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| 1 | Emulsion interfacial polymerization of anticancer peptides:fabricating polypeptide nanospheres with high drug-loading efficiency and enhanced anticancer activity显示文摘The development of drug delivery systems with high drug-loading efficiency, kinetic stability against dilution, as well as enhanced anticancer activity is of crucial importance to the fields of self-assembly and nanomedicine. Herein, we propose a strategy where the anticancer peptide acts as water-soluble monomer to directly participate in emulsion interfacial polymerization for fabricating polypeptide nanospheres. The constructed polypeptide nanospheres hold a high drug loading efficiency of 77%, and can be stably dispersed in highly diluted aqueous solutions. The acid-labile amide linkage in polypeptide nanospheres can be hydrolyzed in tumor acidic environments, thus releasing anticancer peptides selectively. The polypeptide nanospheres achieve significantly enhanced anticancer activity against HCT116 cells in vitro and in vivo through improved mitochondrial and membrane disruption. In addition, its side effects on normal cells can be reduced significantly. It is highly anticipated that more kinds of anticancer drug candidates or anticancer drugs can be applied to fabricate polymeric nanomedicines with improved anticancer activity through this strategy. | Jinpeng Yang Hua Wang Zihe Yin Shuai Zhang Jiang-Fei Xu Xi Zhang | 2022 | Science China Chemistry2022，65，11： | 1 |
| 2 | 3-75 Radiosensitizing Effects of miR-185 on Melanoma Cells显示文摘Melanoma is an aggressive malignancy with high metastasis and low survival rate, of which the incidence rate keeps increasing year by year worldwide while the therapeutic options are still limited up to now[1;2]. Melanoma is considered to be a relatively radioresistant tumor, and radiotherapy has an important role in its treatment, especially in patients with central nervous system metastases[3], so enhancement of cellular radiosensitivity by radiosensitizer is an efficient strategy to improve the outcome of radiotherapy. | He Jinpeng Tian Ning Yang Yanli Jin Liangliang Feng Xiu Hua Junrui Lin Sulan Wang Bing Li He Wang Jufang | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 3 | The Cauchy problem for a class of nonlinear degenerate parabolic-hyperbolic equations显示文摘In this article, we prove a general existence theorem for a class of nonlinear degenerate parabolichyperbolic equations. Since the regions of parabolicity and hyperbolicity are coupled in a way that depends on the solution itself, there is almost no hope of decoupling the regions and then taking into account the parabolic and the hyperbolic features separately. The existence of solutions can be obtained by ?nding the limit of solutions for the regularized equation of strictly parabolic type. We use the energy methods and vanishing viscosity methods to prove the local existence and uniqueness of solution. | Hua Chen Jinpeng Zhan Xin Hu | 2019 | Science China Mathematics2019，62，5： | 0 |
| 4 | Layer-by-layer epitaxy of multi-layer MoS_(2) wafers显示文摘The 2D semiconductor of MoShas great potential for advanced electronics technologies beyond silicon.So far,high-quality monolayer MoSwafers have been available and various demonstrations from individual transistors to integrated circuits have also been shown.In addition to the monolayer,multilayers have narrower band gaps but improved carrier mobilities and current capacities over the monolayer.However,achieving high-quality multi-layer MoSwafers remains a challenge.Here we report the growth of high-quality multi-layer Mo S_(2) 4-inch wafers via the layer-by-layer epitaxy process.The epitaxy leads to well-defined stacking orders between adjacent epitaxial layers and offers a delicate control of layer numbers up to six.Systematic evaluations on the atomic structures and electronic properties were carried out for achieved wafers with different layer numbers.Significant improvements in device performances were found in thicker-layer field-effect transistors(FETs),as expected.For example,the average field-effect mobility(μFE)at room temperature(RT)can increase from~80 cm·V·sfor monolayers to~110/145 cm·V·for bilayer/trilayer devices.The highest RTμFEof 234.7 cm·V·sand record-high on-current densities of 1.70 m A·μmat Vds=2V were also achieved in trilayer MoSFETs with a high on/off ratio of>107.Our work hence moves a step closer to practical applications of 2D MoSin electronics. | Qinqin Wang Jian Tang Xiaomei Li Jinpeng Tian Jing Liang Na Li Depeng Ji Lede Xian Yutuo Guo Lu Li Qinghua Zhang Yanbang Chu Zheng Wei Yanchong Zhao Luojun Du Hua Yu Xuedong Bai Lin Gu Kaihui Liu Wei Yang Rong Yang Dongxia Shi Guangyu Zhang | 2022 | National Science Review2022，9，6： | 0 |
