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3篇 您的检索式:作者名="Jingquan Lan"
    题名 作者 年代 出处 被引量
1Proprotein convertase 1 mRNA and protein expression in ischemic rat cortex after reperfusion显示文摘Proprotein convertase 1(PC1) is a member of the family of proprotein convertases(PCs),which are the processing enzymes of neuropeptides.Previous studies have addressed PC1 effects with regard to the neuroendocrine system.In this study,the developing changes of PC1 mRNA and PC1 protein in rat cortices after transient focal cerebral ischemia were investigated by fluorescent double labeling(both in situ hybridization and immunocytochemistry) using a transient focal cerebral ischemia model in rats.The results were compared with those of sham-operated rat cortices.Both the mRNA and protein levels of PC1 in ischemic cortices decreased gradually at 4,8,and 16 hours of reperfusion after 100 minutes of middle cerebral artery occlusion.After 24 hours of reperfusion,enhanced intensities of signals for PC1 protein were observed,while signals for PC1 mRNA remained low.These results suggest that transient focal cerebral ischemia influences PC1 mRNA and protein expression in cortices of ischemic rats.Thus,PC1 is regulated by ischemic stress.Shuqin Zhan An Zhou Jingquan Lan Tao Yang 2011Neural Regeneration Research2011,6,4:2
2pH-Dependent assembly of hybrids based on Wells-dawson POM/Ag 显示文摘SHA JINGQUAN PENG JUN LAN YAQIAN 2008Chemistry Journal of Inorg Chem2008,47,:1
3Changes in proprotein convertase subtilisin/kexin type 9 mRNA expression in rat cortex after cerebral ischemia显示文摘Oxidized low density lipoprotein is a risk factor for cerebrovascular disease.Proprotein convertase subtilisin/kexin type 9(PCSK9) can increase the level of low density lipoprotein.Therefore,this study assumed that PCSK9 plays important roles in ischemic cerebrovascular disease.The present study established transient focal cerebral ischemia models after 100 minutes of middle cerebral artery occlusion.In situ hybridization demonstrated that PCSK9 mRNA expression increased gradually with prolonged reperfusion time in ischemic cortices.This indicated that transient focal cerebral ischemia upregulated PCSK9 mRNA expression in ischemic cortices.Shuqin Zhan An Zhou Jingquan Lan Tao Yang 2011Neural Regeneration Research2011,6,13:0
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