|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-~ signaling pathway显示文摘人参皂甙 Rh2,从人参属人参提取的 triterpene saponin,对多重癌症的展览药理学活动。然而,人参皂甙 Rh2 的 anticancer 机制是不清楚的。在这研究,我们发现人参皂甙 Rh2 有效地禁止生长并且导致 HL-60 房间的 apoptosis。用 microarray 技术,我们发现了那个肿瘤坏死因素 --(TNF-) 清楚地是起来调整的。而且, anti-TNF- 抗体经由 caspase-8, caspase-9,和 caspase-3 激活的抑制减轻了导致 Rh2 的 HL-60 房间 apoptosis。另外, TNF- 起来规定也在另外的对待 Rh2 的癌症房间线被观察。这些结果证明 TNF- 在人参皂甙起一个关键作用导致 Rh2 的房间 apoptosis。 | Jingjia Huang Kunjian Peng Linghao Wang Bin Wen Lin Zhou Tiao Luo Min Su Jijia Li Zhiyong Luo | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 11 |
| 2 | Selective TBK1/IKKi dual inhibitors with anticancer potency显示文摘 | Jijia Li Jingjia Huang Ji‐Hak Jeong Sun‐Jin Park Rui Wei Jieying Peng Zhiyong Luo Yen Ting Chen Yangbo Feng Jun‐Li Luo | 2014 | Int. J. Cancer2014，，： | 1 |
| 3 | Ginsenoside Rh2 inhibits breast cancer cell growth via ERβ-TNFα pathway显示文摘Ginsenoside Rh2 is one of rare panaxidiols extracted from Panax ginseng and a potential estrogen receptor ligand that exhibits moderate estrogenic activity.However,the effect of Rh2 on growth inhibition and its underlying molecular mechanism in human breast cells are not fully understood.In this study,we tested cell viability by MTT and colony formation assays.Cell growth and cell cycle were determined to investigate the effect of ginsenoside Rh2 by flow cytometry.The expressions of estrogen receptors(ERs),TNFα,and apoptosis-related proteins were detected by qPCR and western blot analysis.The mechanisms of ERαand ERβaction were determined using transfection and inhibitors.Antitumor effect of ginsenoside Rh2 against MCF-7 cells was investigated in xenograft mice.Our results showed that ginsenoside Rh2 induced apoptosis and G1/S phase arrest in MCF-7 cells.Treatment of cells with ginsenoside Rh2 down-regulated protein levels of ERα,and up-regulated mRNA and protein levels of ERβand TNFα.We also found that ginsenoside Rh2-induced TNFαover-expression is through up-regulation of ERβinitiated by ginsenoside Rh2.Furthermore,ginsenoside Rh2 induced MCF-7 cell apoptosis via estrogen receptorβTNFαpathway in vivo.These results demonstrate that ginsenoside Rh2 promotes TNFα-induced apoptosis and G1/S phase arrest via regulation of ERβ. | Kunjian Peng Tiao Luo Jijia Li Jingjia Huang Zizeng Dong Jia Liu Chaoqiong Pi Zizeng Zou Qin Gu Ousheng Liu Jian-Ting Zhang Zhi-Yong Luo | 2022 | Acta Biochimica et Biophysica Sinica2022，54，5： | 1 |
| 4 | Diagnosis and treatment of traumatic optic neuropathy with carotid artery cavernous segment pseudoaneurysm显示文摘 | Zhuang Kang Jingjia Li Yan Zou Qintai Yang | 2013 | The Laryngoscope2013，，11： | 1 |
| 5 | Therapeutic values of chick early amniotic fluid(ceAF)that facilitates wound healing via potentiating a SASP-mediated transient senescence显示文摘Inflammatory,proliferative and remodeling phases constitute a cutaneous wound healing program.Therapeutic applications and medication are available;however,they commonly are comprised of fortified preservatives that might prolong the healing process.Chick early amniotic fluids(ceAF)contain native therapeutic factors with balanced chemokines,cytokines and growth-related factors;their origins in principle dictate no existence of harmful agents that would otherwise hamper embryo development.Instead,they possess a spectrum of molecules driving expeditious mitotic divisions and possibly exerting other functions.Employing both in vitro and in vivo models,we