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| 1 | Optimization of a Single Flash Geothermal Power Plant Powered by a Trans-Critical Carbon Dioxide Cycle Using Genetic Algorithm and Nelder-Mead Simplex Method显示文摘The usage of renewable energies,including geothermal energy,is expanding rapidly worldwide.The low efficiency of geothermal cycles has consistently highlighted the importance of recovering heat loss for these cycles.This paper proposes a combined power generation cycle(single flash geothermal cycle with trans-critical CO_(2) cycle)and simulates in the EES(Engineering Equation Solver)software.The results show that the design parameters of the proposed system are significantly improved compared to the BASIC single flash cycle.Then,the proposed approach is optimized using the genetic algorithm and the Nelder-Mead Simplex method.Separator pressure,steam turbine output pressure,and CO_(2) turbine inlet pressure are three assumed variable parameters,and exergy efficiency is the target parameter.In the default operating mode,the system exergy efficiency was 32%,increasing to 39%using the genetic algorithm and 37%using the Nelder-Mead method. | Yashar Aryanfar Jorge Luis García Alcaraz | 2023 | Energy Engineering2023，120，2： | 0 |
| 2 | G eneralised modelling approach for anaerobic co-digestion of fermentable substrates显示文摘 | Santiago García G en Juan M Lema Jorge Rodríguez | 2013 | Bioresource Technology2013，147，： | 1 |
| 3 | Residual drift demands in moment‐resisting steel frames subjected to narrow‐band earthquake ground motions显示文摘 | Edén Bojórquez Jorge Ruiz‐García | 2013 | Earthquake Engng Struct Dyn2013，，11： | 1 |
| 4 | Analysis,design,and experimentation of a high-voltage power supply for ozone generation based on current-fed parallel resonant push-pull inverter显示文摘 | Marcos Alonso J Jorge García Calleja A J | 2005 | IEEE Transactions on Industry Applications2005，41，5： | 1 |
| 5 | Virtual reality in residents training显示文摘Training in residency programs is highly competitive,it requires the formation of competent physicians that achieve the performance standards that were declared for their technical skills,attitudes and interpersonal abilities.The use of simulation and technology on the medical education has increased considerably.Particularly in ophthalmology the simulators used are:live models from animal or cadavers,mannequins,wet laboratories,simulated patients,part-task moles,laser or surgical models,and more recently,virtual reality(VR).VR places a person in a simulated environment that has a specific sense of self-location,where the participant interacts with the objects within the setting.Teaching with VR refers to the use of the available resources in technology and visualization of structures to improve the educational experience of medical students,residents and physicians in professional continuous development programs.Several authors highlight the benefits of assessing trainees with the tools,they argue that the key contribution of this model is in the formative assessment.Rather than evaluating and putting a score on student’s grades,VR provides a powerful experience for the acquisition of skills.A conclusion is the need to develop studies to document the effects that it has on knowledge,skills and behaviors,and to patient related outcomes. | Mildred Vanessa López Cabrera Jorge Eugenio Valdez García | 2019 | Annals of Eye Science2019，，1： | 0 |
| 6 | Copper(II) assisted hydrolysis of 2,4,6-tris(pyrazol-1-yl)-1,3,5-triazine. Crystal and molecular structure of catena -[CuL(H 2 O)Cl] n (L显示文摘 | Jorge Manzur Carolina Acu?a Andrés Vega Ana María García | 2011 | Inorganica Chimica Acta2011，，1： | 1 |
| 7 | Technological Change:Necessary Organizational Strategy That Affects Workers显示文摘 | Jorge Alberto Conde Vieitez Alberto de la Torre García and María Teresa Vega Rodríguez | 2001 | Psychology in Spain2001，，1： | 1 |
| 8 | Peptidomic analysis of whey protein hydrolysates and prediction of their antioxidant peptides显示文摘Enzymatic hydrolysis of proteins is a breakdown process of peptide bond in proteins,releasing some peptides with potential biological functions.Previous studies on enzymatic hydrolysis of whey proteins have not identified the complete peptide profiles after hydrolysis.In this study,we reconstructed a profile of peptides from whey hydrolysates with two enzymes and different processing conditions.We also developed an ensemble machine learning predictor to classify peptides obtained from whey hydrolysis.A total of 2572 peptides were identified over three process conditions with two enzymes in duplicate.499 peptides were classified and chosen as potential antioxidant peptides from whey proteins.The peptides classified as antioxidants in the hydrolysates had a proportion of 13.1%-24.5%regarding all peptides identified.These results facilitate the selection of promising peptides involved in the antioxidant properties during the enzymatic hydrolysis of whey proteins,aiding the discovery of novel antioxidant peptides. | Jesus Morales García Chibuike C.Udenigwe Jorge Duitama Andrés Fernando González Barrios | 2022 | Food Science and Human Wellness2022，11，2： | 3 |
