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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Neuroendocrine tumors of the gastrointestinal tract: Case reports and literature review显示文摘Neuroendocrine tumors(NET)previously called carcinoid tumors are neoplasms of enterochromaffin/neuroendocrine cell origin which display neurosecretory capacity that may result in the carcinoid syndrome.The annual incidence of patients with NET is 8.4 per 100000;yet many NET remain asymptomatic and clinically undetected.A majority of NET follows a benign course;however,some will display malignant characteristics.NET most commonly occur in the gastrointestinal tract(67%)and bronchopulmonary system(25%).Gastrointestinal NET occur within the stomach,small intestine,liver,and rectum.We report a retrospective study of 11 subjects:Eight with benign carcinoid tumors:duodenal bulb(n=2),terminal ileum(n=1),sigmoid colon(n=2),and rectum(n=3);three with malignant carcinoid:liver(n=1)and intra-abdominal site(n=2).The diagnosis,endoscopic images,outcome,treatment and review of the literature are presented. | William J Salyers Kenneth J Vega Juan Carlos Munoz Bruce W Trotman Silvio S Tanev | 2014 | World Journal of Gastrointestinal Oncology2014，6，8： | 8 |
| 3 | Helicobacter pylori recurrence after eradication in Latin America:Implications for gastric cancer prevention显示文摘AIM To estimate Helicobacter pylori(H. pylori) recurrence rate in Latin America, a region with a significant H. pylori prevalence and gastric cancer burden.METHODS Pub Med, LILACS, Sci ELO, Cochrane databases and abstracts from relevant meetings were reviewed. Information collected included: Participants' characteristics, recruitment strategy, diagnostic modality, treatment arms, follow-up and recurrence rates. Recurrence was calculated using 100-patients-year rates, and data were pooled using a random effects model. The I2 statistic assessed between study heterogeneity. Meta-regression analyses evaluated for effect modifying variables. RESULTS Literature search yielded 163 articles. Twelve studies involving 4848 patients from 9 countries met inclusion criteria. Four hundred and thirty-two reinfections were recorded in 5487 person-years of follow-up. Pooled analysis showed a recurrence rate of 7.9 cases per 100 person-years(95%CI: 5.3-10.5). Meta-regression revealed that neither the antibiotic schema, a second antibiotic course, nor the diagnostic modality had an impact on the observed risk of recurrence. The recurrence rate in the first year after treatment, predominantly recrudescence,was 11.2(6.1-16.4) per 100 patient years. Recurrence in subsequent years, was only 6.2(3.8-8.7).CONCLUSION H. pylori recurrence rates in Latin America are significant, and with geographic variability, yet are acceptable based upon the current literature for consideration of large scale intervention trials. Further research in Latin America is warranted to evaluate the efficacy, cost-effectiveness, and potential adverse outcomes of proposed eradication programs. | Juan E Corral Robertino Mera Corey W Dye Douglas R Morgan | 2017 | World Journal of Gastrointestinal Oncology2017，9，4： | 5 |
| 4 | Pancreatic cancer: Are 'liquid biopsies' ready for prime-time?显示文摘Pancreatic cancer is a disease that carries a poor prognosis. Accurate tissue diagnosis is required. Tumours contain a high content of stromal tissue and therefore biopsies may be inconclusive. Circulating tumour cells(CTCs) have been investigated as a potential 'liquid biopsy' in several malignancies and have proven to be of prognostic value in breast, prostate and colorectal cancers. They have been detected in patients with localised and metastatic pancreatic cancer with sensitivities ranging from 38%-100% using a variety of platforms. Circulating tumour DNA(ct DNA) has also been detected in pancreas cancer with a sensitivity ranging from 26%-100% in studies across different platforms and using different genetic markers. However, there is no clear consensus on which platform is the most effective for detection, nor which genetic markers are the most useful to use. Potential roles of liquid biopsies include diagnosis, screening, guiding therapies and prognosis. The presence of CTCs or ct DNA has been shown to be of prognostic value both at diagnosis and after treatment in patients with pancreatic cancer. However, more prospective studies are required before this promising technology is ready for adoption into routine clinical practice. | Alexandra R Lewis Juan W Valle Mairead G Mc Namara | 2016 | World Journal of Gastroenterology2016，22，32： | 5 |
