|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The predictive value of vascular endothelial growth factor and Ki-67 expression on neoadjuvant therapy in rectal cancer显示文摘调查脉管的内皮生长因素(VEGF ) 和增殖的房间的表情的目的在有直肠的腺癌的病人和他们有 neoadjuvant 的协会的原子抗原(Ki-67 ) 治疗。方法包括两预告的处理肿瘤活体检视和手术后的标本,在直肠的腺癌的 32 种情况中的 Ki-67 和 VEGF 的表情被免疫组织化学用特定的抗体检测,并且与 clinicopathological 因素被相关。结果染色的 VEGF 的紧张显著地与淋巴被相关节的转移( P = 0.033 ),肿瘤侵略的深度( P = 0.007 )并且肿瘤舞台( P = 0.016 ),然而并非与组织学的类型,肿瘤尺寸,病人的年龄和性( P >
0.05 )。VEGF 表示的底层与对 neoadjuvant 治疗的反应的高敏感有重要关联(P = 0.016 ) 。VEGF 表示的短暂增加能在 neoadjuvant 治疗以后被看见(P = 0.035 ) 。把索引(Ki-67-LI ) 标记的 Ki-67 显著地与淋巴节点转移被相关(P = 0.028 ) ,然而并非相关到肿瘤尺寸,病人的年龄和性(P >
0.05 ) 。有更低的 Ki-67-LI 的肿瘤对 neoadjuvant 治疗更敏感(P = 0.032 ) 。Ki-67 水平在 neoadjuvant 治疗以后减少了,但是没有统计意义被发现 P >
0.05 ) 。我们的结果表明的结论在预告的处理的 VEGF 和 Ki-67 的表示直肠的腺癌活体检视可能对 neoadjuvant 的肿瘤反应是预兆的治疗。 | Shumei Jiang RenbenWang Jinming Yu Zhenjiang Zhang Dianbin Mu Zhongfa Xu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，1： | 1 |
| 2 | Using 18 F-Fluorodeoxyglucose Positron Emission Tomography to Estimate the Length of Gross Tumor in Patients With Squamous Cell Carcinoma of the Esophagus显示文摘 | Xiaojun Zhong Jinming Yu Baijiang Zhang Dianbin Mu Weidi Zhang Daotang Li Anqin Han Pingping Song Hui Li Guoren Yang Feng-Ming Kong Zheng Fu | 2009 | International Journal of Radiation Oncology Biology Physics2009，，1： | 1 |
| 3 | Transcatheter Closure of Perimembranous Ventricular Septal Defect Using a Modified Double-Disk Occluder显示文摘 | Yongwen Qin Jinming Chen Xianxian Zhao Dening Liao Ruibin Mu Shengqiang Wang Hong Wu Haoxue Guo | 2008 | The American Journal of Cardiology2008，，12： | 1 |
| 4 | Using 18 F-Fluorodeoxyglucose Positron Emission Tomography to Estimate the Length of Gross Tumor in Patients With Squamous Cell Carcinoma of the Esophagus显示文摘 | Xiaojun Zhong Jinming Yu Baijiang Zhang Dianbin Mu Weidi Zhang Daotang Li Anqin Han Pingping Song Hui Li Guoren Yang Feng-Ming Kong Zheng Fu | 2009 | International Journal of Radiation Oncology Biology Physics2009，，1： | 1 |
| 5 | Transcatheter Closure of Perimembranous Ventricular Septal Defect Using a Modified Double-Disk Occluder显示文摘 | Yongwen Qin Jinming Chen Xianxian Zhao Dening Liao Ruibin Mu Shengqiang Wang Hong Wu Haoxue Guo | 2008 | The American Journal of Cardiology2008，，12： | 1 |
| 6 | Formation of a FCC Al_(54)Ti_(23)C_(23) Metastable Phase by Ball Milling显示文摘The powder mixture of Al, Ti and graphite has been mechanically alloyed in a planetary ball mill.The structural evolution of as-milled powder sample has been characterized by XRD, DTA. The results show that the amorphous phase is formed first at an early milling stage, then crystallization occurs during further milling, leading to formation of a nanocrystalline fcc metastable phase. In contrast, during annealing the amorphous phase is crystallized to the equilibrium phase instead of the fcc phase. This indicates that crystallization during ball milling is different from that induced by | Nianqiang WU Zhizhang LI Guangxin WANG and Jinming MU(Dept. of Materials Science and Engineering, Zhejiang University Hangzhou 310027, China) | 1997 | Journal of Materials Science & Technology1997，13，4： | 0 |
| 7 | Emerging roles and therapeutic potentials of sphingolipids in pathophysiology:emphasis on fatty acyl heterogeneity显示文摘Sphingolipids not only exert structural roles in cellular membranes,but also act as signaling molecules in various physiological and pathological processes.A myriad of studies have shown that abnormal levels of sphingolipids and their metabolic enzymes are associated with a variety of human diseases.Moreover,blood sphingolipids can also be used as biomarkers for disease diagnosis.This review summarizes the biosynthesis,metabolism,and pathological roles of sphingolipids,with emphasis on the biosynthesis of ceramide,the precursor for the biosynthesis of complex sphingolipids with different fatty acyl chains.The possibility of using sphingolipids for disease prediction,diagnosis,and treatment is also discussed.Targeting endogenous ceramides and complex sphingolipids along with their specific fatty acyl chain to promote future drug development will also be discussed. | Jinming Mu Sin Man Lam Guanghou Shui | 2024 | Journal of Genetics and Genomics2024，51，3： | 0 |
