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| 1 | Downregulation of the Basic Peroxidase Isoenzyme from Zinnia elegans by Gibberellic Acid显示文摘Hypocotyl formation during the epigeal germination of seedlings is under strict hormonal regulation. In a 3 d old Zinnia elegans seedling system, gibberellic acid (GA3) exerts an opposite effect to that exerted by light on hypocotyl photomorphogenesis because GA3 promotes an etiolated-like growth with an inhibition of radial (secondary) growth. For this reason, the effect of GA3 on the basic peroxidase isoenzyme from Z. elegans (ZePrx), an enzyme involved in hypocotyl lignin biosynthesis, was studied. The results showed that GA3 reduces ZePrx activity, similarly to the way in which it reduces seedling secondary growth. This hormonal response is supported by the analysis of the ZePrx promoter, which contains four types of GA3-responsive cis-elements: the W Box/O2S; the Pyr Box; the GARE; and the Amy Box. Taken together, these results suggest that ZePrx is directly regulated by GA3, with this effect matching the inhibitory effect of GA on the hypocotyl secondary growth. | María Josefa López Núez-Flores Jorge Gutirrez Laura V.Gómez-Ros Esther Novo Uzal Mariana Sottomayor Alfonso Ros Barceló | 2010 | Journal of Integrative Plant Biology2010，52，2： | 3 |
| 2 | Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences显示文摘Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies. | Carmen Berasain Saioa Gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila | 2010 | World Journal of Gastroenterology2010，16，25： | 2 |
| 3 | Development of Sorbents for SO2 Capture Prepared by Hydration of Fly Ash and Hydrated Lime in Seawater显示文摘 | Josefa Ferna'ndez Jose' Luis Rico Hipo'lito Garct'a | 2008 | Industrial and Engineering Chemistry Research2008，45，2： | 1 |
| 4 | Novel action of estrogen to promote proliferation:integration of cytoplasmic and nuclear pathways显示文摘 | Emily MF Josefa A Magaret AS | 2009 | Steroids2009，74，13： | 1 |
| 5 | Production and morphology of fruit and seeds in Genisteae (Fabaceae) of south west Spain显示文摘 | JOSEFA L JUAN A D ANA O O | 2000 | B ot J L innean Soc2000，132，2： | 1 |
| 6 | Fomation of oxygen complexes by ozonztion of carbonaceous materials prepared from cherry stones 显示文摘 | Vicente G S Pedro M A Josefa J | 2002 | Carbon2002，40，： | 1 |
| 7 | Plant defense peptides显示文摘 | FranciscoGarcía‐Olmedo AntonioMolina Josefa M.Alamillo PabloRodríguez‐Palenzuéla | 2004 | Biopolymers2004，，6： | 1 |
| 8 | Production and morphology of fruit and seeds in Genisteae (Fabaceae) of south- west Spain 显示文摘 | JOSEFA L JUAN A D ANA O O | 2000 | Bot J Linnean Soc2000，132，2： | 1 |
| 9 | Current status and potential of morphometric sperm analysis显示文摘精子是知道的最多样的房间类型,这差异被认为在精子功能反映差别。在精子形态学的差异怎么并且什么角色在种形成期间产生了然而,不同专门化在精子功能玩仍然保持不完全地描绘了。这个工作考察建议向精子解释词法进化的假设,与精子 morphometric 评估的一些方面的一个焦点;morphometrics 的能力也被讨论预言精子 cryoresistance 和男富饶。为这,而不是在不同阶段的精子头的 morphometric 特征的学习,在整个一个过程的精子头 morphometry 的变化的模式的评估与不同精子 cryoconservation 能力允许男性的更好的鉴定。和雇用很多个人的更多的研究,这些新途径被需要在精子功能上有关精子 morphometry 的角色获得新奇结果。未来研究应该瞄准理解精子的原因设计产生他们的差异和机制,把增加的注意给除精子头以外的另外的精子结构。科学、工艺的进展的实现能有益于精子显型和精子功能的同时的考试,证明精子 morphometry 能是为精子评价的一个有用工具。 | Alejandro Maroto-Morales Olga Garcia-Alvarez Manuel Ramon Felipe Martinez-Pastor M Rocio Fernandez-Santos A Josefa Soler Jose Julian Garde | 2016 | Asian Journal of Andrology2016，18，6： | 1 |
