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| 1 | Experimental study on the bolt–cable combined supporting technology for the extraction roadways in weakly cemented strata显示文摘Aiming at the characteristics of the poor steady ability, the short stable time and severe deformation behavior of weakly cemented soft surrounding rock around extraction roadway, a bolt–cable combined supporting technology was proposed. Numerical simulation was performed by using FLAC3 D software to study the effects of different supporting systems. The simulation result proves that those supporting systems have good practical values. Based on real-time monitoring and analysis of the deformation of surrounding rock and the stress of supporting structure, real time information of deformation of surrounding rock and stress state of supporting structure of extraction roadway within weakly cemented strata was obtained. Monitoring results show that large deformation and failure of surrounding rock of extraction roadway within weakly cemented strata can be effectively controlled by the bolt–cable combined supporting technology, which ensures the long-term stability and safety of surrounding rock and supporting structure. | Meng Qingbin Han Lijun Sun Jingwu Min Fengqing Feng Wei Zhou Xing | 2015 | International Journal of Mining Science and Technology2015，25，1： | 13 |
| 2 | Identifying therapeutic targets in gastric cancer: the current status and future direction显示文摘胃的癌症是世界范围的癌症相关的死亡的第三个领先的原因。我们胃的癌症生物学的基本理解落伍于许多另外的癌症类型的。为胃的癌症的当前的标准治疗选择没变化最后 20 年了。因此,有迫切需要建立新奇策略治疗这致命的癌症。有在电流型逻辑和胃肠的 stromal 肿瘤的 Gleevec 的成功的临床的试用为癌症的指向的治疗建立了一个例子。在这评论,我们将在分类总结主要进步,胃的癌症的治疗学的选择。我们将也在胃的癌症为药电阻讨论分子的机制。另外,我们将试图在胃的癌症生物学和药目标建议潜在的未来方向。 | Beiqin Yu Jingwu Xie | 2016 | Acta Biochimica et Biophysica Sinica2016，48，1： | 11 |
| 3 | Clinical implications of hedgehog signaling pathway inhibitors显示文摘Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and carcinogenesis. The first link of Hh signaling to cancer was established through studies of a rare familial disease, Gorlin syndrome, in 1996. Follow-up studies revealed activation of this pathway in basal cell carcinoma, medulloblastoma and, leukemia as well as in gastrointestinal, lung, ovarian, breast, and prostate cancer. Targeted inhibition of Hh signaling is now believed to be effective in the treatment and prevention of human cancer. The discovery and synthesis of specific inhibitors for this pathway are even more exciting. In this review, we summarize major advances in the understanding of Hh signaling pathway activation in human cancer, mouse models for studying Hh- mediated carcinogenesis, the roles of Hh signaling in tumor development and metastasis, antagonists for Hh signaling and their clinical implications. | Hailan Liu Dongsheng Gu Jingwu Xie | 2011 | Chinese Journal of Cancer2011，30，1： | 11 |
| 4 | Effects of{2-[(3-carboxy-1-oxoprogyl)amino]-2-deoxy-D-glucose}on human hepatocellular carcinoma cell line显示文摘Aim: To study the effects of {2-[(3-carboxy-1-oxoprogy 1)amino]-2-deoxy-D-glucose (COPADG) on cultured human hepatocellular carcinoma cells (HepG2).Methods: HepG2 cells were cultured in RPMI-1640 medium. Cell proliferation was determined by MTF assay. Apoptosis was determined by fluorescence microscopy,transmission electron microscopy, agarose gel electrophoresis of DNA fragmentation, and flow cytometry. Results: At the concentration ranging between 1-30μmol/L, COPADG potently inhibited the growth and induced apoptosis of HepG2 cells. Conclusion: COPADG could effectively induce apoptosis in human hepatocellular carcinoma cells. More investigations are warranted for the potential use of this compound as a new agent for the non-surgical management of human hepatocellular carcinoma. | JingWU WeiKOU Ming-taiGAO Yong-ningZHOU Ai-qinWANG Qun-jiXUE LiangQIAO | 2005 | Acta Pharmacologica Sinica2005，26，5： | 10 |
