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3篇 您的检索式：作者名="Joerg Ermann"

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		题名	作者	年代	出处	被引量
	1	Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts显示文摘Multiple regulatory mechanisms control osteoblast differentiation and function to ensure unperturbed skeletal formation and remodeling. In this study we identify histone lysine-specific demethylase 1(LSD1/KDM1 A) as a key epigenetic regulator of osteoblast differentiation. Knockdown of LSD1 promoted osteoblast differentiation of human mesenchymal stem cells(hMSCs)in vitro and mice lacking LSD1 in mesenchymal cells displayed increased bone mass secondary to accelerated osteoblast differentiation. Mechanistic in vitro studies revealed that LSD1 epigenetically regulates the expression of WNT7 B and BMP2. LSD1 deficiency resulted in increased BMP2 and WNT7 B expression in osteoblasts and enhanced bone formation, while downregulation of WNT7 B-and BMP2-related signaling using genetic mouse model or small-molecule inhibitors attenuated bone phenotype in vivo. Furthermore, the LSD1 inhibitor tranylcypromine(TCP) could increase bone mass in mice. These data identify LSD1 as a novel regulator of osteoblast activity and suggest LSD1 inhibition as a potential therapeutic target for treatment of osteoporosis.	Jun Sun Joerg Ermann Ningning Niu Guang Yan Yang Yang Yujiang Shi Weiguo Zou	2018	Bone Research2018，6，3：	5
	2	Donor - type CD4^+ CD25^+ regulatory T cells suppress lethal acute graft - versus - host disease after allogeneic bone marrow transplantation 显示文摘	Petra Hoffmann Joerg Ermann Matthlas Edinger	2002	The Journal of Experimental Medicine2002，196，：	1
	3	After GWAS: mice to the rescue?显示文摘	Joerg Ermann Laurie H Glimcher	2012	Current Opinion in Immunology2012，，：	1

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