| 8 | Green's functions of two-dimensional piezoelectric quasicrystal in half-space and bimaterials显示文摘In this paper,we obtain Green’s functions of two-dimensional(2D)piezoelectric quasicrystal(PQC)in half-space and bimaterials.Based on the elastic theory of QCs,the Stroh formalism is used to derive the general solutions of displacements and stresses.Then,we obtain the analytical solutions of half-space and bimaterial Green’s functions.Besides,the interfacial Green’s function for bimaterials is also obtained in the analytical form.Before numerical studies,a comparative study is carried out to validate the present solutions.Typical numerical examples are performed to investigate the effects of multi-physics loadings such as the line force,the line dislocation,the line charge,and the phason line force.As a result,the coupling effect among the phonon field,the phason field,and the electric field is prominent,and the butterfly-shaped contours are characteristic in 2D PQCs.In addition,the changes of material parameters cause variations in physical quantities to a certain degree. | Xiaoyu FU Xiang MU Jinming ZHANG Liangliang ZHANG Yang GAO | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，2： | 0 |
| 9 | Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation显示文摘Precise metabolic rewiring during heart organogenesis underlies normal cardiac development.Herein,we utilized high-coverage,quantitative lipidomic approaches to construct lipidomic atlases of whole hearts(861 lipids;31 classes)and mitochondria(587 lipids;27 classes)across prenatal and postnatal developmental stages in mice.We uncovered the progressive formation of docosahexaenoyl-phospholipids and enhanced remodeling of C18:2,C20:3,and C20:4 fatty acyl moieties into cardiolipins as cardiac development progresses.A preferential flow of ceramides toward sphingomyelin biosynthesis over complex glycosphingolipid formation was also noted.Using maSigPro and GPclust algorithms,we identified a repertoire of 448 developmentally dynamic lipids and mapped their expression patterns to a library of 550 biologically relevant developmentally dynamic genes.Our combinatorial transcriptomics and lipidomics approaches identified Hadha,Lclat1,and Lpcat3 as candidate molecular drivers governing the dynamic remodeling of cardiolipins and phospholipids,respectively,in heart development.Our analyses revealed that postnatal cardiolipin remodeling in the heart constitutes a biphasic process,which first accumulates polyunsaturated C78-cardiolipins prior to tetralinoleoyl cardiolipin forming the predominant species.Multiomics analyses supplemented with transmission electron microscopy imaging uncovered enhanced mitochondria–lipid droplet contacts mediated by perilipin-5.Our combinatorial analyses of multiomics data uncovered an association between mitochondrial-resident,docosahexaenoic acid-phospholipids and messenger RNA levels of proton-transporting adenosine triphosphate synthases on inner mitochondrial membranes,which adds credence to the membrane pacemaker theory of metabolism.The current findings offer lipid-centric biological insights potentially important to understanding the molecular basis of cardiac metabolic flexibility and disease pathology. | Huan Miao Bowen Li Zehua Wang Jinming Mu Yanlin Tian Binhua Jiang Shaohua Zhang Xia Gong Guanghou Shui Sin Man Lam | 2023 | Research2023，，3： | 0 |
| 10 | Fundamental solutions of critical wedge angles for one-dimensional piezoelectric quasicrystal wedge显示文摘Two problems of a one-dimensional(1D)piezoelectric quasicrystal(QC)wedge are investigated,i.e.,the two sides of the wedge subject to uniform tractions and the wedge apex subject to the concentrated force.By virtue of the Stroh formalism and Barnett-Lothe matrices,the analytical expressions of the displacements and stresses are derived,and the generalized solutions for the critical wedge angles are discussed.Numerical examples are given to present the mechanical behaviors of the wedge in each field.The results indicate that the effects of the uniform tractions and the concentrated force on the phonon field displacement are larger than those on the phason field. | Xiang MU Xiaoyu FU Liangliang ZHANG Zhaowei ZHU Jinming ZHANG Yang GAO | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员