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| 1 | Catheter ablation of atrial fibrillation in elderly population显示文摘Background Although elderly patients have been included in published series of catheter ablation for atrial fibrillation (AF), clinicalbenefit and safety remain still less defined in this population. A retrospective analysis of the results of catheter ablation for AF in a large volumecenter focused on comparison of elderly patients with the rest of the patient cohort was conducted in this study. Methods Consecutive patientswho underwent catheter ablation for AF between January 2001 and December 2016 were analysed. A total population of 3197 patients wasdichotomized by the age of 70 years (394 elderly vs. 2803 younger subjects). Patients were followed in terms of arrhythmia status and sur-vival for a median period of 18 vs. 21 and 35 vs. 57 months, respectively. Results Elderly patients were more frequently females (49% vs.29%, P 〈 0.0001), had a history of hypertension (79% vs. 57%, P 〈 0.0001), diabetes (16% vs. 11%, P 〈 0.01), stroke (9% vs. 6%, P 〈 0.01),coronary/peripheral artery disease (14% vs. 8%, P 〈 0.0001), and CHAzDS2-VASc score (3.1 ± 1.3 vs. 1.5 ± 1.2 s, P 〈 0.0001). Major com-plications were more frequent in elderly (5.3% vs. 3.2%, P = 0.03); however, this difference was driven by vascular complications (3.6% vs.1.9%, P = 0.04). There were comparable rates of cerebrovascular (0.3 vs. 0.3%) or nonvascular complications (1.8 vs. 1.2%). Good arrhyth-mia control was inferior in elderly patients as compared with the rest of the cohort, both without and with antiarrhythmic drugs: 44.2% vs.58.2% (P 〈 0.0001) and 78.2 vs. 83.2% (P 〈 0.01), respectively. Poor arrhythmia control was associated with relative risk of all-cause mor-tality of 2.7 (95% CI: 1.1-6.4) in elderly patients and 1.4 (95% CI: 0.9-2.0) in younger subjects. Conclusions Catheter ablation for AF inelderly patients is safe although somewhat less effective. Good arrhythmia control is associated with better survival, especially in elderly patients. | Josef Kautzner Petr Peichl Marek Sramko Robert Cihak Bashar Aldhoon Dan Wichterle | 2017 | Journal of Geriatric Cardiology2017，14，9： | 9 |
| 2 | U. S. Householder survey of functional gastrointestinal disorders显示文摘 | Douglas A. Drossman Zhiming Li Eileen Andruzzi Robert D. Temple Nicholas J. Talley W. Grant Thompson William E. Whitehead Josef Janssens Peter Funch-Jensen Enrico Corazziari Joel E. Richter Gary G. Koch | 1993 | Digestive Diseases and Sciences1993，，9： | 4 |
| 3 | Laser produced electromagnetic pulses: generation, detection and mitigation显示文摘This paper provides an up-to-date review of the problems related to the generation,detection and mitigation of strong electromagnetic pulses created in the interaction of high-power,high-energy laser pulses with different types of solid targets.It includes new experimental data obtained independently at several international laboratories.The mechanisms of electromagnetic field generation are analyzed and considered as a function of the intensity and the spectral range of emissions they produce.The major emphasis is put on the GHz frequency domain,which is the most damaging for electronics and may have important applications.The physics of electromagnetic emissions in other spectral domains,in particular THz and MHz,is also discussed.The theoretical models and numerical simulations are compared with the results of experimental measurements,with special attention to the methodology of measurements and complementary diagnostics.Understanding the underlying physical processes is the basis for developing techniques to mitigate the electromagnetic threat and to harness electromagnetic emissions,which may have promising applications. | Fabrizio Consoli Vladimir TTikhonchuk Matthieu Bardon Philip Bradford David CCarroll Jakub Cikhardt Mattia Cipriani Robert JClarke Thomas ECowan Colin NDanson Riccardo De Angelis Massimo De Marco Jean-Luc Dubois Bertr Etchessahar Alejro Laso Garcia David IHillier Ales Honsa Weiman Jiang Viliam Kmetik Josef Krása Yutong Li FredériéLubrano Paul McKenna Josefine Metzkes-Ng Alexre Poyé Irene Prencipe Piotr Ra¸czka Rol ASmith Roman Vrana Nigel CWoolsey Egle Zemaityte Yihang Zhang Zhe Zhang Bernhard Zielbauer David Neely | 2020 | High Power Laser Science and Engineering2020，8，2： | 3 |