| 9 | Actualización en la terapia de la hepatitis C. Nuevos fármacos, monitorización de la respuesta y resistencias显示文摘 | Natalia Chueca Porcuna Marta álvarez Estévez Jorge Parra Ruiz José Hernández Quero Federico García García | 2013 | Enfermedades Infecciosas y Microbiologia Clinica2013，，： | 1 |
| 10 | Comparative study of the mechanical behaviour of a cyanoacrylate and a bioadhesive显示文摘 | J. M. García Páez E. Jorge Herrero A. Rocha M. Maestro J. L. Castillo-Olivares I. Millan A. Carrera Sanmartin A. Cordon | 2004 | Journal of Materials Science: Materials in Medicine2004，，2： | 1 |
| 11 | Endovascular Treatment of Complicated Type-B Aortic Dissection with Stent-Grafts: Midterm Results显示文摘 | Jorge Lopera Jario H. Pati?o Carlos Urbina Giovanni García Luis Guillermo Alvarez León Upegui Akkawat Jhanchai Zhong Qian Wilfrido Casta?eda-Zu?iga | 2003 | Journal of Vascular and Interventional Radiology2003，，2： | 1 |
| 12 | Protein kinase clk/STY is differentially regulated during erythroleukemia cell differentiation: a bias toward the skipped splice variant characterizes postcommitment stages显示文摘Clk/STY is a LAMMER protein kinase capable to phosphorylate serine/arginine-rich (SR) proteins that modulate pre-mRNA splicing. Clk/STY alternative splicing generates transcripts encoding a full-length kinase and a truncated catalyti-cally inactive protein. Here we showed that clk/STY, as well as other members of the family (e.g. clk2, clk3 and clk4),are up-regulated during HMBA-induced erythroleukemia cell differentiation. mRNAs coding for the full-length and thetruncated forms were responsible for the overall increased expression. In clk/STY, however, a switch was observed forthe ratio of the two alternative spliced products. In undifferentiated cells the full-length transcript was more abundantwhereas the transcript encoding for the truncated form predominated at latter stages of differentiation. Surprisingly,overexpression of clk/STY did not alter the splicing switch upon differentiation in MEL cells. These results suggest thatclk/STY might contribute to control erythroid differentiation by a mechanism that implicates a balance between thesetwo isoforms. | Ana GARCíA-SACRISTáN■ María J. FERNáNDEZ-NESTOSA Pablo HERNáNDEZ Jorge B.SCHVARTZMAN Dora B. KRIMER | 2005 | Cell Research2005，15，7： | 1 |
| 13 | Stem cell therapy in the management of shoulder rotator cuff disorders显示文摘Rotator cuff tears are frequent shoulder problems that are usually dealt with surgical repair. Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. It is essential to understand the molecular mechanisms that determine this failure. The study of the molecular environment during embryogenesis and during normal healing after injury is key in devising strategies to get a successful repair. Mesenchymal stem cells(MSC) can differentiate into different mesodermal tissues and have a strong paracrine, anti-inflammatory, immunoregulatory and angiogenic potential. Stem cell therapy is thus a potentially effective therapy to enhance rotator cuff healing. Promising results have been reported with the use of autologous MSC of different origins in animal studies: they have shown to have better healing properties, increasing the amount of fibrocartilage formation and improving the orientation of fibrocartilage fibers with less immunologic response and reduced lymphocyte infiltration. All these changes lead to an increase in biomechanical strength. However, animal research is still inconclusive and more experimental studies are needed before human application. Future directions include expanded stem cell therapy in combination with growth factors or different scaffolds as well as new stem cell types and gene therapy. | Maria Valencia Mora Miguel A Ruiz Ibán Jorge Díaz Heredia Raul Barco Laakso Ricardo Cuéllar Mariano García Arranz | 2015 | World Journal of Stem Cells2015，7，4： | 6 |
