)and intrahepatic cholangiocar-cinoma(iCCA)to provide a rationale for further clinical investigation of TAMs as a potential target for treating patients with liver cancer. | Kun Cheng Ning Cai Jinghan Zhu Xing Yang Huifang Liang Wanguang Zhang | 2022 | Cancer Communications2022，42，11： | 10 |
| 5 | Evaluation of concordance between environment and economy in Qinghai Lake Watershed, Qinghai- Tibet Plateau显示文摘金海·莱克分水岭(QLW ) 现在是一系列生态的恢复和环境补习节目的一个热地方。然而,很少信息都不在这个区域在生态系统服务和经济实践的变化上是可得到的。因为生态系统服务和自然资本与社会、经济的开发是密切相关的,在环境和经济之间的词语索引的一个索引(我 C ) 被建议了把生态系统服务价值(R ESV ) 的年度变化率与粗野国内产品(R GDP ) 的作比较。用这个索引,我们在时期为 QLW 估计了在环境和经济(C ) 之间的词语索引 19772004。结果证明从 1977 ~ 2004,在 QLW 的生态系统服务价值从 128.81 | WANG Jianhua TIAN Jinghan LI Xiaoyan MA Yujun YI Wanjuan | 2011 | Journal of Geographical Sciences2011，21，5： | 10 |
| 6 | Dynamic Load Restoration Considering the Interdependencies Between Power Distribution Systems and Urban Transportation Systems显示文摘After a major outage,mobile emergency resources(MERs)can be dispatched via the transportation system(TS)for service restoration to critical loads in the power distribution system(PDS).In this case study,the efficiency of service restoration in the PDS is associated with the traffic efficiency of the TS,and vice versa,because the PDS and TS are mutually coupled through traffic lights and MERs.This paper proposes a service restoration method considering interdependency between the PDS and TS,which is formulated as a mixed-integer linear program(MILP).The objective includes maximizing the efficiency of both PDS restoration and TS.By solving the MILP,the dynamic load restoration and MER dispatch strategies can be obtained.For the PDS,the availability of MERs,including mobile sources and repair crews,relates to their dispatch in the TS,and their relationship is formulated as mathematical models.For the TS,the dynamic traffic flow is modeled using the cell transmission model and the effect of traffic lights is considered.Case studies validate the effectiveness of the proposed method. | Ying Wang Yin Xu Jiaxu Li Chen Li Jinghan He Jiayu Liu Qiqi Zhang | 2020 | CSEE Journal of Power and Energy Systems2020，6，4： | 9 |
| 7 | Brain dynamic mechanisms on the visual attention scale with Chinese characters cues显示文摘The temporal dynamics in brain evoked by the scale of visual attention with the cues of Chinese characters were studied by recording event-related potentials (ERPs). With the fixed orientation of visual attention, 14 healthy young participants performed a search task in which the search array was preceded by Chinese characters cues, '大, 中, 小' (large, medium, small). 128 channels scalp ERPs were recorded to study the role of visual attention scale played in the visual spatial attention. The results showed that there was no significant difference in the ERP components evoked by the three Chinese characters cues except the in-feroposterior N2 latency. The targets evoked P2, N2 amplitudes and latency have significant differences with the different cues of large, middle and small, while P1 and N1 components had no significant difference. The results suggested that the processing of scale of visual attention was mainly concerned with P2, N2 components, while the P1, N1 components were mainly related with | GAO Wenbin WEI Jinghan PENG Xiaohu WEI Xing LUO Yuejia | 2002 | Chinese Science Bulletin2002，47，19： | 8 |
| 8 | Characterization of the promoter of phosphate transporter TaPHT1.2 differentially expressed in wheat varieties显示文摘TaPHT1.2 is a functional,root predominantly expressed and low phosphate(Pi) inducible high-affinity Pi transporter in wheat,which is more abundant in the roots of P-efficient wheat genotypes(e.g.,Xiaoyan 54) than in P-inefficient genotypes(e.g.,Jing 411) under both Pi-deficient and Pi-sufficient conditions.To characterize TaPHT1.2 further,we genetically mapped a TaPHT1.2 transporter,TaPHT1.2-D1,on the long arm of chromosome 4D using a recombinant inbred line population derived from Xiaoyan 54 and Jing 411,and isolated a 1,302 bp fragment of the TaPHT1.2-D1 promoter(PrTaPHT1.2-D1) from Xiaoyan 54.TaPHT1.2-D1 shows collinearity with OsPHT1.2 that has previously been reported to mediate the translocation of Pi from roots to shoots.PrTaPHT1.2-D contains a number of Pi-starvation responsive elements,including P1BS,WRKY-binding W-box,and helix-loop-helix-binding elements.PrTaPHT1.2-D1 was then used to drive expression of β-glucuronidase(GUS) reporter gene in Arabidopsis through Agrobacterium-mediated transformation.Histochemical analysis of transgenic Arabidopsis plants showed that the reporter gene was specifically induced by Pi-starvation and predominantly expressed in the roots.As there is only one SNP between the TaPHT1.2-D1 promoters of Xiaoyan 54 and Jing 411,and this SNP does not exist within the Pi-starvation responsive elements,the differential expression of TaPHT1.2 in Xiaoyan 54 and Jing 411 may not be caused by this SNP. | Jun Miao Jinghan Sun Dongcheng Liu Bin Li Aimin Zhang Zhensheng Li Yiping Tong | 2009 | Journal of Genetics and Genomics2009，36，8： | 8 |
