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| 1 | Telling Duckweed Apart:Genotyping Technologies for the Lemnaceae显示文摘The family of Lemnaceae,commonly called duckweed,comprise five genera and 37 species of aquaticmonocotyledonous plants that are endemic to lakes,ponds and brackish water bodies on most continents. They are angiospermsthat have the highest biomass production rate and have been used to remediate wastewater from both municipal andindustrial sources. With these attractive features,duckweed is poised to be a novel agricultural platform that can complementcurrent terrestrial crops. In addition,their remarkable ability to adapt to diverse climates and conditions may provide newunderstanding of stress tolerance and genome adaptability mechanisms. However,one of the first challenges facing theseapplications is to establish reliable and rapid methods for identification of closely related strains that may have very differentbehaviour or properties. This review article summarizes the state of the arts for this endeavour and provides the outlook for thisquest in the near future. | Klaus J.Appenroth Nikolai Borisjuk Eric Lam | 2013 | 应用与环境生物学报2013，19，1： | 11 |
| 2 | Factors associated with incomplete small bowel capsule endoscopy studies显示文摘AIM:To identify patient risk factors associated with incomplete small bowel capsule endoscopy(CE) studies.METHODS:Data from all CE procedures performed at St.Paul's Hospital in Vancouver,British Columbia,Canada,between December 2001 and June 2008 were collected and analyzed on a retrospective basis.Data collection for complete and incomplete CE study groups included patient demographics as well as a number of potential risk factors for incomplete CE including indication for the procedure,hospitalization,diabetes mellitus with or without end organ damage,limitations in mobility,renal insufficiency,past history of bowel obstruction,abdominal surgery,abdominal radiation therapy and opiate use.Risk factors were analyzed using a univariable and multivariable logistic regression model.RESULTS:From a total of 535 CE procedures performed,158 were incomplete(29.5%).The univariable analysis showed that CE procedures performed for overt gastrointestinal bleeding(P = 0.002),and for patients with a prior history of abdominal surgery(P = 0.023) or bowel obstruction(P = 0.023) were significantly associated with incomplete CE studies.Patients on opiate medications(P = 0.094) as well as hospitalized patients(P = 0.054) were not statistically significant,but did show a trend towards incomplete CE.The multivariable analysis showed that independent risk factors for an incomplete CE procedure include prior history of bowel obstruction [odds ratios(OR) 2.77,P = 0.02,95% confidence intervals(CI):1.17-6.56] and procedures performed for gastrointestinal bleeding(Occult OR 2.04,P = 0.037,95% CI:1.04-4.02 and Overt OR 2.69,P = 0.002,95% CI:1.44-5.05).Patients with a prior history of abdominal surgery(OR 1.46,P = 0.068,95% CI:0.97-2.19),those taking opiate medications(OR 1.54,P = 0.15,95% CI:0.86-2.76) and hospitalized patients(OR 1.82,P = 0.124,95% CI:0.85-3.93) showed a trend towards statistical significance.CONCLUSION:We have identified a number of risk factors for incomplete CE procedures that can be used to risk-stratify patients and guide interventions to improve completion rates. | Mitchell M Lee Andrew Jacques Eric Lam Ricky Kwok Pardis Lakzadeh Ajit Sandhar Brandon Segal Sigrid Svarta Joanna Law Robert Enns | 2010 | World Journal of Gastroenterology2010，16，42： | 10 |
