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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | Predictive value of serum levels of transforming growth factor beta 1 for the short-term effects of radiotherapy and chemotherapy in patients with esophageal cancer显示文摘Objective To investigate variation in levels of transforming growth factor beta 1(TGF-β1)before and after radiotherapy in patients with esophageal cancer in order to evaluate the predictive value of TGF-β1 for the effects of radiotherapy Methods A total of 140 patients with esophageal squamous carcinoma undergoing radical radiation therapy in the Department of Oncology from March 2015 to December 2017 were enrolled.The patients were divided into the effective(115 cases)and ineffective(25 cases)groups according to World Health Organization(WHO)criteria for the evaluation of solid tumors(2009 RECIST standard).TGF-β1 levels were measured in all patients by using enzyme-linked immunosorbent assay(ELISA).Multiple-factor analysis of the predictive value of the treatment efficacy was performed by Cox regression analysis.Results After radiotherapy,36,79,and 25 cases experienced complete response(CR),partial response(PR),and no response(NR),respectively,with a total effective rate of 82.14%.The TGF-β1 level was significantly lower in the effective group than that in the ineffective group(P<0.05)and covariance analysis revealed significantly reduced TGF-β1 level in esophageal cancer patients following radiotherapy.The multi-factor Cox regression model revealed that the predictive value of TGF-β1 for the effect of radiotherapy was largest,with a hazard ratio[HR]of 1.955(P=0.002),followed by exposure dose,with(HR=1.367;P=0.035).Conclusion Serum TGF-β1 level can serve as a predictor for the short-term effects of radiotherapy in patients with esophageal cancer. | Fei Gao Lin Jia Jianjun Han Jisheng Wang Yun Wang | 2018 | Oncology and Translational Medicine2018，4，1： | 4 |
| 3 | Monoclonal antibodies to human telomerase reverse transcfiptase(hTERT) : preparation, characterization and application 显示文摘 | Yang Shaomin Zhang Bo Han Jisheng | 2001 | Hybridoma2001，4，： | 1 |
| 4 | Acupuncture:neuropeptide release produced by electrical stimulation of different frequencies显示文摘 | Han Jisheng | 2003 | Trends Neurosci2003，26，1： | 1 |
| 5 | Spinal kappa-opioid system plays an important role in suppressing morphine withdrawal syndrome in the rat显示文摘 | Cui Cailian Wu Liuzhen Han Jisheng | 2000 | Neurosci Letters2000，295，12： | 1 |
| 6 | Orphanin FQ antagonizes the analgesic effect of 5-HT in rat brain显示文摘Orphanin FQ (OFQ) is a new modulatory peptide which was found in 1994. It mediates in morphine analgesia and electroacupuncture analgesia. The interaction between OFQ and 5-hydroxytryptamine (5-HT) on analgesia was observed using the method of intracerebroventricular microinjection. The results showed that cumulative i. c.v. administration of gradually increasing doses of 5-HT produced a dose-dependent analgesia, and administration of different doses of OFQ separateness had no significant effect on tail flick latency, but 1 or 10 μg OFQ could reverse the analgesia induced by 5-HT, suggesting that OFQ could antagonize the analgesia induced by 5-HT in rat brain. | Yun Wang Aixu Zhang Wei Xu Jaukang Chang Jisheng Han | 1999 | Chinese Science Bulletin1999，44，9： | 1 |
| 7 | Prevention of relapse to heroin by Han' acupoint nerve stimulation 显示文摘 | Han Jisheng Wu Liuzhen Cui Cailian | 2003 | Chin J Integra Med2003，9，1： | 1 |
| 8 | Acupuncture-related techniques for the treatment of opiate addiction:a case of translational medicine显示文摘Drug addiction is a chronic brain disorder characterized by withdrawal symptoms that occur during drug abstinence and a high tendency of relapse.Compared with the currently available pharmacological interventions,acupuncture therapy has the potential to help drug addicts stay away from drugs without major adverse side effects.It has taken decades of research to optimize the parameters of electrical acupoint stimulation for detoxification and for relapse prevention,as well as to establish a safe and easy procedure by which drug addicts can use it on themselves.The discovery that acupuncture can trigger the release of opioid substances from the brain in the 1970s provided the inspiration.Following this,basic research on animals made it possible to understand the mechanisms of action and establish the procedure for treating drug addictions.This article reviews the past,present,and foreseeable future regarding the use of acupuncture-related technique for the treatment of opiate addiction from the perspective of translational medicine. | Jisheng Han Cailian Cui Liuzhen Wu | 2011 | Frontiers of Medicine2011，5，2： | 1 |
| 9 | Acupuncture-related techniques for treatment of opiate addiction: a case of translational medicine 显示文摘 | Han Jisheng Cui Cailian Wu Liuzhen | 2005 | Front Med2005，5，2： | 1 |
