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| 1 | Two-stage vs single-stage management for concomitant gallstones and common bile duct stones显示文摘AIM:To evaluate the safety and effectiveness of twostage vs single-stage management for concomitant gallstones and common bile duct stones.METHODS:Four databases,including PubMed,Embase,the Cochrane Central Register of Controlled Trials and the Science Citation Index up to September 2011,were searched to identify all randomized controlled trials(RCTs).Data were extracted from the studies by two independent reviewers.The primary outcomes were stone clearance from the common bile duct,postoperative morbidity and mortality.The secondary outcomes were conversion to other procedures,number of procedures per patient,length of hospital stay,total operative time,hospitalization charges,patient acceptance and quality of life scores.RESULTS:Seven eligible RCTs [five trials(n = 621) comparing preoperative endoscopic retrograde cholangiopancreatography(ERCP)/endoscopic sphincterotomy(EST) + laparoscopic cholecystectomy(LC) with LC + laparoscopic common bile duct exploration(LCBDE);two trials(n = 166) comparing postoperative ERCP/EST + LC with LC + LCBDE],composed of 787 patients in total,were included in the final analysis.The metaanalysis detected no statistically significant difference between the two groups in stone clearance from the common bile duct [risk ratios(RR) =-0.10,95% confidence intervals(CI):-0.24 to 0.04,P = 0.17],postoperative morbidity(RR = 0.79,95% CI:0.58 to 1.10,P = 0.16),mortality(RR = 2.19,95% CI:0.33 to 14.67,P = 0.42),conversion to other procedures(RR = 1.21,95% CI:0.54 to 2.70,P = 0.39),length of hospital stay(MD = 0.99,95% CI:-1.59 to 3.57,P = 0.45),total operative time(MD = 12.14,95% CI:-1.83 to 26.10,P = 0.09).Two-stage(LC + ERCP/EST) management clearly required more procedures per patient than single-stage(LC + LCBDE) management.CONCLUSION:Single-stage management is equivalent to two-stage management but requires fewer procedures.However,patient's condition,operator's expertise and local resources should be taken into account in making treatment decisions. | Jiong Lu Yao Cheng Xian-Ze Xiong Yi-Xin Lin Si-Jia Wu Nan-Sheng Cheng | 2012 | World Journal of Gastroenterology2012，18，24： | 107 |
| 2 | Decreased osteogenesis of adult mesenchymal stem cel s by reactive oxygen species under cyclic stretch: a possible mechanism of age related osteoporosis显示文摘Age related defect of the osteogenic differentiation of mesenchymal stem cells(MSCs) plays a key role in osteoporosis. Mechanical loading is one of the most important physical stimuli for osteoblast differentiation.Here, we compared the osteogenic potential of MSCs from young and adult rats under three rounds of 2 h of cyclic stretch of 2.5% elongation at 1 Hz on 3 consecutive days. Cyclic stretch induced a significant osteogenic differentiation of MSCs from young rats, while a compromised osteogenesis in MSCs from the adult rats.Accordingly, there were much more reactive oxygen species(ROS) production in adult MSCs under cyclic stretch compared to young MSCs. Moreover, ROS scavenger N-acetylcysteine rescued the osteogenic differentiation of adult MSCs under cyclic stretch. Gene expression analysis revealed that superoxide dismutase 1(SOD1) was significantly downregulated in those MSCs from adult rats. In summary, our data suggest that reduced SOD1 may result in excessive ROS production in adult MSCs under cyclic stretch, and thus manipulation of the MSCs from the adult donors with antioxidant would improve their osteogenic ability. | Jiali Tan Xin Xu Zhongchun Tong Jiong lin Qiujun Yu Yao Lin Wei Kuang | 2015 | Bone Research2015，3，1： | 15 |
