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| 1 | Therapeutic targets of Traditional Chinese Medicine for colorectal cancer显示文摘OBJECTIVE: To explore the role of Traditional Chinese Medicine(TCM) in the prevention and treatment of colorectal cancer and identify possible therapeutic targets of TCM to provide clues for the use of TCM for colorectal cancer prevention and treatment in the clinic and to find novel directions for new drug discovery for colorectal cancer.METHODS: We used Pub Med and Google to search for and collect scientific publications for a full evaluation of current evidence in the literature indicating the potential role of Chinese herbal medicines and their respective ingredients as effective candidatesforcolorectalcancerpreventionandtreatment.RESULTS: We extracted a detailed description of potential therapeutic Chinese herbal medicines and their constituent ingredients that target different mechanisms in colorectal cancer such as gene mutation, dysregulation of signaling pathways, metabolism disorders, and the inflammatory microenvironment, including both conventional and non-conventional approaches.CONCLUSION: TCM may be a promising complementary and alternative therapy for the treatment of colorectal cancer. | Li Weidong Li Chunsheng Zheng Honggang Chen Guohong Hua Baojin | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 14 |
| 2 | Interconnected 1D Co3O4 nanowires on reduced graphene oxide for enzymeless H2O2 detection显示文摘无酶的氢过氧化物(H < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 有高敏感和优秀选择的 2 ) 察觉为临床的诊断是合乎需要的。此处,一个维的公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 nanowires 成功地经由一个简单热水的过程和随后的热处理在减少的 graphene 氧化物(rGO ) 上被构造了。这些公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 nanowires,由小 nanoparticles 集合了,与对方一起被交叉并且在 rGO 上使一只蜘蛛成为像网的结构。公司的形成 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 个 -rGO 混血儿被归因于 DDA 的指导结构、抛锚的角色并且分别地去。产生结构为事散开拥有丰富的活跃地点,电子的面向的传播,和未受阻碍的小径,它资助公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 有优秀 electrocatalytic 性能的 4 个 -rGO 混血儿。作为结果,获得的公司<潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 个 -rGO 混血儿能为 H 用作有效电气化学的催化剂<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”> 2 氧化和高度敏感察觉。在生理的条件下面, H 的氧化电流<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”> 2 与 1.14 妈的敏感从 0.015~0.675 公里关于它的集中线性地变化?????????????? | Lingjun Kong Zhiyu Ren Nannan Zheng Shichao Du Jun Wu Jingling Tang Honggang Fu | 2015 | Nano Research2015，8，2： | 7 |
| 3 | Effect of Zhu-yuan decoction in patients with chronic rhinosinusitis after functional endoscopic sinus surgery显示文摘OBJECTIVE: To investigate the effectiveness and safety of Zhu-yuan decoction(ZYD) in patients after functional endoscopic sinus surgery(FESS).METHODS: A total of 85 patients were randomized into two groups: 44 were treated with intranasal corticosteroids(INC), and 41 were given Chinese herbal medicine(CHM). Patients with chronic rhinosinusitis(CRS) who underwent FESS were prospectively enrolled in the study. Before surgery, they were evaluated by visual analog scale(VAS), nasal endoscopy, computed tomography(CT), and routine blood test. After surgery, they were randomized to take ZYD or INC for 12 weeks and revaluated by VAS; nasal endoscopy at 4, 8, and 12 weeks;and CT at 12 weeks after surgery.RESULTS: In the both groups, VAS and endoscopyscores decreased significantly at 4, 8, and 12 weeks,and CT scores after treatment declined at 12 weeks compared with baseline scores. No significant differences were observed with regard to postoperative VAS, endoscopy, or CT scores between groups.ZYD, combined with surgery, can reduce VAS, nasal endoscopy, and CT scores and has the same efficacy and safety profile as INC in post-FESS management.No fatalities or major adverse events occurred in either group.CONCLUSION: Our findings suggest that ZYD has similar effects and safety profiles in patients after FESS compared with INC. | Li Jing Zheng Chunquan Lin Hai Yang Chen Gu Siyuan Wang Yi Duan Honggang | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 3 |