| 3 | Biliary brush cytology:Factors associated with positive yields on biliary brush cytology显示文摘AIM: To evaluate the yield of brushing biliary strictures and the factors associated with a positive result in biliary strictures. METHODS: Data on all consecutive patients (01/02 -10/05) who were identified to have a biliary stricture and who underwent biliary brush cytology were collected. The yield of positive biliary brush cytology was evaluated and compared to results with the gold standard for diagnosis (defi ned as either defi nitive surgical histology or clinical course). Additionally,associated factors of positive results including stricture location,gender,age,mass size,length of stricture,and dilatation prior to brushing cytology were assessed. RESULTS: From 199 patients who had brushing cytology samples (10 patients were excluded due to lack of gold standard diagnosis),77 patients had positive brushing cytology (yield 41%). Variables associated with positive cytology brushing on initial endoscopic retrograde cholangiography were age 1.02 (1.00-1.05),mass size > 1 cm 2.22 (1.01-4.89) and length of stricture > 1 cm 3.49 (1.18-10.2). The sensitivity of biliary brushing was 61%,its specifi city 98%,the positive predictive value reached 99%,and the negative predictive value was 57%. CONCLUSION: Our results revealed a 41% positive yield from brushing cytology. The sensitivity of biliary brushing cytology in our center was 61% and the specif icity was 98%. Predictors of positive yield include older age,mass size > 1 cm,and stricture length of > 1 cm. | Nasim Mahmoudi Robert Enns Jack Amar Jaber AlAli Eric Lam Jennifer Telford | 2008 | World Journal of Gastroenterology2008，14，4： | 10 |
| 4 | A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice显示文摘瞄准:表示 23-ku pE2 到花费有效地,肝炎 E 病毒(HEV ) 的 3'-portion 包括的 E2 碎片编码的最有希望的子单元疫苗打开读物框架 2 (ORF2 ) 在烟草的质体(Nicotiana 烟 cv。SR1 ) ,在质体调查 transgene 表示和 pE2 累积,并且评估反在老鼠的导出质体的 pE2 的遗传因子的效果。方法:包含米饭 psbA 倡导者驾驶的 E2 碎片的指向质体的向量 pRB94-E2 被构造。在进烟草质体的交货之上,这构造能在质体染色体在 psaB-trnfM 和 trnG-psbC 碎片开始相应再结合,并且导致在二碎片之间插入的 transgene。pRB94-E2 与一个 biolistic 粒子轰炸方法被交付,并且转变质体的工厂被获得在补充 spectinomycin 的媒介上跟随炮轰的叶纸巾的新生。改革工厂的 Transplastomic 地位被 PCR 和南部的污点分析证实, transgene 表示被北污点分析调查,并且 pE2 的累积被 ELISA 测量。而且,蛋白浸出物被用来使老鼠免疫,并且在使免疫的老鼠的浆液样品的 pE2 反应的抗体的存在被 ELISA 学习。结果:PCR 和南部的污点分析证实的 Transplastomic 线能活跃地抄录 E2 mRNA。pE2 多肽象 13.27 microg/g 一样高被积累到水平新鲜叶子。pE2 能刺激使免疫的老鼠产生 pE2 特定的抗体。结论:HEV-E2 碎片能被插入到质体染色体,导出的 recombinant pE2 抗原是在老鼠遗传因子的反。因此,质体可以是为 HEV 疫苗的划算的生产的新奇来源。 | Yuan-Xiang Zhou Maggie Yuk-Ting Lee James Ming-Him Ng Mee-Len Chye Wing-Kin Yip Sze-Yong Zee Eric Lam | 2006 | World Journal of Gastroenterology2006，12，2： | 10 |
| 5 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 6 | Mesenchymal Stem Cells Inhibit Dendritic Cell Differentiation and Function by Preventing Entry Into the Cell Cycle显示文摘 | Rajesh Ramasamy Henrietta Fazekasova Eric W.-F. Lam Inês Soeiro Giovanna Lombardi Francesco Dazzi | 2007 | Transplantation2007，，1： | 2 |
| 7 | Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib显示文摘 | Yuqing Liu Zhuo Wang Shu Qin Kwong Eric Lik Hang Lui Scott L. Friedman Fu Rong Li Reni Wing Chi Lam Guo Chao Zhang Hui Zhang Tao Ye | 2011 | Journal of Hepatology2011，，3： | 2 |
| 8 | The cause of land-use and land-cover change: moving beyond the myths显示文摘 | Eric F Lam bin TurnerB L Helmut J | 2001 | Global Environmental Change2001，11，： | 1 |
| 9 | The expression of interleukin-8 and interleukin-8 receptors in endometrial carcinoma显示文摘 | Lauren Ewington Alexandra Taylor Ruethairat Sriraksa Yoshiya Horimoto Eric W.-F. Lam Mona A. El-Bahrawy | 2012 | Cytokine2012，，2： | 1 |
| 10 | DNA Adduct Formation and DNA Strand Breaks in Green-lipped Mussels ( Perna viridis ) Exposed to Benzopyrene: Dose- and Time-Dependent Relationships显示文摘 | Eric W.K. Ching William H.L. Siu Paul K.S. Lam Lihong Xu Yongyuan Zhang Bruce J. Richardson Rudolf S.S. Wu | 2001 | Marine Pollution Bulletin2001，，7： | 1 |
| 11 | The conserved ELK-homeodomain of KNOTTED-1 contains two regions that signal nuclear localization显示文摘 | Lee Meisel Eric Lam | 1996 | Plant Molecular Biology1996，，1： | 1 |
| 12 | Detection and Localization of Intraepithelial Neoplasia and Invasive Carcinoma Using Fluorescence-Reflectance Bronchoscopy: An International, Multicenter Clinical Trial显示文摘 | Eric Edell Stephen Lam Harvey Pass York E. Miller Thomas Sutedja Timothy Kennedy Gregory Loewen Robert L. Keith | 2009 | Journal of Thoracic Oncology2009，，1： | 1 |
