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| 1 | A combined computational pipeline to detect circular RNAs in human cancer cells under hypoxic stress显示文摘Hypoxia is associated with several diseases,including cancer.Cells that are deprived of adequate oxygen supply trigger tran-scriptional and post-transcriptional responses,which control cellular pathways such as angiogenesis,proliferation,and metabolic adaptation.Circular RNAs(circRNAs)are a novel class of mainly non-coding RNAs,which have been implicated in multiple cancers and attract increasing attention as potential biomarkers.Here,we characterize the circRNA signatures of three different cancer cell lines from cervical(HeLa),breast(MCF-7),and lung(A549)cancer under hypoxia.In order to reliably detect circRNAs,we integrate available tools with custom approaches for quantification and statistical analysis?Using this consolidated computational pipeline,we identify?12000 circRNAs in the three cancer celUines.Their molecular characteristics point to an involvement of complementary RNA sequences as well as trans-acting factors in circRNA biogenesis,such as the RNA-binding protein HNRNPC-Notably,we detect a number of circRNAs that are more abundant than their linear counterparts.In addition,64 circRNAs significantly change in abundance upon hypoxia,in most cases in a cell type-specific manner.In summary,we present a comparative circRNA profiling in human cancer cell lines,which promises novel insights into the biogenesis and function of circRNAs under hypoxic stress. | Antonella Di Liddo Camila de Oliveira Freitas Machado Sandra Fischer Stefanie Ebersberger Andreas WHeumliller Julia EWeigand Michaela Muller-McNicoll Kathi Zarnack | 2019 | Journal of Molecular Cell Biology2019，11，10： | 3 |
| 2 | Intestinal microbiota in patients with nonalcoholic fatty liver disease显示文摘 | Marialena Mouzaki Elena M. Comelli Bianca M. Arendt Julia Bonengel Scott K. Fung Sandra E. Fischer Ian D. McGilvray Johane P. Allard | 2013 | Hepatology2013，，1： | 2 |
| 3 | FGF23 induces left ventricular hypertrophy显示文摘 | Faul Christian Amaral Ansel P Oskouei Behzad Hu Ming-Chang Sloan Alexis Isakova Tamara Gutiérrez Orlando M Aguillon-Prada Robier Lincoln Joy Hare Joshua M Mundel Peter Morales Azorides Scialla Julia Fischer Michael Soliman Elsayed Z Chen J | 2011 | Journal of Clinical Investigation2011，，11： | 1 |
| 4 | Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4显示文摘 | Miriam E. Jaax Krystin Krauel Thomas Marschall Sven Brandt Julia Gansler Birgitt Fürll Bettina Appel Silvia Fischer Stephan Block Christiane A. Helm Sabine Müller Klaus T. Preissner Andreas Greinacher | 2013 | Blood2013，，： | 1 |
| 5 | Reliance on God’s Help as a Measure of Intrinsic Religiosity in Healthy Elderly and Patients with Chronic Diseases. Correlations with Health-Related Quality of Life?显示文摘 | Arndt Büssing Julia Fischer Thomas Ostermann Peter F. Matthiessen | 2009 | Applied Research in Quality of Life2009，，1： | 1 |
| 6 | Reliance on God’s Help as a Measure of Intrinsic Religiosity in Healthy Elderly and Patients with Chronic Diseases. Correlations with Health-Related Quality of Life?显示文摘 | Arndt Büssing Julia Fischer Thomas Ostermann Peter F. Matthiessen | 2009 | Applied Research in Quality of Life2009，，1： | 1 |
| 7 | Approaches and tools for user-driven provenance and data quality information in spatial data infrastructures显示文摘Geospatial data are fundamental in most global-change and sustainability-related domains.However,readily accessible information on data quality and provenance is often missing or hardly accessible for users due to technical or perceptual barriers,for example,due to unstructured metadata information or missing references.Within an interdisciplinary process encompassing perspectives of data users,data producers,and software developers,we identified major needs to facilitate effectivefitness-for-use assessments by data users and developed approaches to address these.We provided a stylized analysis of large-scale land use data to showcase selected approaches.To support data users,interoperable quality and provenance information need to be meaningfully represented.Data producers need efficient workflows and tools supporting them in creating high-quality,structured and detailed quality and provenance information.Our newly developed approaches to increase the availability of structured metadata synthesize new and existing tools to extract metadata or to generate provenance data during processing.Within our approaches to improve interoperability and accessibility we present novel tools to support(i)the creation of curated and linked registers of data quality indicators and thematic terms,and(ii)linked visualization of data quality and provenance information.Following our approaches increases transparency,facilitatesfitness-for-use assessments,and ultimately improves research quality. | Julia Fischer Lukas Egli Juliane Groth Caterina Barrasso Steffen Ehrmann Heiko Figgemeier Christin Henzen Carsten Meyer Ralph Müller-Pfefferkorn Arne Rümmler Michael Wagner Lars Bernard Ralf Seppelt | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 8 | 智能网联汽车——中国会成为创新的领导者吗?显示文摘概述 自2015年下半年以来,中国经济增速放缓,再加上全球整体经济的不确定性、政府反腐的力度以及人民币走弱多种因素的影响,都在一定程度上影响了商业的发展。大多数观察员预计中国将继续经济转型,从投资密集型和以出口为主的经济模式转变成以内需为驱动的更加可持续的经济模式。 | Marco Fischer Kaushik Gnanaserakan Julia Kusber | 2016 | 科技中国2016，0，12： | 0 |
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