| 10 | Relationship between the analgesic effect of electroacupuncture and CCK-8 content in spinal perfusate in rats显示文摘There exists significant individual variation in electroacupuncture (EA) induced analgesia.Rats may be classified as high- and low-responders according to their response to EA analgesia. The content of cholecystokinin octapeptide like immunoreactivity (CCK-8-ir) in the spinal perfusate of highresponder (HR) and low-responder (LR) rats was measured with radioimmunoassay. The result showed that the CCK-8-ir content in LR rats was significantly lower than that in HR rats. There exists a negative correlation between the EA effect and the CCK-8-ir content during EA stimulation. It is concluded that the spinal release of CCK-8 may be one of the key factors determining the effect of EA analgesia. | Suxing Liu Fei Luo Shang Shen Yingxin Yu Jisheng Han | 1999 | Chinese Science Bulletin1999，44，3： | 1 |
| 11 | Improvement for expansion of parabolized stability equation method in boundary layer stability analysis显示文摘An improved expansion of the parabolized stability equation(iEPSE) method is proposed for the accurate linear instability prediction in boundary layers. It is a local eigenvalue problem, and the streamwise wavenumber α and its streamwise gradient dα/dx are unknown variables. This eigenvalue problem is solved for the eigenvalue dα/dx with an initial α, and the correction of α is performed with the conservation relation used in the PSE. The i EPSE is validated in several compressible and incompressible boundary layers. The computational results show that the prediction accuracy of the i EPSE is significantly higher than that of the ESPE, and it is in excellent agreement with the PSE which is regarded as the baseline for comparison. In addition, the unphysical multiple eigenmode problem in the EPSE is solved by using the i EPSE. As a local non-parallel stability analysis tool, the i EPSE has great potential application in the eNtransition prediction in general three-dimensional boundary layers. | Yufeng HAN Jianxin LIU Jisheng LUO | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，12： | 1 |
| 12 | Effect of nocistatin in pain modulation显示文摘Using tail-flick latency as the nociceptive index and von Frey hair to measure the mechanical allodynia, the aim of the present study is to determine whether nocistatin, injected intracerebroventricularly (i.c.v.), would reverse the anti-morphine effect of orphanin FQ (OFQ), and, injected i.c.v. or intrathecally (i.t.), would inhibit the mechanical allodynia in a L5 and L6 spinal nerve ligation model of neuropathic pain in rats. The results show that i.c.v. injection of nocistatin produces no significant changes in the TFL, nor does it affect morphine analgesia. in addition, i.c.v. or i.t. nocistatin produces no significant changes in withdrawal threshold of the nerve-lesioned hind paw. However, nocistatin significantly reverses the antagonistic effect of OFQ on morphine analgesia when it was coinjected i.c.v. with OFQ. The results suggest that nocistatin can reverse the anti-morphine effect of OFQ in rat brain, but cannot inhibit the mechanical allodynia of neuropathic pain in rat brain and spinal cord. | ZHAO Chengshui SUN Ruiqing LI Bingshan WANG Yun LUO Fei WANG Xiaomin CHANG Jaokang HAN Jisheng | 2000 | Chinese Science Bulletin2000，45，8： | 1 |
| 13 | Inhibitory effects of single-trial transcutaneous electrical nerve stimulation at 2 Hz on cue-induced heroin craving and cue-reactivity显示文摘 | Zhong Fei Liuzhen Wu Jisheng Han | 2006 | Addict Biol2006，11，： | 1 |
| 14 | Adenovirus mediated GDNF protects cultured moto-neurons from gluta- mate injury 显示文摘 | Tang Xiaoqing Wang Yun Han Jisheng | 2001 | Neuroreport2001，12，14： | 1 |
| 15 | Chemically derived graphene quantum dots for high-strain sensing显示文摘Graphene quantum dots(GQDs)refer to graphene fragments with a lateral dimension typically less than 100 nm,which possess unique electrical and optical properties due to the quantum confinement effect.In this study,we demonstrate that chemically derived graphene quantum dots show great potential for making highly stretchable and cost-effective strain sensors via an electron tunneling mechanism.Stretch-able strain sensors are critical devices for the field of flexible or wearable electronics which are expected to maintain function up to high strain values(>30%).However,strain sensors based on conventional materials(i.e.metal or semiconductors)or metal nanoparticles(e.g.gold or silver nanoparticles)only work within a small range of strain(i.e.the former have a working range<1%and the latter<3%).In this study,by simply dropcasting solution-processed GQDs between the interdigitated electrodes on polydimethylsiloxane,we obtained devices that can function in the range from 0.06%to over 50%ten-sile strain with both the sensitivity and working range conveniently adjustable by the concentration of GQDs applied.This study provides a new concept for practical applications of GQDs,revealing the poten-tial of this material for smart applications such as artificial skin,human-machine interfaces,and health monitoring. | Shujun Wang Francesco Lenzini Dechao Chen Philip Tanner Jisheng Han David Thiel Mirko Lobino Qin Li | 2023 | Journal of Materials Science & Technology2023，，10： | 1 |