examined ceAF's therapeutic potentials in wound healing and found intriguing involvement of transient senescence,known to be intimately intermingled with Senescence Associated Secretory Phenotypes(SASP)that function in addition to or in conjunction with ceAF to facilitate wound healing.In our cutaneous wound healing models,a low dose of ceAF exhibited the best efficacies;however,higher doses attenuated the wound healing presumably by inducing p16 expression over a threshold.Our studies thus link an INK4/ARF locus-mediated signaling cascade to cutaneous wound healing,suggesting therapeutic potentials of ceAF exerting functions likely by driving transient senescence,expediting cellular proliferation,migration,and describing a homeostatic and balanced dosage strategy in medical intervention. | Mashaal Ahmad Yandi Sun Xueyao Jia Jingjia Li Lihong Zhang Ze Yang Yindan Lin Xueyun Zhang Zara Ahmad Khan Jin Qian Yan Luo | 2022 | Genes & Diseases2022，9，5： | 0 |
| 6 | Predicting climate anomalies:A real challenge显示文摘过去几十年,气候变化和极端气候事件造成的经济损失和灾害显著增加.虽然全球的科学家在理解和预测气候变异方面做出了巨大的努力,但当前在气候预测领域仍然存在几个重大难题.2020年,依托于国家自然科学基金基础科学中心项目的气候系统预测研究中心(CCSP)成立了,该中心旨在应对和处理气候预测领域的三大科学难题:厄尔尼诺-南方涛动(ENSO)预测,延伸期天气预报,年际-年代际气候预测,并为更加准确的气候预测和更加有效的灾害防御提供科学依据.因此,本文介绍了CCSP的主要目标和面对的科学挑战,回顾了CCSP在季风动力过程,陆-气相互作用和模式开发,ENSO变率,季节内振荡,气候预测等方面已取得的重要研究成果.未来CCSP将继续致力于解决上述领域的关键科学问题. | Huijun Wang Yongjiu Dai Song Yang Tim Li Jingjia Luo Bo Sun Mingkeng Duan Jiehua Ma Zhicong Yin Yanyan Huang | 2022 | Atmospheric and Oceanic Science Letters2022，15，1： | 0 |
| 7 | Numerical analysis of deflection control of a gas plasma jet based on magnetohydrodynamic staggered electrode configuration显示文摘To control the deflection of the gas plasma jet, a new analytical method is proposed based on the Magnetohydrodynamic(MHD) technique. Based on the typical MHD power generation model, the applied voltage is applied to the staggered electrodes, that is, a pair of electrodes on the same side wall are connected to generate an axial current in the channel. Under the action of the magnetic field perpendicular to the direction of the flow, the plasma is subjected to electromagnetic forces perpendicular to these two directions, and the jet is deflected. The computational model including the Navier-Stokes equations coupled with electromagnetic source terms, the electric potential equation and Ohm’s law is solved. The deflection of the gas jet under the action of an electromagnetic field is observed, and the maximum deflection angle is about 14.8°. The influences of the electric field, magnetic field, and conductivity on the jet deflection are studied. Results show that although the influences of these three factors on the deflection are similar, and the effect of increasing the electric field strength is slightly greater, priority should be given to increasing the magnetic field strength from the perspective of reducing energy consumption. The Stuart number is introduced to assess the ability of electromagnetic force to control jet deflection. When the electromagnetic parameters are constant, this solution provides better control of low-density and low-speed fluid flows. The calculation results show that using the staggered electrode method configuration is feasible in terms of controlling the deflection of a plasma jet deflection. | Jingjia ZHANG Junwei LI Zelin ZHANG Zhijun WEI | 2022 | Chinese Journal of Aeronautics2022，35，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员