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| 1 | Biomimetic polycaprolactone-chitosan nanofibrous substrate influenced cell cycle and ECM secretion affect cellular uptake of nanoclusters显示文摘Biomimetic cell culture substrates are developed as an alternative to the conventional substrates.They provide necessary biochemical and biophysical cues to the cells from their surrounding environment for their optimal growth,behaviour and physiology.Changes in physiology of cells growing on biomimetic substrate can essentially affect results of in vitro biological experiments such as drug cytotoxicity,nanoparticle internalization or signalling pathways.As majority of ECM proteins are fibrous in nature,nanofibrous scaffolds have more biomimicking properties.Therefore,in this study,we developed ECM mimicking polycaprolactone-chitosan nanofiber substrate and evaluated its effect on cell morphology,proliferation,cell cycle and ECM production.Further,cellular uptake of BSA-AuNCs has been assessed on conventional and biomimetic substrate in order to demonstrate the effect of these events on cellular properties.It was observed that the cells that were grown for 15 days on the nanofibers,had majority of cells in the proliferative phase of cell cycle compared to TCPS.Moreover,these cells showed extensive collagen and fibronectin production.Due to these conditions C3H10T1/2 cells displayed higher cell internalization of BSA-AuNCs.Overall,this study indicates that the nano-topographical and biochemical environment could alter the cell proliferative behaviour and ECM production,which affects the cell internalization of BSA-AuNCs.Also,PCL-chitosan nanofibrous substrate could be a better alternative to TCPS for cell culture studies. | Dhwani Jhala Hilal Rather Dhaval Kedaria Juhi Shah Sanjay Singh Rajesh Vasita | 2019 | Bioactive Materials2019，4，1： | 4 |
| 2 | Development of cost effective personnel armour through structural hybridization显示文摘The objective of the present study is to develop cost effective thermoplastic hybrid laminate using Dyneema®HB50 and Tensylon®HSBD 30A through structural hybridization method.Laminates having 20 mm thickness were fabricated and subjected to 7.6239 mm mild steel core projectile with an impact velocity of 730±10 ms1.Parameters such as energy absorption,back face deformation and rate of back face deformation were measured as a function of hybridization ratio.It was observed that hybrid laminate with 50:50 ratio(w/w)of Tensylon®and Dyneema®with Tensylon®as front face showed 200%more energy absorption when compared to 100%Tensylon®laminate and showed equal energy absorption as that of expensive 100%Dyneema®laminate.Moreover,hybrid laminate with TD50:50 ratio showed 40%lower in terms of final back face deformation than Dyneema®laminate.Rate of back face deformation was also found to be slow for hybrid laminate as compared to Dyneema®laminate.Dynamic mechanical analysis showed that,Tensylon®laminate has got higher stiffness and lower damping factor than Dyneema®and hybrid laminates.The interface between Tensylon®and Dyneema®layers was found to be separating during the penetration process due to the poor interfacial bonding.Failure behaviour of laminates for different hybridization ratios were studied by sectioning the impacted laminates.It was observed that,the Tensylon®laminate has undergone shear cutting of fibers as major failure mode whereas the hybrid laminate showed shear cutting followed by tensile stretching,fiber pull out and delamination.These inputs are highly useful for body armour applications to design cost effective armour with enhanced performance. | P.Rama Subba Reddy T.Sreekantha Reddy I.Srikanth Juhi Kushwaha V.Madhu | 2020 | Defence Technology(防务技术)2020，16，6： | 2 |
