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| 1 | The application of nanoparticles in cancer immunotherapy:Targeting tumor microenvironment显示文摘The tumor development and metastasis are closely related to the structure and function of the tumor microenvironment(TME).Recently,TME modulation strategies have attracted much attention in cancer immunotherapy.Despite the preliminary success of immunotherapeutic agents,their therapeutic effects have been restricted by the limited retention time of drugs in TME.Compared with traditional delivery systems,nanoparticles with unique physical properties and elaborate design can efficiently penetrate TME and specifically deliver to the major components in TME.In this review,we briefly introduce the substitutes of TME including dendritic cells,macrophages,fibroblasts,tumor vasculature,tumor-draining lymph nodes and hypoxic state,then review various nanoparticles targeting these components and their applications in tumor therapy.In addition,nanoparticles could be combined with other therapies,including chemotherapy,radiotherapy,and photodynamic therapy,however,the nanoplatform delivery system may not be effective in all types of tumors due to the heterogeneity of different tumors and individuals.The changes of TME at various stages during tumor development are required to be further elucidated so that more individualized nanoplatforms could be designed. | Muyue Yang Jipeng Li Ping Gu Xianqun Fan | 2021 | Bioactive Materials2021，6，7： | 21 |
| 2 | Machining character- istics of Nickel-based alloy with positive polarity blasting erosion arc machining 显示文摘 | Xu Hui Gu Lin Chen Jipeng | 2015 | The International Journal of Advanced Manufacturing Technology2015，，： | 1 |
| 3 | Novel phosphorus-containing hyperbranched polysiloxane and its high performance flame retardant cyanate ester resins显示文摘 | Juhua Ye Guozheng Liang Aijuan Gu Zhiyong Zhang Jipeng Han Li Yuan | 2012 | Polymer Degradation and Stability2012，，： | 1 |
| 4 | Machining characteristics of nickel-based alloy with positive polarity blasting erosion arc machining 显示文摘 | Xu Hui Gu Lin Chen Jipeng | 2015 | The International Journal of Advanced Manufacturing Technology2015，79，5： | 1 |
| 5 | Machining charac- teristics of nickel-based alloy with positive polarity blast- ing erosion arc machining显示文摘 | XU Hui GU Lin CHEN Jipeng | 2015 | International Journal of Ad- vanced Manufacturing Technology2015，79，58： | 1 |
| 6 | Simulation of temperature distribution and discharge crater of SiC_(p)/Al composites in a single-pulsed arc discharge显示文摘SiC_(p)/Al composites are difficult-to-cut materials.In recent years,electrical arc discharge machining has been developed to improve the machinability of these materials.However,there is a big challenge to build a satisfactory heat transfer model of SiC_(p)/Al composites in the arc machining.This is not only because of the material property difference between the reinforcement and matrix material but also because of the micro-dimension Si C reinforcements.This paper established a new heat conduction simulation model considering the Si C particle-Al matrix interface and the phase change effects in a single-pulsed arc discharge of SiC_(p)/Al composites.A novel Si C particle-Al matrix cell geometric model was designed firstly.Then,the temperature distribution at a different depth from the workpiece surface was analyzed,the influence of sic volume fraction on temperature field was studied,and the contribution of the interface thermal resistance and latent heat were explained.To demonstrate the validity of the new numerical model,comparisons and verifications were employed.Finally,the method of improving the model was proposed and the machining mechanism of arc discharge of SiC_(p)/Al matrix materials was discussed.It was found that high temperature is prone to concentrate on the surface layers of the workpiece especially when the Si C fraction is high,also,the temperature fluctuates respectively at the evaporation point of aluminum and Si C,and the Si C-Al resistance has less influence on temperature distribution compared to latent heat,etc.The model build in this work improves the simulation accuracy observably compared to the previous model,and the simulation work will help to acquire a detailed mechanism of material removal of SiC_(p)/Al composites in the arc discharge machining. | Jipeng CHEN Lin GU Wansheng ZHAO Mario GUAGLIANO | 2021 | Chinese Journal of Aeronautics2021，34，9： | 0 |
| 7 | Research on Short-Term Load Forecasting of Distribution Stations Based on the Clustering Improvement Fuzzy Time Series Algorithm显示文摘An improved fuzzy time series algorithmbased on clustering is designed in this paper.The algorithm is successfully applied to short-term load forecasting in the distribution stations.Firstly,the K-means clustering method is used to cluster the data,and the midpoint of two adjacent clustering centers is taken as the dividing point of domain division.On this basis,the data is fuzzed to form a fuzzy time series.Secondly,a high-order fuzzy relation with multiple antecedents is established according to the main measurement indexes of power load,which is used to predict the short-term trend change of load in the distribution stations.Matlab/Simulink simulation results show that the load forecasting errors of the typical fuzzy time series on the time scale of one day and one week are[−50,20]and[−50,30],while the load forecasting errors of the improved fuzzy time series on the time scale of one day and one week are[−20,15]and[−20,25].It shows that the fuzzy time series algorithm improved by clustering improves the prediction accuracy and can effectively predict the short-term load trend of distribution stations. | Jipeng Gu Weijie Zhang Youbing Zhang Binjie Wang Wei Lou Mingkang Ye Linhai Wang Tao Liu | 2023 | Computer Modeling in Engineering & Sciences2023，，9： | 0 |
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