| 4 | Fecal microbiota transplantation through mid‐gut for refractory C rohn’s disease: Safety, feasibility, and efficacy trial results显示文摘 | Bota Cui Qiang Feng Honggang Wang Min Wang Zhaoyuan Peng Pan Li Guangming Huang Zheng Liu Ping Wu Zhining Fan Guozhong Ji Xin Wang Kaichun Wu Daiming Fan Faming Zhang | 2015 | J Gastroenterol Hepatol2015，，1： | 3 |
| 5 | Expression of Neuropeptide Y in Human Pituitary Adenoma显示文摘OBJECTIVE Neurppeptide Y (NPY) acts as a neuroendocrine modulator in the anterior pituitary, and NPY mRNA and NPY-immunoreactivity have been detected in normal human anterior pituitaries. However, only a few studies of NPY expression in human pituitary adenomas have been published. Our study was conducted to determine whether or not adenoma-tous cells express NPY, to investigate the relationship between NPY expression and the subtypes of pituitary adenoma and to explore the clinical significance of NPY. METHODS The study included tissues from 58 patients with pituitary adenomas who underwent surgery because of their clinical diagnosis. Using a highly specific anti-NPY polyclonal antibody, immunohistochemi-cal analysis was performed on the surgically removed pituitary adenomas. Six fresh specimens also were examined using immuno-electron microscopy. NPY was labeled with colloidal gold in order to study the distribution of NPY at the subcellular level. RESULTS The NPY expression level was significantly different among subgroups of pituitary adenomas (P<0.05). NPY was immuno-detected in 58.6% of all adenomas, in 91.7% of gonadotrophic adenomas and in 14.3% of prolactinomas. NPY expression was slightly lower in invasive pituitary adenomas compared to noninvasive adenomas, but the difference was not significant (t=1.81, P>0.05). Of particular interest was the finding that vascular endothelial cells showed positive NPY expression in some pituitary adenomas. Parts of strongly positive tumor cells were seen in channels formed without endothelial cells, but which contained some red blood cells in a formation similar to so-called vasculogenic mimicry. Im-muno-electron microscopy demonstrated that 4 of the 6 fresh specimens displayed positive NPY staining with a high density of gold particles located mainly in the secretory granulas. In addition, gold particles were sparsely detected in the rough endoplasmic reticulum and cell matrix. CONCLUSION NPY exists in pituitary adenomas and its expression level was related to the types and biological characteristics of the pituitary adenomas. NPY may have a depressive effect on tumor cellular proliferation in pituitary adenomas. NPY possibly participates in modulating an-giogenesis and hemodynamic changes in pituitary adenomas. | Laizhao Chen Jingjian Ma Anchao Zheng Honggang Zheng | 2006 | Chinese Journal of Clinical Oncology2006，3，1： | 3 |
| 6 | IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas显示文摘The insulin-like growth factor 1 receptor(IGF-1R)governs several signaling pathways for cell proliferation,survival,and antiapoptosis.Thus,targeting IGF-1R appears as a reasonable rationale for tumor treatment.However,clinical studies showed that inhibition of IGF-1R has very limited efficacy due to the development of resistance to IGF-1R blockade in tumor cells.Here,we discovered that prolonged treatment of colon cancer cells with IGF-1R inhibitors(BMS-754807 and GSK1838705A)stimulates p70 KDa ribosomal protein S6 kinase 1(p70S6K1)activation,a well-known kinase signaling for cell survival.We also found that p70S6K1 activation by IGF-1R inhibition is independent of K-Ras and PIK3CA mutations that frequently occur in colon cancer.Besides the increased p70S6K1 phosphorylation,the phosphorylation of mitogen-activated protein kinase kinase 1 and 2(MEK1/2)was elevated in the cells treated with BMS-754807.Interestingly,the increases in MEK1/2 and p70S6K1 phosphorylation were also observed when cells were subjected to the treatment of AKT inhibitor