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| 1 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 2 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 3 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 4 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 5 | 显示文摘 | Kapteijn Freek Heiszwolf Johan J Nijhuis T A (Xander) | 1999 | CATTECH1999，3，： | 2 |
| 6 | Separation mechanism in dehydration of water/organic binary liquids bypcrvaporation through microporous silica 显示文摘 | Sekulic J Johan E Elshof T Dave H A | 2005 | Journal of Membrane Science2005，254，12： | 1 |
| 7 | Aspects of innovation theory based on knowledge-management显示文摘 | JON-ARILD J OLSEN B JOHAN O | 1999 | International Journal of Information Management1999，19，2： | 1 |
| 8 | Diferential feeding of worker larve affects caste characters in honeybee,Apis mellifera capensis显示文摘 | MIKE H JOHAN NM WILLEM J | 2003 | Behav Ecol Sociobiol2003，，54： | 1 |
| 9 | Interaction of the antidepressant mirtazapine with α 2 -adrenoceptors modulating the release of 5-HT in different rat brain regions in vivo显示文摘 | H. J?rgen Bengtsson Julianna Kele Johan Johansson Stephan Hjorth | 2000 | Naunyn-Schmiedeberg’s Archives of Pharmacology (-)2000，，4： | 1 |
| 10 | Antifungal effect of dairy propi- onibacteria-contribution of organic acids 显示文摘 | Helen L Hans J Johan S | 2005 | International Journal of Food Microbiology2005，98，： | 1 |
| 11 | Antitumor effect radioactive cisplatin on nude mice显示文摘 | Johan A Johan W Anders J | 2001 | Int J Radiat Oncol Biol Phy2001，49，3： | 1 |
| 12 | Mineral absorption and excretion as affected by microbial phytase,and their effect on energy metabolism in young piglets 显示文摘 | Arie K K Walter J J G Johan W S | 2005 | J Nutr2005，135，： | 1 |
| 13 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 14 | Cervical arthroplasty with the Bryan Disc:4-year results显示文摘 | Gofifn J Johan VL Frank VC | | 0，，5： | 1 |
| 15 | Identification of stem cells in small intestine and colon by marker gene Lgr5 显示文摘 | Barker N Johan H Van Es J H | 2007 | Nature2007，449，7165： | 1 |
| 16 | Cervical arthroplasty with the Bryan Disc:4-year results显示文摘 | Goffin J Johan VL Frank VC | 2006 | Spine J2006，6，5： | 1 |
| 17 | Laparoscopic correction of perforated peptic ulcer: first choice?A review of literature显示文摘 | Marietta J O E Bertleff Johan F Lange | 2010 | Surgical Endoscopy2010，32，6： | 1 |
| 18 | A clinical analysis of 4-and 6-year follow-up results after cervical disc re- placement surgery using the Bryan cervical disc pros- thesis显示文摘 | Goffin J Johan VL Frank YC | 2010 | J Neurosurg Spine2010，12，3： | 1 |
| 19 | Experimental investigation of the Tra-nsformation and Release to Gas Phase of Potas- sium and Chlorine during Straw Pyrolysis 显示文摘 | P A Jensen F J Frandsen K D Johan - senetal | 2000 | Energy & Fuels2000，14，6： | 1 |
| 20 | Collusion, reputation damage and intereste in codes of conduct: the case of a Dutch constructioncompany显示文摘 | Johan J Graafland | 2004 | Business Ethics: A EuropesnReview2004，13，23： | 1 |
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