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| 1 | Management of necrotizing pancreatitis显示文摘Infection complicating pancreatic necrosis leads to persisting sepsis, multiple organ dysfunction syndrome and accounts for about half the deaths that occur following acute pancreatitis. Severe cases due to gallstones require urgent endoscopic sphincterotomy. Patients with pancreatic necrosis should be followed with serial contrast enhanced computed tomography (CE-CT) and if infection is suspected fine needle aspiration of the necrotic area for bacteriology (FNAB) should be undertaken. Treatment of sterile necrosis should initially be non-operative. In the presence of infection necrosectomy is indicated. Although traditionally this has been by open surgery, minimally invasive procedures are a promising new alternative. There are many unresolved issues in the management of pancreatic necrosis. These include, the use of antibiotic prophylaxis, the precise indications for and frequency of repeat CE-CT and FNAB,and the role of enteral feeding. | John Slavin Paula Ghaneh Robert Sutton Mark Hartley Peter Rowlands Conall Garvey Mark Hughes John Neoptolemos | 2001 | World Journal of Gastroenterology2001，7，4： | 21 |
| 2 | 局部无缝垂直参考基准面的建立方法研究显示文摘为在局域建立一个无缝垂直参考基准面,提出了两步转换的思想和方法,即从大地高到正高然后到海图高。利用该方法,构造了Saint John河高程转换模型,并在该河段建立了无缝垂直参考基准面,且得到了实际验证。 | 赵建虎 张红梅 John E Hughes Clarke | 2006 | 武汉大学学报(信息科学版)2006，31，5： | 12 |
| 3 | Determination of Precise Instantaneous Height at Multibeam Transducer显示文摘克服缺点传统多微笑调查并且数据处理,一个新方法为即时高度的精确决心被介绍在多,由 GPS 高度和举的混合的横梁变换器发信号。信号需要被态度修正首先改正到变换器中心的 Beforesignal 混合, GPS 高度和举。第二, GPS 高度需要被举支票和修正本身检查并且修改。黄油价值和快速傅里叶变换(快 Fourier 转变) 在信号混合被使用。最后,快速傅里叶变换被认为在信号处理适当。新方法高效地克服传统的方法的缺点,并且这是由 MBS 的证明的井(多微笑深测术的系统) 实验。 | ZHAO Jianhu ZHANG Hongmei John E. Hughes Clarke | 2007 | Geo-Spatial Information Science2007，10，4： | 6 |
| 4 | Functional Analysis of a Rice Oxidosqualene Cyclase through Total Gene Synthesis显示文摘Dear Editor, Plants produce a large range of triterpenoids that serve as chemical defenses against pathogens.For example,β-amyrin synthase (AsbAS1) performs the initial enzymatic step in the biosynthesis of the potent antimicrobial avencins in oats (Haralampidis et al.,2001).Additionally,other triterpenoids such as glycyrrhizin and QS21 are known to have beneficial or detrimental effects for human health (Osbourn et al.,2011).For some time,heterologous expression of plant oxidosqualene cyclases (OSCs) in yeast has been a powerful methodology for the functional characterization of this important family of triterpene biosynthetic enzymes.The foundational work in this area employed the lanosterol-deficient Saccharomyces cerevisiae strain SMY1 to characterize the function of Arabidopsis thaliana cycloartenol synthase (CAS)(Corey et al.,1993). | Juncong Sun Xia Xu Zheyong Xue John Hugh Snyder Xiaoquan Qi | 2013 | Molecular Plant2013，6，5： | 4 |
| 5 | Lower gastrointestinal bleeding: Association with Sevelamer use显示文摘Stercoral ulceration results from impaction of hard fecal mass on the colonic wall and is a relatively unknown cause of lower gastrointestinal bleeding. In this report, we describe a case of lower gastrointestinal bleeding due to stercoral ulceration resulting from Sevelamer, a drug which is commonly associated with constipation. | Pankaj Madan Suverta Bhayana Prakash Chandra John I Hughes | 2008 | World Journal of Gastroenterology2008，14，16： | 3 |
| 6 | Discrimination and Quantification of True Biological Signals in Metabolomics Analysis Based on Liquid Chromatography-Mass Spectrometry显示文摘 | Duan, Lixin Molnar, Istvan Snyder, John Hugh Shen, Guo-an Qi, Xiaoquan | 2016 | Molecular Plant2016，9，8： | 3 |
| 7 | Long-Term Outcomes for Patients with Post–Liver Transplant Anastomotic Biliary Strictures Treated by Endoscopic Stent Placement显示文摘 | Joseph Morelli Hugh E Mulcahy Ira R Willner John T Cunningham Peter Draganov | 2003 | Gastrointestinal Endoscopy2003，，3： | 2 |