or genetic knockdown of AKT2 but not AKT1,suggesting that AKT2 inhibition stimulates MEK1/2 phosphorylation to activate p70S6K1.Conversely,inhibition of MEK1/2 by MEK1/2 inhibitor(U0126)or knockdown of MEK1 and MEK2 by corresponding mek1 and mek2 siRNA enhanced AKT phosphorylation,indicating mutual inhibition between AKT and MEK.Furthermore,the combination of BMS-754807 and U0126 efficiently decreased the cell viability and increased cleaved caspase 3 and apoptosis in vitro and in vivo.Our data suggest that the treatment of colon tumor cells with IGF-1R inhibitors stimulates p70S6K1 activity via MEK1/2 to promote survival,providing a new strategy for colorectal cancer therapeutics. | Qing Wang Yan Zhang Jiang Zhu Honggang Zheng Shuntai Chen Li Chen Hsin-Sheng Yang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 7 | Extinction of the zero-phonon line and the first-order phonon sideband in excitonic luminescence of ZnO at room temperature: the self-absorption effect显示文摘It is firmly demonstrated in experiment that the self-absorption(SA) effect can lead to the extinction of the zero-phonon line and the first-order longitudinal optical phonon sideband of free excitonic luminescence of ZnO at room temperature. Moreover, effectiveness degree of SA effect is found to be dependent on both absorption coefficient and travelling distance of emitted photons, as well as even lattice temperature, which is uniquely reflected by the redshift amount in emission peak in ZnO. It is also unambiguously proved that the SA effect still strictly obeys the Beer-Lambert law of absorption. This work not only uncovers the long-term puzzle of significant redshift of emission peak of ZnO at higher temperatures, but also shows that the SA effect may have to be carefully taken into consideration in the study of spontaneous emission, laser and relevant optoelectronic processes in luminescent materials and optoelectronic devices. | Honggang Ye Zhicheng Su Fei Tang Changcheng Zheng Guangde Chen Jian Wang Shijie Xu | 2017 | Science Bulletin2017，62，22： | 2 |
| 8 | Block Copolymer Networks Composed of Poly(ε-caprolactone) and Polyethylene with Triple Shape Memory Properties显示文摘In this contribution, we reported a novel synthesis of block copolymer networks composed of poly(ε-caprolactone)(PCL) and polyethylene(PE) via the co-hydrolysis and condensation of α,ω-ditriethoxylsilane-terminated PCL and PE telechelics. First, α,ω-dihydroxylterminated PCL and PE telechelics were synthesized via the ring-opening polymerization of ε-caprolactone and the ring-opening metathesis polymerization of cyclooctene followed by hydrogenation of polycyclooctene. Both α,ω-ditriethoxylsilane-terminated PCL and PE telechelics were obtained via in situ reaction of α,ω-dihydroxyl-terminated PCL and PE telechelics with 3-isocyanatopropyltriethoxysilane. The formation of networks was evidenced by the solubility and rheological tests. It was found that the block copolymer networks were microphase-separated. The PCL and PE blocks still preserved the crystallinity. Owing to the formation of crosslinked networks, the materials displayed shape memory properties. More importantly, the combination of PCL with PE resulted that the block copolymer networks had the triple shape memory properties, which can be triggered with the melting and crystallization of PCL and PE blocks. The results reported in this work demonstrated that triple shape memory polymers could be prepared via the formation of block copolymer networks. | Honggang Mei Bingjie Zhao Yuan Gao Lei Li Liyue Liu Sixun Zheng | 2022 | Chinese Journal of Polymer Science2022，40，2： | 1 |
