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| 1 | Curcumin inhibits the invasion of lung cancer cells by modulating thePKCα/Nox-2/ROS/ATF-2/MMP-9 signaling pathway显示文摘 | Zhigang Fan Xiaoyi Duan Hui Cai Li Wang Min Li Jingkun Qu Wanjun Li Yongheng Wang Jiansheng Wang | 2015 | Oncology Reports2015，，2： | 2 |
| 2 | Transcriptomic analysis reveals putative osmoregulation mechanisms in the kidney of euryhaline turbot Scophthalmus maximus responded to hypo-saline seawater显示文摘Turbot harbor a relatively remarkable ability to adapt to opposing osmotic challenges and are an excellent model species to study the physiological adaptations of flounder associated with osmoregulatory plasticity.The kidney transcriptome of turbot treated 24 h in water of hypo-salinity(salinity 5)and seawater(salinity 30)was sequenced and characterized.In silico analysis indicated that all unigenes had significant hits in seven databases.The functional annotation analysis of the transcriptome showed that the immune system and biological processes associated with digestion,absorption,and metabolism played an important role in the osmoregulation of turbot in response to hypo-salinity.Analysis of biological processes associated with inorganic channels and transporters indicated that mineral absorption and bile secretion contributed to iono-osmoregulation resulting in cell volume regulation and cell phenotypic plasticity.Moreover,we analyzed and predicted the mechanisms of canonical signaling transduction.Biological processes involved in renin secretion,ECM-receptor interaction,adherens junction,and focal adhesion played an important role in the plasticity phenotype in hypo-stress,while the signal transduction network composed of the MAPK signaling pathway and PI3K-Akt signaling pathway with GABAergic synapse,worked in hypoosmoregulation signal transduction in the turbot.In addition,analysis of the tissue specificity of targeted gene expression using qPCR during salinity stress was carried out.The results showed that the kidney,gill,and spleen were vital regulating organs of osmotic pressure,and the osmoregulation pattern of euryhaline fish dif fered among species. | CUI Wenxiao MA Aijun HUANG Zhihui WANG Xin’an SUN Zhibin LIU Zhifeng ZHANG Wei YANG Jingkun ZHANG Jinsheng QU Jiangbo | 2020 | Journal of Oceanology and Limnology2020，38，2： | 1 |
| 3 | Ecological Barrier Deterioration Driven by Human Activities Poses Fatal Threats to Public Health due to Emerging Infectious Diseases显示文摘The coronavirus disease 2019(COVID-19)and concerns about several other pandemics in the 21st century have attracted extensive global attention.These emerging infectious diseases threaten global public health and raise urgent studies on unraveling the underlying mechanisms of their transmission from animals to humans.Although numerous works have intensively discussed the cross-species and endemic barriers to the occurrence and spread of emerging infectious diseases,both types of barriers play synergistic roles in wildlife habitats.Thus far,there is still a lack of a complete understanding of viral diffusion,migration,and transmission in ecosystems from a macro perspective.In this review,we conceptualize the ecological barrier that represents the combined effects of cross-species and endemic barriers for either the natural or intermediate hosts of viruses.We comprehensively discuss the key influential factors affecting the ecological barrier against viral transmission from virus hosts in their natural habitats into human society,including transmission routes,contact probability,contact frequency,and viral characteristics.Considering the significant impacts of human activities and global industrialization on the strength of the ecological barrier,ecological barrier deterioration driven by human activities is critically analyzed for potential mechanisms.Global climate change can trigger and expand the range of emerging infectious diseases,and human disturbances promote higher contact frequency and greater transmission possibility.In addition,globalization drives more transmission routes and produces new high-risk regions in city areas.This review aims to provide a new concept for and comprehensive evidence of the ecological barrier blocking the transmission and spread of emerging infectious diseases.It also offers new insights into potential strategies to protect the ecological barrier and reduce the wide-ranging risks of emerging infectious diseases to public health. | Dayi Zhang Yunfeng Yang Miao Li Yun Lu Yi Liu Jingkun Jiang Ruiping Liu Jianguo Liu Xia Huang Guanghe Li Jiuhui Qu | 2022 | Engineering2022，8，3： | 0 |
| 4 | Inhaled heparin polysaccharide nanodecoy against SARS-CoV-2 and variants显示文摘To the Editor:As of January 27,2022,there were 363,062,293 cases and 5,645,884deaths from the COVID-19 pandemic1.The prevalent mutated strains have aggravated the global pandemic2.SARS-Co V-2 is highly mutable,and the mutations on the spike(S)protein resulted in a high transmission of COVID-19 and vaccine breakthrough infection3.For example,there is a notable decrease in neutralizing ability of BNT162b2 vaccination-elicited antibodies against the Delta and other variants4,5,and attenuation of peak viral burden and vaccine effectiveness are reduced with Delta variant6. | Bin Tu Huiyuan Wang Xinran An Jingkun Qu Qianqian Li Yanrong Gao Mingjie Shi Hong Qiu Yongzhuo Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 0 |
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