| 9 | Salmeterol attenuates the inflammatory response in asthma and decreases the pro-inflammatory cytokine secretion of dendritic cells显示文摘Salmeterol 是长行动的 β激活 adenylate cyclase 的 2 收缩筋,引起长持续的 bronchodilation 并且被用于许多年到控制气喘。然而,很少信息都不关于 salmeterol 的 immunoregulatory 效果是可得到的。我们发现 salmeterol 减少在表示了肿瘤坏死 factor-alpha, interleukin-1 和 interleukin-6 的质问变应原的老鼠的一个模型的支持 inflammatory cytokines 的生产。树枝状的房间(DC ) 是介绍抗原的房间并且在航线充当哨兵。我们发现了那 salmeterol (10 −5 mol/l ) 减少了 lipopolysaccharide 引起的发炎(0.1 µ g/ml ) 在激活的鼠科的骨头导出髓的 DC。而且,西方的污点证明这保护的效果被禁止通过原子 factor-kappa B 发信号部分调停(NF-κ B ) ,激活 mitogen 的蛋白质 kinase (MAPK ) 小径和津贴的戏剧性地减少的层次。我们建议 salmeterol 由 modulating DC 调整导致变应原的气喘的发炎。在结论,我们提供 DC 是为对气喘的 salmeterol 的行动负责的目标免疫者房间的证据。 | Zhenli Hu Ruohua Chen Zhijian Cai Lei Yu Yang Fei Lixia Weng Jinghan Wang Xiahui Ge Tianyi Zhu Jianli Wang Chong Bai | 2012 | Cellular & Molecular Immunology2012，9，3： | 8 |
| 10 | Neuronal-like cell differentiation of non-adherent bone marrow cell-derived mesenchymal stem cells显示文摘Non-adherent bone marrow cell-derived mesenchymal stem cells from C57BL/6J mice were separated and cultured using the 'pour-off' method.Non-adherent bone marrow cell-derived mesenchymal stem cells developed colony-forming unit-fibroblasts,and could be expanded by supplementation with epidermal growth factor.Immunocytochemistry showed that the non-adherent bone marrow cell-derived mesenchymal stem cells exposed to basic fibroblast growth factor/epidermal growth factor/nerve growth factor expressed the neuron specific markers,neurofilament-200 and NeuN,in vitro.Non-adherent bone marrow cell-derived mesenchymal stem cells from β-galactosidase transgenic mice were also transplanted into focal ischemic brain (right corpus striatum) of C57BL/6J mice.At 8 weeks,cells positive for LacZ and β-galactosidase staining were observed in the ischemic tissues,and cells co-labeled with both β-galactosidase and NeuN were seen by double immunohistochemical staining.These findings suggest that the non-adherent bone marrow cell-derived mesenchymal stem cells could differentiate into neuronal-like cells in vitro and in vivo. | Yuxin Wu Jinghan Zhang Xiaoming Ben | 2013 | Neural Regeneration Research2013，8，22： | 5 |
| 11 | Mapping and validation of a dominant salt tolerance gene in the cultivated soybean(Glycine max) variety Tiefeng 8显示文摘Salt is an abiotic stress factor that strongly affects soybean growth and production. A single dominant gene has been shown to confer salt tolerance in the soybean cultivar Tiefeng 8.The objective of the present study was to genetically map the salt-tolerance gene in an F2:3population and a recombinant inbred line(RIL) population derived from a cross between two cultivated soybeans, Tiefeng 8(tolerant) and 85-140(sensitive). The F2:3families and RILs were treated with 200 mmol L-1Na Cl to evaluate salt tolerance. The F2:3population showed 1(42 tolerant): 2(132 segregating): 1(65 sensitive) segregation, indicating a single dominant gene for salt tolerance in Tiefeng 8. A sequence-characterized amplified region(SCAR) marker from a previously identified random amplified polymorphic DNA(RAPD)marker and four insertion/deletion polymorphism(In Del) markers were developed within the mapping region. Using these markers along with SSR markers, the salt-tolerance gene was mapped within 209 kb flanked by SCAR marker QS08064 and SSR marker Barcsoyssr_3_1301 on chromosome 3. Three markers that cosegregated with the salt tolerance gene and SCAR marker QS08064 were used to genotype 35 tolerant and 23 sensitive soybean accessions. These markers showed selection efficiencies of 76.2% to94.2%. The results indicate that these markers will be useful for marker-assisted breeding and facilitating map-based cloning of the salt tolerance gene in soybean. | Rongxia Guan Jiangang Chen Jinghan Jiang Guangyu Liu Ying Liu Lei Tian Lili Yu Ruzhen Chang Li-juan Qiu | 2014 | The Crop Journal2014，2，6： | 5 |
