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| 1 | Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders显示文摘Recent research has been uncovering the role of the gut microbiota for brain health and disease.These studies highlight the role of gut microbiota on regulating brain function and behavior through immune,metabolic,and neuronal pathways.In this review we provide an overview of the gut microbiota axis pathways to lay the groundwork for upcoming sessions on the links between the gut microbiota and neurogenerative disorders.We also discuss how the gut microbiota may act as an intermediate factor between the host and the environment to mediate disease onset and neuropathology.Based on the current literature,we further examine the potential for different microbiota-based therapeutic strategies to prevent,to modify,or to halt the progress of neurodegeneration. | Carolina Gubert Juciano Gasparotto Livia H.Morais | 2022 | Gastroenterology Report2022，10，1： | 2 |
| 2 | Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models显示文摘 | Maurilio da Silva Morrone Adriano Martimbianco de Assis Ricardo Fagundes da Rocha Juciano Gasparotto Andressa Córneo Gazola Geison Modesti Costa Silvana Maria Zucolotto Leonardo H. Castellanos Freddy A. Ramos Eloir Paulo Schenkel Flávio Henrique Reginatto | 2013 | Food and Chemical Toxicology2013，，： | 1 |
| 3 | Toxicological effects of mining hazard elements显示文摘Mining plays a prominent role in the economy worldwide since human efforts have been more concentrated in extraction than recycling of natural resources.Ores composed of various minerals vary according to the geological evolution.These are raw materials for the conventional industries or fossil fuels for power generation.They can also be used in new technologies.The mining industry triggers intense environmental impacts.Human exposure to multiple small particles from mining effluent,such as dust,uranium,iron,lead,zinc,silicon,titanium,sulfur,nitrogen,platinum,chromium,vanadium,manganese,and mercury,is a health risk.Such elements can have several pathological effects,such as respiratory and cardiovascular,multiple chronic inflammation,and neurodegenerative diseases.Additionally,mining results in severe soil,water(surface and aquifer),and air contamination,reaching large areas far away from the source.Negligence of mining companies,with the recovery of ancient mined areas during the early development of environmental laws and regulations,compromises environmental integrity for more extended periods,increasing coverage of the affected areas.This review evaluates the toxicological effects on humans exposed to the mining wastes and the impact of these compounds on the ecosystem.The results of our evaluation can be used by the government,manufacturers,scientists,private environmental organizations,decision-makers,and readers from different areas of knowledge to explore the potential risk of mining to the ecosystem and human health. | Leonardo Lucas da Silva-Rego Leonardo Augusto de Almeida Juciano Gasparotto | 2022 | Energy Geoscience2022，3，3： | 0 |
| 4 | Coal as an energy source and its impacts on human health显示文摘Attempts to secure more energy,food,and infrastructure leave a trail of environmental contamination and human health hazards.Coal is a fossil fuel and nonrenewable energy source that is combusted and used to generate electricity.A coal-fired power plant is a prodigious generator of environmental pollution,releasing large quantities of particles as aerosols in the atmosphere.The inhalation of hazardous substances such as coal micro-particles,nanoparticles,and its by-products constitutes an invisible risk to human health.Although coal is predominantly composed of carbon,there are many other constituents including sulfur,nitrogen,organometallic compounds,and minerals,that contribute to the formation of extremely toxic secondary compounds that come in contact with the atmosphere.The continuous inhalation of these hazardous substances triggers many diseases such respiratory and cardiovascular disease,systemic inflammation,and neurodegeneration.Due to coal heterogeneity,it is extremely complex to establish all the effects of the molecules in the organism.Each cell can undergo different modifications depending on the stressing molecule.On that account,inhaling air contaminated with these particles can be highly dangerous and unpredictable.This review covers the impact of coal inhalation on the lungs,immune system,heart,reproductive system,brain,DNA,and,in general,the human health.For this review,Medline and Scopus databases were accessed,including human epidemiological,review studies,and coal characterization studies over the years.Coal as an energy source must be utilized with appropriate measures of environmental protection and to safeguard human health. | Juciano Gasparotto Katia Da Boit Martinello | 2021 | Energy Geoscience2021，2，2： | 0 |
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