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106篇 您的检索式:作者名="Jingping Wang"
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1Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway显示文摘Puerarin,a major isoflavonoid derived from the Chinese medical herb radix puerariae(Gegen),has been reported to inhibit neuronal apoptosis and play an anti-inflammatory role in focal cerebra ischemia model rats.Recent findings regarding stroke pathophysiology have recognized that anti-inflammation is an important target for the treatment of ischemic stroke.The cholinergic anti-inflammatory pathway is a highly robust neural-immune mechanism for inflammation control This study was to investigate whether activating the cholinergic anti-inflammatory pathway can be involved in the mechanism of inhibiting the inflammatory response during puerarin-induced cerebra ischemia/reperfusion in rats.Results showed that puerarin pretreatment(intravenous injection)reduced the ischemic infarct volume,improved neurological deficit after cerebra ischemia/reperfusion and decreased the levels of interleukin-1β,interleukin-6 and tumor necrosis factor-αin brain tissue.Pretreatment with puerarin(intravenous injection)attenuated the inflammatory response in rats,which was accompanied by janus-activated kinase 2(JAK2)and signal transducers and activators of transcription 3(STAT3)activation and nuclear factor kappa B(NF-κB)inhibition.These observations were inhibited by the alpha7 nicotinic acetylcholine recepto(α7nAchR)antagonistα-bungarotoxin(α-BGT).In addition,puerarin pretreatment increased the expression ofα7nAchR mRNA in ischemic cerebral tissue.These data demonstrate that puerarin pretreatment strongly protects the brain against cerebral ischemia/reperfusion injury and inhibits the inflammatory response.Our results also indicated that the anti-inflammatory effect of puerarin may partly be mediated through the activation of the cholinergic anti-inflammatory pathway.Xiaojie Liu Zhigang Mei Jingping Qian Yongbao Zeng Mingzhi Wang 2013Neural Regeneration Research2013,8,34:39
2Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy显示文摘Tumor models were simulated in purebred Beagles at the T9-10 levels of the spinal cord and treated with spinal image-guided radiation therapy or conventional radiation therapy with 50 or 70 Gy total radiation. Three months after radiation, neuronal injury at the T9-10 levels was observed, including reversible injury induced by spinal image-guided radiation therapy and apoptosis induced by conventional radiation therapy. The number of apoptotic cells and expression of the proapoptotic protein Fas were significantly reduced, but expression of the anti-apoptotic protein heat shock protein 70 was significantly increased after image-guided radiation therapy compared with the conventional method of the same radiation dose. Moreover, the spinal cord cell apoptotic index positively correlated with the ratio of Fas/heat shock protein 70. These findings indicate that 3 months of radiation therapy can induce a late response in the spinal cord to radiation therapy; image-guided radiation therapy is safer and results in less neuronal injury compared with conventional radiation therapy.Wanlong Xu Xilinbaoleri Hao Liu Ruozheng Wang Jingping Bai 2012Neural Regeneration Research2012,7,35:23
3Segmentation of Hematoxylin-Eosin stained breast cancer histopathological images based on pixel-wise SVM classifier显示文摘Hematoxylin-Eosin(HE) staining is the routine diagnostic method for breast cancer(BC), and large amounts of HE stained histopathological images are available for analysis. It is emergent to develop computational methods to efficiently and objectively analyze these images, with the aim of providing potentially better diagnostic and prognostic information for BC. This work focuses on analyzing our in-house HE stained histopathological images of breast cancer tissues. Since tumor nests(TNs) and stroma morphological characteristics can reflect the biological behaviors of breast invasive ductal carcinoma(IDC), accurate segmentation of TNs and the stroma is the first step towards the subsequent quantitative analysis. We first propose a method based on the pixel-wise support vector machine(SVM) classifier for segmenting TNs and the stroma, then extract four morphological characters related to the TNs from the images and investigate their relationships