| 12 | Magnetic polyamidoamine dendrimers for magnetic separation and sensitive determination of organochlorine pesticides from water samples by high-performance liquid chromatography显示文摘Organochlorine pesticides(OCPs)have received much attention due to their toxicity.Reliable methods to monitor their residues in the environment are needed.Here,magnetic polyamidoamine dendrimers were prepared by co-precipitation,Michael addition,and amidation.The magnetic polyamidoamine dendrimers demonstrated good adsorption ability for OCPs—this feature was utilized to construct a sensitive tool for monitoring OCPs in water samples.The proposed method provided remarkable linearity from 0.1 to 500μg/L and satisfactory limits of detection from 0.012 to 0.029μg/L.The spiked recoveries of the four target analytes were 91.8%-103.5%with relative standard deviations less than 4.5%.The magnetic materials had good reusability.The results indicated that the resulting method was an efficient,easy,rapid,economical,and eco-friendly tool for monitoring OCPs in aqueous samples. | Qingxiang Zhou Yalin Wu Yi Sun Xueying Sheng Yayan Tong Jinghan Guo Boyao Zhou Jingyi Zhao | 2021 | Journal of Environmental Sciences2021，33，4： | 5 |
| 13 | Review of protection and fault handling for a flexible DC grid显示文摘With the development of power electronics technology,the flexible DC grid will play a significant role in promoting the transformation and reformation of the power grid.It is immune to commutation failure and has high flexibility in power control and renewable energy grid integration.However,the protection and fault handling technology for a flexible DC grid is a big challenge because of the limited overcurrent capability of the converters.This paper summarizes the development of the flexible DC grid,and analyzes the fault characteristics in detail.Next,the applicability,advantages and disadvantages of the existing protection principle,fault isolation and recovery schemes are reviewed.Finally,the key problems and development trend of the future flexible DC grid are pointed out and forecasted respectively. | Jinghan He Keao Chen Meng Li Yiping Luo Chenguang Liang Yin Xu | 2020 | Protection and Control of Modern Power Systems2020，5，1： | 5 |
| 14 | Automatic Matching of Multi-scale Road Networks under the Constraints of Smaller Scale Road Meshes显示文摘In this paper,we propose a new method to achieve automatic matching of multi-scale roads under the constraints of smaller scale data.The matching process is:Firstly,meshes are extracted from two different scales road data.Secondly,several basic meshes in the larger scale road network will be merged into a composite one which is matched with one mesh in the smaller scale road network,to complete the N∶1(N>1)and 1∶1 matching.Thirdly,meshes of the two different scale road data with M∶N(M>1,N>1)matching relationships will be matched.Finally,roads will be classified into two categories under the constraints of meshes:mesh boundary roads and mesh internal roads,and then matchings between the two scales meshes will be carried out within their own categories according to the matching relationships.The results show that roads of different scales will be more precisely matched using the proposed method. | Hongxing PEI Renjian ZHAI Fang WU Jinghan LI Xianyong GONG Zheng WU | 2019 | Journal of Geodesy and Geoinformation Science2019，2，4： | 4 |
| 15 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 16 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 17 | A new coordinated backup protection scheme for distribution network containing distributed generation显示文摘This paper proposes a new backup protection scheme,named coordinated backup protection(CBP)scheme,for distribution networks containing distributed generation.The proposed protection scheme takes into account the issues faced by traditional backup protection,such as difficulty in setting parameters and complex cooperation,and considers the features of distribution networks,such as changeable power flow because of high penetration of distributed generation sources and insufficient measuring quantities.The CBP scheme includes two aspects:coordinated substation protection and regional master substation protection,who also work as nearby backup protection and remote backup protection respectively.The two protections support each other by local information coordination and regional information sharing,in order to improve the reliability of fault identification.The configuration principles and performances of the proposed backup protection scheme are addressed in the paper.Different fault conditions in the IEEE 14-node system have been used to illustrate and verify the feasibility of the CBP scheme. | Jinghan He Lin Liu Fanfan Ding Changcheng Li Dahai Zhang | 2017 | Protection and Control of Modern Power Systems2017，2，1： | 3 |
