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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 4 | Elucidation of the mecha- nism by which catecholamine stress hormones liberate iron from the innate immune defense proteins transferrin and lactoferrin 显示文摘 | Sara MS Raminder S Jonathan W | 2010 | Jour- nal of Bacteriology2010，192，2： | 1 |
| 5 | Burkitt lymphoma in adults显示文摘 | Archibald S Perkins Jonathan W Friedberg | 2008 | Hematology2008，2008，： | 1 |
| 6 | Costefficient methods for marine pollution monitoring at Casey Station, East Antarctica:The choice of sieve meshsize and taxonom ic resolu- tion 显示文摘 | BELINDA W T MARTIN J R JONATHAN S S | 2003 | Marine Pollution Bulletin2003，46，： | 1 |
| 7 | The role of the aryl hydrocarbon receptor nuclear translocator(ARNT) in hypoxic induction of gene expression显示文摘 | S Morwenna Wood Jonathan M Gleadle Christopher W Pugh | 1996 | The Journal of Biological Chemistry1996，271，15： | 1 |
| 8 | Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmaeology 显示文摘 | Adam S Keith W Jonathan C | 2010 | Behavioural Pharmacology2010，21，： | 1 |
| 9 | Room temperature ionic liquids as novel media for 'clean' liquid-liquid extraction显示文摘 | Jonathan G H Heather D W Richard P S | 1998 | ChemicalCommunications1998，，16： | 1 |
| 10 | Direct Comparison of GAPDH, β-actin, Cyclophilin, and 28S rRNA as internal standards for quantifying RNA levels under hypoxia 显示文摘 | Zhong H Jonathan W S | 1999 | Biochemical and Biophysical Research Communications1999，259，3： | 1 |
| 11 | A survey of active network research显示文摘 | David L T Jonathan M S David J W | 2002 | IEEE Communications Magazine2002，35，22： | 1 |
| 12 | Room temperature ionic liquids as novel media for 'clean' liquidliquid extraction 显示文摘 | Jonathan G H Heather D W Richard P S | 1998 | Chemical Communications1998，，16： | 1 |
| 13 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 14 | Deformable dose accumulation with image guided radiotherapy for final dose evaluation in pelvic cases 显示文摘 | YUNFENG C JONATHAN W P AMY S H | 2012 | J Nucl Ned Radiat Ther2012，2，： | 1 |
| 15 | A survey of active networks research显示文摘 | Jonathan M S Sincoskie W D Wetherall D | 1997 | IEEE Communications Magazine1997，35，： | 1 |
| 16 | Meta-Analysis of Calcium Supplementation for the Prevention of Postmenopausal Osteoporosis显示文摘 | Beverley S George W Ann C Nicole Z Vivian R Lauren G Zulma O Joan P Jonathan A Peter T Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 17 | Cost-efficient methods for marine pollution monitoring at Casey Station, East Antarctica: the choice of sieve meshsize and taxonomic resolution 显示文摘 | Belinda W T Martin J R Jonathan S S | 2003 | Marine Pollution Bulletin2003，46，： | 1 |
| 18 | The epidemiology and clinical impact of pandemic influenza显示文摘 | Jonathan S Nguyen Van Tam Alan W Hampson | 2003 | Vaccibine2003，21，： | 1 |
| 19 | Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex显示文摘 | Huang Ying Wu Zhiping Riwanto Meliana Gao Shengqiang Levison Bruce S Gu Xiaodong Fu Xiaoming Wagner Matthew A Besler Christian Gerstenecker Gary Zhang Renliang Li Xin-Min DiDonato Anthony J Gogonea Valentin Tang W H Wilson Smith Jonathan D | 2013 | Journal of Clinical Investigation2013，，9： | 1 |
| 20 | Cost-efficient methods for marine pollution monitoring at Casey Station, East Antarctica: the choice of sieve mesh-size and taxonomic resolution显示文摘 | Belinda W T Martin J R Jonathan S S | 2003 | Marine Pollution Bulletin2003，46，： | 1 |
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