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| 1 | 普拉克索缓释剂和速释剂治疗中国帕金森病患者的疗效及安全性对比评估:一项随机、双盲、双模拟平行组研究显示文摘帕金森病是一种慢性神经系统退行性疾病,主要临床表现为运动症状和非运动症状。早期帕金森病患者常应用多巴胺受体激动剂单药治疗,以延迟左旋多巴诱发的运动并发症;晚期帕金森病患者多应用左旋多巴联合多巴胺受体激动剂治疗,可减少已发生的运动并发症。普拉克索速释剂和缓释剂是非麦角类多巴胺受体激动剂,对D2家族受体呈现高度选择性,对D3受体更具亲和力,显示其良好的疗效和不良反应小的优势。虽已有国际研究证实普拉克索缓释剂和速释剂的疗效,但是还没有两者对中国帕金森病患者的对比评估研究。我们对普拉克索缓释剂和速释剂联合左旋多巴治疗在中国帕金森病患者中的疗效进行非劣效性评估。 | 王瑛 孙圣刚 朱遂强 刘春风 刘艺鸣 狄晴 商慧芳 任艳 陆长虹 Mark Forrest Gordon Nolwenn Juhel 陈生弟 | 2015 | 中华神经科杂志2015，48，4： | 11 |
| 2 | The efficacy and safety of pramipexole ER versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study显示文摘Objective:To evaluate the non-inferiority of pramipexole extended-release(ER)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group study.Methods:Subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-time.Subjects received treatment with pramipexole ER(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRS(Parts II+III)total score.Results:For the primary endpoint,the adjusted mean changes(standard error)of UPDRS Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for ER and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).Since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole ER and IR was demonstrated.The incidence of adverse events(AEs)was 68.8%in the ER arm and 73.6%in the IR arm with few severe AEs(ER:2.1%;IR:3.8%).Conclusion:Based on the UPDRS II+III score,pramipexole ER was non-inferior to pramipexole IR.The safety profiles of pramipexole ER and IR were similar.These results were based on comparable mean daily doses and durations of treatment for both formulations. | Ying Wang Shenggang Sun Suiqiang Zhu Chunfeng Liu Yiming Liu Qing Di Huifang Shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel Shengdi Chen for the Pramipexole ER Study Team | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 3 | Cholesterol-lowering effect of non-viscous soluble dietary fiber NUTRIOSE FB in hypercholesterolemic hamsters 显示文摘 | Juhel C Tosini F Steib M | 2007 | Ann Nutr Metab2007，51，1： | 1 |
| 4 | Prophylaxis of thrombosis in- duced by chemotherapy or central venous catheters 显示文摘 | Voog E Lazard E Juhel L | 2007 | Presse Med2007，36，2： | 1 |
| 5 | Effects of graded amaunts(0-50 g)of dietary at on postprandial lipemia and lipoproteins in nomolipidemic adults 显示文摘 | Dubois C Beaumier G Juhel C | 1998 | Am J Clin Nutr1998，67，： | 1 |
| 6 | In vlvo exposure to microcystins induces DNA damage in the haemocytes of the zebra mussel, Drelssena polymorpha, as measured with the comet assay显示文摘 | Juhel G O' Halloran J Culloty S C | 2007 | Environ ol Mutagen2007，48，1： | 1 |
| 7 | Peripheral analgesic effect of intra-articular clonidine显示文摘 | Gentili M Juhel A Bonnet F | | 0，，03： | 1 |
| 8 | Impact of sevofl urane anesthesia on brain oxygenation in children younger than 2 years显示文摘 | Rhondali Q juhel Sv Mathews Sv | 2014 | Paediatr Anaesth2014，24，7： | 1 |
| 9 | Cholesterol-lowering effect of non-viscous soluble dietary fiber NUTRIOSE (R) 6 in moderately hypercholesterolemic hamsters显示文摘 | JUHEL C TOSINI F STEIB M | 2011 | Indian J Exp Biol2011，49，3： | 1 |
| 10 | Muhiresidue chromatographic method for the determination of macrolide residues in muscle by high -performance liquid chromatography with UV detection 显示文摘 | Juhel Gaugain M Anger B Laurentie M | 1999 | AOAC Int1999，82，5： | 1 |
| 11 | Green tea extract inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro显示文摘 | Juhel C Armand M Pafumi Y | 2000 | The Journal of Nutritional Bioche- mistry2000，11，1： | 1 |
| 12 | Peripheral analgesic effect of intra-articular clonidine显示文摘 | Gentili M Juhel A Bonnet F | 1996 | Pain1996，64，3： | 1 |
| 13 | Vertebrobasilar isehemia after cervical spine manipulation: a ease report 显示文摘 | Tinel D Bliznakova E Juhel C | 2008 | Annales Readaptation Medeeine Physique2008，51，5： | 1 |
| 14 | A study of dehydration of fish using successive pressure drops (DDS) and con- trolled instantaneous pressure drop (DIC) 显示文摘 | Haddad J Juhel F Louka N | 2004 | Drying Technology2004，22，3： | 1 |
| 15 | Green tea extract (AR25a) inhibits lipolysis of triglyeerides in gastric and duodenal medium in vitro 显示文摘 | Christine Juhel Martine Armand Yan Pafumi | 2000 | The Journal of Nutritional Biochemistry2000，11，1： | 1 |
| 16 | A Study of Dehydration of Fish Using Successive Pressure Drops (DDS)and Controlled Instantaneous Pressure Drop (DIC)显示文摘 | Joseph H Juhel F Louka N | 2004 | Drying Technology2004，22，3： | 1 |
| 17 | 物流业在经济发展中的作用显示文摘 | Marc Juhel | 2000 | 物流科技2000，23，3： | 1 |
| 18 | Effect of the Microcystin-Producing Cyanobacterium, Microcystis aeruginosa, on Immune Functions of the Zebra Mussel Dreissena polymorpha显示文摘 | JUHEL G RAMSAY R M DAVENPORT J | 2015 | Journal of Shellfish Research2015，34，2： | 1 |
| 19 | Peripheral analgesic effect of intra-articular clonidine 显示文摘 | Gentili M Juhel A Bonnet F | 1996 | Pain1996，64，3： | 1 |
| 20 | Screening of Quinolone Residues in Pig Muscle by Planar Chromatography 显示文摘 | Juhel - Gaugain M Abjean J P | 1998 | Chromatographia1998，47，12： | 1 |
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