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| 1 | 精索静脉曲张导致的睾丸功能障碍发病机理中TNF相关的调亡诱导配体的角色显示文摘不育男性中频发的精索静脉曲张备受关注,面向治疗的分子水平的研究也随之增加。本研究的目的是探讨大鼠模型中肿瘤坏死因子相关凋亡诱导配体(TRAIL)及其受体在精索静脉曲张起的睾丸功能障碍中的作用。大鼠被随机分为三组:对照组,假手术组和精索静脉曲张组。部分结扎左肾静脉与左睾丸构建大鼠精索静脉曲张模型。对手术13周后的大鼠进行分析。睾丸细胞内DNA片段程度用末端脱氧核苷酸转移酶的脱氧尿苷三磷酸缺口未端标记法(TUNEL)检测。用约翰逊得分评估肾小管退化情况。用免疫组化和Westernblot技术检测TRAIL及其受体的表达。检测了细胞凋亡指数,约翰逊得分,TRAIL和TRAIL受体的表达。数据以平均值±标准偏差(s.d.)表示,并用计算机软件进行了分析。用Kruskal—Wallis和Dunn’s多重比较试验进行数捌分析。与假手术组和对照组相比,精索静脉曲张的大鼠生殖细胞凋亡指数增加(P=0.0031),约翰逊得分显著下降(P〈0.0001)。免疫组化和Western blot分析表明,精索静脉曲张后,生殖细胞中的TRAIL-R1和TRAIL—R4的表达增加,TRAIL—R2的表达下降。在TRAIL和TRAIL—R3受体的表达上,各组间没有显著差异。这一研究结果表明,TRAIL及其受体可能神精索静脉曲张引起的罩丸功能障碍的发病机制中有潜在的作用。 | Orcun Celik Omer Kutlu Merih Tekcan CUer Celik-Ozenci Ismail T Koksal | 2013 | Asian Journal of Andrology2013，15，2： | 12 |
| 2 | Risk Markers for Contrast-Induced Nephropathy显示文摘 | Omer T | 2007 | American Journal of the Medical Sciences2007，334，4： | 1 |
| 3 | A Hybrid Individual-Zonal Travel Cost Model for Estimating the Consumer Surplus of Golfing in Colorado 显示文摘 | JOHN L OMER T PHILIP W | 2009 | Jourual of Sports Economics2009，10，2： | 1 |
| 4 | Vulvar syringoma exacerbated during pregnancy显示文摘 | Cem Turan Mustafa Ugur Lale Kutluay Selahattin Kükner Tülin Dabakoglu Tugrul Aydogdu Yusuf Ergün Omer Cobanoglu | 1996 | European Journal of Obstetrics and Gynecology1996，，1： | 1 |
| 5 | Isolation of a specific potato tuber inducing substance from potato leaves 显示文摘 | Koda Y Omer E A Yoshihara T | 1988 | Plant and Cell Physiology1988，29，： | 1 |
| 6 | Determination of antioxidant activity and antioxidant compounds in wild edible mushrooms 显示文摘 | Mahfuz E Omer I Ibrahim T | 2007 | Journal of Food Composition and Analysis2007，20，34： | 1 |
| 7 | Dissolved organic carbon (DOC) as a parameter of compost maturity显示文摘 | Sharon Z N Omer M Jorge T | 2005 | Soil Biology & Biochemistry2005，，37： | 1 |
| 8 | Risk factors for invasive fungal disease after allogeneic hematopoietic stem cell transplantation: a single center experience显示文摘 | Omer AK Ziakas PD Anagnostou T | 2013 | Boil Blood Marrow Transplant2013，19，8： | 1 |
| 9 | Epidemiological studies on tropical theileriosis (Theileria annulata infection of cattle) in Kurdistan Region, Iraq显示文摘 | A1-Saeed A T M Omer L T Abdo J | 2010 | Parasitology Research2010，106，2： | 1 |
| 10 | Research utilization in a multicultural nursing setting inSaudi Arabia: Barriers and facilitators 显示文摘 | Omer T | 2012 | Journal of NursingResearch2012，20，1： | 1 |
| 11 | Peanut butter intake,GSTM1 genotype and hepatocellular carcinoma:a case-control study in Sudan 显示文摘 | OMER R E VERHOEF L VAN'T V P | 2001 | Cancer Causes Control2001，12，1： | 1 |
| 12 | Risk factors for invasive fungal disease after allogeneie hematopoietic stem cell transplantation : a single center experience 显示文摘 | Omer AK Ziakas PD Anagnostou T | 2013 | Biol Blood Marrow Transplant2013，19，8： | 1 |
| 13 | Ductoscopy in the Evaluation and Management of Nipple Discharge 显示文摘 | Sedat K Omer B Mehmet T | 2010 | Ann Surg Oncol2010，17，： | 1 |
| 14 | Exploring the term of the auditor-client relationship and the quality of earnings: A case for mandatory auditor rotation显示文摘 | Myers J Myers L Omer T | 2003 | The Accounting Review2003，，3： | 1 |
| 15 | Dissolved organic carbon (DOC) as a pa- rameter of compost maturity显示文摘 | Sharon Z Omer M Jorge T | 2005 | Soil Biology & Biochemistry2005，2，： | 1 |
| 16 | Serum transforming growth factor-beta1(TGF-β1) in patients with cirrhosis ,chornic hepatisis B and chronic hepatitis C显示文摘 | Cengiz k Ender T Omer T | 2004 | European Cytokine Network2004，15，2： | 1 |
| 17 | The effect of turbulence on noise emissions from a micro-scale horizontal axis wind turbine显示文摘 | Rogers T Omer S | 2012 | Renewable Energy2012，41，： | 1 |
| 18 | Dissolved organic carbon (DOC) as a parameter of compost maturity显示文摘 | Sharon Z Omer M Jorge T | 2005 | Soil Biology & Biochemistry2005，37，11： | 1 |
| 19 | Exploring the term of the auditor-client relationship and the quality of earnings: a case for mandatory au- ditor rotation? 显示文摘 | Myers J N Myers L A Omer T C | 2003 | The Accounting Review2003，78，3： | 1 |
| 20 | A simplified crack model for weld fracture in steel moment connections 显示文摘 | T D Righiniotis E Omer A Y Elghazouli | 2002 | Engi- neering Structures2002，24，： | 1 |
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