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| 1 | A novel mechanism of inhibiting in-stent restenosis with arsenic trioxide drug-eluting stent: Enhancing contractile phenotype of vascular smooth muscle cells via YAP pathway显示文摘Objective:Arsenic trioxide(ATO or As2O3)has beneficial effects on suppressing neointimal hyperplasia and restenosis,but the mechanism is still unclear.The goal of this study is to further understand the mechanism of ATO's inhibitory effect on vascular smooth muscle cells(VSMCs).Methods and results:Through in vitro cell culture and in vivo stent implanting into the carotid arteries of rabbit,a synthetic-to-contractile phenotypic transition was induced and the proliferation of VSMCs was inhibited by ATO.F-actin filaments were clustered and the elasticity modulus was increased within the phenotypic modulation of VSMCs induced by ATO in vitro.Meanwhile,Yes-associated protein(YAP)nuclear translocation was inhibited by ATO both in vivo and in vitro.It was found that ROCK inhibitor or YAP inactivator could partially mask the phenotype modulation of ATO on VSMCs.Conclusions:The interaction of YAP with the ROCK pathway through ATO seems to mediate the contractile phenotype of VSMCs.This provides an indication of the clinical therapeutic mechanism for the beneficial bioactive effect of ATO-drug eluting stent(AES)on in-stent restenosis(ISR). | Yinping Zhao Guangchao Zang Tieying Yin Xiaoyi Ma Lifeng Zhou Lingjuan Wu Richard Daniel Yunbing Wang Juhui Qiu Guixue Wang | 2021 | Bioactive Materials2021，6，2： | 13 |
| 2 | Effect of intraplaque angiogenesis to atherosclerotic rupture-prone plaque induced by high shear stress in rabbit model显示文摘Atherosclerotic prone-rupture plaque is mainly localized in the region of the entrance to the stenosiswith high shear stress and the reasons are largely unknown. Our hypothesis is that such a distributionof cells in atherosclerotic plaque may depend on the angiogenesis. Silastic collars inducedregions of high shear stress (20.6865.27 dynes/cm2) in the upstream flow and low shear stress(12.2561.28 dynes/cm2) in the downstream flow in carotid arteries. Compared with the low shearstress region, plaques in the high shear stress region showed more intraplaque haemorrhaging,less collagen and higher apoptotic rates of vascular smooth muscle cells;endothelial cells (ECs) inthe high shear stress region were characterized with integrity and high endothelial nitric oxidesynthase (eNOS) expression (1570.36345.5% vs 172.9649.9%). The number of intraplaque microvesselsis very high in the high shear stress region (1561.8 n/mm2 vs 3.560.4 n/mm2), and themicrovessels in the plaque show ECs were abnormal, with membrane blebs, intracytoplasmic vacuolesand leukocyte infiltration. Our current study reveals that the integrity of the endothelium andthe vulnerability of atherosclerotic plaques are simultaneously localized in high shear stress regions,and we provide evidence for the first time that microvessels in the intraplaque maybe responsiblefor rupture-prone plaque formation in the high shear stress region. | Juhui Qiu Daoxi Lei Jianjun Hu Tieying Yin Kang Zhang Donghong Yu Guixue Wang | 2017 | Regenerative Biomaterials2017，4，4： | 12 |
| 3 | High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis显示文摘Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary syndrome and ischemic strokes.Inhibition of thrombosis is one of the important tasks developing biomedical materials such as intravascular stents and vascular grafts.Shear stress(SS)influences the formation and development of atherosclerosis.The current review focuses on the vulnerable plaques observed in the high shear stress(HSS)regions,which localizes at the proximal region of the plaque intruding into the lumen.The vascular outward remodelling occurs in the HSS region for vascular compensation and that angiogenesis is a critical factor for HSS which induces atherosclerotic vulnerable plaque formation.These results greatly challenge the established belief that low shear stress is important for expansive remodelling,which provides a new perspective for preventing the transition of stable plaques to high-risk atherosclerotic lesions. | Yi Wang Juhui Qiu Shisui Luo Xiang Xie Yiming Zheng Kang Zhang Zhiyi Ye Wanqian Liu Hans Gregersen GuixueWang | 2016 | Regenerative Biomaterials2016，3，4： | 8 |
