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| 1 | NaCl对水稻谷氨酸合酶和谷氨酸脱氢酶的胁迫作用显示文摘在 Na Cl的胁迫下 ,水稻幼苗根和叶的谷氨酸合酶和谷氨酸脱氢酶的活性随着营养液中的 Na Cl浓度的升高而降低 ;游离 NH+ 4 在叶中积累 ,在根中未见明显变化。与根相比 ,叶对 Na Cl的胁迫作用更为敏感。叶的 NADH- GOGAT和 NADH- GDH活性在 Na Cl胁迫下降低的程度明显大于根。无论是否有 Na Cl存在 ,根的 NADH- GDH活性明显高于叶。 GS/GDH比值分析提示 ,在对照下 ,根中的 NH+ 4 的同化以 GS- GOGAT途径为主 ;而在 Na Cl胁迫下 ,GS- GOGAT途径明显削弱 ,GDH途径在 NH+ 4 的同化中的作用明显加强。无论是否有 Na Cl的存在 ,叶的 NH+ 4 同化途径都是以 GS- GOGAT为主。 | 林清华 李常健 彭进 张楚富 Peng Shaobing Bennett John | 2000 | 武汉植物学研究2000，18，3： | 34 |
| 2 | Chemical poison and regeneration of SCR catalysts for NOx removal from stationary sources显示文摘有 NH 3 的没有 x 的选择催化减小(SCR ) 是一种有效技术不把 x 从静止来源移开,例如开火煤的发电厂和工业锅炉。一些在苍蝇灰的元素撤销催化剂由于活跃地点上的强壮的化学吸着。毒物可以由简单地堵住活跃地点行动或由一个电子相互作用改变反应物和产品的吸附行为。这评论主要集中于在 V 2 O 5-based 催化剂,环境良性的催化剂和低温度催化剂。几普通毒物包括 alkali/alkaline 地球金属, 2 和重金属等等因此被提交,他们催化剂上的毒害的机制被讨论。毒害的催化剂的新生方法和毒物抵抗催化剂的发展也被比较并且分析。最后,在发展毒害抵抗催化剂的未来研究方向和为 SCR 催化剂的灵巧的有效新生方法被建议。 | Junhua LI Yue PENG Huazhen CHANG Xiang LI John C. CRITTENDEN Jiming HAO | 2016 | Frontiers of Environmental Science & Engineering2016，10，3： | 12 |
| 3 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 4 | Deformation response of roof in solid backfilling coal mining based on viscoelastic properties of waste gangue显示文摘Solid backfill mining(SBM)is a form of green mining,the core of which is to control and minimize the deformation and movement of strata above longwall coal mines.Establishing a mechanical model that can reliably describe roof deformation by considering the viscoelastic properties of waste gangue is important as it assists in improving mine designs and reducing the environmental impact on the surface.In this paper,the time-dependent deformation characteristics of gangue under different stress levels were obtained by using lateral confinement compression,that reliably represents the compaction of goaf.The viscoelastic foundation model for gangue mechanical response is different from the traditionally used elastic foundation model,as it considers the time factor and viscoelasticity.A mechanical model using a thin plate on a fractional viscoelastic foundation was established,and the roof deflection,bending moment,time-dependent,viscous and other characteristics of SBM were included and analyzed.Compared with the existing elastic foundation model,the proposed fractional order viscoelastic foundation model has higher accuracy with laboratory data.The plate deflection increases by 50.9%and the bending moment increases by 37.9%after 100 days,which the elastic model would not have been able to predict. | Peng Huang Jixiong Zhang Xingjie Yan Anthony John Spencer Spearing Meng Li Shiwei Liu | 2021 | International Journal of Mining Science and Technology2021，31，2： | 8 |
| 5 | Mapping landslide susceptibility at the Three Gorges Reservoir, China, using gradient boosting decision tree,random forest and information value models显示文摘This work was to generate landslide susceptibility maps for the Three Gorges Reservoir(TGR) area, China by using different machine learning models. Three advanced machine learning methods, namely, gradient boosting decision tree(GBDT), random forest(RF) and information value(InV) models, were used, and the performances were assessed and compared. In total, 202 landslides were mapped by using a series of field surveys, aerial photographs, and reviews of historical and bibliographical data. Nine causative factors were then considered in landslide susceptibility map generation by using the GBDT, RF and InV models. All of the maps of the causative factors were resampled to a resolution of 28.5 m. Of the 486289 pixels in the area,28526 pixels were landslide pixels, and 457763 pixels were non-landslide pixels. Finally, landslide susceptibility maps were generated by using the three machine learning models, and their performances were assessed through receiver operating characteristic(ROC) curves, the sensitivity, specificity,overall accuracy(OA), and kappa coefficient(KAPPA). The results showed that the GBDT, RF and In V models in overall produced reasonable accurate landslide susceptibility maps. Among these three methods, the GBDT method outperforms the other two machine learning methods, which can provide strong technical support for producing landslide susceptibility maps in TGR. | CHEN Tao ZHU Li NIU Rui-qing TRINDER C John PENG Ling LEI Tao | 2020 | Journal of Mountain Science2020，17，3： | 7 |