| 5 | Inflammation and nutrition in children with chronic kidney disease显示文摘Chronic inflammation and nutritional imbalance are important comorbid conditions that correlate with poor clinical outcomes in children with chronic kidney disease(CKD). Nutritional disorders such as cachexia/protein energy wasting, obesity and growth retardation negatively impact the quality of life and disease progression in children with CKD. Inadequate nutrition has been associated with growth disturbances in children with CKD. On the other hand, over-nutrition and obesity are associated with poor outcomes in children with CKD. The exact mechanisms leading to these unfavorable conditions are not fully elucidated and are most likely multifactorial. In this review, we focus on the pathophysiology of nutrition disorders and inflammation and their impact on clinical outcomes in children with CKD. | Juan Tu Wai W Cheung Robert H Mak | 2016 | World Journal of Nephrology2016，5，3： | 3 |
| 6 | Screening of subclinical hepatic encephalopathy显示文摘 | Michael Groeneweg Wendy Moerland Juan C Quero Wim C.J Hop Paul F Krabbe Solko W Schalm | 2000 | Journal of Hepatology2000，，5： | 2 |
| 7 | Current control strategy for brushless DC motors based on a common DC signal显示文摘 | Juan W Dixon Ivan A Leal | 2009 | IEEE Transaction on Power Electronics2009，17，2： | 1 |
| 8 | Energy-management system for a hybrid electric vehicle, using ultracapacitors and neural networks显示文摘 | Jorge M Micah E O Juan W D | 2006 | IEEE Transactions on Industrial Electronics2006，，53： | 1 |
| 9 | Mineralization of dinitrntoluenes and trinitrotoluene of spent acid in toluene nitration process by Fentnn oxidation 显示文摘 | Chen W S Juan C N Wei K M | 2005 | Chemosphere2005，60，： | 1 |
| 10 | Short selling and the price discovery process 显示文摘 | Borhmer E Juan W | 2013 | Review of Financial Studies2013，，2： | 1 |
| 11 | Frequency stabilizationof excited CO2 lasers 显示文摘 | JUAN Y B STRZELE S | 2002 | SPIE2002，3729，： | 1 |
| 12 | Comparative effects of angiotensin II receptor blockade (eandcsartan) with angiotensin-eonverting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathy 显示文摘 | WATANABE K JUAN W NARASIMMAN G | 2003 | J Cardiovasc Pharmaeol2003，41，1： | 1 |
| 13 | PWM regenerative rectifiers: state of the art 显示文摘 | Rodr guez Jos 6 R Dixon Juan W Espinoza Jos 6 R | 2005 | IEEE Trans on Industrial Electronics2005，52，1： | 1 |
| 14 | Quinapril inhibits progression of heart failure and fibrosis in rats with dilated cardiomyopathy after myoearditis显示文摘 | Juan W Nakazawa M Wataanabe K | 2003 | Mol Cell Biochem2003，251，12： | 1 |
| 15 | Adenovirus-mediated hemeoxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice显示文摘 | JUAN S H LEE T S TSENG K W | 2001 | Circulation2001，104，13： | 1 |
| 16 | Discrete-time current regulator design for AC machine drives 显示文摘 | Hongrae Kim Michael W Degner Juan M Guerrero | 2010 | IEEE Transactions on Industrial Applica- tions2010，46，4： | 1 |
| 17 | Indirect current control of a unity power factor sinusoidal current boost type three-phase rectifier显示文摘 | Dixon Juan W Ool Boon Teck | 1998 | IEEE Trans on Industrial Electronics1998，35，4： | 1 |
| 18 | Diet quality of older Americans in 1994-1996 and 2001-2002 as measured by the Healthy Eating Index-2005 显示文摘 | Juan W Y Guenther P M Kott P S | 2008 | Nutrition insights2008，，： | 1 |
| 19 | Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis显示文摘 | Juan G Traganos F James W M | 1998 | Cytometry1998，32，2： | 1 |
| 20 | Improving passive filter compensation performance with active techniques显示文摘 | Darwin R Luis M Juan W D | 2003 | IEEE trans on industrial electronics2003，50，1： | 1 |
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