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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 3 | 显示文摘 | Ju H Y Kwon C Li Q | 1995 | Appl Phys Rev Lett1995，75，： | 2 |
| 4 | Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress显示文摘BACKGROUND Chronic stress during pregnancy may increase visceral hyperalgesia of offspring in a sex-dependent way.Combining adult stress in offspring will increase this sensitivity.Based on the evidence implicating estrogen in exacerbating visceral hypersensitivity in female rodents in preclinical models,we predicted that chronic prenatal stress(CPS)+chronic adult stress(CAS)will maximize visceral hyperalgesia;and that estrogen plays an important role in colonic hyperalgesia.AIM The aim was to illuminate the role of estrogen in colonic hyperalgesia and its underlying mechanisms.METHODS We established a CPS plus CAS rodent model in which the balloon was used to distend the colorectum.The single-fiber recording in vivo and patch clamp experiments in vitro were used to monitor the colonic neuron’s activity.The reverse transcription-polymerase chain reaction,western blot,and immunofluorescence were used to study the effects of CPS and CAS on colon primary afferent sensitivity.We used ovariectomy and letrozole to reduce estrogen levels of female rats respectively in order to assess the role of estrogen in female-specific enhanced primary afferent sensitization.RESULTS Spontaneous activity and single fiber activity were significantly greater in females than in males.The enhanced sensitization in female rats mainly came from lowthreshold neurons.CPS significantly increased single-unit afferent fiber activity in L6-S2 dorsal roots in response.Activity was further enhanced by CAS.In addition,the excitability of colon-projecting dorsal root ganglion(DRG)neurons increased in CPS+CAS rats and was associated with a decrease in transient Atype K+currents.Compared with ovariectomy,treatment with the aromatase inhibitor letrozole significantly reduced estrogen levels in female rats,confirming the gender difference.Moreover,mice treated with letrozole had decreased colonic DRG neuron excitability.The intrathecal infusion of estrogen increased brain-derived neurotrophic factor(BDNF)protein levels and contributed to the response to visceral pain.Western blotting showed that nerve growth factor protein was upregulated in CPS+CAS mice.CONCLUSION This study adds to the evidence that estrogen-dependent sensitization of primary afferent colon neurons is involved in the development of chronic stress-induced visceral hypersensitivity in female rats. | Jing-Hong Chen Ying Sun Pei-Jun Ju Jin-Bao Wei Qing-Jie Li John H Winston | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 5 | Giant magnetoresistance in La1-xSrxMnOz films near room temperature显示文摘 | Ju H L Kwon C Qi Li | 1994 | Appl Phys Lett1994，65，： | 2 |
| 6 | On New Stability Criterion for Delay - Differential Systems of Neutral Type 显示文摘 | JU H P KWON O | 2005 | Applied Mathematics and Computation2005，162，： | 1 |
| 7 | Characterization of UV-cured polyester acrylate films containing acrylate functional polydimethylsiloxane显示文摘 | Kim H K Ju H T Hong J W | 2003 | European Polymer Journal2003，39，11： | 1 |
| 8 | Finite element analyses of wave propagations due to high-speed train across bridges 显示文摘 | Ju S H | 2002 | International Journal of Numerical Method Engineering2002，54，9： | 1 |
| 9 | Two flaps andZ-plasty technique for correction of longitudinal era lobe cleft显示文摘 | JU H S RHIE J W | 2005 | Br J Plast Surg2005，58，4： | 1 |
| 10 | Nucleic acid biosensor for detection of hepatitis B virus using 2,9-dimethyl- 1,10-phenanthroline copper complex as electrochemical indicator显示文摘 | Li X Ju H Ding C | 2007 | Analytica ChimicaActa2007，582，1： | 1 |
| 11 | Effect of steam treatment on soluble phenolic content and antioxidant activity of the Chaga mushroom (Inonotus obliquus)显示文摘 | JU H K CHUNG H W HONG S S | 2010 | Food Chemistry2010，119，： | 1 |
| 12 | Thermomechanical cracking due to moving frictional loads显示文摘 | HUANG J H JU F D | 1985 | Wear1985，102，12： | 1 |
| 13 | Current status of laparoendoscopic single-site surgery in urology显示文摘 | Stolzenburg JU Kallidonis P Till H | 2009 | World J Urol2009，27，6： | 1 |
| 14 | Prediction methodol- ogy for ground vibration induced by passing trains on bridge structures 显示文摘 | Chen Y J Ju S H Ni S H | 2007 | Journal of Sound and Vibration2007，302，45： | 1 |
| 15 | Netzhautablusung bei kindem und jundenlichen显示文摘 | LAATIKAINEN L TARKANEN A HAR JU H | 1984 | Klin Monatsbl Augenheilkd1984，185，1： | 1 |
| 16 | XML-Based Network Management for IP Networks 显示文摘 | CHOI Mijung JAMES W H JU H T | 2003 | ETRI Journal2003，25，6： | 1 |
| 17 | Silver Ion-Selective Electrodes Based on Novel Containing Benzothiazolyl Calixarene显示文摘 | Chen L Ju H Zeng X | 2001 | Anal Chim Acta2001，437，2： | 1 |
| 18 | 显示文摘 | Ding S J Ju C P Lin J H C | 2000 | Journal of Materials Science:Materials in Medicine2000，11，1： | 1 |
| 19 | Analysis of reduction of Geobacillus stearothermophilus spores treated with high hydrostatic pressure and mild heat in milk buffer显示文摘 | Gao Y L Ju X R Jiang H H | 2006 | Journal of Biotechnology2006，125，3： | 1 |
| 20 | Correlation betweenserum vascular endothelial growth factor and endostatin levels in patients with breast cancer显示文摘 | Zhao J Yan F Ju H | 2004 | Cancer Left2004，204，1： | 1 |
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