| 3 | Randomized controlled trial of the absorbency of four dressings and their effects on the evaporation of burn wounds显示文摘背景创伤调味品被划分成传统、新的类型。新调味品被认为加速创伤愈合。这研究的目的是从灼伤 surface.Methods 在蒸发上在新调味品和他们的效果的吸收性上补充贫乏的数据四调味品的水吸收率(碳纤维调味品, hydrogel 调味品,银 nanoparticle 调味品,并且矿脂铁纱)被沉浸重量获得方法测量。有部分厚度的灼伤创伤随机被分到四的 10%superficial 的 120 个住院病人的一个总数组织,有 30 个参加者的各个。碳纤维调味品, hydrogel 调味品,和银 nanoparticle 调味品在组 A, B,和 C 被用作主要调味品,和传统的矿脂铁纱在组 D 被用作控制。从正常皮肤和裸体创伤,并且从被每四调味品盖住的创伤的多点蒸发被测量在天灼伤以后 1 , 3 , 5 ,并且 7 由在 21 -22 的条件下面的 EP-I 蒸发计,吸收四调味品评估的周围的温度和74%-78% humidity.Results 与碳纤维调味品是988%,96%与银 nanoparticle ,41%与矿脂铁纱,并且6%与 hydrogel 。从裸体灼伤创伤的蒸发比从正常皮肤(P0.01 ) 高关于 1/3。与没有应用调味品的创伤相比,从处理创伤的蒸发减少了并且是时间依赖者(P0.01 ) 。有碳纤维调味品的创伤的蒸发是最低((13. | CHEN Jiong HAN Chun-mao SU Guo-liang TANG Zhi-jian SU Shi-jie LIN Xiao-wei | 2007 | Chinese Medical Journal2007，，20： | 14 |
| 4 | Dysregulation of the miR-146a-Smad4 axis impairs osteogenesis of bone mesenchymal stem cells under inflammation显示文摘Osteoporosis is a common disease that affects patient quality of life, especially among the elderly population.Although inflammation contributes significantly to osteoporosis, the underlying mechanism is unclear. In this study, we found that tumor necrosis factor(TNF)-α, an inflammatory environment mimic, inhibits osteogenesis of bone mesenchymal stem cells(BMSCs), induces mi R-146 a and decreases Smad4. Moreover,overexpression of mi R-146 a inhibited the osteogenic ability of BMSCs, whereas blocking mi R-146 a partially rescued the osteogenesis deficiency under TNF-α treatment. Molecularly, mi R-146 a decreased Smad4 expression at the protein level by binding to an element located in the Smad4 30-untranslated region, and restoration of Smad4 reversed the inhibitory effects of mi R-146 a on osteogenesis. Together, our results showed that the inflammatory environment mimic TNF-α inhibits osteogenesis via upregulation of mi R-146 a and subsequent downregulation of Smad4, thus suggesting that therapeutic manipulation of mi R-146 a maybe a potential strategy to improve osteogenesis in the context of osteoporosis. | Wei Kuang Liwei Zheng Xin Xu Yao Lin Jiong Lin Jiahua Wu Jiali Tan | 2017 | Bone Research2017，5，4： | 13 |
| 5 | Moisture vapor transmission rates of various transparent dressings at different temperatures and humidities显示文摘背景透明调味品通常被用来盖住中央静脉的导管地点。然而,他们可能不允许足够的潮湿蒸汽传播,这被建议了,导致支持细菌的生长的本地湿。我们比较了潮湿蒸汽传播率(MVI-Rs ) 不同,当前使用透明、传统的铁纱调味品。我们试图在不同温度和 humidities.Methods 决定 MVTR 调味品被用来封上包含 20 ml deionized 水的 50-ml 塑料离心机试管:在组 1 的试管被平常的铁纱的 12 层盖住,与 IV3000 组织 2,与 OPSITE FLEXIGRID 组织 3,与 3M HP Tegaderm 组织 4,并且与 3M Tegaderm 组织 5。试管笔直地被放在一个人工的气候内阁以便调味品不正在摸水,以便在与皮肤的接触模仿医药调味品的条件。平均 MVTR 在不同条件下面被决定。MVTR 与从在他们的方面上生的组 2-5 的试管也是坚定的,允许调味品摸水因此模仿有出汗的皮肤的调味品的接触,或与流出物伤害了皮肤。当不在与水 surface.Results 组的接触 1 表明了最高的 MVTR 时,我们也由在与那些的与水表面的接触比较他们的 MV-rRs 计算了调味品的自我反应的能力,由组列在后面 2 , 4 , 3 和 5 在下列温度和湿度与正常皮肤调味品在模仿的条件下面联系:20C/30% , 20/60% , 20/90% , 37/30% , 37/60% 和 37/90% 。当相对湿度(RH ) 增加了时, MVTR 减少了。MVTR 在不同调味品和 RH 之中显著地不同:在高温度(37 ) 和高湿度(90%) ,在组 2 的透明调味品的 MVTR 比组 1 的高(P < 0.01 ) 。反应 MVTR 在组 2 是最高的(10.2-16.3 时间 > MVTR ) 当组 4 的最高是第二时(2.6-9.6 时间 > MVTR ).Conclusions RH 和温度在不同调味品的 MVTR 上有重要效果。在组 2 使用的 IV3000 透明调味品象平常的铁纱一样有效。这些结果建议那增加的感染由于低 MVTR 评价可能别是一个问题。为 cathetsr 相关的感染的这些观察的临床的含意需要进一步在 multicenter 研究被调查。 | LIN Yu-shuang CHEN Jiong LI Qiang PAN Ke-ping | 2009 | Chinese Medical Journal2009，，8： | 13 |
| 6 | Single-incision laparoscopic appendectomy vs conventional laparoscopic appendectomy:Systematic review and meta-analysis显示文摘AIM: To assess the differences in clinical benefits and disadvantages of single-incision laparoscopic appendectomy(SILA) and conventional laparoscopic appendectomy(CLA).METHODS: The Cochrane Library,MEDLINE,Embase,Science Citation Index Expanded,and Chinese Biomedical Literature Database were electronically searched up through January 2013 to identify randomized controlled trails(RCTs) comparing SILA with CLA.Data was extracted from eligible studies to evaluate the pooled outcome effects for the total of 1068 patients.The meta-analysis was performed using Review