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| 1 | Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis显示文摘 | Chaoying Hu Liu Qian Yi Miao Qiuyu Huang Ping Miao Ping Wang Qiwen Yu Hong Nie Jiying Zhang Dongyi He Rong Xu Xuehua Chen Bingya Liu Dongqing Zhang | 2012 | Cellular & Molecular Immunology2012，9，3： | 18 |
| 2 | The role of GLI2-ABCG2 signaling axis for 5Fu resistance in gastric cancer显示文摘Gastric cancer is a leading cause of cancer-related mortality worldwide, and options to treat gastric cancer are limited. Fluorouracil(5Fu)-based chemotherapy is frequently used as a neoadjuvant or an adjuvant agent for gastric cancer therapy. Most patients with advanced gastric cancer eventually succumb to the disease despite the fact that some patients respond initially to chemotherapy. Thus, identifying molecular mechanisms responsible for chemotherapy resistance will help design novel strategies to treat gastric cancer. In this study, we discovered that residual cancer cells following 5Fu treatment have elevated expression of hedgehog(Hg) target genes GLI1 and GLI2, suggestive of Hh signaling activation. Hh signaling, a pathway essential for embryonic development, is an important regulator for putative cancer stem cells/residual cancer cells. We found that high GLI1/GLI2 expression is associated with some features of putative cancer stem cells, such as increased side population. We demonstrated that GLI2 knockdown sensitized gastric cancer cells to 5Fu treatment, decreased ABCG2 expression, and reduced side population. Elevated GLI2 expression is also associated with an increase in tumor sphere size, another marker for putative cancer stem cells. We believe that GLI2 regulates putative cancer stem cells through direct regulation of ABCG2. ABCG2 can rescue the GL12 shRNA effects in 5Fu response, tumor sphere formation and side population changes, suggesting that ABCG2 is an important mediator for GLI2-associated 5Fu resistance. The relevance of our studies to gastric cancer patient care is reflected by our discovery that high GLI1/GLI2/ABCG2 expression is associated with a high incidence of cancer relapse in two cohorts of gastric cancer patients who underwent chemotherapy(containing 5Fu). Taken together,we have identified a molecular mechanism by which gastric cancer cells gain 5Fu resistance. | Beiqin Yu Dongsheng Gu Xiaoli Zhang Bingya Liu Jingwu Xie | 2017 | Journal of Genetics and Genomics2017，44，8： | 9 |
| 3 | CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer显示文摘(CEACAM6 ) Carcinoembryonic 抗原相关的房间粘附分子 6 证明在许多 humancancers 的增加的表示,和它的在表示上与提高的移植被联系,侵略,并且在 vivo 转移。这里,我们报导 CEACAM6 在房间衬里的胃的癌症(GC ) 和肿瘤纸巾是起来调整的。在 MKN-45 和 SGC-7901 GC 房间的 Over-expressionof CEACAM6 在 athymic 老鼠在 vitro 和转移支持了移植和侵略,而 MKN-28 和 SNU-16 GC 房间的移植和侵略被 knockdownof CEACAM6 压制。当 CEACAM6 是 over-expressedin SGC-7901 房间时,我们也观察到类固醇受体激活剂(C-SRC ) phosphorylation 被增加。一起拿,这些结果建议 CEACAM6 在 GC 作为 oncoprotein 工作并且可以是 importantmetastatic biomarker 和治疗学的目标。 | Yunqiang Zhang Mingde Zang Jianfang Li Jun Ji Jianian Zhang Xiaolei Liu Ying Qu Liping Su Chen Li Yinyan Yu Zhenggang Zhu Bingya Liu Min yan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 5 |
| 4 | Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer显示文摘 | Hanshao Liu Lin Zhu Bingya Liu Liu Yang Xianxin Meng Wei Zhang Yueyun Ma Huasheng Xiao | 2011 | Cancer Letters2011，，： | 3 |
| 5 | Serum proteomics for gastric cancer显示文摘 | Wentao Liu Qiumeng Yang Bingya Liu Zhenggang Zhu | 2014 | Clinica Chimica Acta2014，，： | 2 |
| 6 | Different roles of galectin-9 isoforms in modulating E-selectin expression and adhesion function in LoVo colon carcinoma cells显示文摘 | Feng Zhang Minhua Zheng Ying Qu Jianfang Li Jun Ji Bo Feng Aiguo Lu Jianwen Li Mingliang Wang Bingya Liu | 2009 | Molecular Biology Reports2009，，5： | 1 |
| 7 | Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK显示文摘 | Ming Wang Chenglong Li Hui Nie Xin Lv Ying Qu Beiqin Yu Liping Su Jianfang Li Xuehua Chen Jingfang Ju Yingyan Yu Min Yan Qinlong Gu Zhenggang Zhu Bingya Liu | 2012 | FEBS Letters2012，，16： | 1 |
| 8 | Identification of a new target region by loss of heterozygosity at 5p15.33 in sporadic gastric carcinomas: genotype and phenotype related显示文摘 | Yun Lu Yingyan Yu Zhenggang Zhu Heng Xu Jun Ji Lei Bu Bingya Liu Haisong Jiang Yanzhen Lin Xiangyin Kong Landian Hu | 2004 | Cancer Letters2004，，2： | 1 |
| 9 | Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer显示文摘 | Xiongyan Wu Xuehua Chen Quan Zhou Pu Li Beiqin Yu Jianfang Li Ying Qu Jun Yan Yingyan Yu Min Yan Zhenggang Zhu Bingya Liu Liping Su | 2013 | Cancer Letters2013，，1： | 1 |
| 10 | miR-126 functions as a tumour suppressor in human gastric cancer显示文摘 | Runhua Feng Xuehua Chen Yingyan Yu Liping Su Beiqin Yu Jianfang Li Qu Cai Min Yan Bingya Liu Zhenggang Zhu | 2010 | Cancer Letters2010，，1： | 1 |