| 9 | Generalized cryptanalysis of RSA with small public exponent显示文摘In this paper, we demonstrate that there exist weak keys in the RSA public-key cryptosystem with the public exponent e = N~α N^(0.5). In 1999, Boneh and Durfee showed that when α≈ 1 and the private exponent d = N~β< N^(0.292), the system is insecure. Moreover, their attack is still effective for 0.5 < α < 1.875.We propose a generalized cryptanalytic method to attack the RSA cryptosystem with α≤0.5. For c = [(1-α)/α] and e^(γc)≡ d(mod e^c), when γ, β satisfy γ < 1+1/c-1/(2αc) and β < αc +7/6- αγc-1/3(6α + 6αc + 1- 6αγc)^(1/2), we can perform cryptanalytic attacks based on the LLL algorithm. The basic idea is an application of Coppersmith's techniques and we further adapt the technique of unravelled linearization, which leads to an optimized lattice.Our advantage is that we achieve new attacks on RSA with α 0.5 and consequently, there exist weak keys in RSA for most α. | Mengce ZHENG Honggang HU Zilong WANG | 2016 | Science China(Information Sciences)2016，59，3： | 1 |
| 10 | PSWF-based Direct-Sequence UWB Transmission Using Orthogonal Ternary Code Sets显示文摘 | Chihong Cho Honggang Zhang Zheng Zhou | 2006 | IEEE CCNC2006，，： | 1 |
| 11 | Transformation of Commodity Poly(hydroxyether of bisphenol A)into Vitrimers via Post Crosslinking with Hindered Urea Bonds显示文摘In this contribution,we reported the preparation of vitrimers by using commodity thermoplastics via post crosslinking with hindered urea bonds(HUBs).First,three hindered urea diisocyanates(HUDIs)were synthesized via the reactions of N,N'-di-tert-butylethylenediamine,N,N'-diethylethylenediamine,and piperazine with isophorone diisocyanate(IPDI).Thereafter,these HUDIs were used as the crosslinking agents to crosslink poly(hydroxyether of bisphenol A)(PH),a commodity thermoplastics.Fourier transform infrared(FTIR)spectroscopy and dynamic mechanical thermal analyses(DMTA)indicated that the PH thermosets were successfully obtained.It was found that the thermosets displayed the behavior of vitrimers.The PH thermosets can be reprocessed at elevated temperature without using catalyst and the mechanical strengths of vitrimers were recovered as high as 95%.The reprocessing properties are attributable to dynamic exchange reaction of hindered urea bonds,contingent on types of hindered urea bonds. | Hao Ding Bingjie Zhao Honggang Mei Lei Li Sixun Zheng | 2020 | Chinese Journal of Polymer Science2020，38，9： | 1 |
| 12 | A radar waveform bandwidth selection strategy for wideband tracking显示文摘Dear editor, The performance of radar target detection and tracking is greatly influenced by waveform bandwidth. Ref. proposes that very narrowband waveforms are usually employed for search, narrowband waveforms are used for tracking, and wideband waveforms are used for classification. Ref. considers that ballistic missiles may impose the challenge of closely space objects (CSO), and tracking in a CSO environment may motivate high-resolution tracking waveforms to ensure firm tracks on individual objects. Thus, according to practical requirements, narrowband and wideband waveforms are employed for target cued search/acquisition and stable tracking, respectively . | Shaoqiang CHANG Honggang ZHANG Teng LONG Quanhua LIU Le ZHENG | 2019 | Science China(Information Sciences)2019，62，4： | 1 |
| 13 | Study on realgas equations of high pressure hydrogen 显示文摘 | Chen Honggang Zheng Jinyang Xu Ping | 2010 | International Journal of Hydrogen Energy2010，35，7： | 1 |
| 14 | An application of stochastic resonance for energy harvest- ing in a bistable vibrating system显示文摘 | Rencheng Zheng Kimihiko Nakano Honggang Hu | 2014 | Journal of Sound and Vibration2014，，333： | 1 |
| 15 | Research on Online Leakage Assessment显示文摘Leakage assessment is the most common approach applied for assessing side-channel information leakage and validating the effectiveness of side-channel countermeasures.Established evaluation approaches are usually based on Test Vector Leakage Assessment(TVLA)that deployed in a divide and conquer flow with offline computations,which causes two apparent shortcomings in required memory and time.In this paper,a lightweight framework of online leakage assessment is proposed.The problems were analyzed and the evaluation approach was further validated with a Field Programmable Gate Array(FPGA).The experimental results show that it can implement online processing on newly collected data,and instantly stop to give the result when detecting credible leakage.The online leakage assessment can significantly economize on memory and time.It has good performance when there is limited memory or real-time evaluations are needed. | Zhengguang Shi Fan Huang Mengce Zheng Wenlong Cao Ruizhe Gu Honggang Hu Nenghai Yu | 2020 | 国际计算机前沿大会会议论文集2020，，2： | 0 |