| 10 | Production and morphology of fruit and seeds in Genisteae (Fabaceae) of south-west Spain 显示文摘 | JOSEFA L JUAN A D ANA O O | 2000 | Bot J Linnean Soc2000，132，2： | 1 |
| 11 | A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer's disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation显示文摘 | Ester A Vicent C Josefa M | | BrainPathology0，，： | 1 |
| 12 | Production and mor- phology of fruit and seeds in Genisteae (Fabaceae) of south-west Spain 显示文摘 | Josefa L Juan A D Ana O O | 2000 | Bot J Linnean Soc2000，132，2： | 1 |
| 13 | Cross talk among calcium, hydrogen per- oxide, and nitric oxide and activation of gene expres- sion involving calmodulins and calcium-dependent pro- tein kinases in Ulva compressa exposed to copper ex- cess 显示文摘 | Gonzalez A de los Angeles Cabrera M Josefa Henr quez M | 2012 | Plant Physiology2012，158，3： | 1 |
| 14 | Esophageal capsule endoscopy in patients refusing conventional endoscopy for the study of suspected esophageal pathology显示文摘 | Andre′s Sa′nchez-Yagüe A′ngel Caunedo-A′lvarez Josefa Mar′a Garc′a-Montes Javier Romero-Va′zquez Francisco Javier Pellicer-Bautista Juan Manuel Herrer′as-Gutie′rrez | 2006 | European Journal of Gastroenterology & Hepatology2006，，9： | 1 |
| 15 | Comparison between diabetic and non-diabetic patients after successful percutaneous coronary intervention for chronic total occlusions in the drug-eluting stent era显示文摘 | Juan Ruiz-Garcia Rui Teles José-Ramón Rumoroso Henrique Cyrne Carvalho Francisco Javier Goicolea José Moreu Josefa Mauri Vicente Mainar Eulogio García Raul Moreno | 2015 | Revista Portuguesa de Cardiologia (English Editio2015，，4： | 1 |
| 16 | Extremely halophilic bacteria in Crystallizer PONDS from solar salterns显示文摘 | Josefa A Ramon R | | 0，，07： | 1 |
| 17 | Evaluation of the visual function in obstructive sleep apnea syndrome patients and normal-tension glaucoma by means of the multifocal visual evoked potentials显示文摘 | Esperanza Gutiérrez-Díaz Consuelo Pérez-Rico María Josefa Atauri Enrique Mencía-Gutiérrez Román Blanco | 2012 | Graefe’s Archive for Clinical and Experimental Ophthalmology2012，，11： | 1 |
| 18 | New enantioselective synthesis of 4-hydroxy-2-oxopyrolidine-N-acetamide ( oxiracetam ) from malic acid 显示文摘 | JESUS FA JOSEFA A NIEVES M | 1992 | Tetrahedron: Asymmetry1992，3，11： | 1 |
| 19 | New Enantios- elective Synthesis of 4-hydroxy-2-oxopyrrolidine-N- acetamide ( Oxiracetam ) from Malic Acid 显示文摘 | Jesus F A Josefa A Nieves M | 1992 | Tet- rahedron: Asymmetry1992，3，11： | 1 |
| 20 | Detection of Helicobacter pylori and clarithromycin resistance in gastric biopsies of pediatric patients by using a commercially available real-time polymerase chain reaction after NucliSens semiautomated DNA extraction显示文摘 | Sonia Agudo Teresa Alarcón Pedro Urruzuno María Josefa Martínez Manuel López-Brea | 2010 | Diagnostic Microbiology & Infectious Disease2010，，3： | 1 |
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