| 4 | Study on the Sensitivity and Vulnerability of Wheat to Climate Change in China显示文摘Based on B2 climate change scenario produced by PRECIS (providing regional climates for impacts studies), which wasdeveloped by the UK Hadley Center, and the wheat yield data outputted by CERES-wheat model, the sensitivity andvulnerability of wheat production to the future climate change in China were studied through analyzing the yield variationusing the GIS (geographical information system) techniques. Results showed that, by the 2070s, there will be threenegative sensitive areas of rain-fed wheat, i.e., northeastern China, the region of the middle and lower reaches of theYangtze River, and part of the Loess Plateau. Irrigated wheat is generally sensitive to the future climate change for mostareas of China, with a lower sensitive degree and a distribution of sensitive areas similar to the rain-fed wheat. For theirrigated wheat, northeast and northwest of China are strongly negative sensitive, while the middle and lower reaches ofthe Yangtze River, the coastal areas of southern China and the southwest of China, are moderately negative sensitive tothe climate change. With the appropriate adaptation to the climate change, the rain-fed wheat in most regions of China willnot be vulnerable and even has a yield increase, while the irrigated wheat will still have a larger vulnerable area (occupyingabout 2/3 of its total area in China), with the highly vulnerable regions distributed in northeastern China and northwesternChina, and the medium and light vulnerable areas distributed along the middle and lower reaches of the Yangtze River,Yunnan and Guizhou provinces. | SUNFang YANGXiu LINEr-da JUHui XIONGWei | 2005 | Agricultural Sciences in China2005，4，3： | 4 |
| 5 | Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress显示文摘Extracellular vesicles(EVs)are increasingly used as delivery vehicles for drugs and bioactive molecules,which usually require intravascular administration.The endothelial cells covering the inner surface of blood vessels are susceptible to the shear stress of blood flow.Few studies demonstrate the interplay of red blood cell-derived EVs(RBCEVs)and endothelial cells.Thus,the phagocytosis of EVs by vascular endothelial cells during blood flow needs to be elucidated.In this study,red blood cell-derived extracellular vesicles(RBCEVs)were constructed to investigate endothelial cell phagocytosis in vitro and animal models.Results showed that low magnitude shear stress including low shear stress(LSS)and oscillatory shear stress(OSS)could promote the uptake of RBCEVs by endothelial cells in vitro.In addition,in zebrafish and mouse models,RBCEVs tend to be internalized by endothelial cells under LSS or OSS.Moreover,RBCEVs are easily engulfed by endothelial cells in atherosclerotic plaques exposed to LSS or OSS.In terms of mechanism,oxidative stress induced by LSS is part of the reason for the increased uptake of endothelial cells.Overall,this study shows that vascular endothelial cells can easily engulf EVs in areas of low magnitude shear stress,which will provide a theoretical basis for the development and utilization of EVs-based nano-drug delivery systems in vivo. | Xian Qin Kun Zhang Juhui Qiu Nan Wang Kai Qu Yuliang Cui Junli Huang Li Luo Yuan Zhong Tian Tian Wei Wu Yi Wang Guixue Wang | 2022 | Bioactive Materials2022，7，3： | 3 |
| 6 | Ultrafine VN nanodots induced generation of abundant cobalt single-atom active sites on nitrogen-doped carbon nanotube for efficient hydrogen evolution显示文摘Development of highly active and stable non-noble electrocatalysts with well-defined nanostructures is crucial for efficient hydrogen evolution reaction(HER). Herein, a novel three-dimensional(3D) selfsupported electrode consists of vanadium nitride(VN) nanodots and Co nanoparticles co-embedded and highly active single Co atoms anchored in N-doped carbon nanotubes supported on carbon cloth(VN-Co@CoSAs-NCNTs/CC) is fabricated via a one-step in situ nanoconfined pyrolysis strategy, which shows remarkable enhanced HER electrocatalytic activity in acidic medium. During pyrolysis, the formed VN nanodots induce the generation of atomic Co Nxsites in NCNTs, contributing to superior electrocatalytic activity. Experimental and density functional theory(DFT) calculation results reveal that the electrode has multiple accessible active sites, fast reaction kinetics, low charge/mass transfer resistances,high conductivity, as well as downshifted d-band center with a thermodynamically favorable hydrogen adsorption free energy(△G_(H·)), all of which greatly boost the HER performance. As a result, the VNCo@CoSAs-NCNTs/CC electrode displays superb catalytic performance toward HER with a low overpotential of 29 mV at 10 mA cm^(-2) in acidic medium, which could maintain for at least 60 h of stable performance. This work opens a facile avenue to explore low-cost, high performance, but inexpensive metals/nitrogen-doped carbon composite electrocatalysts for HER. | Yan Cheng Juhui Gong Bo Cao Xuan Xu Peng Jing Shien-Ping Feng Rui Cheng Baocang Liu Rui Gao Jun Zhang | 2022 | Journal of Energy Chemistry2022，31，5： | 1 |