| 16 | Supramolecular precursor derived loofah sponge-like Fe_(2)O_(x)/C for effective synergistic reaction of Fenton and photocatalysis显示文摘Fenton or photocatalytic degradations of organic contaminants are recognized as promising approaches to address the increasing environmental pollution issues.Herein,we develop the effective synergistic catalysis reaction of Fenton and photocatalysis based on a loofah sponge-like Fe_(2)O_(x)/C nanocomposite,which exhibits excellent nitrobenzene photocatalytic degradation property.It is noted that Fe2O3 nanoparticles with surface Fe^(2+) species were encapsulated with an ultrathin carbon layer(denoted as Fe_(2)O_(x)/C)via a supramolecular self-sacrificing template and following thermal treatment process.The experimental results indicated that the thin layer carbon coating not only inhibited the Fe iron leaching from the Fe_(2)O_(x)but also prompted the separation and transferring of electrons–hole pairs.The introduction of Fe_(2)O_(x)/C enables the Fenton reaction to induce a rapid Fe^(2+)/Fe^(3+)cycle,and meanwhile,together with the photocatalytic reaction to produce continuous active substances for the subsequent degradation catalytic reaction without successive H2O2,resulting in the inexpensive and the effective photocatalytic procedure.As a result,100%nitrobenzene(100 mg/L)was degraded and 97%of the organic carbon was mineralized in 90 min using the Fe_(2)O_(x)/C(0.1 g/L)at a low H_(2)O_(2) dosage(0.50 mM),under air mass(AM)1.5 irradiation.Theoretical calculations confirmed that the Fe_(2)O_(x)/C-600 with thin carbon layer promoted the dissociation of H2O2 and the·OH desorption.The synergistic catalysis of this work may provide new ideas for low-cost and more efficient treatment of pollutants. | Chen Zhao Shien Guo Qi Li Jianan Liu Mang Zheng Xudong Xiao Baojiang Jiang Honggang Fu | 2022 | Nano Research2022，15，3： | 0 |
| 17 | Preliminary study on heat flux measurement data of TT-0 flight test显示文摘With the explosive development of aerospace science,the design of the new generation airliner at higher speeds is attracting more attentions.To achieve this goal,it is necessary to achieve accurate prediction of the aerodynamic heating/force loads and successful reduction of drag and heat flux.As a remedy for the existing studies which are based upon the CFD and wind tunnel tests,this study presents a flight test for the drag and heat reduction spike technology.The principal goals of this flight test were to provide reference for verifying the accuracy of the prediction technology on ground and promote the development of the drag and heat reduction technology.By adopting the OS-X rocket,the TT-0 test vehicle designed by Shenyang Aircraft Design&Research Institute reached a maximum Mach number of 5.8 and a maximum altitude of 38 km.Hypersonic and supersonic pressure data by pressure scanning valves and heat fluxes by gauges at different locations were obtained successfully.Also,heat fluxes obtained by in-house CFD code are illustrated in comparison with the flight data.The results indicate that the numerical errors are large in most cases.More technologies,such as more CFD codes and more numerical procedures,should be adopted to conduct studies on this issue in the future. | Enwei LU Linxuan ZUO Zheng GUO Honggang ZENG Wei ZHU Feng QU | 2021 | Chinese Journal of Aeronautics2021，34，5： | 0 |