| 11 | miR-126 functions as a tumour suppressor in human gastric cancer显示文摘 | Runhua Feng Xuehua Chen Yingyan Yu Liping Su Beiqin Yu Jianfang Li Qu Cai Min Yan Bingya Liu Zhenggang Zhu | 2010 | Cancer Letters2010，，1： | 1 |
| 12 | Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK显示文摘 | Ming Wang Chenglong Li Hui Nie Xin Lv Ying Qu Beiqin Yu Liping Su Jianfang Li Xuehua Chen Jingfang Ju Yingyan Yu Min Yan Qinlong Gu Zhenggang Zhu Bingya Liu | 2012 | FEBS Letters2012，，16： | 1 |
| 13 | Discovery and genetic characterization of intestinal metaplasia in the Helicobacter felis-infected mouse model of gastric cancer显示文摘Gastric adenocarcinoma(GA)remains a leading cause of cancer-related deaths in the world [1].Of the different types of GA,intestinal-type GA is especially a major world-wide concern not only because this type of GA accounts for a large proportion of the global incidences but also because it is believed to be acquired,and thus possibly preventable.In particular,Helicobacter pylori-induced chronic inflammation is suggested to lead to the transformation of normal gastric mucosa to chronic gastritis,gastric atrophy,intestinal metaplasia(IM),dysplasia,and finally intestinal-type GA,as first proposed by Correa [2].Thus,IM tissue,characterized by the presence of cells resembling those derived from the intestine-specific lineage such as goblet cells that are not present in the normal stomach,is considered to be a critical precancerous tissue en route to GA [3].Furthermore,the transition to IM is believed to be the ‘point of no return’since the IM tissue does not revert back to normal gastric tissue after the eradication of H.pylori [4].However,the precise details of the IM tissue that are critical to the subsequent development of GA are not presently understood. | Jiangrong Chen Chunchao Zhu Chaojie Wang Xiaodan Zhang Jian Ni Daniel M.Czajkowsky Bingya Liu Yan Guo | 2019 | Acta Biochimica et Biophysica Sinica2019，51，2： | 1 |
| 14 | MiR-199a-3p promotes gastric cancer progression by targeting ZHX1显示文摘 | Zhenqiang Wang Xingjie Ma Qiang Cai Xinjing Wang Beiqin Yu Qu Cai Bingya liu Zhenggang Zhu Chen Li | 2014 | FEBS Letters2014，，： | 1 |
| 15 | Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis显示文摘 | Yanan Zheng Lu Chen Jianfang Li Beiqin Yu Liping Su Xuehua Chen Yingyan Yu Min Yan Bingya Liu Zhenggang Zhu | 2011 | Clinical Biochemistry2011，，17： | 1 |
| 16 | Cetuximab Inhibits Gastric Cancer Growth in vivo, Independent of KRAS Status显示文摘 | Min Shi Hailong Shi Jun Ji Qu Cai Xuehua Chen Yingyan Yu Bingya Liu Zhenggang Zhu Jun Zhang | 2014 | Current Cancer Drug Targets2014，，2： | 1 |
| 17 | A Long-wavelength Emissive Phenothiazine Derived Fluorescent Probe for Detecting HOCI Upregulation in 5-FU Stimulated Living Cells显示文摘The endogenous hypochlorous acid(HOCI) has been evidenced in a variety of cellular courses. However, the role of HOCI in most pathophysiological processes still keeps unclear because of the limited detecting tools. In this work, we presented the pre- paration of a phenothiazine-derived fluorescent probe CIO-1 for HOCI detection with a cyanopyridinium moiety to improve its water solubility and lengthen its emission wavelength. The HOCI-promoted oxidation of sulfur atom in the probe resulted in a 460-fold emission intensity enhancement at 635 nm with high selectivity and sensitivity(detection limit: 1.12 nmol/L). The rapid response(5 s) also endowed the probe with real-time detection ability. Successfully, CIO-1 was devoted to the bioimaging of endogenous HOCI in inflamed RAW 264.7 cells and 5-fluorouracil-treated MCF-7 cells. | WANG Bingya GUO Xiaomei LIU Zuodong WU Yongquan HOU Ji-Ting | 2022 | Chemical Research in Chinese Universities2022，38，2： | 0 |
| 18 | Regulation of pancreatic cancer metastasis through the Gli2-YAP1 axis via regulation of anoikis显示文摘Pancreatic cancer,mostly pancreatic ductal adenocarcinoma(PDAC),is often metastatic upon the initial diagnosis,and has a high mortality rate.However,the primary and the matched metastatic cancers often share the same driver gene mutations.1,2 Gene expression comparison between primary and metastatic PDAC tissues revealed high expression of Gli2 and YAP1 in the metastatic PDAC.Gli2 is an important player in non-canonical hedgehog signaling,and YAP1 is an essential cell polarity gene.In this study,we investigated the effects of Gli2 and YAP1 on pancreatic cancer cell function in 3D culture and in mouse models.We further determined the relationship between Gli2 and YAP1.These studies further our understanding of pancreatic cancer metastasis. | Beiqin Yu Dongsheng Gu Xiaoli Zhang Bingya Liu Jingwu Xie | 2022 | Genes & Diseases2022，9，6： | 0 |
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