| 7 | Multi-scale variation characteristics of polar vortex at 10 hPa in the Southern Hemisphere显示文摘By use of 1948-2007 NCEP/NCAR reanalysis monthly geopotential data, a set of circulation indices are defined to characterize the polar vortex at 10 hPa in the Southern Hemisphere, including area-(S), intensity-(P) and centre position-(λc , φc) indices. Sea-sonal variation, interannual anomalies and their possible causes of 10 hPa polar vortex in the Southern Hemisphere are analyzed by using these indices, the relationship between 10 hPa polar vortex strength and the Antarctic Oscillation are analyzed as well. The results show that: (1) the polar region at 10 hPa in the Southern Hemisphere is controlled by anticyclone (cyclone) from Dec. to Jan. (from Mar. to Oct.), Feb. and Nov. are circulation transition seasons. (2) Intensity index (P) and area index (S) of anticy-clone (cyclone) in Jan. (Jul.) show a significant spike in the late 1970s, the anticyclone (cyclone) enhances (weakens) from ex-tremely weak (strong) oscillation to near the climatic mean before a spike, anticyclone tends to the mean state from very strong oscillation and cyclone oscillates in the weaker state after the spike. (3) There is significant interdecadal change for the anticyclone center in Jan., while markedly interannual variation for cyclone center in July. (4) The ozone anomalies can cause the interannual anomaly of the polar anticyclone at 10 hPa in the Southern Hemisphere in Jan. (positive correlation between them), but it is not related to the polar cyclone anomalies. (5) There is notable negative correlation between the polar vortex intensity index P and the Antarctic Oscillation index (AAOI), thus AAOI can be represented by P. | LiPing Li JuHui Ma PanXing Wang Dong Guo MingKen Duan ShuXuan Guan | 2010 | Research in Cold and Arid Regions2010，2，1： | 1 |
| 8 | Industrial Safety and Dust Control显示文摘 | Jiang Juhui Yu Jishun Li Wu | 2001 | 27(12):16-202001，27，12： | 1 |
| 9 | Analysis of SO2and NOx emissions using two-fluid method coupled with eddy dissipation concept reaction submodel in circulating fluidized bed combustors显示文摘 | Yu Guangbin Chen Juhui Li Jiuru | 2014 | Energy Fuels2014，28，： | 1 |
| 10 | Kinetic Determination of Ultratrace Amounts of Ascorbic Acid with Spectrofluorimetric Detection显示文摘 | Suling Feng Xiaolan Chen Jing Fan Guien Zhang Juhui Jiang Xinjun Wei | 1998 | Analytical Letters1998，，3： | 1 |
| 11 | trans-2-Enoyl-CoA Reductase Tecr-Driven Lipid Metabolism in Endothelial Cells Protects against Transcytosis to Maintain Blood-Brain Barrier Homeostasis显示文摘The transport and metabolism of lipids in cerebrovascular endothelial cells(ECs)have been hypothesized to regulate blood-brain barrier(BBB)maturation and homeostasis.Long-chain polyunsaturated fatty acids(LCPUFAs)as the important lipids components of cell membranes are essential for the development and function of BBB,but the direct links of lipid metabolism and ECs barrier function remain to be established.Here,we comprehensively characterize the transcriptomic phenotype of developmental cerebrovascular ECs in single-cell resolution and firstly find that trans-2-enoyl-CoA reductase(Tecr),a verylong-chain fatty acid synthesis,is highly expressed during barriergenesis and decreased after BBB maturation.EC-specific knockout of Tecr compromises angiogenesis due to delayed vascular sprouting.Importantly,EC-specific deletion of Tecr loss restrictive quality of vascular permeability from neonatal stages to adulthood,with high levels of transcytosis,but maintains the vascular tight junctions.Moreover,lipidomic analysis shows that the expression of Tecr in ECs is associated with the containing of omega-3 fatty acids,which directly suppresses caveolae vesicles formation.These results reveal a protective role for Tecr in BBB integrity and suggest that Tecr as a novel therapeutic target in the central nervous system(CNS)diseases associated with BBB dysfunction. | Jinxuan Wang Jianxiong Xu Guangchao Zang Tao Zhang Qi Wu Hongping Zhang Yidan Chen Yi Wang Weixi Qin Shuang Zhao Erdai Qin Juhui Qiu Xiaojuan Zhang Lin Wen Yeqi Wang Guixue Wang | 2022 | Research2022，，3： | 1 |
| 12 | Identification of a novel estrogen receptor β1 binding partner, inhibitor of differentiation-1, and role of ERβ1 in human breast cancer cells显示文摘 | Li Chen Juhui Qiu Cheng Yang Xinghua Yang Xianchun Chen Jun Jiang Xiangdong Luo | 2009 | Cancer Letters2009，，2： | 1 |