with the patients' 8-year disease free survival(8-DFS). The evaluation result shows that the classification based segmentation method is able to distinguish between TNs and stroma with 87.1% accuracy and 80.2% precision,suggesting that the proposed method is promising in segmenting HE stained IDC histopathological images. The Kaplan-Meier survival curves show that three morphological characters(number of TNs, total perimeter, and average area of TNs) in the images have statistical correlations with 8-DFS of the patients, illustrating that the segmented images can help to identify new morphological factors in IDC TNs for the prediction of BC prognosis.QU AiPing CHEN JiaMei WANG LinWei YUAN JingPing YANG Fang XIANG QingMing MASKEY Ninu YANG GuiFang LIU Juan LI Yan 2015Science China(Information Sciences)2015,58,9:12
4Large aperture N31 neodymium phosphate laser glass for use in a high power laser facility显示文摘Large aperture Nd:phosphate laser glass is a key optical element for an inertial confinement fusion(ICF) facility. N31,one type of neodymium doped phosphate glasses, was developed for high peak power laser facility applications in China. The composition and main properties of N31 glass are given, together with those of LHG-8, LG-770, and KGSS-0180 Nd:phosphate laser glasses, from Hoya and Schott, and from Russia. The technologies of pot melting, continuous melting, and edge cladding of large size N31 phosphate laser glass are briefly described. The small signal gain profiles of N31 glass slabs from both pot melting and continuous melting at various values of the pumping energy of the xenon lamp are presented. N31 glass is characterized by a stimulated emission cross section of 3.8 × 10-20cm2 at 1053 nm,an absorption coefficient of 0.10–0.15% cm-1at laser wavelength, small residual stress around the interface between the cladding glass and the laser glass, optical homogeneity of ~2 × 10-6in a 400 mm aperture, and laser damage threshold larger than 42 J/cm2 for a 3 ns pulse width at 1064 nm wavelength.Lili Hu Shubin Chen Jingping Tang Biao Wang Tao Meng Wei Chen Lei Wen Junjiang Hu Shunguang Li Yongchun Xu Yasi Jiang Junzhou Zhang Zhonghong Jiang 2014High Power Laser Science and Engineering2014,2,1:8
5Object-based image analysis for mapping geomorphic zones of coral reefs in the Xisha Islands, China显示文摘Mapping regional spatial patterns of coral reef geomorphology provides the primary information to understand the constructive processes in the reef ecosystem. However, this work is challenged by the pixel-based image classification method for its comparatively low accuracy. In this paper, an object-based image analysis(OBIA)method was presented to map intra-reef geomorphology of coral reefs in the Xisha Islands, China using Landsat 8satellite imagery. Following the work of the Millennium Coral Reef Mapping Project, a regional reef class hierarchy with ten geomorphic classes was first defined. Then, incorporating the hierarchical concept and integrating the spectral and additional spatial information such as context, shape and contextual relationships, a large-scale geomorphic map was produced by OBIA with accuracies generally more than 80%. Although the robustness of OBIA has been validated in the applications of coral reef mapping from individual reefs to reef system in this paper, further work is still required to improve its transferability.XU Jingping ZHAO Jianhua LI Fang WANG Lin SONG Derui WEN Shiyong WANG Fei GAO Ning 2016Acta Oceanologica Sinica2016,35,12:7
6Hilbert Transferin Applied to Separation of Waves显示文摘The analytical method (AM) for separation of composite waves is presented based on the Hilbert transform. It is ap-plicable to both regular and irregular trains of waves. The wave data series measured with two wave gauges in the experi-ments are separated into two series of incident and reflected waves. Then, the reflection coefficient can be easily ob-tained. The arrival of reflected waves can also be detected for improvement of the accuracy of the reflection coefficient.The reflection performance of the physical model can be estimated exactly without calculation of wave height and phasedifference. Numerical samples developed to test the method are proved to be accurate. Physical experiments are conduct-ed and compared with Goda's method and satisfactory results are obtained.SUN Hequan(孙鹤泉) WANG Yongxue(王永学) PENG Jingping(彭静萍) 2002China Ocean Engineering2002,17,2:7