Manager 5.2.0.For dichotomous data and continuous data,the risk ratio(RR) and the mean difference(MD) were calculated,respectively,with 95%CI for both.For continuous outcomes with different measurement scales in different RCTs,the standardized mean difference(SMD) was calculated with 95%CI.Sensitivity and subgroup analyses were performed when necessary.RESULTS: Six RCTs were identified that compared SILA(n = 535) with CLA(n = 533).Five RCTs had a high risk of bias and one RCT had a low risk of bias.SILA was associated with longer operative time(MD = 5.68,95%CI: 3.91-7.46,P < 0.00001),higher conversion rate(RR = 5.14,95%CI: 1.25-21.10,P = 0.03) and better cosmetic satisfaction score(MD = 0.52,95%CI: 0.30-0.73,P < 0.00001) compared with CLA.No significant differences were found for total complications(RR = 1.15,95%CI: 0.76-1.75,P = 0.51),drain insertion(RR = 0.72,95%CI: 0.41-1.25,P = 0.24),or length of hospital stay(SMD = 0.04,95%CI:-0.08-0.16,P = 0.57).Because there was not enough data among the analyzed RCTs,postoperative pain was not calculated.CONCLUSION: The benefit of SILA is cosmetic satisfaction,while the disadvantages of SILA are longer operative time and higher conversion rate. | Yu-Long Cai Xian-Ze Xiong Si-Jia Wu Yao Cheng Jiong Lu Jie Zhang Yi-Xin Lin Nan-Sheng Cheng | 2013 | World Journal of Gastroenterology2013，19，31： | 8 |
| 7 | Role of interleukin-8 in the progression of estrogen receptor-negative breast cancer显示文摘背景雌激素受体(嗯) 是乳癌的很重要的 biomarker。嗯删除一致地与肿瘤前进,复发,转移和差的预后被联系了,但是生物机制仍然是不清楚的。嗯 interieukin-8 (IL-8 ) 的否定乳癌快车高水平。嗯表示罐头 downregulate IL-8 promotor 活动。作为多功能的 cytokine, IL-8 在肿瘤开始和开发举办许多重要生物活动。旨在在嗯否定的乳癌前进调查 IL-8 的角色,我们把 RNA 干扰技术用于明确地击倒在房间线 MDA-MB-231.Methods 介入 pRNA-IL-8 和控制是的嗯否定的乳癌的 IL-8 表示 transfected 进嗯(-) MDA-MB-231。增长,房间 apotosis,和侵略能力在 transfected, untransfected 和否定 transfected 房间被记录。这些房间被注入裸体鼠标估计 tumorigenicity,增长,转移和 microvessel 密度(MVD ) 在 vitro 的 .Results, IL-8 的减少的表示与被联系减少了房间侵略(P0.001 ) ,但是没在房间增长(P0.05 ) 上有效果。在 vivo, neutrophils 渗入显著地与 untransfected 相比并且否定地在 pRNA-IL-8 transfected 房间被禁止 transfected 房间(P=0.001, P0.001 ) 。更少的转移在 transfected 房间被发现与相比否定地 transfected 房间(0% 对 80% , P=0.048 ) 。不过,我们与控制相比在 transfected 房间观察了更少的 MVD 在里面裸体老鼠(P0.001 ).Conclusions IL-8 禁止嗯否定的乳癌房间生长并且在 vivo 支持它的转移,它可以被相关, neutrophils 渗入由 IL-8 导致了。 | YAO Chen LIN Ying YE Cai-sheng BI Jiong ZHU Yi-fan WANG Shen-ming | 2007 | Chinese Medical Journal2007，，20： | 8 |
| 8 | Admissibility analysis and control synthesis for switched linear singular systems显示文摘The problem of admissibility analysis and control synthesis of discrete-time switched linear singular (SLS) systems for arbitrary switching laws is solved.By using the switched Lyapunov function approach,some new sufficient conditions under which the SLS system is admissible for arbitrary switching laws are derived in terms of linear matrix inequalities(LMIs).Based on the admissibility results,control synthesis is then to design switched state feedback and static output feedback controllers,guaranteeing that the resulting closed-loop system is admissible.The presented results can be viewed as the extensions of previous works on switched Lyapunov function approach from the regular switched systems to singular switched cases.Examples are provided to demonstrate the reduced conservatism and effectiveness of the proposed conditions. | Lin Jinxing Fei Shumin Shen Jiong | 2009 | Journal of Systems Engineering and Electronics2009，20，5： | 4 |
| 9 | The synthesis of benzoxaboroles and their applications in medicinal chemistry显示文摘Benzoxaborole,as a versatile scaffold,plays important roles in organic synthesis,molecular recognition and supramolecular chemistry.It is also a privileged structure in medicinal chemistry due to its desirable physicochemical and drug-like properties.Recently,benzoxaboroles were widely applied as antifungal,antibacterial,antiviral,anti-parasite,and anti-inflammatory agents.This review covers the properties,synthetic methods and applications of benzoxaboroles in medicinal chemistry. | ZHANG Jiong ZHU MingYan LIN YiNan ZHOU HuChen | 2013 | Science China Chemistry2013，56，10： | 3 |
