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| 1 | Gallstone ileus,clinical presentation,diagnostic and treatment approach显示文摘Gallstone ileus is a mechanical intestinal obstruction due to gallstone impaction within the gastrointestinal tract. Less than 1% of cases of intestinal obstruction are derived from this etiology. The symptoms and signs of gallstone ileus are mostly nonspecific. This entity has been observed with a higher frequency among the elderly, the majority of which have concomitant medical illness. Cardiovascular, pulmonary, and metabolic diseases should be considered as they may affect the prognosis. Surgical relief of gastrointestinal obstruction remains the mainstay of operative treatment. The current surgical procedures are:(1) simple enterolithotomy;(2) enterolithotomy, cholecystectomy and fistula closure(one-stage procedure); and(3) enterolithotomy with cholecystectomy performed later(two-stage procedure). Bowel resection is necessary in certain cases after enterolithotomy is performed. Large prospective laparoscopic and endoscopic trials are expected. | carlos m nuno-guzmán maría eugenia marín-contreras mauricio figueroa-sánchez jorge l corona | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 11 |
| 2 | Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound显示文摘AIM To study mucosal addressin cellular adhesion molecule-1(MAd CAM-1) and vascular endothelial growth factor(VEGF)-targeted contrast enhanced ultrasound(CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate(DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAd CAM-1-targeted contrast agent was used to detect and quantify MAd CAM-1 expression. Inflammatory driven colorectal azoxymethane(AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis(healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss(r2 = 0.74) and histological damage(r2 = 0.86)(P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAd CAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel(9.6 d B ± 1.6 vs 12.9 d B ± 1.4 vs 18 d B ± 3.33, P < 0.05). Employing the AOM/DSSinduced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa(healthy mucosa, 1.6 d B ± 1.4 vs 42 d, 18.2 d B ± 3.3 vs 84 d, 18.6 d B ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings(VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). CONCLUSION Molecularly targeted CEUS is a highly specific and noninvasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo. | Markus Brückner Jan Heidemann Tobias M Nowacki Friederike Cordes Jorg Stypmann Philipp Lenz Faekah Gohar Andreas Lügering Dominik Bettenworth | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 3 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 4 | How plants communicate using the underground information superhighway显示文摘 | Harsh Pal Bais Sang-Wook Park Tiffany L Weir Ragan M Callaway Jorge M Vivanco | 2003 | Trends in Plant Science2003，，1： | 2 |
| 5 | A Critical Overview of Internal and External Cylin- der Contact Force Models 显示文摘 | Pereira Candida M Ramalho Amilcar L Ambr6si Jorge A | 2011 | Nonlinear Dynamics2011，63，： | 1 |
| 6 | Intraspecific and interspecific interactions mediated by a phytotoxin,(-)-catechin,secreted by the roots of Centaurea maculosa显示文摘 | Tiffany L Weir Harsh Pal Bais Jorge M Vivanco | 2003 | Journal of Chemical Ecology2003，29，11： | 1 |
| 7 | Muscle fiber type characterization and myosin heavy chain (MyHC) isoform expression in Mediterranean buffaloes显示文摘 | Francisco C L Jorge A M Carani F R | 2011 | Meat Science2011，88，3： | 1 |
| 8 | Short comments on self-synchronization of two non-ideal sources supported by a flexible portal frame structure显示文摘 | BALTHAZAR M JOSE M JORGE L | 2004 | Journal of Vibration and Control2004，10，12： | 1 |
| 9 | The topology of complete minimal surfaces of finite total gaussian curvature 显示文摘 | JORGE L P M MEEKS III W H | 1983 | Topology1983，22，2： | 1 |
| 10 | Design and development of the cooling system of a 2 kW nominal power open-cathode polymer electrolyte fuel cell stack 显示文摘 | Ana M L Jorge B Vicente R | 2012 | Int J Hydrogen Energy2012，37，8： | 1 |
| 11 | Biochemical and physiological mechanism mediated by allelochemicals显示文摘 | Tiffany L W Sang W P Jorge M V | 2004 | Current Opinion in Plant Biology2004，7，： | 1 |
| 12 | The effect of different training programs on antioxidant status,oxidative stress,and metabolic control in type 2diabetes显示文摘 | De Oliveira V N Bessa A Jorge M L | 2012 | Appl Physiol Nutr Metab2012，37，2： | 1 |
| 13 | Vision-based active safety system for automatic stopping显示文摘 | VICENTE M DAVID F L JORGE V | 2012 | Expert systems with applications2012，39，11： | 1 |
| 14 | “Radicle” biochemistry:the biology of root-specific metabolism显示文摘 | Hector E F Jorge M V Victor M L V | 1999 | Trends in Plant Science1999，4，6： | 1 |
| 15 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 16 | Pseudo-accoramodation with intraocular lenses im- planted in the bag显示文摘 | Altan-Yaycioglu R Gozum N Gucukoglu A Jorge L Tetsuro O Tatsuya M | 2002 | JRefrat Surg2002，18，3： | 1 |
| 17 | The effect of chromium on the microstructure/toughness relationship of C-Mn weld metal deposits 显示文摘 | Jorge J C F Souza L F G Rebellon J M A | 2001 | Materials Characteriza-tion2001，，47： | 1 |
| 18 | Myocardial infarction area quantification using high-resolution SPECT images in rats显示文摘 | Luciano F L Jorge M Eduardo E V | 2013 | Arq Bras Cardiol2013，101，1： | 1 |
| 19 | Effect of rosemary (Rosmarinus o~cinalis) extracts on the oxidative stability and sensory acceptability of soybean oil 显示文摘 | DIAS L S MENIS M E C JORGE N | 2015 | Journal of Science of Food and Agriculture2015，95，： | 1 |
| 20 | Synergy effect in the photoc atalytic degradation of phenol on a suspended mixture of ti- tania and activated carbon显示文摘 | Juan M Jorge L Herrmann L M | 1998 | Applied Catalysis1998，18，6： | 1 |
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