| 1 | Protection Against Lethal Multidrug-Resistant Bacterial Infections Using Macrophage Cell Therapy显示文摘Multidrug-resistant(MDR)bacterial infections exert a tremendous burden on the public health system throughout the developing and developedworld.Slowing development of novel antibiotic scaffolds,over-prescription of antibiotics,extensive agricultural antibiotic use,and the increasingly complex hospitalized patient populations undergoing treatment,all fuel the rise of highly MDR“superbugs.”Unfortunately,host-directed therapies to boost immune resistance to infection are not currently available for treatment of MDR pathogens.Hematopoietic cells are endowed with a variety ofmechanismsto control microbial invasion.Macrophages in particular have long been appreciated as potent antimicrobial immune cells equipped with several receptors that allow for rapid recognition,phagocytosis,and killing of pathogenic microbes,coupled to secretion of immunostimulatory cytokines to further orchestrate a robust multifaceted antibacterial immune response.To investigate the utility of macrophages as a cell therapy for MDR bacterial infections,we developed a therapeutically translatable process to generate,harvest,and cryopreserve monocyte-derived macrophages(ICONIMACTM).These cells effectively killed both Gram-positive and Gram-negative MDR pathogens in vitro,and conferred protection in vivo against experimental lethal peritonitis and lung infection.Our discoveries provide a proof-of-concept for a novel immunotherapeutic approach against MDR bacterial infections,urgently needed to supplement the diminishing antibiotic pipeline. | Robert Tacke Josh Sun Satoshi Uchiyama Anya Polovina Deborah G.Nguyen Victor Nizet | 2019 | Infectious Microbes & Diseases2019，1，2： | 1 |
| 2 | 君山美学生活馆显示文摘“居民们不必因为每天都走在同样的街道而感到无聊…道路的脉络不仅存在于单一的维度,而是沿着上下起伏的梯台、拱桥和悬浮着的街道多维度地编织,结合各种不同的路线,或在高处、或在地面,每一个人每天都可以尝试用新的路线到达同一个目的地的乐趣。”——伊塔洛•卡尔维诺,《看不见的城市》阳光城君山美学生活馆坐落于北京市郊群山起伏、河流蜿蜒的密云水库附近。曾经的文化中心只是一栋两层高的普通售楼处,改造后将转变为一个具有会所和销售功能的地标性文化中心。如恩在原有的庭院建筑类型的基础上,设计了两段交错的路线,划分出两段不同的旅程:一段供高尔夫俱乐部的会员使用,另一段用于销售中心的客户。每一个空间设计都紧贴自然为本的概念,主庭院和小花园之间的层次让建筑与自然和谐相融。 | 郭锡恩 胡如珊 杨延蕙 郭鹏 Utsav Jain Ellen Chen Zoe Gao Wuyahuang Li Josh Murphy Alexandra Heijink Hwajung Song Lara Depedro Jason Jia 鲁永新 陈晓雯 Mona He Cindy Sun Jacqueline Yam | 2020 | 世界建筑导报2020，35，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员