| 4 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 5 | Estimating GFR Using Serum Cystatin C Alone and in Combination With Serum Creatinine: A Pooled Analysis of 3,418 Individuals With CKD显示文摘 | Lesley A. Stevens Josef Coresh Christopher H. Schmid Harold I. Feldman Marc Froissart John Kusek Jerome Rossert Frederick Van Lente Robert D. Bruce Yaping (Lucy) Zhang Tom Greene Andrew S. Levey | 2008 | American Journal of Kidney Diseases2008，，3： | 2 |
| 6 | Dynamic capital structure choice: Theory and tests 显示文摘 | Fischer Edwin O Robert Heinkel Josef Zechner | 1989 | Journal of Finance1989，，44： | 1 |
| 7 | Fracture strength and fatigue of polysilicon determined by a novel thermal actuator 显示文摘 | Hergen Kapels ROBERT Aigner Josef Binder | 2000 | Trans Electron Devices2000，47，7： | 1 |
| 8 | Differential Sensitivity to JAK Inhibitory Drugs by Isogenic Human Erythroblasts and Hematopoietic Progenitors Generated from Patient‐Specific Induced Pluripotent Stem Cells显示文摘 | Zhaohui Ye Cyndi F. L iu Lucie Lanikova Sarah N. Dowey Chaoxia He Xiaosong Huang Robert A. Brodsky Jerry L. Spivak Josef T. Prchal Linzhao Cheng | 2014 | Stem Cells2014，，1： | 1 |
| 9 | The role of debt and preferred stock as a solution to adverse investment incentives显示文摘 | Heinkel Robert Josef Zechner | 1990 | Journal of Financial and Quantitative Anal- ysis1990，，25： | 1 |
| 10 | Variations in Both [alpha]-Spectrin (SPTA1) and [beta]-Spectrin (SPTB) in a Neonate with Prolonged Jaundice in a Family where Nine Individuals Had Hereditary Elliptocytosis显示文摘 | Christensen Robert D Nussenzveig Roberto H Reading N Scott Agarwal Archana M Prchal Josef T Yaish Hassan M | 2013 | Neonatology2013，，： | 1 |
| 11 | Synergy between CD26/DPP-IV Inhibition and G-CSF Improves Cardiac Function after Acute Myocardial Infarction显示文摘 | Marc-Michael Zaruba Hans Diogenes Theiss Markus Vallaster Ursula Mehl Stefan Brunner Robert David Rebekka Fischer Lisa Krieg Eva Hirsch Bruno Huber Petra Nathan Lars Israel Axel Imhof Nadja Herbach Gerald Assmann Ruediger Wanke Josef Mueller-Hoecker Gerha | 2009 | Cell Stem Cell2009，，4： | 1 |
| 12 | The Role of Debt and Preferred Stock as a Solution to Adverse Investment Incentives显示文摘 | Robert Heinkel Josef Zechner | 1990 | Journal of Finan- cial and Quantitative Analysis March1990，，25： | 1 |
| 13 | The impact of institutional trading on stock prices显示文摘 | Laikonishok Josef and Shleifer Andrei and Vishny Robert W | 1992 | Journal of Financial Eco- nomics1992，32，1： | 1 |
| 14 | U. S. Householder survey of functional gastrointestinal disorders显示文摘 | Dr Douglas A. Drossman MD Zhiming Li MD Eileen Andruzzi Robert D. Temple PhD Nicholas J. Talley MD W. Grant Thompson MD William E. Whitehead PhD Josef Janssens MD Peter Funch-Jensen MD Enrico Corazziari MD Joel E. Richter MD Gary G. Koch PhD | 1993 | Digestive Diseases and Sciences1993，，9： | 1 |
| 15 | Contrarian Investment,Extrapolation,and Risk显示文摘 | Shleifer Andrei Vishny Robert W | 1994 | Journal of Finance1994，49，5： | 1 |
| 16 | On Combining Classifiers显示文摘 | Josef K Mohamad H Robert P W | 1998 | IEEE Transactions on Pattern Analysis and Machine Intelligence1998，20，3： | 1 |
| 17 | Pitting corrosion of carbon steel caused by iron bacteria显示文摘 | David Straosvetsky Robert Armon Josef Yahalom | 2001 | International Biodeterioration & Biodegration2001，47，： | 1 |
| 18 | On combining classifiers显示文摘 | Josef Kittler Mohamad Hatef Robert P W Duin Jiri Ma- tas | 1998 | IEEE Trans on Pattern Analysis and Machine Intelligence1998，20，3： | 1 |
| 19 | Fracture- Strength and Fatigue of Polysilicon Determined by a Novel Thermal Actuator 显示文摘 | Hergen Kapels Robert Aigner Josef Binder | 2000 | IEEE TRANSACTIONS ON ELECTRON DEVICES2000，47，： | 1 |
| 20 | Diode laser transcleral cyclophotocoagulation for refractory glaucoma 显示文摘 | Andrea M Jeffrey ML Hermann T Robert R Josef R Guenthur G | 1997 | J Glaucoma1997，10，： | 1 |
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