7Understanding the structural evolution of Au/WO_(2.7) compounds in hydrogen atmosphere by atomic scale in situ environmental TEM显示文摘Hydrogen energy is a resuscitated clean energy source and its sensitive detection in air is crucial due to its very low explosive limit.Metal oxide decorated with noble metal nanoparticles has been used for the enhancement of gas detection and exhibits superior sensitivity.Understanding the intrinsic mechanism of the detection and the enhancement mechanism is thus becoming a fundamental issue for the further development of novel metal/oxide compound gas-sensing materials.However,the correlation between the microstructural evolution,the charge transport and the complex sensing process has not yet been directly revealed and its atomic mechanism is still debatable.In this study,an Au/WO_(2.7) compound was synthesized and exhibited a strongly enhanced gas sensitivity to many reductive gases,especially H2.Aberration-corrected environmental transmission electron microscopy was used to investigate the atomic-scale microstructural evolution in situ during the reaction between H_(2) and Au/WO_(2.7) compound.Swing and sintering processes of the Au particles on the WO_(2.7) surface were observed under heating and gaseous environments,and no injection of hydrogen atoms was suggested.First principle calculations verified the swing and sintering processes,and they can be explained by the enhancement of H2 sensitivity.Fei Hui Chong Li Yanhui Chen Chunhui Wang Jingping Huang Ang Li Wei Li Jin Zou Xiaodong Han 2020Nano Research2020,13,11:6
8STAT3 mediates resistance of CD44^+CD24^(-/low) breast cancer stem cells to tamoxifen in vitro显示文摘We sought to determine whether STAT3 mediated tamoxifen resistance of breast cancer stem cells in vitro.The capacities for mammosphere formation and STAT3 expression of CD44+CD24-/low MCF-7 and MCF-7 were observed.The CD44+CD24-/low subpopulation ratio and its sensitivity to adriamycin were analyzed in MCF-7 and TAM resistant(TAM-R) cells.Cell cycle,apoptosis,STAT3 and phospho-STAT3 changes were observed af-ter treatment with tamoxifen.Small interference RNA-mediated knockdown of STAT3 in TAM-R cells was also performed.CD44+CD24-/low MCF-7 showed higher capacities for mammosphere formation and STAT3 expression than total MCF-7.The CD44+CD24-/low subpopulation was also upregulated in TAM-R cells with less sensitivity to adriamycin than MCF-7.Cell cycle changes,anti-apoptotic effects and STAT3 changes were also found.Mean-while,the knock-down of STAT3 in TAM-R resulted in an increase in sensitivity to tamoxifen.It is concluded that STAT3 plays an essential role in breast cancer stem cells,which correlated with tamoxifen resistance.Xiaoyan Wang Guozhu Wang Yi Zhao Xiaoan Liu Qiang Ding Jingping Shi Yin Ding Shui Wang 2012The Journal of Biomedical Research2012,26,5:6
9Cognitive effects of atypical antipsychotic drugs in first-episode drug-nave schizophrenic patients显示文摘Cognitive impairment is a core feature of schizophrenia. The present randomized open study enrolled antipsychotic-nave patients who were experiencing their first episode of schizophrenia. After baseline neurocognitive tests and clinical assessment, subjects were randomly assigned to olanzapine, risperidone and aripiprazole treatment groups. A battery of neurocognitive tests showed that risperidone produced cognitive benefits in all five cognitive domains, including verbal learning and memory, visual learning and memory, working memory, processing speed, and selective attention; olanzapine improved processing speed and selective attention; and aripiprazole improved visual learning and memory, and working memory. However, the three atypical antipsychotic drugs failed to reveal any significant differences in the composite cognitive scores at the study endpoint. In addition, the three drugs all significantly improved clinical measures without significant differences between the drugs after 6 months. These results suggest that the atypical antipsychotics, olanzapine, risperidone and aripiprazole may improve specific cognitive domains with similar global clinical efficacy. In clinical practice, it may be feasible to choose corresponding atypical antipsychotics according to impaired cognitive domains.Juan Wang Maorong Hu Xiaofeng Guo Renrong Wu Lehua Li Jingping Zhao 2013Neural Regeneration Research2013,8,3:3