| 5 | Variations in the Lower Level of the PBL Associated with the Yellow Sea Fog-New Observations by L-Band Radar显示文摘The Chinese east coastal areas and marginal seas are foggy regions. The development of effective forecasting methods rests upon a comprehensive knowledge of the fog phenomena. This study provides new observations associated with the sea fogs over the northwestern Yellow Sea by means of L-band radar soundings with a high vertical resolution of 30 m. The monthly temperature lapse rate, the Richardson Numbers, and the humidity show obvious seasonal variations in the lower level of the planetary boundary layer (PBL) that are related to the onset, peak and end of the Yellow Sea fog season. The typical pattern of stratification for the sea fog season in the northwestern Yellow Sea is that a stable layer of about 400 m thick caps a 150 m conditionally unstable layer. Besides, the differences between fogs and stratus clouds in terms of humidity, turbulence and temperature are analyzed, which is of significance for sea fog forecast and detection by satellites. The thickness of the sea fogs varies in different stages of the fog season, and is associated with the temperature inversion. The numerical simulation proves that the seasonal variations obtained by the radar well represent the situations over the Yellow Sea. | ZHANG Suping REN Zhaopeng LIU Jingwu YANG Yuqiang WANG Xingong | 2008 | Journal of Ocean University of China2008，7，4： | 10 |
| 6 | The Impact of Genomic Prof ling for Novel Cancer Therapy–Recent Progress in Non-Small Cell Lung Cancer显示文摘There is high expectation for significant improvements in cancer patient care after completion of the human genome project in 2003.Through pains-taking analyses of genomic profiles in cancer patients,a number of targetable gene alterations have been discovered,with some leading to novel therapies,such as activating mutations of EGFR,BRAF and ALK gene fusions.As a result,clinical management of cancer through targeted therapy has finally become a reality for a subset of cancers,such as lung adenocarcinomas and melanomas.In this review,we summarize how gene mutation discovery leads to new treatment strategies using non-small cell lung cancer(NSCLC)as an example.We also discuss possible future implications of cancer genome analyses. | Jingwu Xie Xiaoli Zhang | 2016 | Journal of Genetics and Genomics2016，43，1： | 9 |
| 7 | The role of GLI2-ABCG2 signaling axis for 5Fu resistance in gastric cancer显示文摘Gastric cancer is a leading cause of cancer-related mortality worldwide, and options to treat gastric cancer are limited. Fluorouracil(5Fu)-based chemotherapy is frequently used as a neoadjuvant or an adjuvant agent for gastric cancer therapy. Most patients with advanced gastric cancer eventually succumb to the disease despite the fact that some patients respond initially to chemotherapy. Thus, identifying molecular mechanisms responsible for chemotherapy resistance will help design novel strategies to treat gastric cancer. In this study, we discovered that residual cancer cells following 5Fu treatment have elevated expression of hedgehog(Hg) target genes GLI1 and GLI2, suggestive of Hh signaling activation. Hh signaling, a pathway essential for embryonic development, is an important regulator for putative cancer stem cells/residual cancer cells. We found that high GLI1/GLI2 expression is associated with some features of putative cancer stem cells, such as increased side population. We demonstrated that GLI2 knockdown sensitized gastric cancer cells to 5Fu treatment, decreased ABCG2 expression, and reduced side population. Elevated GLI2 expression is also associated with an increase in tumor sphere size, another marker for putative cancer stem cells. We believe that GLI2 regulates putative cancer stem cells through direct regulation of ABCG2. ABCG2 can rescue the GL12 shRNA effects in 5Fu response, tumor sphere formation and side population changes, suggesting that ABCG2 is an important mediator for GLI2-associated 5Fu resistance. The relevance of our studies to gastric cancer patient care is reflected by our discovery that high GLI1/GLI2/ABCG2 expression is associated with a high incidence of cancer relapse in two cohorts of gastric cancer patients who underwent chemotherapy(containing 5Fu). Taken together,we have identified a molecular mechanism by which gastric cancer cells gain 5Fu resistance. | Beiqin Yu Dongsheng Gu Xiaoli Zhang Bingya Liu Jingwu Xie | 2017 | Journal of Genetics and Genomics2017，44，8： | 9 |