| 3 | Dengue:epidemiology,prevention and pressing need for vaccine development显示文摘Dengue fever is a mosquito born viral infection,and the complicated form of dengue is dengue hemorrhagic fever(DHF).In the recent decades incidence and distribution of dengue has increased dramatically.Dengue viruses belong to family flaviviridae with four serotypes and are transmitted mainly by mosquito Aedes aegypti.Today almost two-fifth of world’s population (2.5 million) is at risk of dengue and no specific antiviral drug or vaccine is available against it.Uncontrolled population growth in Africa and South East Asia has increased number of susceptible hosts in urban and semi urban areas.About 40%of world population resides in the high risk area for dengue transmission.According to latest estimates by WHO,yearly 50 to 100 million infections occur globally,this includes around 500 000 DHF and 22 000 deaths,mostly among children.Only symptomatic treatment in the form of analgesic,antipyretics and body fluid management is provided to the patient.Prevention strategies mainly focus on two approaches, firsdy on activities to control vector and secondly on activities to protect human from mosquito bite but there is always concerns regarding their sustainably and effectiveness.Theoretically development of an effective dengue vaccine is feasible and production of an effective and affordable vaccine could be a viable option to save humans from this dreadful disease. Conceptually vaccine production is possible,but it has to be tetravalent,providing immunity against all serotypes.Few candidate vaccines are in advance stage of their development:however international cooperation is needed to make these vaccines available on cheaper rates to the poor and vulnerable countries.Objective of this review is to discuss various aspects related to dengue,its epidemiology,available preventive methods,need for vaccine and challenges in its development. | Kuldeep Kumar Pankaj Kumar Singh Juhi Tomar Swati Baijal | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 2 |
| 4 | Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence显示文摘BACKGROUND Patients with an in-breast tumor recurrence(IBTR)after breast-conserving therapy have a high risk of distant metastasis and disease-related mortality.Classifying clinical parameters that increase risk for recurrence after IBTR remains a challenge.AIM To describe primary and recurrent tumor characteristics in patients who experience an IBTR and understand the relationship between these characteristics and disease outcomes.METHODS Patients with stage 0-II breast cancer treated with lumpectomy and adjuvant radiation were identified from institutional databases of patients treated from 2003-2017 at our institution.Overall survival(OS),disease-free survival,and local recurrence-free survival(LRFS)were estimated using the Kaplan Meier method.We identified patients who experienced an isolated IBTR.Concordance of hormone receptor status and location of tumor from primary to recurrence was evaluated.The effect of clinical and treatment parameters on disease outcomes was also evaluated.RESULTS We identified 2164 patients who met the eligibility criteria.The median follow-up for all patients was 3.73[interquartile range(IQR)2.27-6.07]years.Five-year OS was 97.7%(95%CI:96.8%-98.6%)with 28 deaths;5-year LRFS was 98.0%(97.2-98.8)with 31 IBTRs.We identified 37 patients with isolated IBTR,19(51.4%)as ductal carcinoma in situ and 18(48.6%)as invasive disease,of whom 83.3%had an in situ component.Median time from initial diagnosis to IBTR was 1.97(IQR:1.03-3.5)years.Radiotherapy information was available for 30 of 37 patients.Median whole-breast dose was 40.5 Gy and 23 patients received a boost to the tumor bed.Twenty-five of thirty-two(78.1%)patients had concordant hormone receptor status,HER-2 receptor status,and estrogen receptor(ER)(P=0.006)and progesterone receptor(PR)(P=0.001)status from primary to IBTR were significantly associated.There were no observed changes in HER-2 status from primary to IBTR.The concordance between quadrant of primary to IBTR was 10/19[(62.2%),P=0.008].Tumor size greater than 1.5 cm(HR=0.44,95%CI:0.22-0.90,P=0.02)and use of endocrine therapy upfront(HR=0.36,95%CI:0.18-0.73,P=0.004)decreased the risk of IBTR.CONCLUSION Among patients with early stage breast cancer who had breast conserving surgery treated with adjuvant RT,ER/PR status and quadrant were highly concordant from primary to IBTR.Tumor size greater than 1.5 cm and use of adjuvant endocrine therapy were significantly associated with decreased risk of IBTR. | Juhi M Purswani Fauzia Shaikh S Peter Wu Jennifer Chun Kim Freya Schnabel Nelly Huppert Carmen A Perez Naamit K Gerber | 2020 | World Journal of Clinical Oncology2020，11，1： | 2 |