10Synthesis,structural characterization and properties of a 3D infinitely extended structural rare earth coordination compound of K_3{[Sm(H_2O)_7]_2Na[α-SiW_(11)O_(39)Sm(H_2O)_4]_2}·14 H_2O显示文摘A 3D infinitely extended structural rare earth coordination compound with a formula of K3{[Sm(H2O)7]2Na[a-SiW11O39Sm(H2O)4]2}·14H2O has been synthesized by reaction of Sm2O3,HClO4,NaOH with a-K8SiW11O39·nH2O,and characterized by IR,UV spectra,ICP,TG-DTA,cyclic voltammetry,variable-temperature magnetic susceptibility and X-ray single-crystal diffrac-tion.X-ray single-crystal diffraction indicates that the title compound crystallizes in a triclinic lat-tice,Pi space group,with a = 1.2462(3) nm,b = 1.2652(3) nm,c = 1.8420(4) nm,α = 87.45(3)°,β = 79.91(3)°,γ = 82.57(3)°,Z = 1,R1 = 0.0778,wR2 = 0.1610.Structural analysis reveals that Sm3+(1) coordination cation has incorporated into the vacant site of [α-SiW11O39]8? entity,forming the [α-SiW11O39Sm(H2O)4]5? subunit.The two adjacent [a-SiW11O39Sm(H2O)4]5? subunits are combined with each other through two Sm(1)-O-W bridges accompanying the formation of dim-mer structural unit [α-SiW11O39Sm(H2O)4]210? of the title compound.The neighboring dimmer structural units [α-SiW11O39Sm(H2O)4]210? are linked to form the 1D chainlike structure by means of two Sm3+(2) and a Na+(1) coordination cations.The K+(1) cations connect the 1D packing chains constructing the 2D netlike structure,and adjacent netlike layers are also grafted by K+(2) cations to build the novel 3D infinitely extended structure.The result of TG-DTA curves manifests that the decomposition temperature of the title polyanionic framework is 554℃.The cyclic volt-ammetry measurements show that the title polyanion has the two-step redox processes in aqueous solution with pH = 3.1.Variable temperature magnetic susceptibility indicates the title compound obeys the Cruie-Weiss Law in the higher temperature range from 110 to 300 K,while in the lower temperature range from 2 to 110 K the comparatively strong antiferromagnetism in-teractions can be observed.WANG Jingping ZHAO Junwei NIU Jingyang 2005Science China Chemistry2005,48,4:2
11Experimental Study on the Combustion and Energy Flows of Vehicle Engine Under NEDC of Cold Start显示文摘To enhance the fuel economy of a vehicle powered by a gasoline engine under road conditions,an energy flow test of a vehicle was performed experimentally under the New European Driving Cycle of cold start.The energy distributions and related influencing factors were analyzed using the test data.Results show that the effective power and thermal efficiency are mainly affected by the engine load except in the early stage of the New European Driving Cycle.Because of the retarded CA50 and longer CA10-90,the effective thermal efficiency is lower in the early phase of driving conditions.Initially,the heat transfer loss mainly comprises the loss of the heating,ventilation,and air conditioning system.The radiator then plays the major role,with its percentage affected by the engine load and decreasing under the extra-urban driving cycle.The exhaust gas loss is decided by the temperature and flow rate of the exhaust gas,while its percentage is mainly affected by the temperature of the exhaust gas.In the early phase of driving conditions,the retarded spark advance angle leads to a higher temperature of the exhaust gas and a greater exhaust gas loss.The pumping loss and its percentage are mainly determined by the engine speed under the urban driving cycle,and both decrease under the extra-urban driving cycle except at maximum vehicle speed.Zhichao Zhao Zaiqiang Meng Lu Li Shuqian Wang Jianqin Fu Jingping Liu 2019Automotive Innovation2019,2,4:2
12In situ construction of ligand nano-network to integrin αvβ3 for angiogenesis inhibition显示文摘Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid tumors.As an integrin significantly ove rexpressed in human tumor vascular endothelial cells,αvβ3 is a suitable targeting site for anti-angiogenesis of tumor.We designed and prepared a selfassembling peptide(SAP)with the ability to targeting αvβ3 and self-assembly.SAP formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin αvβ3 on the surface of human umbilical vein endothelial cells(HUVECs).The SAP network stably anchored on HUVECs over 24h,which consequently resulted in high-efficient inhibition of vascularization.In vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%.In vivo anti-angiogenesis array based on chick chorioallantoic membrane(CAM)model exhibited that the SAP had an inhibition rate up to 63.1%.These results indicated the outstanding anti-angiogenic ability of SAP,potentially for tumor therapy.Ziming Chen Kuo Zhang Jiaqi Fan Yu Fan Chao Yang Wen Tian Yuan Li Wenliang Li Jingping Zhang Hao Wang Lei Wang 2020Chinese Chemical Letters2020,31,12:2