| 8 | Study on preparation and properties of CeO_2/epoxy resin composite coating on sintered NdFeB magnet显示文摘The CeO_2/epoxy resin composite coating was deposited on NdFeB substrate by cathode electrophoresis method for enhancing the anticorrosion and anti-wear performances. The morphologies and structures were characterized by a scanning electron microscope and an X-ray diffractometer. The micro hardness of the composite coating was evaluated by a microhardness tester. The corrosive behaviors of the coatings were studied by potentiodynamic polarization curve, electrochemical impedance spectroscopy and neutral salt spray tests. The concentration of CeO_2 nanoparticles(NPs) in the electrophoresis bath was optimized according to the coating structures and anticorrosion performances. The results show that CeO_2 NPs can enhance the microhardness of the composite coatings. Moreover, the nanoparticles disperse uniformly in the matrix when the concentration is lower than 30 g/L. The microhardness of CeO_2/epoxy resin(30 g/L) composite coating is about 63% higher than that of the blank epoxy resin coating. And the NSS time of the CeO_2/epoxy resin(30 g/L) composite coated sample can reach 1248 h.Meanwhile, the composite coatings possess no deteriorate influence on the magnetic properties of NdFeB substrates. The anticorrosion mechanisms of the composite coatings on the NdFeB substrate are deeply discussed. | Pengjie Zhang Minggang Zhu Wei Li Guangqing Xu Xiulian Huang Xiaofei Yi Jingwu Chen Yucheng Wu | 2018 | Journal of Rare Earths2018，36，5： | 8 |
| 9 | The cytokine milieu in the interplay of pathogenic Th1/ Th17 cells and regulatory T cells in autoimmune disease显示文摘The propagation and regulation of an immune response is driven by a network of effector and regulatory T(Treg)cells.The interplay of effector T and Treg cells determines the direction of the immune response towards inflammation or its resolution in an autoimmune disease setting.In autoimmune diseases,this interplay shifts the balance in favor of the development of autoreactive effector T cells,resulting in inflammatory pathology.The objective of an effective therapeutic approach for autoimmune disease is to restore this balance.In this review,we describe the characteristics and development of pathogenic T helper 1(Th1)and Th17 cells and the beneficial Treg cells in autoimmune diseases and the crucial roles of the cytokine milieu in influencing the balance of these T-cell subsets.Given the importance of cytokines,we discuss current immunotherapeutic strategies using cytokine or cytokine receptor antibodies for the treatment of autoimmune diseases. | Stewart Leung Xuebin Liu Lei Fang Xi Chen Taylor Guo Jingwu Zhang | 2010 | Cellular & Molecular Immunology2010，7，3： | 8 |
| 10 | CyclinB1、CDK1在胃癌中的表达及其意义显示文摘目的 :探讨胃癌发生中CyclinB1、CDK1表达异常及其临床病理学意义。方法 :采用免疫组织化学ABC法检测CyclinB1、CDK1在 15例正常胃组织、35例胃癌组织 (其中 15例为低分化腺癌 ,2 0例为中、高分化腺癌 )中的表达。结果 :CyclinB1、CDK1阳性表达多数定位于细胞质 ,少数在细胞核和细胞质中同时表达 ;在胃正常粘膜中CyclinB1、CDK1表达阳性率分别为 13.3% (2 / 15 )、6 .7% (1/ 15 ) ,胃癌组织中表达阳性率分别为 94 .3% (33/ 35 )、91.4 % (32 / 35 ) ,有统计学意义 (P <0 .0 1) ;在低分化腺癌、中高分化腺癌CyclinB1、CDK1均有表达 ,不同分化程度胃癌之间阳性表达差异有统计学意义 (P <0 .0 1)。结论 :CyclinB1、CDK1在不同分化程度胃癌中有过表达现象 ,可能是胃癌发生中早期分子事件 。 | 马晓丽 黄淑红 黄敬爱 邱超 Jingwu Xie 张红卫 | 2004 | 中国现代普通外科进展2004，7，5： | 7 |
| 11 | Effect of 2-(3-carboxy-1-oxopropyl) amino-2-deoxy-D-glucose on human esophageal cancer cell line显示文摘AIM: TO determine whether 2-(3-carboxy-l-oxopropyl) amino-2-deoxy-D-glucose (COPADG), a derivative of D-amino-glucose, inhibited the growth of human esophageal cancer cell line Eca-109. METHODS: Effects of COPADG on Eca-109 cells cultured in RPMI 1640 medium were examined by a tetrazoliumbased colorimetric assay (MTT assay). RESULTS: COPADG inhibited the growth of Eca-109 cells in a dose- and time-dependent manner; the maximumin hibition rate was 83.75%. CONCLUSION: COPADG can directly inhibit the proliferation of Eca-109 cells, which may serve as the experimental evidence for development of new drugs for esophageal cancer therapy. | JingWu HongLu YunZhou LiangQiao RuiJi Ai-QingWang Wei-MinLiu Qun-JiXue | 2004 | World Journal of Gastroenterology2004，10，22： | 7 |