| 18 | Gene expression profiles in intracranial aneurysms显示文摘In this study, we extracted total RNA from 15 intracranial aneurysms and 17 superficial temporal artery samples, then performed genome-wide expression profiling using the Affymetrix U133 Plus 2.0 GeneChip. Genes that were differentially expressed between intracranial aneurysms and arterial samples were identified using significance analysis for microarrays, and the expression patterns of three randomly-selected genes were verified by real-time polymerase chain reaction analysis. We identified 3 736 differentially-expressed genes out of the 47 000 assayed transcripts. A total of 179 genes showed a >10-fold change in expression between the aneurysms and the arterial samples. Genes involved in the proliferation, migration, and apoptosis of vascular muscle cells, atherosclerosis, extracellular matrix disruption, and inflammatory reactions were associated with the formation of intracranial aneurysms. There were no significant differences in gene expression profile between unruptured and ruptured aneurysms. | Lanbing Yu Jinghan Fan Shuo Wang Dong Zhang Rong Wang Yuanli Zhao Jizong Zhao | 2014 | Neuroscience Bulletin2014，30，1： | 3 |
| 19 | Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence in situ hybridization in patients with newly diagnosed multiple myeloma: a single-center study in China显示文摘This study aimed to investigate the prevalence,clinical characteristics,and prognostic impact of 1p32.3 deletion in patients with newly diagnosed multiple myeloma (MM).A retrospective analysis was conducted on 411 patients with newly diagnosed MM;among which,270 received bortezomib-based therapies,and 141 received thalidomide-based therapies.Fluorescence in situ hybridization (FISH) was performed to detect six cytogenetic abnormalities,namely,del(1p32.3),gain(1q21),del(17p13),del(13q14),t(4;14),and t(11;14).Results showed that 8.3% of patients with MM were detected with del(1p32.3) and had significantly more bone marrow plasma cells (P =0.025),higher β2-microglobulin levels (P =0.036),and higher lactate dehydrogenase levels (P =0.042) than those without del(1p32.3).Univariate analysis showed that patients with del(1p32.3) under thalidomide-based therapies were strongly associated with short progression-free survival (PFS) (median PFS 11.6 vs.31.2 months,P =0.002) and overall survival (OS) (median OS 16.8 vs.45.9 months,P < 0.001).Multivariate analysis revealed that del(1p32.3) remained a powerful independent factor with worse PFS (P =0.006) and OS (P =0.016) for patients under thalidomide-based treatments.Patients with del(1 p32.3) under bortezomib-based treatments tended to have short PFS and OS.In conclusion,del(1p32.3) is associated with short PFS and OS in patients with MM who received thalidomide-or bortezomib-based treatments. | Huanping Wang Haitao Meng Jinghan Wang Yinjun Lou Yile Zhou Peipei Lin Fenglin Li Lin Liu Huan Xu Min Yang Jie Jin | 2020 | Frontiers of Medicine2020，14，3： | 2 |
| 20 | Self-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy显示文摘The use of functional nanoparticles as peroxidase-like(POD-like)catalyst has recently become a focus of research in cancer therapy.Phthalocyanine is a macrocyclic conjugated metal ligand,which is expected to achieve a high POD-like catalytic activity,generating free radicals and inhibiting the proliferation of cancer cells.In this paper,we synthesized phthalocyanine nanocrystals with different structures through noncovalent self-assembly confined within micro-emulsion droplets,and manganese phthalocyanine(MnPc)possessing a metal–N–C active center was used as the building block.These nano-assemblies exhibit shape-dependent POD-like catalytic activities,because the emulsifier and MnPc co-mixed assembly reduced the close packing between MnPc molecules and exposed more active sites.The assembly had a water-dispersed nanostructure,which is conducive to accumulation at tumor sites through the enhanced permeability and retention effect(EPR).Because of a highly efficient microenvironmental response,the assembly showed higher catalytic activity only emerged under the acidic tumor-like microenvironment,but caused less damage to normal tissues in biomedical applications.In vivo and in vitro catalytic therapy tests showed excellent anti-tumor effects.This work explored a new way for the application of metal–organic macromolecules such as MnPc as nanozymes for catalytic tumor therapy. | Jinghan Wang Shanqing Gao Xiao Wang Haozhen Zhang Xitong Ren Juewen Liu Feng Bai | 2022 | Nano Research2022，15，3： | 2 |
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