| 6 | A deep learning-integrated micro-CT image analysis pipeline for quantifying rice lodging resistance-related traits显示文摘Lodging is a common problemin rice,reducing its yield andmechanical harvesting efficiency.Rice architecture is a key aspect of its domestication and a major factor that limits its high productivity.The ideal rice culm structure,includingmajor_axis_culm,minor axis_culm,andwall thickness_culm,is critical for improving lodging resistance.However,the traditionalmethod ofmeasuring rice culms is destructive,time consuming,and labor intensive.In this study,we used a high-throughput micro-CT-RGB imaging system and deep learning(SegNet)todevelopa high-throughputmicro-CTimageanalysis pipelinethatcanextract 24 riceculmmorphological traits and lodging resistance-related traits.When manual and automatic measurements were compared at themature stage,the mean absolute percentage errors for major_axis_culm,minor_axis_culm,andwall_thickness_culmin 104 indica rice accessionswere 6.03%,5.60%,and 9.85%,respectively,and the R^(2) valueswere 0.799,0.818,and 0.623.We also builtmodels of bending stress using culmtraits at the mature and tillering stages,and the R^(2) values were 0.722 and 0.544,respectively.The modeling results indicated that this method can quantify lodging resistance nondestructively,even at an early growth stage.In addition,we also evaluated the relationships of bending stress toshoot dryweight,culm density,and drought-related traits and found that plants with greater resistance to bending stress had slightly higher biomass,culm density,and culm area but poorer drought resistance.In conclusion,we developed a deep learning-integrated micro-CT image analysis pipeline to accurately quantify the phenotypic traits of rice culms in4.6 min per plant;this pipeline will assist in future high-throughput screening of large rice populations for lodging resistance. | Di Wu Dan Wu Hui Feng Lingfeng Duan Guoxing Dai Xiao Liu Kang Wang Peng Yang Guoxing Chen Alan P.Gay John H.Doonan Zhiyou Niu Lizhong Xiong Wanneng Yang | 2021 | Plant Communications2021，2，2： | 7 |
| 7 | Efficient first-principles prediction of solid stability:Towards chemical accuracy显示文摘The question of material stability is of fundamental importance to any analysis of system properties in condensed matter physics and materials science.The ability to evaluate chemical stability,i.e.,whether a stoichiometry will persist in some chemical environment,and structure selection,i.e.what crystal structure a stoichiometry will adopt,is critical to the prediction of materials synthesis,reactivity and properties.Here,we demonstrate that density functional theory,with the recently developed strongly constrained and appropriately normed(SCAN)functional,has advanced to a point where both facets of the stability problem can be reliably and efficiently predicted for main group compounds,while transition metal compounds are improved but remain a challenge.SCAN therefore offers a robust model for a significant portion of the periodic table,presenting an opportunity for the development of novel materials and the study of fine phase transformations even in largely unexplored systems with little to no experimental data. | Yubo Zhang Daniil A.Kitchaev Julia Yang Tina Chen Stephen T.Dacek Rafael A.Sarmiento-Pérez Maguel A.L.Marques Haowei Peng Gerbrand Ceder John P.Perdew Jianwei Sun | 2018 | npj Computational Materials2018，，1： | 7 |
| 8 | 甲醇合成反应热力学分析及实验研究显示文摘比较了近年来文献中甲醇合成反应平衡常数的各种计算方法 ,采用固定床反应器在反应温度为 2 30~ 2 70℃和反应压力为 5~ 8MPa的条件下对甲醇合成反应热力学进行了实验研究。结果表明 ,不同计算方法的预测结果存在较大的差异 ,而采用 Reid的热容数据及 SRK方程得到的计算结果与实验结果吻合很好 。 | 刁杰 王金福 王志良 金涌 John C Tao Xiang-Dong Peng | 2001 | 化学反应工程与工艺2001，17，1： | 7 |
| 9 | Human ACE2-Functionalized Gold“Virus-Trap”Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS Detection显示文摘The current COVID-19 pandemic urges the extremely sensitive and prompt detection of SARS-CoV-2 virus.Here,we present a Human Angiotensin-converting-enzyme 2(ACE2)-functionalized gold“virus traps”nanostructure as an extremely sensitive SERS biosensor,to selectively capture and rapidly detect S-protein expressed coronavirus,such as the current SARS-CoV-2 in the contaminated water,down to the single-virus level.Such a SERS sensor features extraordinary 106-fold virus enrichment originating from high-affinity of ACE2 with S protein as well as“virus-traps”composed of oblique gold nanoneedles,and 109-fold enhancement of Raman signals originating from multi-component SERS effects.Furthermore,the identification standard