| 12 | Deciphering the role of hedgehog signaling in pancreatic cancer显示文摘Pancreatic cancer,mostly pancreatic ductal adenocarcinoma(PDAC),is a leading cause of cancer-related death in the US,with a dismal median survival of 6 months.Thus,there is an urgent unmet need to identify ways to diagnose and to treat this deadly cancer.Although a number of genetic changes have been identified in pancreatic cancer,their mechanisms of action in tumor development,progression and metastasis are not completely understood.Hedgehog signaling,which plays a major role in embryonic development and stem cell regulation,is known to be activated in pancreatic cancer;however,specific inhibitors targeting the smoothened molecule failed to improve the condition of pancreatic cancer patients in clinical trials.Furthermore,results regarding the role of Hh signaling in pancreatic cancer are controversial with some reporting tumor promoting activities whereas others tumor suppressive actions.In this review,we will summarize what we know about hedgehog signaling in pancreatic cancer,and try to explain the contradicting roles of hedgehog signaling as well as the reason(s) behind the failed clinical trials.In addition to the canonical hedgehog signaling,we will also discuss several non-canonical hedgehog signaling mechanisms. | Dongsheng Gu Kelly E Schlotman Jingwu Xie | 2016 | The Journal of Biomedical Research2016，30，5： | 7 |
| 13 | Observations of nonlinear oscillation phenomena in metallic solids显示文摘A great number of in situ observations proved that at normal temperature and pressure there exists a nonlinear oscillation phenomenon in the solid alloys. This kind of oscillation phenomenon exhibits fluid-like character in localized areas, fluctuating with crystal rotation, cell’s moving, expansion and contraction. | Houxiu Gao Yuqin Yang Jingwu Yang Anwei Liu | 1999 | Chinese Science Bulletin1999，44，1： | 6 |
| 14 | The Effect of the East China Sea Kuroshio Front on the Marine Atmospheric Boundary Layer显示文摘Various satellite data,JRA-25(Japan reanalysis of 25 years) reanalyzed data and WRF(Weather Research Forecast) model are used to investigate the in situ effect of the ESKF(East China Sea Kuroshio Front) on the MABL(marine atmospheric boundary layer).The intensity of the ESKF is most robust from January to April in its annual cycle.The local strong surface northerly/northeasterly winds are observed right over the ESKF in January and in April and the wind speeds decrease upward in the MABL.The thermal wind effect that is derived from the baroclinic MABL forced by the strong SST gradient contributes to the strong surface winds to a large degree.The convergence zone existing along the warm flank of the ESKF is stronger in April than in January corresponding to the steeper SST(sea surface temperature) gradient.The collocations of the cloud cover maximum and precipitation maximum are basically consistent with the convergence zone of the wind field.The clouds develop higher(lower) in the warm(cold) flank of the ESKF due to the less(more) stable stratification in the MABL.The lowest clouds are observed in April on the cold flank of the ESKF and over the Yellow Sea due to the existence of the pronounced temperature inversion.The numerical experiments with smoothed SST are consistent with the results from the ovservations. | ZHANG Suping LIU Jingwu MENG Xiangui | 2010 | Journal of Ocean University of China2010，9，3： | 5 |
