3篇
您的检索式：作者名="Jingjian Ma"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neural stem cell transplantation with Nogo-66 receptor gene silencing to treat severe traumatic brain injury显示文摘Inhibition of neurite growth, which is mediated by the Nogo-66 receptor (NgR), affects nerve regeneration following neural stem cell (NSC) transplantation. The present study utilized RNA interference to silence NgR gene expression in NSCs, which were subsequently transplanted into rats with traumatic brain injury. Following transplantation of NSCs transfected with small interfering RNA, typical neural cell-like morphology was detected in injured brain tissues, and was accompanied by absence of brain tissue cavity, increased growth-associated protein 43 mRNA and protein expression, and improved neurological function compared with NSC transplantation alone. Results demonstrated that NSC transplantation with silenced NgR gene promoted functional recovery following brain injury. | Dong Wang Jianjun Zhang Jingjian Ma Yuan Mu Yinghui Zhuang | 2011 | Neural Regeneration Research2011，6，10： | 9 |
| 2 | Expression of Neuropeptide Y in Human Pituitary Adenoma显示文摘OBJECTIVE Neurppeptide Y (NPY) acts as a neuroendocrine modulator in the anterior pituitary, and NPY mRNA and NPY-immunoreactivity have been detected in normal human anterior pituitaries. However, only a few studies of NPY expression in human pituitary adenomas have been published. Our study was conducted to determine whether or not adenoma-tous cells express NPY, to investigate the relationship between NPY expression and the subtypes of pituitary adenoma and to explore the clinical significance of NPY. METHODS The study included tissues from 58 patients with pituitary adenomas who underwent surgery because of their clinical diagnosis. Using a highly specific anti-NPY polyclonal antibody, immunohistochemi-cal analysis was performed on the surgically removed pituitary adenomas. Six fresh specimens also were examined using immuno-electron microscopy. NPY was labeled with colloidal gold in order to study the distribution of NPY at the subcellular level. RESULTS The NPY expression level was significantly different among subgroups of pituitary adenomas (P<0.05). NPY was immuno-detected in 58.6% of all adenomas, in 91.7% of gonadotrophic adenomas and in 14.3% of prolactinomas. NPY expression was slightly lower in invasive pituitary adenomas compared to noninvasive adenomas, but the difference was not significant (t=1.81, P>0.05). Of particular interest was the finding that vascular endothelial cells showed positive NPY expression in some pituitary adenomas. Parts of strongly positive tumor cells were seen in channels formed without endothelial cells, but which contained some red blood cells in a formation similar to so-called vasculogenic mimicry. Im-muno-electron microscopy demonstrated that 4 of the 6 fresh specimens displayed positive NPY staining with a high density of gold particles located mainly in the secretory granulas. In addition, gold particles were sparsely detected in the rough endoplasmic reticulum and cell matrix. CONCLUSION NPY exists in pituitary adenomas and its expression level was related to the types and biological characteristics of the pituitary adenomas. NPY may have a depressive effect on tumor cellular proliferation in pituitary adenomas. NPY possibly participates in modulating an-giogenesis and hemodynamic changes in pituitary adenomas. | Laizhao Chen Jingjian Ma Anchao Zheng Honggang Zheng | 2006 | Chinese Journal of Clinical Oncology2006，3，1： | 3 |
| 3 | On Pentavalent Arc-Transitive Graphs显示文摘在这份报纸,所有五价的弧及物的图的描述被给。每张五价的弧及物的盖住图是盖住图的常规简单或基本的 abelian,这被显示出。特别地,盖住组的基本 abelian 是 3, 5 或 25 的亚群。 | Jingjian Li Jicheng Ma | 2018 | Algebra Colloquium2018，25，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员