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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils显示文摘Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection. | Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 3 | A family of power-factor-correction controllers显示文摘 | Keyue M Smedly | 1997 | IEEE Transactions on Power Electronics1997，11，5： | 1 |
| 4 | Time Quantity One-Cycle Control for Power-Factor Correctors显示文摘 | Zheren Lai Keyue M Smedley Yunhong Ma | | 0，，2： | 1 |
| 5 | A family of continuous-conduction-mode power-factor- correction controllers based on the general width modulator 显示文摘 | Zheren Lai Keyue Ma Smedley | 1998 | IEEE Transactions on Election1998，13，3： | 1 |
| 6 | Highly ordered iron oxide nanotube arrays as electrodes for electrochemical energy storage显示文摘 | Keyu Xie Jie Li Yanqing Lai Wei Lu Zhi’an Zhang Yexiang Liu Limin Zhou Haitao Huang | 2011 | Electrochemistry Communications2011，，6： | 1 |
| 7 | Virus-like particle vaccine by intranasal vaccination elicits protective immunity against respiratory syncytial viral infection in mice显示文摘呼吸 syncytial 病毒(RSV ) 是在婴儿和孩子的更低的呼吸感染的一个领先的原因,但是仍然没有可得到的准许的疫苗。在这份报告,我们基于 Bac-to-Bac baculovirus 表达式系统开发了像病毒的粒子(VLP ) 疫苗,由一个流行性感冒病毒矩阵(M1 ) 组成蛋白质和 RSV 熔化蛋白质(F) 或 glycoprotein (G) 。这些 RSV VLP 被西方的污点分析和电子显微镜学识别。有 RSV-F VLP, RSV-G VLP,或两个的 intranasally 使免疫的女 BALB/c 老鼠(i.n ) 对 RSV 显示出病毒特定的抗体回答。全部的 IgG, IgG1, IgG2a,和 mucosal IgA 与 RSV-F 正 RSV-G VLP 在老鼠被检测,揭示细胞的有势力和 mucosal 免疫者回答。而且,我们发现这些混合 RSV VLP 对实时 RSV 挑战授与提高的保护,在病毒的复制和组织病理学说的变化的明显的变细与病毒的感染联系了的肺的出现重要减少。这些结果证明由 intranasal 种痘的 RSV-F 正 RSV-G VLP 是保证使用棉花老鼠和首领模型的进一步的评估的一个有希望的疫苗的候选人。 | Mengying Cai Cheng Wang Yufeng Li Hongjing Gu Sujing Sun Yueqiang Duan Chengcai Lai Keyu Wang Xiaolan Yang Li Xing Peirui Zhang Zhaohai Wang Shaogeng Zhang Xiaodong Guo Shubing Liu Yigang Tong Xiliang Wang Penghui Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 1 |
| 8 | A new extension of one-cycle control and its application to swishing power ampli-tiers显示文摘 | Smedley Keyue M | 1996 | IEEE Transactions on Power Electronics1996，11，1： | 1 |
| 9 | Time Quantity One cycle Control for Power Factor Correctors显示文摘 | Zheren Lai Keyue M smedley Yunhong Ma | | 0，，02： | 1 |
| 10 | Lithium oxalyldifluoroborate/carbonate electrolytes for LiFePO 4 /artificial graphite lithium-ion cells显示文摘 | Jie Li Keyu Xie Yanqing Lai Zhi’an Zhang Fanqun Li Xin Hao Xujie Chen Yexiang Liu | 2010 | Journal of Power Sources2010，，16： | 1 |
| 11 | Time quantity one cycle control for power factor correctors 显示文摘 | ZHEREN LAI KEYUE M SMEDLEY | 1997 | IEEE Transactions on Power Electronics1997，12，2： | 1 |
| 12 | Time quantity one-cycle control for power-factor correctors 显示文摘 | Zheren Lai Keyue M Smedley | 1997 | IEEE Transactions on Power Electronics1997，12，2： | 1 |
| 13 | Time quantity one-cycle control for power factor correctors显示文摘 | Keyue M Smedley Yunhong Ma | 1996 | IEEE Transaction on Power Electronics1996，，： | 1 |
| 14 | A new PWM controller with one-cycle response显示文摘 | K MARK SMITH JR ZHEREN LAI KEYUE M SMEDLEY | 1999 | IEEE Transactions on Power Electronics1999，14，1： | 1 |
| 15 | A new extension of one-cycle control and its application to switching power amplifiers显示文摘 | Lai Zheren Keyue M Smedley | 1996 | IEEE Transactions on Power Electronics1996，11，1： | 1 |
| 16 | 显示文摘 | Xiea Keyu Li Jie Lai Yanqing | 2011 | Electro-chemistry Communications2011，13，： | 1 |
| 17 | A general const ant frequency pulsewidth modulator and its applications显示文摘 | Zhere Lai keyue M Smedley | | 0，，04： | 1 |
| 18 | Time quantity one-cycle control for power factor correctors显示文摘 | Lai Zheren Smedley Keyue M Ma Yunhong | 1997 | IEEE Trans on Power Electronics1997，12，2： | 1 |
| 19 | Smedley and Yunhong Ma, Time Quantity One-Cycle Control for Power Factor Correctors显示文摘 | Zheren Lai Keyue M | 1996 | IEEE Transaction on Power Electronics1996，，： | 1 |
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