| 15 | Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells显示文摘规章的 T 房间(Treg ) 在免疫系统动态平衡起重要作用,并且可以被压制涉及反肿瘤免疫的 Th1 免疫反应也涉及肿瘤免疫忍耐。我们以前报导了有稀释激活的自体同源的 T 房间的那免疫导致提高的反肿瘤免疫并且在调整 Th1 回答 invivo 上面。然而,内在的分子的机制很好没被理解。这里,我们证明 Tregfunction 是显著地, down 在老鼠调整了稀释激活的自体同源的 T 房间的那收到的免疫。我们发现那 Foxp3 表情从使免疫的老鼠在 CD4+CD25+ T 房间减少了。而且,从使免疫的老鼠获得的 CD4+CD25+Foxp3+ Treg 从天真的老鼠与那些相比展出了减少的免疫力的抑制能力。进一步的分析证明使免疫的鼠标的浆液包含 anti-CD25 抗体(大约 30 ng/ml, p<0.01 对控制) 的高水平。与在 Treg 的 down 规定的 anti-CD25 反应的一个角色一致,到天真的鼠标的从使免疫的鼠标的浆液的采纳转移在接受者鼠标在 Treg 人口和功能导致了重要减少。在使免疫的老鼠被触发 anti-CD25 反应能被 CD25 在激活的自体同源的 T 房间为免疫使用了的 ConA 被导致到高水平的事实解释。我们的结果第一次证明有稀释激活的自体同源的 T 房间的那免疫唤起 anti-CD25 抗体生产,它导致阻碍的 CD4+CD25+Foxp3+Treg 扩大和功能体内。我们建议那阻抑的 Treg 功能多半在使免疫的老鼠贡献提高的 Th1 反应并且是位于 boostedanti 肿瘤免疫下面的机制的至少部分。 | Qi Cao Li Wang Fang Du Huiming Sheng Yan Zhang Juanjuan Wu Baihua Shen TianweiShen Jingwu Zhang Dangsheng Li Ningli Li | 2007 | Cell Research2007，17，7： | 5 |
| 16 | Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45β显示文摘Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reactions to deplete autoreac-tire T cells,which are involved in autoimmune diseases.However,it is unknown whether attenuated activated healthyautologous T-cell immunization could increase anti-tumor immune responses.To this end,C57B1/6 mice were immunizedwith attenuated activated autologous T cells.The splenocytes from immunized mice showed a higher proliferative abil-ity than that from naive mice.The special phenotype analysis showed that there were more CDS+T cells and CD62L+T cells in immunized mice after 24 h of culture with 10% fetal calf serum complete medium in vitro(P<0.01).Theseresults demonstrated that this immunization may activate T cells in vivo.Furthermore,the splenocytes from immunizedmice revealed resistance to activation-induced cell death(AICD)in vitro.To further study the relative genes that areresponsible for the higher proliferation and resistance to AICD,the expression of Fas/Fas ligand(FasL)and GADD45βwas measured by real-time PCR.The results indicated that GADD45β transcription was higher in the splenocytes fromimmunized mice than that in the naive mice.In addition,the Fas expression showed a parallel higher,but FasL did notchange obviously.To investigate the biologic functions induced by immunization in vivo,a tumor model was establishedby EL-4 tumor cell inoculation in C57/B1 mice.Mice receiving autologous T-cell immunization had significantly inhibitedtumor growth in vivo(P<0.01).This study implicated that immunization with attenuated activated autologous T cellsenhances anti-tumor immune responses that participate in tumor growth inhibition. | Li Wang~(1,2,*) Fang Du~(1,2,*) Qi Cao~(1,2) Huiming Sheng~(1,2) Baihua Shen~(1,2) Yan Zhang~(1,2) Yingna Diao~(1,2) Jingwu Zhang~(1,2) Ningli Li~(1,2) ~1Shanghai diao Tong UniversiO,School of Medicine,280 Chongqing Road,Shanghai 200025,China ~2Shanghai Institute of Immunology,280 Chongqing Road,Shanghai 200025,China | 2006 | Cell Research2006，16，8： | 5 |
| 17 | Coupling of Hierarchical Al_(2)O_(3)/TiO_(2) Nanofibers into 3D Photothermal Aerogels Toward Simultaneous Water Evaporation and Purification显示文摘Serious freshwater shortage and environmental pollution boost the rapid development of solar-driven water production.Although improved evaporation rate has achieved in recent years,undesirable impurity(e.g.,pollutant components)can also be inevitably evaporated and collected as impurity in produced freshwater.This work reports new ultra-light three-dimensional(3D)aerogels assembled by hierarchical Al_(2)O_(3)/TiO_(2) nanofibers and reduced graphene oxide(RGO)for excit-ing synchronized solar-driven evaporation and water purification.Hydrophilic Al_(2)O_(3)/TiO_(2) fibrous channels linked up the graphene hot-spots and water body for sufficient water supply and bulk water insulation.Meanwhile,featured with thermal insulation effect,the Al_(2)O_(3)/TiO_(2) nanofibers effectively locked the converted heat with less energy loss from sunlight.The introducing of Al_(2)O_(3)/TiO_(2) nanofibers into RGO aerogel led to the effective interfacial evaporation for a more rapid water evaporation rate(2.19 kg·m−2·h−1,normalized to evaporation area including both top and side surface),which was 36%higher than that of pristine RGO aerogel.Moreover,simultaneous with the strong steam generation,Al_(2)O_(3)/TiO_(2) nanofibers in situ removed the pollutants within steam by photodegradation,achieving polluted wastewater purification with high con-taminant removal ratio of 91.3%.Our work on coupling Al_(2)O_(3)/TiO_(2) nanofibers into photothermal aerogel provides attractive solutions for the challenges of clean water scarcity and serious environmental pollution. | Xiangyu Meng Wanlin Xu Zhihui Li Jianhui Yang Jingwu Zhao Xixi Zou Yueming Sun Yunqian Dai | 2020 | Advanced Fiber Materials2020，2，2： | 4 |