| 14 | Timing, method and discontinuation of hydrocortisone administration for septic shock patients显示文摘AIM To characterize the prescribing patterns for hydrocortisone for patients with septic shock and perform an exploratory analysis in order to identify the variables associated with better outcomes.METHODS This prospective cohort study included 59 patients with septic shock who received stress-dose hydrocortisone.It was performed at 2 critical care units in academic hospitals from June 1st, 2015, to July 31 st, 2016. Demographic data, comorbidities, medical management details, adverse effects related to corticosteroids, and outcomes were collected after the critical care physician indicated initiation of hydrocortisone. Univariate comparison between continuous and bolus administration of hydrocortisone was performed, including multivariate analysis, as well as Kaplan-Meier analysis to compare the proportion of shock reversal at 7 d after presentation. Receiver operating characteristic(ROC) curves determined the best cut-off criteria for initiation of hydrocortisone associated with the highest probability of shock reversal. We addressed the effects of the taper strategy for discontinuation of hydrocortisone, noting risk of shock relapse and adverse effects.RESULTS All-cause 30-d mortality was 42%. Hydrocortisone was administered as a continuous infusion in 54.2% of patients; time to reversal of shock was 49 h longer in patients who were given a bolus administration [59 h(range, 47.5-90.5) vs 108 h(range, 63.2-189); P = 0.001]. The maximal dose of norepinephrine after initiation of hydrocortisone was lower in patients on continuous infusion [0.19 μg/kg per minute(range, 0.11-0.28 μg)] compared with patients who were given bolus [0.34 μg/kg per minute(range, 0.16-0.49); P = 0.004]. Kaplan-Meier analysis revealed a higher proportion of shock reversal at 7 d in patients with continuous infusion compared to those given bolus(83% vs 63%; P = 0.004). There was a good correlation between time to initiation of hydrocortisone and time to reversal of shock(r = 0.80; P < 0.0001); ROC curve analysis revealed that the best criteria for prediction of shock reversal was a time to initiation of hydrocortisone of ≤ 13 h after administration of norepinephrine, with an area under the curve of 0.81(P < 0.001). The maximal dose of norepinephrine at initiation of hydrocortisone with the highest association with shock reversal was ≤ 0.28 μg/kg per minute, with an area under the curve of 0.75(P = 0.0002). On a logistic regression model, hydrocortisone taper was not associated with a lower risk of shock relapse(RR = 1.29; P = 0.17) but was related to a higher probability of hyperglycemia [odds ratio(OR), 5.3; P = 0.04] and hypokalemia(OR = 10.6; P = 0.01). CONCLUSION Continuous infusion of hydrocortisone could hasten the resolution of septic shock compared to bolus administration. Earlier initiation corresponds with a higher probability of shock reversal. Tapering strategy is unnecessary. | Miguel A Ibarra-Estrada Quetzalcóatl Chávez-Pe?a Claudia I Reynoso-Estrella Jorge Rios-Zerme?o Pável E Aguilera-González Miguel A García-Soto Guadalupe Aguirre-Avalos | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 15 | Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer显示文摘 | Moisé s Blanco-Calvo Nuria Tarrí o Margarita Reboredo Mar Haz-Conde Jorge Garcí a Marí a Quindó s Angé lica Figueroa Luis Antó n-Aparicio Lourdes Calvo Manuel Valladares-Ayerbes | 2014 | Future Oncol2014，，7： | 2 |
| 16 | Impact of SARS-CoV-2 on neuropsychiatric disorders显示文摘Evolving data show a variable expression of clinical neurological manifestations in patients suffering with coronavirus disease 2019(COVID-19)from early disease onset.The most frequent symptoms and signs are fatigue,dizziness,impaired consciousness,ageusia,anosmia,radicular pain,and headache,as well as others.Based on the high number of series of cases reported,there is evidence for the implication of the immune system in the pathological mechanism of COVID-19.Although the exact role of the immunological mechanism is not elucidated,two main mechanisms are suggested which implicate the direct effect of severe acute respiratory syndrome coronavirus 2 infection in the central nervous system and neuroinflammation.In the context of neurological manifestations associated with COVID-19,neuropsychiatric disorders show an exacerbation and are described by symptoms and signs such as depression,anxiety,mood alterations,psychosis,post-traumatic stress disorder,delirium,and cognitive impairment,which appear to be common in COVID-19 survivors.A worsened score on psychopathological measures is seen in those with a history of psychiatric comorbidities.We review the neuropsychiatric manifestations associated with COVID-19 and some critical aspects of the innate and adaptive immune system involved in mental health disorders occurring in COVID-19. | Maria Angeles Robinson-Agramonte Carlos-Alberto Goncalves Elena Noris-García NaybíPréndes Rivero Anna Lisa Brigida Stephen Schultz Dario Siniscalco Ramiro Jorge García García | 2021 | World Journal of Psychiatry2021，11，7： | 1 |
