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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | 哮喘治疗的新进展显示文摘没有强有力的循证医学证据表明饮食方法或Buteyko技术对哮喘的临床管理有很大益处需要进一步研究确定当哮喘控制欠佳时患者应该怎么做小剂量吸入皮质激素可以和长效β2激动剂联合应用,以提供安全有效的哮喘控制静脉镁制剂和白三烯受体拮抗剂对急性哮喘可能具有一些作用,但仍需进一步评价将来哮喘治疗是否能得到炎症生物标志或患者基因型认识的帮助。 | Graeme P Currie Graham S Devereux Daniel K C Lee Jon G Ayres 刘艳(译) 代华平(校) | 2005 | 英国医学杂志中文版2005，8，4： | 3 |
| 3 | Does cultural socialization predict multiple bases and foci of commitment?显示文摘 | Michael Clugston Jon P Howell Peter W Dorfman | 2000 | Journal of Management2000，，1： | 1 |
| 4 | Knowledge management : a strategic agenda显示文摘 | QUITAS P LA FREER P JON ES G | 1997 | Long Range Planning1997，30，3： | 1 |
| 5 | The role of the thi- oredoxin and glutaredoxin pathways in reducing pro- teindisulfide bonds in the Escherichia coli cytoplasm 显示文摘 | WILLIAM A P ARNE H JON B | 1997 | J Biol Chem1997，272，15： | 1 |
| 6 | Localization of a susceptibilitylocus for schizophrenia on chromosome 5显示文摘 | Robin S Jon B Hannes P | 2008 | Nature2008，336，10： | 1 |
| 7 | Sequential quadratic programming for large-scale nonlinear optimization显示文摘 | Boggs P T Jon W T | 1995 | Journal of Computational and Applied Mathematics1995，124，1： | 1 |
| 8 | The Psychology of Ownership Work Environment Structure, Organizational Commitment, and Citizenship Behaviors 显示文摘 | MICHAEL P O'DRISCOLL JON L PIERCE ANN-MARIE COGHLAN | 2006 | Group Organization Management2006，31，6： | 1 |
| 9 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 10 | The marine planning framework for South Australia:a new ecosystem-based zoning policy for marine management显示文摘 | Val D Rosemary P Jon E | 2008 | Marine Policy2008，32，： | 1 |
| 11 | Natural frequency of curved gird- er显示文摘 | Chai H Y Jon P F | 1981 | Journal of the Engineering Mechanics Divi- sion April1981，107，： | 1 |
| 12 | Setting a Precautionary Catch Limit for Antarctic Krill 显示文摘 | ROGER P H JON L W NAGANOBU M | 2002 | Oceanography2002，15，3： | 1 |
| 13 | Hierarchical vector basis functions of arbitrary order for triangular and tetrahedral finite elements 显示文摘 | Jon P W | 1999 | IEEE Trans on Antennas Propagat1999，47，8： | 1 |
| 14 | Behavioral responses of hatchling painted turtles (Chrysemys picta) and snapping turtles (Chelydra serpenlina) at subzero temperatures显示文摘 | Jon P Costanzo Jacqueline D Litzgus Richard E LeeJr | 1999 | Journal of Thermal Biology1999，24，3： | 1 |
| 15 | A review of bioconcentration factor ( BCF) and bioaccumulation factor(BAF) assessments for organic chemicals in aquatic organisms 显示文摘 | Jon A Amot Frank A P C | 2006 | Environmental Reviews2006，14，4： | 1 |
| 16 | Adaptive route optimi-zation in hierarchical mobile IPv6 networks 显示文摘 | SANGHEON P SHEN X M JON W M | 2007 | IEEE Transactions onMobile Computing2007，6，8： | 1 |
| 17 | Bioisosteric modifications of 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5 显示文摘 | Jon V Elsebet N Dan P | 2004 | JMed Chem2004，47，27： | 1 |
| 18 | Three newly isolated plant growth - promoting bacilli facilitate the seedling growth of canola,Brassica campestris显示文摘 | Sibdas G Jon N P Rebecca D L | 2003 | Plant Physiol Biochem2003，41，： | 1 |
| 19 | Exploring sandplay therapy:Application to individuals with traumatic brain injury显示文摘 | Cynthia P Jon L Steven P | 2008 | International Journal of Play Therapy2008，17，2： | 1 |
| 20 | Detection of Ehrlichia phagocytophila DNA in Ixodes ricinus ticks from areas in Switzerland where tick-borne fever is endemic显示文摘 | Nicola P Jon BH Hans L | 1998 | J Clin Microbiol1998，36，： | 1 |
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