of virus signals is established by machine-learning and identification techniques,resulting in an especially low detection limit of 80 copies mL^(−1) for the simulated contaminated water by SARS-CoV-2 virus with complex circumstance as short as 5 min,which is of great significance for achieving real-time monitoring and early warning of coronavirus.Moreover,here-developed method can be used to establish the identification standard for future unknown coronavirus,and immediately enable extremely sensitive and rapid detection of novel virus. | Yong Yang Yusi Peng Chenglong Lin Li Long Jingying Hu Jun He Hui Zeng Zhengren Huang Zhi-Yuan Li Masaki Tanemura Jianlin Shi John R.Lombardi Xiaoying Luo | 2021 | Nano-Micro Letters2021，13，7： | 6 |
| 10 | Autonomic Disturbances in Acute Cerebrovascular Disease显示文摘Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network. We summarize the structures of the central autonomic network and the clinical tests used to evaluate the functions of the autonomic nervous system.We review the clinical and experimental findings as well as management strategies of post-stroke autonomic disturbances including electrocardiographic changes, cardiac arrhythmias, myocardial damage, thermoregulatory dysfunction, gastrointestinal dysfunction, urinary incontinence, sexual disorders, and hyperglycemia. The occurrence of autonomic disturbances has been associated with poor outcomes in stroke patients. Autonomic nervous system modulation appears to be an emerging therapeutic strategy for stroke management in addition to treatments for sensorimotor dysfunction. | Jun Mo Lei Huang Jianhua Peng Umut Ocak Jianmin Zhang John H.Zhang | 2019 | Neuroscience Bulletin2019，35，1： | 6 |
| 11 | Mass balance-based regression modeling of Cd and Zn accumulation in urban soils of Beijing显示文摘Accumulation of heavy metals in urban soil can pose adverse impacts on public health and terrestrial ecosystems. We developed a mass balance-based regression model to simulate the heavy metal accumulation in urban soils as a function of time and to explore connections between metal concentration and urbanization processes. Concentrations of Cd and Zn in 68 residential soil samples in the urban area of Beijing were used. The background concentrations, the loss rates and the input fluxes of Cd and Zn in urban soils of Beijing during the last three decades were estimated using a regression of the time series of accumulations of the metals. Based on the regression estimates, we simulated the general trends of Cd and Zn accumulation in the soils from 1978 to 2078. The concentrations of Cd and Zn in urban soil generally increased with the population growth, vehicle use and coal consumption. The mean concentrations of Cd and Zn in urban soil of Beijing would increase by 3 fold over the next 70 years for the current development scenario. The mass balance-based regression approach, which is able to reconstruct the history data of urban soil pollution, provides fundamental information for urban planning and environmental management. | Chi Peng Meie Wang Weiping Chen Andrew C.Chang John C.Crittenden | 2017 | Journal of Environmental Sciences2017，29，3： | 6 |
| 12 | Potential therapeutic options for coronavirus disease 2019:using knowledge of past outbreaks to guide future treatment显示文摘In December 2019,initial cases of the novel coronavirus(2019-nCoV)infection,termed coronavirus disease 2019(COVID-19),were first reported in Wuhan,China.[1]In humans,infections with the human coronavirus 229E,OC43,NL63,and HKU1 usually result in mild,selflimiting upper respiratory tract infections.However,other variants have rapid transmission rates and can cause severe respiratory syndrome and death.These variants include severe acute respiratory syndrome coronavirus(SARSCoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and the current 2019-nCoV. | John Lin Jing Ouyang Xiao-Rong Peng Stephane Isnard Brandon Fombuena Jean-Pierre Routy Yao-Kai Chen | 2020 | Chinese Medical Journal2020，，11： | 6 |
| 13 | 孤啡肽基因敲除小鼠电针镇痛作用增强显示文摘目的 :孤啡肽是阿片受体样受体 (ORL1)的内源性配基 ,它能调节疼痛与镇痛反应以及针刺镇痛反应 ,但各个实验室所得结果各不相同。本文利用OFQ基因敲除的小鼠为工具 ,观察内源性OFQ在针刺镇痛中的作用。方法 :采用本实验室建立的小鼠电针方法 ,选用穴位足三里 (SP 36)与三阴交 (SP 6) ,电针参数采用韩氏仪恒流方波输出 ,强度 1.0 1.2 1.4mA ,每 10min递增一级。痛阈的改变以热辐射甩尾来评价。结果 :与野生型小鼠相比 ,OFQ基因敲除小鼠基础痛阈明显延长 ,对 10 0Hz电针镇痛反应显著增强 ,但不影响 2Hz电针镇痛。结论 :在整体情况下 ,内源性OFQ有紧张性的致痛敏作用 ,并对 10 0Hz针刺镇痛有拮抗作用。 | 万有 Bonnie Peng John E.Pintar 韩济生 | 2001 | 中国疼痛医学杂志2001，7，3： | 6 |