| 13 | CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer显示文摘Background:Overexpression of Aurora-A(AURKA)is a feature of breast cancer and associates with adverse prognosis.The selective Aurora-A inhibitor alisertib(MLN8237)has recently demonstrated promising antitumor responses as a single agent in various cancer types but its phase III clinical trial was reported as a failure since MLN8237 did not show an apparent effect in prolonging the survival of patients.Thus,identification of potential targets that could enhance the activity of MLN8237 would provide a rationale for drug combination to achieve better therapeutic outcome.Methods:Here,we conducted a systematic synthetic lethality CRISPR/Cas9 screening of 507 kinases using MLN8237 in breast cancer cells and identified a number of targetable kinases that displayed synthetic lethality interactions with MLN8237.Then,we performed competitive growth assays,colony formation assays,cell viability assays,apoptosis assays,and xenograft murine model to evaluate the synergistic therapeutic effects of Haspin(GSG2)depletion or inhibition with MLN8237.For mechanistic studies,immunofluorescence was used to detect the state of microtubules and the localization of Aurora-B and mitotic centromere-associated kinesin(MCAK).Results:Among the hits,we observed that Haspin depletion or inhibition marginally inhibited breast cancer cell growth but could substantially enhance the killing effects of MLN8237.Mechanistic studies showed that co-treatment with Aurora-A and Haspin inhibitors abolished the recruitment of Aurora-B and mitotic centromere-associated kinesin(MCAK)to centromeres which were associated with excessive microtubule depolymerization,kinetochore-microtubule(KT-MT)attachment failure,and severe mitotic catastrophe.We further showed that the combination of MLN8237 and the Haspin inhibitor CHR-6494 synergistically reduced breast cancer cell viability and significantly inhibited both in vitro and in vivo tumor growth.Conclusions:These findings establish Haspin as a synthetic lethal target and demonstrate CHR-6494 as a potential combinational drug for promoting the therapeutic effects of MLN8237 on breast cancer. | Ailin Chen Shijun Wen Fang Liu Zijian Zhang Meiling Liu Yuanzhong Wu Bin He Min Yan Tiebang Kang Eric W-F Lam Zifeng Wang Quentin Liu | 2021 | Cancer Communications2021，41，2： | 1 |
| 14 | Type II enteropathy‐associated T‐cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group显示文摘 | Eric Tse Harinder Gill Florence Loong Seok Jin Kim Siok‐Bian Ng Tiffany Tang Young‐Hyeh Ko Wee‐Joo Chng Soon‐Thye Lim Won Seog Kim Yok‐Lam Kwong | 2012 | Am J Hematol2012，，7： | 1 |
| 15 | Caspase-like protease involvement in the control of plant cell death显示文摘 | Eric Lam Olga del Pozo | 2000 | Plant Molecular Biology2000，，3： | 1 |
| 16 | Prospective analysis of fluoroscopy duration during ERCP: critical determinants显示文摘 | Edward Kim Mark McLoughlin Eric C. Lam Jack Amar Michael Byrne Jennifer Telford Rob Enns | 2010 | Gastrointestinal Endoscopy2010，，1： | 1 |
| 17 | FOXM1: From cancer initiation to progression and treatment显示文摘 | Chuay-Yeng Koo Kyle W. Muir Eric W.-F. Lam | 2011 | BBA - Gene Regulatory Mechanisms2011，，1： | 1 |
| 18 | Limits-to-arbitrage, investment frictions, and the asset growth anomaly显示文摘 | F.Y. Eric C. Lam K.C. John Wei | 2011 | Journal of Financial Economics2011，，1： | 1 |
| 19 | Detection and localizationof intraepithelial neoplasia and invasive carcinoma using fluorescence-re- flectance bronchoscopy 显示文摘 | Eric Edell MD stephen Lam MD FCCP | 2009 | AM J Thorac Onco12009，4，1： | 1 |
| 20 | Investment Fric-tions,and the Asset Growth Anonmaly显示文摘 | Lam Eric John Wei Limit-to-Arbitrage | 2011 | Journal of Finan-cial Economics2011，102，1： | 1 |
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