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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 3 | Phosphorylation and metabolism of sucrose and its five linkage-isomeric α-Dglucosyl-D-fructoses by Klebsiella pneumoniae显示文摘 | John T Stanley A Frieder W | 2001 | Carbohydrate Research2001，331，2： | 1 |
| 4 | Methods for the Detection of Polyether Ionophore Residues in Poultry显示文摘 | Christopher T Elliott D Glenn Kennedy W John McCaughey | 1998 | Analyst1998，123，： | 1 |
| 5 | Desulfurization of jet fuel by π-complexation adsorption with metal halides supported on MCM-41 and SBA-15 mesoporous materials显示文摘 | Yuhe W Ralph T Y John M | 2007 | Chemical engineering science2007，52，3： | 1 |
| 6 | An analysis of the severity and accident duration of truck-involved freeway accidents 显示文摘 | Golob T F Wilfred W R John D L | 1987 | Accident Analysis & Prevention1987，19，5： | 1 |
| 7 | A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China显示文摘 | You-lin Qiao John W Sellors Paul S Eder Yan-ping Bao Jeanette M Lim Fang-hui Zhao Bernhard Weigl Wen-hua Zhang Roger B Peck Ling Li Feng Chen Qing-jing Pan Attila T Lorincz | 2008 | Lancet Oncology2008，，10： | 1 |
| 8 | Edward modeling of two-dimensional spiral inductors显示文摘 | M Dishman John T Dickens Fred W Whelan | 1980 | IEEE Transactions on Components Hybrids and Manufacturing Technology1980，3，4： | 1 |
| 9 | Importance of the forest canopy to flux of methylmercury and total mercury to boreal ecosystems显示文摘 | Vincent L Louis S T John W M Kelly C A | 2001 | Environmental Science and Technology2001，35，： | 1 |
| 10 | 显示文摘 | Barns T J Britton John N H Coffey W J | 2000 | Canadian Economic Geographer2000，44，1： | 1 |
| 11 | Janbu, Bjerrum and Kjaernsli's chart reinterpreted显示文摘 | John T Christian W Danid Carrier | 1978 | Canadian Geotechnical loural1978，15，： | 1 |
| 12 | Influence ofinterfacial on the properties of PVC/cellulosic fiber compo-sites显示文摘 | Laurent M M Raymond T W John J B | 1998 | Polym Compos1998，19，4： | 1 |
| 13 | Dynamic response of layered structures subject to blast effects of non-nuclear weaponry显示文摘 | JOHN R H DAVID J R | 1987 | Computers and Structures1987，26，12： | 1 |
| 14 | The Kuroshio east of Taiwan:Modes of variability and relationship to interior ocean mesoscale eddies显示文摘 | ZHANG Dong Xiao LEE T N JOHNS W E | 2001 | J Phys Oceanogr2001，31，4： | 1 |
| 15 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 16 | A Hybrid Individual-Zonal Travel Cost Model for Estimating the Consumer Surplus of Golfing in Colorado 显示文摘 | JOHN L OMER T PHILIP W | 2009 | Jourual of Sports Economics2009，10，2： | 1 |
| 17 | Effects of chronic turbidity on density and growth of steelheads and coho salmon显示文摘 | John W Sigler T C Jomn B | 1984 | Transactions of the American Fisheries Society1984，113，： | 1 |
| 18 | Examining the global environmental impact of regional consumption activities-Part 1: A technical note on combining input-output and ecological footprint analysis显示文摘 | Karen T Manfred L Thomas W John B | 2007 | Ecological Economics2007，62，： | 1 |
| 19 | Pelvic injuries in the polytraumatized patiant显示文摘 | John T Ertel W | 2005 | Orthopade2005，34，9： | 1 |
| 20 | Desulfurization of Fuel Oil by Oxidation and Extraction 显示文摘 | Patrick S T James R K John W E | 1990 | Industrial & Engineering Chemist Research1990，29，3： | 1 |
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