| 14 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 15 | Changes of Levels of Glutamine Synthetase Isoforms in Roots and Leaves in Responseto Nitrogen Fertilizer Application at Different Growth Stages in Irrigated Rice显示文摘Nitrogen is a key element to control the growth and yield of crops. Fertilizer urea nitrogen(N)60,45,and 30 kg/hm2 was applied at three different stages, midtillering, panicle initiation, and flowering,of the growth and development of rice plants. respectively. At both midtillering and panicle initiation, the total activity of glutamine synthetase (GS) in rice roots and leaves ovas increased remarkably as a result of a large amount of ammonia absorbed by roots. Native-PAGE and activity staining showed that the increase of total activity in rice roots and leaves was due to the synthesis of GSrb in roots and GSZ in leaves and that the activity of GSra in roots and GSI in leaves remained constant. The results shoaled that the assimilation of external nitrogen was carried out by GSrb but not GSra in rice roots and that the activitry. of GS2 ovas induced also by the external nitrogen, and that GSrb played main role in meeting the needs of the rapid tillering for nitrogen. At flowering, the activity of GS in rice roots and leaves did not change almost after topdressing.These rssults suggest that the change of GS activity in rice roots may use as a measure of the utilization efficiency of the fertilizer. | Zhang Chufu Peng Shaobing John Bennett | 1998 | Wuhan University Journal of Natural Sciences1998，3，4： | 4 |
| 16 | Charge‑Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS‑CoV‑2 S Protein Detection显示文摘The outbreak of coronavirus disease 2019 has seriously threatened human health.Rapidly and sensitively detecting SARSCoV-2 viruses can help control the spread of viruses.However,it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitivity.Therefore,it is worthwhile to search novel semiconductor-based substrates with excellent SERS sensitivity.Herein we report,for the first time,Nb2C and Ta2C MXenes exhibit a remarkable SERS enhancement,which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic enhancement.Their SERS sensitivity is optimized to 3.0×10^6 and 1.4×10^6 under the optimal resonance excitation wavelength of 532 nm.Additionally,remarkable SERS sensitivity endows Ta2C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein.Moreover,its detection limit is as low as 5×10^−9 M,which is beneficial to achieve real-time monitoring and early warning of novel coronavirus.This research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology. | Yusi Peng Chenglong Lin Li Long Tanemura Masaki Mao Tang Lili Yang Jianjun Liu Zhengren Huang Zhiyuan Li Xiaoying Luo John RLombardi Yong Yang | 2021 | Nano-Micro Letters2021，13，3： | 3 |
| 17 | A sulfonate-based Cu(Ⅰ) metal-organic framework as a highly efficient and reusable catalyst for the synthesis of propargylamines under solvent-free conditions显示文摘A new highly efficient and reusable Cu(Ⅰ)-MOF has been developed for the synthesis of propargylamine compounds via the three-component reaction of secondary amines,alkynes.and aromatic aldehydes under solvent-free conditions.The desired propargylamines were obtained in good to excellent yields with a low catalyst loading.The catalyst may be recovered and reused for up to 5 cycles without major loss of activity.This protocol has the advantages of excellent yields,low catalyst loading,and catalyst recyclability. | Peng Li Sridhar Regati Hui-Cai Huang Hadi D.Arman Bang-Lin Chen John C.-G.Zhao | 2015 | Chinese Chemical Letters2015，26，1： | 3 |
| 18 | Tunneling or propping: Evidence from connected transactions in China显示文摘 | Winnie Qian Peng K.C. John Wei Zhishu Yang | 2010 | Journal of Corporate Finance2010，，2： | 3 |
| 19 | Effects of Early Intensive Blood Pressure-Lowering Treatment on the Growth of Hematoma and Perihematomal Edema in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT)显示文摘 | Craig S. Anderson Yining Huang Hisatomi Arima Emma Heeley Christian Skulina Mark W. Parsons Bin Peng Qiang Li Steve Su Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Lewis B. Morgenstern John Chalmers Ji Guang Wang | 2010 | Stroke2010，，2： | 3 |
| 20 | Response of glutamine synthetase isoforms to nitrogen sources in rice ( Oryza sativa L.) roots显示文摘 | Chufu Zhang Shaobing Peng Xinxiang Peng Arlene Q. Chavez John Bennett | 1997 | Plant Science1997，，2： | 2 |
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