| 5 | The Gevrey smoothing effect for the spatially inhomogeneous Boltzmann equations without cut-off显示文摘In this article we study the Gevrey regularization effect for the spatially inhomogeneous Boltzmann equation without angular cut-off.This equation is partially elliptic in the velocity direction and degenerates in the spatial variable.We consider the nonlinear Cauchy problem for the fluctuation around the Maxwellian distribution and prove that any solution with mild regularity will become smooth in the Gevrey class at positive time with the Gevrey index depending on the angular singularity.Our proof relies on the symbolic calculus for the collision operator and the global subelliptic estimate for the Cauchy problem of the linearized Boltzmann operator. | Hua Chen Xin Hu Wei-Xi Li Jinpeng Zhan | 2022 | Science China Mathematics2022，65，3： | 0 |
| 6 | 重离子辐射引起的衰老人黑色素瘤细胞产生的衰老相关分泌表型显示文摘Senescence is a cell fate that can be induced by intra/extracellular stresses such as DNA damage,oncogenic mutations,telomere shorting,and inflammation[1].Senescent cells develop a characteristic secretion profile including a range of cytokines,chemokines,proteases,and other factors,which is termed the senescence-associated secretory phenotype(SASP)[2].Accumulating evidence indicates that SASP factors provoke multiple chronic diseases,even tumorigenesis and aggressiveness[3].Our recent studies reveal that heavy ion could induce senescence with lower dose than X-ray in various tumor cells[4;5].However,very little is known about the SASP of senescent tumor cells induced by heavy ions.In the present study,human melanoma cell line 92-1 cells were exposed to 10 Gy of carbon ion beams or X-rays,respectively.The cell culture supernatants were harvested 3 days post-irradiation,and the SASP were measured using human antibody arrays including 507 factors. | He Jinpeng Hua Junrui Long Kaiqing Feng Xiu Wei Wenjun Wang Jufang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 7 | 黄芪多糖通过介导碳离子照射BMCSs后MAPK信号通路减轻G1期相关旁观者效应显示文摘Although it has been demonstrated that Astragalus polysaccharide(APS)have various pharmacological effects,there has been no studies concerning the inhibitory effects of APS on the radiation induced bystander effects(RIBE).In this study,A549 cells were irradiated with 2 Gy carbon ions to obtain conditioned medium.BMSCs was incubated with the conditioned medium or APS.The levels of reactive oxygen species(ROS)and TGF-were detected by ELISA.Cell survival,genomic instability,DNA damages and cell cycle were detected by CCK-8 assay,colony formation assay,the micronucleus test,immunofluorescence assay and flow cytometry assay,respectively.The protein and phosphorylation protein expression of p38,c-Jun N-terminal kinase(JNK),extracellular regulated protein kinases(ERK1/2),P65,cyclooxygenase-2(COX-2),cell cycle related proteins and TGF-receptor(TGF-R)in bystander effect cells were detected by western blot.The result showed that APS decreased the colony rate of bystander cells by inducing cell cycle arrest at G1 phase via extrinsic and intrinsic DNA damage. | Zhang Liying Liu Yongqi He Jinpeng Zhang Yiming wang Lei Zhang Lixin Wei Kongxi Zhou Heng Hua Junrui Li Yangyang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 8 | 蛇床子素通过抑制mir-34c表达防治尾吊大鼠模拟微重力导致的骨质流失显示文摘Bone loss is one of the major barriers for human deep space exploration.To date,there has been less effective measures against bone metabolism derangement during long-term spaceflights[1;2].Traditional Chinese Medicine(TCM)has been used for bone and joint diseases for thousands of years.Osthole(OST),an O-methylated coumarin,is originally extracted from the fruits of Cnidium monnieri which is a main osteoporosis treatment agent in TCM.Studies have demonstrated that OST have multiple pharmacological and biological features including neuroprotective,immunomodulatory,anticancer,hepatoprotective,cardiovascular protective,and antimicrobial activities[3].In addition,numerous studies also suggested that OST has better bone protection effects by enhancing the differentiation and maturation of osteoblasts[4;5].However,the functions of OST in regulation of bone loss induced by microgravity remain unclear. | Feng Xiu He Jinpeng Hua Junrui Long Kaiqin Zhang Yanan Wang Jufang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 9 | MiR-5094 Suppresses Cell Proliferation during Cellular Radiation Response via STAT5b显示文摘MicroRNAs(miRNAs)play important roles in the regulation of cellular stress responses[1].In our previous study,190 up-regulated miRNAs and 231 down-regulated miRNAs were detected in HeLa cells after 2 Gy X-ray irradiation using Solexa sequencing. | Ding Nan Hua Junrui He Jinpeng Wang Jufang | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 10 | Effect of Intake Conditions and Nozzle Geometry on Spray Characteristics of Group-Hole Nozzle显示文摘The group-hole nozzle concept is proposed to meet the requirement of nozzle hole minimization and reduce the negative impact of poor spatial spray distributions.However,there are limited