13The Effects of Temperature, Light and Moisture on the Seed Germination of Siphonostegia chinensis Benth显示文摘To explore the optimum temperature,light intensityand water conditions for seed germination of Siphonostegia chinensis Benth.,seed germination experiment were carried out under different temperatures(5/15,10/20,15/25,20/30℃),different light intensity(14h light/10h darkness,complete darkness)and different concentrations(0%,5%,10%,15%,20%)of PEG-6000 solution.In terms of concentration,5%PEG was regarded as the low level,10%and 15%as the medium level,and 20%as the high level.The results showed that(1)Germination rate,germination potential,and germination index were increased with the rise of temperature.In addition,seed germination was significantly higher under the dark conditions than that with the 14h light/10h darkness.(2)No seed germination occurred when the temperature was below 10/20 C at 14h light/10h darkness.(3)Under 14h light/10h darkness,the germination rate,germination potential and germination index first increased and then decreased with the increase of PEG concentration.The low concentration was more beneficial to the seed germination.(4)Under the condition of complete darkness,the germination rate,germination potential and germination index decline with fluctuation with the increase of PEG concentration.Seed germination of Siphonostegia chinensis Benth.was inhibited in high concentration of PEG.Shuaiqun Fan Kaiyu Qin Jingping Li Qinggui Zhang Fenguo Zhang Yongji Wang 2019Journal of Botanical Research2019,1,2:2
14A New Family of Ce6MoO15 as Fast Oxide Ion Conductor显示文摘A novel solid solution Ce6MoO15 was achieved. Their structure and oxide ionic conductivity were studied.Based on Ce6MoO15, rare earth element substitution on cerium site shows that all resulting oxides enhance the conductivity further, and have high oxide-ion conductivity, which may be a kind of promising material for SOFCs.Feng Jing Bo Qibing Che Ping Wang Jingping Liu Jianfen Lu Minfeng Zhang Deping Fang Daqing Cao Xueqiang Meng Jian 2004Journal of Rare Earths2004,22,z2:2
15Retrieval of Total Suspended Matters Using Field Spectral Data in Shitoukoumen Reservoir,Jilin Province,Northeast China显示文摘From August to October in 2006,three times of field spectral measurements with a Field Spec FR spectroradiometer(Analytical Spectral Devices,Inc.,USA) were carried out in Shitoukoumen Reservoir,Jilin Province,Northeast China. Owing to the serious soil and water loss in the upstream,reflectance curves of the reservoir were characterized by high concentrations of total suspended matter(TSM) . Extending the spectral analysis to 1200nm in the near-infrared band,this research revealed an obvious reflectance peak around 1070nm which was caused by the strong backscattering of high TSM. The method of partial least squares(PLS) regression was applied to retrieving the TSM. Reflectance in two spectral bands,i.e.,675-948nm and 1029-1105nm,were used as variables to develop PLS models. Traditional linear regression,first derivative model and logarithmic model were also used for the comparison of different models. Results showed that the PLS model based on Rrs(675) -Rrs(948) gave out best results with high precision and stability. Although the PLS model based on Rrs(1029) -Rrs(1105) did not have an outstanding performance due to lots of noise,the reflectance peak in the near-infrared band was an important TSM feature and its efficient exploitation would have a considerable significance in TSM remote sensing.XU Jingping ZHANG Bai LI Fang SONG Kaishan WANG Zongming LIU Dianwei ZHANG Guangxin 2009Chinese Geographical Science2009,19,1:2