| 16 | Acupuncture-related techniques for the treatment of opiate addiction:a case of translational medicine显示文摘Frontiers of Medicine 2011,5(2):141–150 A mistake appeared in the sentence on lines 4–6 on the right column of page 148.The sentence“Low frequency(represented by 2 Hz)EA is most effective for suppressing the withdrawal syndromes and high frequency(100 Hz)EA is best for alleviating craving.”should be changed to“Low frequency(represented by 2 Hz)EA is most effective for alleviating craving and high frequency(100 Hz)EA is best for suppressing the withdrawal syndromes.” | Jisheng Han Cailian Cui Liuzhen Wu | 2011 | Frontiers of Medicine2011，5，3： | 0 |
| 17 | Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection显示文摘The systemic benefits of anti-inflammatory pharmacotherapy vary across cardiovascular diseases in clinical practice.We aimed to evaluate the application of artificial intelligence to acute type A aortic dissection(ATAAD)patients to determine the optimal target population who would benefit from urinary trypsin inhibitor use(ulinastatin).Patient characteristics at admission in the Chinese multicenter 5A study database(2016-2022)were used to develop an inflammatory risk model to predict multiple organ dysfunction syndrome(MODS). | Hong Liu Haiyang Li Lu Han Yingyuan Zhang Ying Wu Liang Hong Jinong Yang Jisheng Zhong Yuqi Wang Dongkai Wu Guoliang Fan Junquan Chen Shengqiang Zhang Xingxing Peng Zhihua Zeng Zhiwei Tang Zhanjie Lu Lizhong Sun Sichong Qian Yongfeng Shao Hongjia Zhang on behalf of the Additive Anti-inflammatory Action for Aortopathy&Arteriopathy(A)Investigators | 2023 | The Innovation2023，4，4： | 0 |
| 18 | Research advances in gene therapy for Parkinson's disease显示文摘During the long period of time when people have been seeking for an effective therapeutic method for PD, the gene therapy has shown greater and greater advantages over other methods. It can be performed mainly in two ways: ex vivo and in vivo. With the former, TH gene as well as some neurotrophic factor genes (such as GDNF, BNDF genes) can be invited to some cell lines or primary cells thus forming engineered cells and then implanting them into brain. While with the latter, viral vectors including HSV-1, Ad, AAV that can be utilized to construct recombinant viruses, or non-virus vectors can be used to delived DNA into brain directly. The present review summarizes the recent research advances in the gene therapy for PD, and it is reasonable for us to predict a notable progress in prevention and treatment for PD in the next decade. | MA Duanduan, WANG Xiaomin * and HAN Jisheng Neuroscience Research Institute, Beijing Medical University, Beijing 100083, China. * Corresponding author. | 1998 | Chinese Science Bulletin1998，43，5： | 0 |
| 19 | COEXISTENCE OF FOS-LIKE PROTEIN IN TYROSINE HYDROXYLASE-LIKE IMMUNOREACTIVE NEURONS IN THE HINDBRAIN OF ARTS FOLLOWING PERIPHERAL ELECTRICAL STIMULATION显示文摘In the present study we have found that proto-oncogene c-fos protein can expressin the noradrenergic neurons of rat hindbrain following peripheral electrical stimulation. Ratswere given peripheral electrical stimulation via thin stainless steel pins inserted into the pointsnear knee joint (S36) and ankle joint (Sp6) which mimic the manipulation of electroacupuncture(EA) performed in humans. Animals were perfused for double staining immunohistochemistry 2hafter the termination of EA. In rats subjected to EA stimulation Fos-like protein was found in thetyrosine hydroxylase (TH)-like immunoreactive neurons in rat hindbrain. The Fos and TH coex-isting neurons were distributed in the locus coeruleus, solitary tract nucleus, ventrolateral medul-la, periaqeductal gray, as well as superior colliculus. The percentage of the coexisting neuronscompared with the total number of neurons containing Fos-like protein in these nuclei rangedfrom 6% to 32%. The results suggest that the noradrenergic neurons in these regions may be ac-tivted by acupuncture stimulation. | Ji Rurong Fang Yuan Zhang Qin Han Jisheng, Department of Physiology, Beijing Medical University, Beijing 100083, China | 1993 | Chinese Journal of Biomedical Engineering(English Edition)1993，2，1： | 0 |
| 20 | ACUPUNCTURE RESEARCH & NEUROSCIENCE DEVELOPMENT显示文摘Acupuncture has been used in China for more than 2,000 years for the treatment of various kinds of diseases and symptoms. It is especially effective in the treatment of pain. In the late 1950s, there emerged a novel medical practice entitled 'acupuncture anesthesia' (AA), i.e., acupuncture was claimed to be effective | Han Jisheng(Neuroscience Research Center, Beijing Medical University) | 1998 | Bulletin of the Chinese Academy of Sciences1998，12，1： | 0 |
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