| 13 | Experimental and mechanism research of SO2 removal by cast iron scraps in a magnetically fixed bed显示文摘 | Jiang Juhui Li Yahong Cai Weimin | 2008 | Journal of Hazardous Material2008，153，1： | 1 |
| 14 | Mechano-sensitive TET1s inhibits endothelial athero-susceptible phenotype through regulating YAP phosphorylation显示文摘Atherosclerosis is a chronic progressive disease and one of the major causes of cardio-cerebral vascular diseases.Accumulating evidence indicates that endothelial dysfunc-tion is the initiating step in atherosclerosis.The pattern of local blood flow becomes disturbed(low and oscillatory shear stress[OSS])in the curved or branched segments of the arterial tree,causing endothelial cells(ECs)to exhibit athero-susceptible phenotypes,such as hyperproliferation and inflammation. | Lu Huang Kai Qu Caihong Wang Daoxi Lei Wenhua Yan Tianhan Li Zhengjun Hou Juhui Qiu Guixue Wang | 2023 | Genes & Diseases2023，10，4： | 1 |
| 15 | PARIS: a proteomic analysis and resources indexation system显示文摘 | Wang Juhui Christophe Caron Michel-Yves Mistou | 2004 | Bioinformatics2004，20，1： | 1 |
| 16 | Corrigendum to“A novel mechanism of inhibiting in-stent restenosis with arsenic trioxide drug-eluting stent:Enhancing contractile phenotype of vascular smooth muscle cells via YAP pathway”[Bioact.Mater.62(February 2021)375-385]显示文摘The authors regret the publication of incorrect fund numbers in the acknowledgment section of the article.The number“cstc2019jcyj-zdxm0033”has been updated as“cstc2019jcyj-zdxmX0028”.The corrected acknowledgment section is as follows:This study was supported in part by grants from the National Natural Science Foundation,China(31971242,31701275),the Natural Science Foundation of Chongqing,China(cstc2020jcjy-msxmX0189),the Chongqing Research Program of Basic Research and Frontier Technology,China(cstc2019jcjy-dxmX0028),Open Fund for Key Laboratory of Biorheological Science and Technology,Ministry of Education,China(CQKLBST-2019-010),Innovation Talent Project of 2020 for Chongqing Primary and secondary School,China(CY200405)and the National Key R&D Program,China(2016YFC1102305).The support from the Chongqing Engineering Laboratory in Vascular Implants,China,the Public Experiment Centre of State Bioindustrial Base(Chongqing)and the National“111 Plan”,China(B06023)are gratefully acknowledged. | Yinping Zhao Guangchao Zang Tieying Yin Xiaoyi Ma Lifeng Zhou Lingjuan Wu Richard Daniel Yunbing Wang Juhui Qiu Guixue Wang | 2022 | Bioactive Materials2022，7，2： | 1 |
| 17 | Definition and analysis of the circulation indices of polar vortex at 10 hPa in the Northern Hemisphere显示文摘A set of circulation indices are defined and calculated to characterize monthly mean polar vortex at 10 hPa geopotential height chart in the Northern Hemisphere,including area-(S),intensity-(P) and center position (λc,φc)-indices by use of 1948-2007 NCEP/NCAR 10 hPa monthly height data.These indices series are used to investigate the seasonal variation and interannual anomaly of polar vortex,along with the relations with global warming,ozone anomaly and Arctic Oscillation (AO).The results show that (1) there is anticyclonic (cyclonic) from Jun.to Aug.(from Sep.to Mar.).The change of spring circulation pattern is slower than that of autumn.(2) S can be replaced by P due to the interannual synchronal variations of the intensity and area for polar vortex.The interannual (interdecadal) variations of P are significant in Jan.(Jul.).(3) The anomalies of system center position in Jan.are more evident than that in Jul.(4) The variations of mean temperature at mid-stratosphere in the vicinity of pole zone in Jan.are different from that in Jul.,but they are synchronal with the corresponding P and not significant correlation with the trend of global warming.However,the relationship between P and total O3 in Jul.are obvious.(5) There is so notable correlation between P and AO that P can represent AO. | LiPing Li ShuXuan Guan PanXing Wang JuHui Ma | 2009 | Research in Cold and Arid Regions2009，1，6： | 1 |
| 18 | Effect of 3- aminopropyltriethoxysilane and N,N-dimethyldodecylamine as modifiers of Na+-montmorillonite on SBR/organoelay nanoeomposites 显示文摘 | Kim Wook-Soo Yi Juhui Lee Dong-Hyun Kim Li-Jin Son Wook-Jung Bae Jong-Woo Kim Wonho | 2010 | Journal of Applied Polymer Science-2010，116，： | 1 |
| 19 | Research on power saving positive torque and constant power pumping unit and tracking technique system 显示文摘 | Xu Jinehao Li Juhui Chen Jian | 2012 | Procedia Engineering2012，29，3： | 1 |
| 20 | Experimental and mechanism re- search of SO2 removal by east iron scraps in a magnetical- ly fxed bed 显示文摘 | Juhui Jiang Yahong Li | 2008 | Journal of hazardous materials2008，153，： | 1 |
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