| 5 | Prevalence and associa tions of 25-hydroxyvitamin D deficiency in US children NHANES 2001- 2004 显示文摘 | Juhi K Paul M Frederick JK | 2009 | Pediatrics2009，124，3： | 1 |
| 6 | Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction显示文摘 | Juhi H Kalthoff H | 1994 | J Clin Oncol1994，12，4： | 1 |
| 7 | A Review on Cooperative Com- munication Protocols in Wireless World显示文摘 | Garg Juhi Mehta Priyanka | 2013 | International Jour- nal of Wireless & Mobile Networks2013，5，2： | 1 |
| 8 | Cryptoeoccal meningitis in a tertiary care hospital显示文摘 | Juhi T BibhaBati M Aradhana B | 2009 | 50(2) :95--992009，50，2： | 1 |
| 9 | Specific detect of icarcino embryonic antigen expressing tumor cells in bone marrow as rates by polmerase chain reaction显示文摘 | Gerhard M Juhi H Kalthoff H | 1994 | Clin Oncol1994，12，4： | 1 |
| 10 | Acute pain induces insulin resistance in hummans显示文摘 | Greisen J JuhI CB Grofte T | 2001 | Anesthesiology2001，95，3： | 1 |
| 11 | Tribological charac- terization of microarc oxidized alumina coatings for biologi- cal applications显示文摘 | Juhi B Presenjit K Hong L | 2009 | Vacuum2009，，83： | 1 |
| 12 | Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction 显示文摘 | Cerhard M Juhi H Kalthoff H | 1994 | J Clin Oncol1994，12，4： | 1 |
| 13 | Acute Pain Induce Insulin Reaiatance in Humans显示文摘 | GREISEN J JUHI C B GROFTE T | 2001 | Anesthesiology2001，95，3： | 1 |
| 14 | Evaluation of pretest clinical score for the diagnosis of heparin induced thrombocytopenia in two clinical settings 显示文摘 | Lo GK Juhi D Warkentin TE | 2006 | J Thromb Haemost2006，4，4： | 1 |
| 15 | Microbiome data analysis with applications to pre-clinical studies using QIIME2: Statistical considerations显示文摘Diversity analysis and taxonomic profiles can be generated from marker-gene sequence data with the help of many available computational tools.The Quantitative Insights into Microbial Ecology Version 2(QIIME2)has been widely used for 16S rRNA data analysis.While many articles have demonstrated the use of QIIME2 with suitable datasets,the application to preclinical data has rarely been talked about.The issues involved in the pre-clinical data include the low-quality score and small sample size that should be addressed properly during analysis.In addition,there are few articles that discuss the detailed statistical methods behind those alpha and beta diversity significance tests that researchers are eager to find.Running the program without knowing the logic behind it is extremely risky.In this article,we first provide a guideline for analyzing 16S rRNA data using QIIME2.Then we will talk about issues in pre-clinical data,and how they could impact the outcome.Finally,we provide brief explanations of statistical methods such as group significance tests and sample size calculation. | Shesh N.Rai Chen Qian Jianmin Pan Jayesh P.Rai Ming Song Juhi Bagaitkar Michael Merchant Matthew Cave Nejat K.Egilmez Craig J.McClain | 2021 | Genes & Diseases2021，8，2： | 1 |
| 16 | Differentiating between igutismspectrum disoorders and other developmental disabilities in children who failed a screening in strument for ASD显示文摘 | Pamela V Jamie Juhi | 2007 | JAutism Dev Disord2007，37，3： | 1 |
| 17 | Comparison between measured and calculated changes in the lung function after operation for pulmonary cancer显示文摘 | Juhi B Frost N A | 1975 | Acta Anaesthesial Scand1975，57，1： | 1 |
| 18 | Can Children with Autism Recover? If So, How?显示文摘 | Molly Helt Elizabeth Kelley Marcel Kinsbourne Juhi Pandey Hilary Boorstein Martha Herbert Deborah Fein | 2008 | Neuropsychology Review2008，，4： | 1 |
| 19 | Differ-entiating between au-tismspectrumdisorders and other developmental disabilitiesin children who failed a screeninginstrument for ASD显示文摘 | Pamela V Jamie Juhi | 2007 | JAutism Dev Disord2007，，37： | 1 |
| 20 | Tribological characterization of microarc oxidized alumina coatings for biological applications显示文摘 | Juhi Baxi Presenjit Kar Hong Liang Aytekin Polat Metin Usta Ahmet Hikmet Ucisik | 2008 | Vacuum2008，，： | 1 |
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