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| 1 | Proprotein convertase 1 mRNA and protein expression in ischemic rat cortex after reperfusion显示文摘Proprotein convertase 1(PC1) is a member of the family of proprotein convertases(PCs),which are the processing enzymes of neuropeptides.Previous studies have addressed PC1 effects with regard to the neuroendocrine system.In this study,the developing changes of PC1 mRNA and PC1 protein in rat cortices after transient focal cerebral ischemia were investigated by fluorescent double labeling(both in situ hybridization and immunocytochemistry) using a transient focal cerebral ischemia model in rats.The results were compared with those of sham-operated rat cortices.Both the mRNA and protein levels of PC1 in ischemic cortices decreased gradually at 4,8,and 16 hours of reperfusion after 100 minutes of middle cerebral artery occlusion.After 24 hours of reperfusion,enhanced intensities of signals for PC1 protein were observed,while signals for PC1 mRNA remained low.These results suggest that transient focal cerebral ischemia influences PC1 mRNA and protein expression in cortices of ischemic rats.Thus,PC1 is regulated by ischemic stress. | Shuqin Zhan An Zhou Jingquan Lan Tao Yang | 2011 | Neural Regeneration Research2011，6，4： | 2 |
| 2 | Abnormal amygdala connectivity in patients with primary insomnia: Evidence from resting state fMRI显示文摘 | Zhaoyang Huang Peipeng Liang Xiuqin Jia Shuqin Zhan Ning Li Yan Ding Jie Lu Yuping Wang Kuncheng Li | 2011 | European Journal of Radiology2011，，6： | 1 |
| 3 | Abnormal amygdala connectivity in patients with primary insomnia: Evidence from resting state fMRI显示文摘 | Zhaoyang Huang Peipeng Liang Xiuqin Jia Shuqin Zhan Ning Li Yan Ding Jie Lu Yuping Wang Kuncheng Li | 2011 | European Journal of Radiology2011，，6： | 1 |
| 4 | Changes in proprotein convertase subtilisin/kexin type 9 mRNA expression in rat cortex after cerebral ischemia显示文摘Oxidized low density lipoprotein is a risk factor for cerebrovascular disease.Proprotein convertase subtilisin/kexin type 9(PCSK9) can increase the level of low density lipoprotein.Therefore,this study assumed that PCSK9 plays important roles in ischemic cerebrovascular disease.The present study established transient focal cerebral ischemia models after 100 minutes of middle cerebral artery occlusion.In situ hybridization demonstrated that PCSK9 mRNA expression increased gradually with prolonged reperfusion time in ischemic cortices.This indicated that transient focal cerebral ischemia upregulated PCSK9 mRNA expression in ischemic cortices. | Shuqin Zhan An Zhou Jingquan Lan Tao Yang | 2011 | Neural Regeneration Research2011，6，13： | 0 |
| 5 | Dynamic changes in proprotein convertase 2 activity in cortical neurons after ischemia/reperfusion and oxygen-glucose deprivation显示文摘In this study, a rat model of transient focal cerebral ischemia was established by performing 100 minutes of middle cerebral artery occlusion, and an in vitro model of experimental oxygen-glucose deprivation using cultured rat cortical neurons was established. Proprotein convertase 2 activity gradually decreased in the ischemic cortex with increasing duration of reperfusion. In cultured rat cortical neurons, the number of terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate-biotin nick end labeling-positive neurons significantly increased and proprotein convertase 2 activity also decreased gradually with increasing duration of oxygen-glucose deprivation. These experimental findings indicate that proprotein convertase 2 activity decreases in ischemic rat cortex after reperfusion, as well as in cultured rat cortical neurons after oxygen-glucose deprivation. These changes in enzyme activity may play an important pathological role in brain injury. | Shuqin Zhan An Zhou Chelsea Piper Tao Yang | 2013 | Neural Regeneration Research2013，8，1： | 0 |
| 6 | Increased hypoxia-inducible factor 1alpha expression in rat brain tissues in response to aging显示文摘The present study observed changes in rat neural cells at various ages (3, 18, 24, and 30 months). With age, neural cells became large and were sparsely arranged, and the number of Nissl bodies decreased. In addition, hypoxia-inducible factor 1α expression increased with increasing age in hippocampal CA1 and CA3 regions, motor cortex, and the first subfolium, especially from 3 to 18 months. In the open-field test, grid crossing decreased with increasing age, especially from 18 months. The number of rearings reached a peak in the 18 months group, and then subsequently decreased. The results suggested that hypoxia-inducible factor 1α played an important role in the nervous system aging process. | Huqing Wang Haiqin Wu Hena Guo Guilian Zhang Ru Zhang Shuqin Zhan | 2012 | Neural Regeneration Research2012，7，10： | 0 |
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