| 8 | How functional programming mattered显示文摘In 1989 when functional programming was still considered a niche topic, Hughes wrote a visionary paper arguing convincingly ‘why functional programming maters'. More than two decades have passed. Has functional programming really matered? Our answer is a resounding ‘Yes!'. Functional programming is now at the forefront of a new generation of programming technologies, and enjoying increasing popularity and inluence. In this paper, we review the impact of functional programming, focusing on how it has changed the way we may construct programs, the way we may verify programs, and fundamentally the way we may think about programs. | Zhenjiang Hu John Hughes Meng Wang | 2015 | National Science Review2015，2，3： | 2 |
| 9 | Systematic review and meta‐analysis of continuous local anaesthetic wound infiltration versus epidural analgesia for postoperative pain following abdominal surgery显示文摘 | N. T. Ventham M. Hughes S. O’Neill N. Johns R. R. Brady S. J. Wigmore | 2013 | Br J Surg2013，，10： | 2 |
| 10 | 多波束测量中换能器瞬时精密高程的确定显示文摘分析了GPS高程信号和Heave信号的频段特征,利用数字信号处理技术,提取了GPS高程和Heave中的有效频段信号,合成了一个全新的信号。该合成信号能够全面反映多波束换能器的实际垂直运动,并能够克服传统多波束测量和数据处理方法的缺陷,大大提高了多波束在垂直方向的成果精度。实验证明了该方法的正确性和可行性。 | 赵建虎 张红梅 John E Hughes Clarke 王胜平 | 2006 | 武汉大学学报(信息科学版)2006，31，11： | 2 |
| 11 | The application of the QSSA via reaction lumping for the reduction of complex hydrocarbon oxidation mechanisms显示文摘 | Kevin J. Hughes Mike Fairweather John F. Griffiths Richard Porter Alison S. Tomlin | 2009 | Proceedings of the Combustion Institute2009，，1： | 2 |
| 12 | Regulation of the immune response by soybean isoflavones显示文摘 | Madhan Masilamani John Wei Hugh A. Sampson | 2012 | Immunologic Research2012，，1： | 2 |
| 13 | Eosinophilic esophagitis attributed to gastroesophageal reflux: Improvement with an amino acid-based formula显示文摘 | Kevin J. Kelly Audrey J. Lazenby Peter C. Rowe John H. Yardley Jay A. Perman Hugh A. Sampson | 1995 | Gastroenterology1995，，： | 2 |
| 14 | As-rigid-as-possible shape manipulation显示文摘 | Takeo Igarashi Tomer Moscovich John F. Hughes | 2005 | ACM Transactions on Graphics (TOG)2005，，3： | 2 |
| 15 | The effect of resisted sprint training on maximum sprint kinetics and kinematics in youth显示文摘 | Michael C. Rumpf John B. Cronin Ikhwan N. Mohamad Sharil Mohamad Jon L. Oliver Michael G. Hughes | 2015 | European Journal of Sport Science2015，，： | 1 |
| 16 | Management compensation and earnings-based covenants as signaling devices in credit markets显示文摘 | Carolyn B. Levine John S. Hughes | 2005 | Journal of Corporate Finance2005，，5： | 1 |
| 17 | 'Disease and development' in Africa显示文摘 | John M Hunter | 1970 | Soci al Science and Medicine1970，3，： | 1 |
| 18 | 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design显示文摘 | Hugh Calkins Karl Heinz Kuck Riccardo Cappato Josep Brugada A. John Camm Shih-Ann Chen Harry J.G. Crijns Ralph J. Damiano D. Wyn Davies John DiMarco James Edgerton Kenneth Ellenbogen Michael D. Ezekowitz David E. Haines Michel Haissaguerre Gerhard Hindric | 2012 | Heart Rhythm2012，，： | 1 |
| 19 | Fecal Water as a Non-Invasive Biomarker in Nutritional Intervention: Comparison of Preparation Methods and Refinement of Different Endpoints显示文摘 | Annett Klinder Pernilla C. Karlsson Yvonne Clune Roisin Hughes Michael Glei Joseph J. Rafter Ian Rowland John K. Collins Beatrice L. Pool-Zobel | 2007 | Nutrition and Cancer2007，，2： | 1 |
| 20 | Functionalised polysiloxanes as injectable, in situ curable accommodating intraocular lenses显示文摘 | Xiaojuan Hao Justine L. Jeffery John S. Wilkie Gordon F. Meijs Anthony B. Clayton Jason D. Watling Arthur Ho Viviana Fernandez Carolina Acosta Hideo Yamamoto Mohamed G.M. Aly Jean-Marie Parel Timothy C. Hughes | 2010 | Biomaterials2010，，32： | 1 |
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