researches on the effects of intake conditions and nozzle geometry on spray characteristics of the group-hole nozzle.Therefore,in this study,an accurate spray model coupled with the internal cavitating flow was established and computational fluid dynamics(CFD)simulations were done to study the effects of intake conditions and nozzle geometry on spray characteristics of the group-hole nozzle.Experimental data obtained using high-speed digital camera on the high-pressure common rail injection system was used to validate the numerical model.Effects of intake conditions(injection pressure and temperature)and nozzle geometry(orifice entrance curvature radius and nozzle length)on the flow and spray characteristics of the group-hole nozzle were studied numerically.The differences in Sauter mean diameter(SMD),penetration length and fuel evaporation mass between single-hole nozzle and group-hole nozzle under different nozzle geometry were also discussed.It was found that the atomization performance of the group-hole nozzle was better than that of the single-hole nozzle under same intake conditions,and the atomization effect of the short nozzle was better than that of the long nozzle.With increase in the orifice entrance curvature radius,the average velocity and turbulent kinetic energy of the fuel increased,which was conducive to improving the injection rate and flow coefficient of the nozzle.Meanwhile,the penetration length and SMD value rose,while evaporation mass dropped.When the ratio of the orifice entrance curvature radius(R)to the diameter of injection hole(D)was 0.12,the spray characteristics reached a constant state due to elimination of cavitation.Conclusions were made based on these.This study is expected to be a guide for the design of the group-hole nozzle. | Jianfeng Pan Jinpeng Hua Jiaqi Yao Abiodun Oluwaleke Ojo | 2023 | Energy Engineering2023，120，7： | 0 |
| 11 | 淫羊藿苷通过提高骨磷灰石稳定性抵御尾吊大鼠骨流失显示文摘Bone metabolism derangement induced by space microgravity is severe threaten to the health of astronauts[1].Exercise is the primary countermeasure in long-duration spaceflights,despite the outcomes remain debatable[2,3].In addition,pharmacological interventions cannot be used to protect against the osteoporosis induced by space environment due to various side effects[4,5]. | He Jinpeng Feng Xiu Shi Wengui Hua Junrui Li He Wang Jufang | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 12 | miR-300靶向apaf1降低电离辐射引发p53突变型肺癌细胞的凋亡显示文摘microRNAs(miRNAs)play important roles in the cellular response to ionizing radiation(IR)through regulating key mediators of DNA damage response pathways,such as ATM[1]and ATR[2].It has been revealed that miR-300 is involved in the cellular chemo-and radio-resistance in ovarian and gastric cancers[3,4].In recent study,we found that miR-300 abrogated IR-induced G2 cell cycle arrest in human lung cancer cells through targeting p53[5].However,the effects of miR-300 on the cellular sensitivity to IR in p53 mutant cells still need further investigation。 | He Jinpeng Feng Xiu Hua Junrui Wei Wenjun Wang Jufang | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 13 | 血清辐射敏感MicroRNA的鉴定及作为电离辐射标志物的应用显示文摘Ionizing radiation widely exists in environmental or industrial accidents,spaceflights and radiation therapy for cancer[1].Decades of researches have been dedicated to the discovery of inherent biomarkers of ionizing radiation exposure.The long-established gold standard biomarker of radiation exposure,such as cytogenetic analysis of peripheral blood lymphocytes,requires complex analysis and strict experimental condition[2].Recently,the studies have renewed search for rapid and simple methods to identify exposed individuals within large populations and to predict health effects in early stage[3].microRNAs(miRNAs)are small(19 to 24 nucleotides in length)endogenous noncoding RNA molecules and play an important role in the regulation of gene expression[4]. | Wei Wenjun Wang Jufang He Jinpeng Hua Junrui | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 14 | 4-67 miR-300 Modulates the Cellular Radiosensitivity Through Targeting p^53 in Human Non-small Cell Lung Cancer A549 Cells显示文摘microRNAs(miRNAs)perform crucial roles in mediation of the cellular radiosensitivity by influencing DNA damage repair,cell cycle checkpoint,apoptosis,radio-related signal transduction pathway and microenvironment[1-3].Our previous study have suggested that miR??300,whose expression is correlated positively with the cellular resistance to chemotherapy drug cis-platin in human ovarian cancer cells[4],is involved in the cellular response to the DNA damages induced by ionizing radiation[5].However,the underlying molecular mechanisms remain unclear. | He Jinpeng Wei Wenjun Feng Xiu Hua Junrui Lu Zhiwei Jin Liangliang Ding Nan Zhang Yanan Li He Wang Jufang | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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