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| 1 | Simultaneous Curvature and Temperature Sensing Based on a Novel Mach-Zehnder Interferometer显示文摘A novel fiber inline Mach-Zehnder interferometer(MZI)is proposed for simultaneous measurement of curvature and temperature.The sensor composes of single mode-multimode-dispersion compensation-multimode-single mode fiber(MMF-DCF-MMF)structure,using the direct fusion technology.The experimental results show curvature sensitivities of−12.82 nm/m^(−1) and−14.42 nm/m^(−1) in the range of 0−0.65 m^(−1) for two resonant dips,as well as temperature sensitivities of 57.6 pm/and 74.3℃pm/within the range of 20℃℃−150.In addition,℃the sensor has unique advantages of easy fabrication,low cost,high fringe visibility of 24 dB,and high sensitivity,which shows a good application prospect in dual-parameters of sensing of curvature and temperature. | Xiaoyan SUN Haifeng DU Xinran DONG Youwang HU Ji’an DUAN | 2020 | Photonic Sensors2020，10，2： | 4 |
| 2 | Multidrug dissolvable microneedle patch for the treatment of recurrent oral ulcer显示文摘Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral ulcers.The ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin C.In vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone alone.Cell proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C alone.The healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in rats.ROUMN as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral ulcers.The rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers. | Yuqiong Wang An’an Sheng Xinran Jiang Shanshan Yang Long Lin Mingzhu Yang Fengshuo Zhu Yongyan Hu Jian Li Lingqian Chang | 2023 | Bio-Design and Manufacturing2023，6，3： | 1 |
| 3 | New analytic solutions to 2D transient heat conduction problems with/without heat sources in the symplectic space显示文摘The two-dimensional(2D)transient heat conduction problems with/without heat sources in a rectangular domain under different combinations of temperature and heat flux boundary conditions are studied by a novel symplectic superposition method(SSM).The solution process is within the Hamiltonian system framework such that the mathematical procedures in the symplectic space can be implemented,which provides an exceptional direct rigorous derivation without any assumptions or predetermination of the solution forms compared with the conventional inverse/semi-inverse methods.The distinctive advantage of the SSM offers an access to new analytic heat conduction solutions.The results obtained by the SSM agree well with those obtained from the finite element method(FEM),which confirms the accuracy of the SSM. | Dian XU Xinran ZHENG Dongqi AN Chao ZHOU Xiuwen HUANG Rui LI | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，8： | 0 |
| 4 | Inhaled heparin polysaccharide nanodecoy against SARS-CoV-2 and variants显示文摘To the Editor:As of January 27,2022,there were 363,062,293 cases and 5,645,884deaths from the COVID-19 pandemic1.The prevalent mutated strains have aggravated the global pandemic2.SARS-Co V-2 is highly mutable,and the mutations on the spike(S)protein resulted in a high transmission of COVID-19 and vaccine breakthrough infection3.For example,there is a notable decrease in neutralizing ability of BNT162b2 vaccination-elicited antibodies against the Delta and other variants4,5,and attenuation of peak viral burden and vaccine effectiveness are reduced with Delta variant6. | Bin Tu Huiyuan Wang Xinran An Jingkun Qu Qianqian Li Yanrong Gao Mingjie Shi Hong Qiu Yongzhuo Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 0 |
| 5 | Abiotic Hydrocarbons Generation Simulated by Fischer-Tropsch Synthesis under Hydrothermal Conditions in Ultradeep Basins显示文摘FTT experiments with water as a hydrogen source and three types of possible carbon sources in the subsurface(diiron nonacarbonyl,siderite and formic acid,representing CO,CO_(2)and a simple organic acid,respectively)were carried out in this study.Our experimental results showed that n-alkanes with the highest carbon number of C_(33)were produced when CO was used as a carbon source(series A);a variety of polycyclic aromatic hydrocarbons(PAHs)were detected in series B with CO_(2)as a carbon source;gaseous hydrocarbons were also detected with formic acid added(series C).The different products in the three series showed that there were different hydrocarbon generation mechanisms and reaction processes with different carbon sources.The generation of long-chain n-alkanes in series A provided experimental support for the formation of abiogenic petroleum underground,which was of significance to early membranes on the Earth.PAHs in series B provide experimental support for the possibility of an abiotic source of reduced carbon on other planets.The carbon isotopes of gaseous hydrocarbons produced by CO exhibited a partial reversed order(δ^(13)C_(1)<δ^(13)C_(2)>δ^(13)C_(3)>δ^(13)C_(4)>δ^(13)C_(5)),while the gaseous hydrocarbons produced by CO_(2)and HCOOH showed a positive order(δ^(13)C_(1)<δ^(13)C_(2)<δ^(13)C_(3)<δ^(13)C_(4)<δ^(13)C_(5)).Based on these,the alkylene mechanism and the carbonyl insertion mechanism were used to reasonably explain these characteristics. | ZHAO Zhongfeng LIU Xinran LU Hong Peng Ping’an | 2022 | Acta Geologica Sinica(English Edition)2022，96，4： | 0 |
| 6 | Localized delivery of nanomedicine and antibodies for combating COVID-19显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has been a major health burden in the world.So far,many strategies have been investigated to control the spread of COVID-19,including social distancing,disinfection protocols,vaccines,and antiviral treatments.Despite the significant achievement,due to the constantly emerging new variants,COVID-19 is still a great challenge to the global healthcare system.It is an urgent demand for the development of new therapeutics and technologies for containing the wild spread of SARS-CoV-2.Inhaled administration is useful for the treatment of lung and respiratory diseases,and enables the drugs to reach the site of action directly with benefits of decreased dose,improved safety,and enhanced patient compliance.Nanotechnology has been extensively applied in the prevention and treatment of COVID-19.In this review,the inhaled nanomedicines and antibodies,as well as intranasal nanodrugs,for the prevention and treatment of COVID-19 are summarized. | Bin Tu Yanrong Gao Xinran An Huiyuan Wang Yongzhuo Huang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
| 7 | A subpopulation of CD146^(+) macrophages enhances antitumor immunity by activating the NLRP3 inflammasome显示文摘As one of the main tumor-infiltrating immune cell types, tumor-associated macrophages (TAMs) determine the efficacy of immunotherapy. However, limited knowledge about their phenotypically and functionally heterogeneous nature restricts their application in tumor immunotherapy. In this study, we identified a subpopulation of CD146+ TAMs that exerted antitumor activity in both human samples and animal models. CD146 expression in TAMs was negatively controlled by STAT3 signaling. Reducing this population of TAMs promoted tumor development by facilitating myeloid-derived suppressor cell recruitment via activation of JNK signaling. Interestingly, CD146 was involved in the NLRP3 inflammasome-mediated activation of macrophages in the tumor microenvironment, partially by inhibiting transmembrane protein 176B (TMEM176B), an immunoregulatory cation channel. Treatment with a TMEM176B inhibitor enhanced the antitumor activity of CD146+ TAMs. These data reveal a crucial antitumor role of CD146+ TAMs and highlight the promising immunotherapeutic approach of inhibiting CD146 and TMEM176B. | Lin Jing Yunhe An Tanxi Cai Jianquan Xiang Baoming Li Jiang Guo Xinran Ma Ling Wei Yanjie Tian Xiaoyan Cheng Xuehui Chen Zheng Liu Jing Feng Fuquan Yang Xiyun Yan Hongxia Duan | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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