| 10 | Robust stability and stabilization for uncertain discrete-time switched singular systems with time-varying delays显示文摘The problems of robust stability and stabilization via memoryless state feedback for a class of discrete-time switched singular systems with time-varying delays and linear fractional uncertainties are investigated.By constructing a novel switched Lyapunov-Krasovskii functional,a delay-dependent criterion for the unforced system to be regular,causal and uniformly asymptotically stable is established in terms of linear matrix inequalities(LMIs).An explicit expression for the desired memoryless state feedback stabilization controller is also given.The merits of the proposed criteria lie in their less conservativeness and relative simplicity,which are achieved by considering additionally useful terms(ignored in previous methods) when estimating the upper bound of the forward difference of the Lyapunov-Krasovskii functional and by avoiding utilizing any model augmentation transformation.Some numerical examples are provided to illustrate the validity of the proposed methods. | Jinxing Lin Shumin Fei Jiong Shen | 2010 | Journal of Systems Engineering and Electronics2010，21，4： | 2 |
| 11 | Carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography:A meta-analysis and systematic review显示文摘AIM:To assess the safety and efficacy of carbon dioxide (CO2) insufflation during endoscopic retrograde cholangiopancreatography (ERCP). METHODS:The Cochrane Library, Medical Literature Analysis and Retrieval System Online, Excerpta Medica Database, Science Citation Index Expanded, Chinese Biomedical Literature Database, and references in relevant publications were searched up to December 2011 to identify randomized controlled trials (RCTs) comparing CO2 insufflation with air insufflation during ERCP. The trials were included in the review irrespec-tive of sample size, publication status, or language. Study selection and data extraction were performed by two independent authors. The meta-analysis was performed using Review Manager 5.1.6. A random-effects model was used to analyze various outcomes.Sensitivity and subgroup analyses were performed if necessary. R ESULTS:Seven double-blind RCTs involving a total of 818 patients were identified that compared CO2 insufflation (n = 404) with air insufflation (n = 401) during ERCP. There were a total of 13 post-random- ization dropouts in four RCTs. Six RCTs had a high risk of bias and one had a low risk of bias. None of the RCTs reported any severe gas-related adverse events in either group. A meta-analysis of 5 RCTs (n = 459) indicated that patients in the CO2 insufflation group had less post-ERCP abdominal pain and distension for at least 1 h compared with patients in the air insuf-flation group. There were no significant differences in mild cardiopulmonary complications [risk ratio (RR) = 0.43, 95% CI:0.07-2.66, P = 0.36], cardiopulmonary (e.g., blood CO2 level) changes [standardized mean difference (SMD) = -0.97, 95% CI: -2.58-0.63, P = 0.23], cost analysis (mean difference = 3.14, 95% CI:-14.57-20.85, P = 0.73), and total procedure time (SMD = -0.05, 95% CI:-0.26-0.17, P = 0.67) between the two groups. C ONCLUSION:CO2 insufflation during ERCP appears to be safe and reduces post-ERCP abdominal pain and discomfort. | Yao Cheng Xian-Ze Xiong Si-Jia Wu Jiong Lu Yi-Xin Lin Nan-Sheng Cheng Tai-Xiang Wu | 2012 | World Journal of Gastroenterology2012，18，39： | 2 |
| 12 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 13 | Risk factors for postoperative seromas in Chinese breast cancer patients显示文摘 | LIN Yan-ping YIN Wen-jin YAN Ting-ting ZHOU Li-heng DI Geng-hong WU Jiong SHEN Zhen-zhou SHAO Zhi-min LU Jin-song | 2011 | Chinese Medical Journal2011，，9： | 2 |