| 17 | Safety and visual outcomes following posterior chamber phakic intraocular lens bilensectomy显示文摘Background:To evaluate the safety,efficacy,refractive outcomes and causes for bilensectomy(phakic intraocular lens–pIOL–explantation with cataract surgery and pseudophakic intraocular lens implantation)in patients previously implanted with posterior chamber pIOLs.Methods:This multi-center retrospective study included 87 eyes of 55 patients who underwent bilensectomy for posterior chamber pIOL with a follow up time of 12 months.The uncorrected and best corrected distance visual acuities(UDVA,CDVA),endothelial cell density before and after bilensectomy were assessed,as well as the cause of bilensectomy and intra or postoperative complications.Results:There was a statistically significant improvement in uncorrected and best corrected visual acuities after bilensectomy(p=0.00).The main reason for bilensectomy was cataract development(93.1%of the cases),followed by miscalculation of lens size,and corneal edema.The endothelial cell count remained stable without a statistically significant change after surgery(p=0.67).The refractive efficacy index was 0.8,none of the patients lost lines of CDVA after surgery,73%of the patients were within±1 D(spherical equivalent)of the target refraction.Intraoperative complications were one posterior capsule rupture with the intraocular lens(IOL)implanted in the sulcus,and 3 eyes required the use of pupil expanders for adequate pupil dilation.Postoperatively,one eye developed retinal detachment.The three pIOLs models explanted were the Implantable Collamer Lens(ICL),Implantable Phakic Contact Lens(IPCL)and the Phakic Refractive Lens(PRL).Conclusions:Good safety and visual outcomes were observed 1 year after bilensectomy for posterior chamber phakic intraocular lenses(PC pIOLs).There were few intra and postoperative complications and there was no significant endothelial cell loss after the bilensectomy procedure. | Veronica Vargas Jorge L.Alió Rafael I.Barraquer Justin Christopher D’Antin Cristina García Francisco Duch Joan Balgos Jorge LAliódel Barrio | 2020 | Eye and Vision2020，7，1： | 0 |
| 18 | New Record of Black Turtle Chelonia mydas agassizii in High Latitudes of Eastern South Pacific Ocean显示文摘 | Benjamín Cáceres Murrie Anelio Aguayo Lobo Diana Scholfield Fabiola Arcos Nicolás Muroz García Javier Cabello Stom Jorge Acevedo | 2018 | Journal of Life Sciences2018，12，3： | 0 |
| 19 | GOECP/SEOR clinical recommendations for lung cancer radiotherapy during the COVID-19 pandemic显示文摘The coronavirus disease 2019 crisis has had a major and highly complex impact on the clinical practice of radiation oncology worldwide.Spain is one of the countries hardest hit by the virus,with devastating consequences.There is an urgent need to share experiences and offer guidance on decision-making with regard to the indications and standards for radiation therapy in the treatment of lung cancer.In the present article,the Oncological Group for the Study of Lung Cancer of the Spanish Society of Radiation Oncology reviews the literature and establishes a series of consensus-based recommendations for the treatment of patients with lung cancer in different clinical scenarios during the present pandemic. | Felipe Couñago Arturo Navarro-Martin Javier Luna Nuria Rodríguez de Dios Aurora Rodríguez Francesc Casas Rafael García Antonio Gómez-Caamaño Jorge Contreras Javier Serrano | 2020 | World Journal of Clinical Oncology2020，11，8： | 0 |
| 20 | Performance between the Hydraulic Gradient Method and the Perturbation Method for the Analysis of Water Supply Networks显示文摘The HGM(Hydraulic Gradient Method),it is used in most of the current commercial software,such as EPANET,WaterCAD,MikeNet,among others,the same that corresponds to an iterative method that depends on initial estimated parameters and programming structures that ensure convergence to obtain results with the highest precision,in addition to this the method makes use of non-linear equation systems.Likewise,the execution time for large extensions of water distribution networks is considerably high.On the other hand,the PM(Perturbation Method),is a new direct solution method,which makes use of principles of quantum mechanics to transform nonlinear equations into simpler linear systems.Obtaining a simple and robust optimization method that only requires simple and direct mathematical processes.Using the MathCad and Python programming languages as a verification tool,multiple tests were carried out,the results for the hydraulic parameters showing that the flow rates and pressures obtained by the HGM and the PM are extremely similar,in the same way the execution time(time run)have been 77.09%favorable to the PM.In other words,the PM presents efficiency to estimate the hydraulic characteristics such as the pressures at the nodes and the velocities in the pipes of the drinking water distribution networks. | Iván Ayala Bizarro Elviz Quispe García Marco Lopez Barrantes Freddy Marrero Saucedo Omar CaballeroSanchez Hugo Lujan Jeri Carlos Gaspar Paco Jorge Ortega Vargas | 2020 | Journal of Environmental Science and Engineering(A)2020，9，6： | 0 |
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