16Identification of the metabolites of polybrominated diphenyl ether 99 and its related cytochrome P450s显示文摘Objective:To investigate the metabolites of polybrominated diphenyl ether 99(BDE-99)and its related cytochrome P450s in an in vitro system.Methods:Rat primary hepatocytes were isolated and treated with BDE-99 for 24-72 h.Metabolites were then extracted from the hepatocytes and media,and detected by GC/MS.Several mRNAs of metabolic enzymes were also extracted from the same cells and the gene expression levels were determined using quantitative real-time PCR.In addition,selected recombinant cytochrome P450s(CYPs) were expressed in a bacurovirus/sf9 system,and these were further used to explore the metabolism of BDE-99 in vitro.The parent depletion approach was used for screening the ability of CYPs to eliminate BDE-99.Results: A reductively debrominated metabolite,BDE-47,and three oxidative metabolites,2,4,5-tribromophenol,5-OH-BDE-47,and 5'-OH-BDE-99,were identified from the BDE-99-treated rat hepatocytes,whereas no MeO metabolite was detected in the system.RT-PCR analysis showed that CYP 3A23/3A1,1A2,and 2B1/2 were induced by BDE-99.Furthermore,using the heterological expressed CYP proteins in in vitro BDE-99 metabolism experiments we found that CYP1A2 and CYP3A4 showed the highest metabolic efficiency for BDE-99,with the metabolic clearance rates of CYP1A2 and CYP3A4 being 30.3%and 27.7%,respectively.CYP1A1 and CYP2A6 displayed relatively low clearance rates,while CYP2E1 seemed not to be associated with the BDE-99 metabolism.Conclusions:In our in vitro rat primary hepatocyte metabolism system,four metabolites of BDE-99 were identified,and CYP3A4 and CYP1A2 were demonstrated to be involved in the BDE-99 metabolism.Huibin Dong Ziyin Li Xiaoming Man Jingping Zhou Huiyuan Lu Shoulin Wang 2010The Journal of Biomedical Research2010,24,3:2
17Efficiency and purity control in the preparation of pure and/or aluminum-doped barium ferrites by hydrothermal methods using ferrous ions as reactants显示文摘Ying Liu Michael G.B. Drew Jingping Wang Milin Zhang Yue Liu 2009Journal of Magnetism and Magnetic Materials2009,,3:1
18Unsupervised content-preserving transformation for optical microscopy显示文摘The development of deep learning and open access to a substantial collection of imaging data together provide a potential solution for computational image transformation,which is gradually changing the landscape of optical imaging and biomedical research.However,current implementations of deep learning usually operate in a supervised manner,and their reliance on laborious and error-prone data annotation procedures remains a barrier to more general applicability.Here,we propose an unsupervised image transformation to facilitate the utilization of deep learning for optical microscopy,even in some cases in which supervised models cannot be applied.Through the introduction of a saliency constraint,the unsupervised model,named Unsupervised content-preserving Transformation for Optical Microscopy(UTOM);can learn the mapping between two image domains without requiring paired training data while avoiding distortions of the image content.UTOM shows promising performance in a wide range of biomedical image transformation tasks,including in silico histological staining,fluorescence image restoration,and virtual fluorescence labeling.Quantitative evaluations reveal that UTOM achieves stable and high-fidelity image transformations across different imaging conditions and modalities.We anticipate that our framework will encourage a paradigm shift in training neural networks and enable more applications of artificial intelligence in biomedical imaging.Xinyang Li Guoxun Zhang Hui Qiao Feng Bao Yue Deng Jiamin Wu Yangfan He Jingping Yun Xing Lin Hao Xie Haoqian Wang Qionghai Dai 2021Light(Science & Applications)2021,10,3:1
19LncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBL-mediated degradation of β-catenin显示文摘LncMIR31HG acts as a host gene for miR-31,also known as LncHIFCAR(long non-coding HIF-1 co-activating RNA),whose deregulation has been reported to promote the development of various human cancers,including lung cancer,colorectal cancer,etc.1,2 However,the biological functions and molecular mechanisms of MIR31HG in gastric cancer are unclear.Wen Peng Jiayi Zhang Shenghao Wang Feng Wang a Kun Wang Rui Geng Xiangfei Ding Jingping Zhang Biao Li Xiaoxue Ke Muhan Lü Hongjuan Cui 2023Genes & Diseases2023,10,3:1
20Effect of surface morphology of lead dioxide particles on their ozone generating performance显示文摘Wang Jingping Li Xiang Guo Linghua 2008Applied Surface Science2008,254,:1
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