| 14 | Kupffer cells contribute to concanavalin A-induced hepatic injury through a Th1 but not Th17 type response-dependent pathway in mice显示文摘BACKGROUND:Increasing evidence suggests that a close interaction of Kupffer cells with T cells plays a central role in concanavalin A-induced hepatic injury in mice,but the underlying mechanisms remain obscure.The present study aimed to determine the relative roles of Th1 and Th17 type responses in concanavalin A-induced hepatic injury in mice, and to investigate whether or not Kupffer cells contribute to hepatic injury via a Th1 or Th17 type response-dependent pathway. METHODS:Immune-mediated hepatic injury was induced in C57BL/6 mice by intravenous injection of concanavalin A. Kupffer cells were inactivated by pretreatment with gadolinium chloride 24 hours before the concanavalin A injection.The interferon-gamma(IFN-γ)and interleukin-17(IL-17)pathways were blocked by specific neutralizing antibodies.Hepatic injury was assessed using serum transferase activity and pathological analysis.Expression of inflammatory cytokines within the liver was detected by real-time polymerase chain reaction and immunohistochemistry. RESULTS:Neutralization of IFN-γsignificantly attenuated concanavalin A-induced hepatic injury.However,neutralization of IL-17 failed to suppress the injury.Inactivation of Kupffer cells by gadolinium chloride pretreatment protected against concanavalin A-induced injury and significantly reduced hepatic cytokine levels including TNF-α,IL-6 and IFN-γbut not IL-17.CONCLUSION:Our findings suggest that Kupffer cells contribute to concanavalin A-induced hepatic injury via a Th1 type response-dependent pathway and production of inflammatory cytokines including TNF-α,IL-6 and IFN-γ. | Lin Chen,Xiao-Jun Xie,Yu-Fu Ye,Lin Zhou,Hai-Yang Xie,Qin-Fen Xie, Jiong Tian and Shu-Sen ZhengZhejiang University School of Medicine,Hangzhou 310003,ChinaKey Laboratory of Combined Multi-organ Transplantation,Ministry of Public Health Department of Hepatobiliary and Pancreatic Surgery Department of Nephrology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 2 |
| 15 | Mouse neural stem cells cultured in vitro and expressing an exogenous gene显示文摘Neural stem cells are the multipotential, self-renewing cells in central nerve system, and play an essential role in the development and differentiation of nerve system. Neural stem cells can be used to treat the nerve system diseases, especially, the transplantation of neural stem cells to rescue the degenerated neural cells has become a very promising therapeutic way. We successfully cultured neural stem cells isolated from the brains of embryonic mice in vitro and determined their distribution in the E17 mice brains. The neural stem cells were transfected with adenoviral vector carrying GFP (green fluorescence protein) gene and then highly expressed the exogenous gene. It paves the way for gene therapy of degenerative nerve system diseases. | Jiong Tang Hong Yu Lizhu Lin Haoquan Wu Shouyuan Zhao Changben Li | 2001 | Chinese Science Bulletin2001，46，7： | 2 |
| 16 | Associations of Daytime Napping with Incident Cardiovascular Diseases and Hypertension in Chinese Adults:A Nationwide Cohort Study显示文摘Objective This study aimed to examine the associations of daytime napping with incident risks of cardiovascular diseases(CVDs)and hypertension(HTN).Methods Data for napping and CVD outcomes in 25 provinces were collected from baseline(2010)and three waves of follow-up(2012-2017)investigations of the China Family Panel Studies.Cox frailty models with random intercepts for the surveyed provinces were used to assess the longitudinal effects of daytime napping on CVD and HTN.Results Compared with non-nappers,30+min nappers had higher risks of