| 18 | Discovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice显示文摘Stapled peptides with significantly enhanced pharmacological profiles have emerged as promising therapeutic molecules due to their remarkable resistance to proteolysis and performance to penetrate cells.The all-hydrocarbon peptide stapling technique has already widely adopted with great success,yielding numerous potent peptide-based molecules.Based on our prior efforts,we conceived and prepared a double-stapled peptide in this study,termed FRNC-1,which effectively attenuated the bone resorption capacity of mature osteoclasts in vitro through specific inhibition of phosphorylated GSK-3β.The double-stapled peptide FRNC-1 displayed notably improved helical contents and resistance to proteolysis than its linear form.Additionally,FRNC-1 effectively prevented osteoclast activation and improved bone density for ovariectomized(OVX)mice after intravenous injection and importantly,after oral(intragastric)administration.The double-stapled peptide FRNC-1 is the first orally effective peptide that has been validated to date as a therapeutic candidate for postmenopausal osteoporosis(PMOP). | Wei Cong Huaxing Shen Xiufei Liao Mengjun Zheng Xianglong Kong Zhe Wang Si Chen Yulei Li Honggang Hu Xiang Li | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 19 | Recent advances in chemical protein synthesis:method developments and biological applications显示文摘The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes,the study of which necessitates advanced methods to produce proteins with precision and versatility.Chemical protein synthesis,a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins,has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery,including post-translationally modified proteins,proteins comprised of unnatural amino acids,as well as mirror-image proteins.This review summarizes recent strides in synthetic method developments for chemical protein synthesis,including innovative techniques in solid-phase peptide synthesis,the challenges presented by difficult sequences in either synthesis or folding and the exploration of novel ligation reactions using both chemical and enzymatic methods.Furthermore,the review also delves into newly developed protocols for site-selective protein modifications and the generation of stapled or macrocyclized peptides/miniproteins,highlighting the power of chemical methods to make structurally diverse proteins.Recent applications of synthetic proteins in investigating post-translational modifications(phosphorylation,lipidation,glycosylation,ubiquitination,etc.),mirror-image biological processes and drug development are further discussed.Together,these topics provide a comprehensive overview of the current landscape of chemical protein synthesis. | Suwei Dong Ji-Shen Zheng Yiming Li Huan Wang Gong Chen Yongxiang Chen Gemin Fang Jun Guo Chunmao He Honggang Hu Xuechen Li Yanmei Li Zigang Li Man Pan Shan Tang Changlin Tian Ping Wang Bian Wu Chuanliu Wu Junfeng Zhao Lei Liu | 2024 | Science China Chemistry2024，67，4： | 0 |
| 20 | Low-complexity detection based on maximum cumulative measure and Laurent decomposition for multi-h CPM signal显示文摘In order to solve the problem of high computational complexity in demodulation for multi-h continuous phase modulation(CPM) signal, a maximum cumulative measure combing with the Laurent decomposition(MCM-LD) scheme is proposed to reduce the number of the grid states and the required number of matched filters, which degrades the demodulation complexity at the receiver.The advanced range telemetry(ARTM) Tier Ⅱ CPM signal is adopted to evaluate the performance in simulation. The results show that, compared with the traditional maximum likelihood sequence detection(MLSD), MCM-LD can respectively reduce the numbers of grid states and matched filters from 256 to 32 and 128 to 48 with negligible performance loss, which effectively degrades the computational complexity for multi-h CPM signal. | Zheng Zhidong Yu Yanming Liu Ning Yuan Honggang Lou Ning | 2022 | The Journal of China Universities of Posts and Telecommunications2022，29，6： | 0 |
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