| 18 | Stability analysis of bank slope under conditions of reservoir impounding and rapid drawdown显示文摘Stability of an ancient landslide in a reservoir area is analyzed by using centrifugal model tests, soil laboratory tests and numerical analysis. Special attention is paid to variation in water level, simulation of large-scale heterogeneous prototype slope, and strength reduction of sliding zone soils after slope sliding. The results of centrifugal model test show that reservoir impounding can reduce sliding resistance at the slope toe, followed by toe collapsing and front cracking of slope. Rapid drawdown can produce hydrodynamic pressure towards reservoir at the front of slope. Deformation is observed in the middle and upper slope, which reduces the slope stability further and forms the pull-typed landslide trend. Reinforcement of slope toe is effective for preventing the progressive failure. The results of laboratory test show that slope toe sliding will lead to the redistribution of soil density and moisture content, which will reduce the shear strength of soil in sliding zone, and the cohesion of immersed soil is reduced gradually and finally vanishes with time. The numerical results show that the strength reduction method used in finite element method (FEM) is very effective in capturing the progressive failure induced by reservoir water level fluctuations, and the evolution of failure surface derived from numerical simulation is very similar to that observed in centrifugal model test. | Xiaoping Chen Jingwu Huang | 2011 | Journal of Rock Mechanics and Geotechnical Engineering2011，3，S1： | 4 |
| 19 | Implications of hedgehog signaling antagonists for cancer therapy显示文摘刺猬(Hh ) 小径,开始由埃里克·威斯豪斯博士和克里斯蒂安娜·努斯雷恩沃尔哈德博士二个诺贝尔获奖者在果蝇发现了是为房间区别,织物极性和房间增长的一个主要管理者。包括我们的,从许多实验室的研究在很基础的房间癌并且在约 30% 真皮外的人的癌症揭示这条小径的激活,包括 medulloblastomas,胃肠,肺,胸和前列腺癌症。因此, Hh 发信号的指向的抑制可能在对待并且阻止人的癌症的许多类型是有效的,这被相信。甚至更多激动是为 Hh 小径的特定的发信号的对手的发现和合成,它在新奇癌症治疗学有重要临床的含意。这评论在在人的癌症的不同类型表明激活的 Hh 的当前的理解讨论主要进展,表明激活的 Hh 的分子的基础,为在人的癌症表明抑制和他们的潜在的临床的申请的 Hh 的主要对手治疗。 | Jingwu Xie | 2008 | Acta Biochimica et Biophysica Sinica2008，40，7： | 4 |
| 20 | A new multi-parallel-beam collimators with improved sensitivity for SPECT显示文摘In this paper, a new design of multi-parallel-beam (MPB) collimators with projection multiplexing is proposed. In the MPB system, two different oblique parallel channels are introduced in a conventional parallel-beam collimator. The sensitivity of the single photon emission computed tomography (SPECT) system is improved by allowing projection overlapping. Comparative simulation studies were performed in the MPB collimators, general purpose parallel-beam (GPPB) collimators and high sensitivity parallel-beam (HSPB) collimators. In the simulation, attenuation, scattering and the impact of detector response were neglected. Simulation results show that the sensitivity is improved for the MPB collimator comparing with parallel-beam collimator. The behavior of spatial resolution is only different near the front face of the collimators and approaches that of the GPPB with increasing depth. Proper pre-filtering is helpful for the image reconstruction in the MPB collimators. Comparing with the HSPB collimator, the MPB can achieve a similar sensitivity and better resolution. The simulation ot the U87 cells, and their expression levels were higher in the 10 Gy group than in the 0 Gy group. The differential gene expression in DCX-U87 cells before and after radiation is helpful for future investigations into the mechanisms of radiation therapy in neurogliocytoma cells. | MA Jiayi ZHAO Jingwu SHI Xiaodong ZHANG Kevin HUANG Runshen | 2012 | Nuclear Science and Techniques2012，23，2： | 3 |
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