CVD and HTN,while no significant associations were observed among<30 min nappers.Incident risks among 30-to<60-min nappers increased by 22%[hazard ratio(HR)1.22,95% confidence interval(CI)1.08-1.39]for CVD and 21%(1.21,1.04-1.41)for HTN,respectively,with corresponding HRs of CVD and HTN of 1.27(1.09-1.47)and 1.38(1.16-1.65)among≥60 min nappers.Nap-associated CVD risks varied by subgroups,with stronger associations in participants with lower body mass index(<24 kg/m^(2)),physically inactive persons,smokers,and participants with longer nighttime sleep(≥7 h/night).Significant effects of daytime napping were observed on rural and northern residents only,highlighting great regional variations in CVD risks associated with napping habits.Conclusions This cohort study revealed strong evidence that long daytime napping(≥30 min)is associated with an increased incidence of cardiovascular events. | WANG Lu WANG Ke LIU Lin Jiong ZHANG Yuan Yuan SHU Hai Nan WANG Kai ZHOU Pei Xuan ZHANG Yun Quan | 2022 | Biomedical and Environmental Sciences2022，35，1： | 2 |
| 17 | Immune genetic optimization algorithm based on multilayer fuzzy control显示文摘 | LIN Jinxing SHEN Jiong XIAO Guotao | 2005 | Journal of Southeast University2005，35，1： | 1 |
| 18 | PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE)-a population-based prospective cohort study: rationale, design and baseline participant characteristics显示文摘Background and purpose Cardiovascular diseases and dementia are two major diseases in the elderly.Atherosclerosis is associated with future vascular events and cognitive impairment.The PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events(PRECISE)study is a population-based prospective cohort study with comprehensive evaluation of multiterritorial artery stenosis and plaque using advanced vascular imaging techniques and prospective collection of vascular events and cognitive assessments.Methods Between May 2017 and September 2019,the PRECISE study enrolled 3067 community-dwelling adults with ages between 50 and 75 years cluster sampled from six villages and four communities of Lishui city in China.Data are collected in face-to face interviews at baseline,2-year and 4-year follow-up visits.Brain MRI including high-resolution sequences for intracranial and carotidal arteries and CT angiography for thoracoabdominal arteries were performed at baseline and will be rescanned after 4 years.Cardiovascular/cerebrovascular events and cognitive assessment will be prospectively collected after the enrollment.Blood and urine samples were collected and biomarkers were tested at baseline.Results A total of 3067 subjects were enrolled,among which 53.5%were female with an average age of 61.2±6.7 years.Among them,2.8%,8.1%,43.1%and 21.6%had a history of stroke,coronary heart diseases,hypertension and diabetes mellitus,respectively.Conclusions The PRECISE study is a population-based prospective cohort study with comprehensive evaluation of atherosclerotic stenosis and plaque using advanced vascular imaging techniques.Data from this cohort provide us an opportunity to precisely evaluate polyvascular atherosclerosis and its association with future vascular events and cognitive impairment. | Yuesong Pan Jing Jing Xueli Cai Yilong Wang Suying Wang Xia Meng Chunlai Zeng Jiong Shi Jiansong Ji Jinxi Lin Lingchun Lyu Zhe Zhang Lerong Mei Shiping Li Shan Li Wanlin Zhu Hao Li Tiemin Wei Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 1 |
| 19 | Modeling photobleached optical polymer waveguides 显示文摘 | Jiong Ma Sihan Lin Wei Feng | 1995 | Appl Opt1995，34，24： | 1 |
| 20 | Down-regulation of FoxM1 leads to the inhibition of epithelial-mesenchymal transition in gastric cancer cells显示文摘 | Lifeng Miao Xianze Xiong Yixin Lin Yao Cheng Jiong Lu Jie Zhang Nansheng Cheng | 2014 | Cancer Genetics2014，，： | 1 |
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