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| 1 | The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North Africa.To develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the guidelines.Based on the findings of evidencebased medicine in China and abroad,domestic experts have iteratively developed these guidelines to provide proper management of NPC.Overall,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC. | Ling-Long Tang Yu-Pei Chen Chuan-Ben Chen Ming-Yuan Chen Nian-Yong Chen Xiao-Zhong Chen Xiao-Jing Du Wen-Feng Fang Mei Feng Jin Gao Fei Han Xia He Chao-Su Hu De-sheng Hu Guang-Yuan Hu Hao Jiang Wei Jiang Feng Jin Jin-Yi Lang Jin-Gao Li Shao-Jun Lin Xu Liu Qiu-Fang Liu Lin Ma Hai-Qiang Mai Ji-Yong Qin Liang-Fang Shen Ying Sun Pei-Guo Wang Ren-Sheng Wang Ruo-Zheng Wang Xiao-Shen Wang Ying Wang Hui Wu Yun-Fei Xia Shao-Wen Xiao Kun-Yu Yang Jun-Lin Yi Xiao-Dong Zhu Jun Ma | 2021 | Cancer Communications2021，41，11： | 22 |
| 2 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 3 | Performance of Multiple Risk Assessment Tools to Predict Mortality for Adult Respiratory Distress Syndrome with Extracorporeal Membrane Oxygenation Therapy: An External Validation Study Based on Chinese Single-center Data显示文摘 | Lei Huang Tong Li Lei Xu Xiao-Min Hu Da-Wei Duan Zhi-Bo Li Xin-Jing Gao Jun Li Peng Wu Ying-Wu Liu Song Wang Yu-Heng Lang | 2016 | Chinese Medical Journal2016，，14： | 13 |
| 4 | The multiple-parameter fractional Fourier transform显示文摘The fractional Fourier transform(FRFT) has multiplicity,which is intrinsic in frac-tional operator.A new source for the multiplicity of the weight-type fractional Fou-rier transform(WFRFT) is proposed,which can generalize the weight coefficients of WFRFT to contain two vector parameters M,N ∈ZM.Therefore a generalized frac-tional Fourier transform can be defined,which is denoted by the multiple-parameter fractional Fourier transform(MPFRFT).It enlarges the multiplicity of the FRFT,which not only includes the conventional FRFT and general multi-fractional Fourier transform as special cases,but also introduces new fractional Fourier transforms.It provides a unified framework for the FRFT,and the method is also available for fractionalizing other linear operators.In addition,numerical simulations of the MPFRFT on the Hermite-Gaussian and rectangular functions have been performed as a simple application of MPFRFT to signal processing. | LANG Jun TAO Ran RAN QiWen WANG Yue | 2008 | Science in China(Series F)2008，51，8： | 12 |
| 5 | Energy-efficient methods for production methane from natural gas hydrates显示文摘Gas hydrates now are expected to be one of the most important future unconventional energy resources. In this paper, researches on gas hydrate exploitation in laboratory and field were reviewed and discussed from the aspects of energy efficiency. Different exploiting methods and different types of hydrate reservoir were selected to study their effects on energy efficiencies. Both laboratory studies and field tests have shown that the improved technologies can help to increase efficiency for gas hydrate exploitation. And it also showed the trend that gas hydrate exploitation started to change from permafrost to marine. Energy efficiency ratio(EER) and energy return on energy invested(EROI) were introduced as an indicator of efficiency for natural gas hydrate exploitation. An energy-efficient hydrate production process, called 'Hydrate Chain Energy System(HCES)', including treatment of flue gas, replacement of CH4 with CO2, separation of CO2 from CH4, and storage and transportation of CH4 in hydrate form, was proposed for future natural gas hydrate exploitation.In the meanwhile, some problems, such as mechanism of CO2 replacement, mechanism of CO2 separation,CH4 storage and transportation are also needed to be solved for increasing the energy efficiency of gas hydrate exploitation. | Jun Chen Yan-Hong Wang Xue-Mei Lang Shuan-Shi Fan | 2015 | Journal of Energy Chemistry2015，24，5： | 8 |
| 6 | The discrete multiple-parameter fractional Fourier transform显示文摘As a generalization of the Fourier transform (FT), the fractional Fourier transform (FRFT) has many applications in the areas of optics, signal processing, information security, etc. Therefore, the efficient discrete computational method is the vital fundament for the application of the fractional Fourier transform. The multiple-parameter fractional Fourier transform (MPFRFT) is a generalized fractional Fourier transform, which not only includes FRFT as special cases, but also provides a unified framework for the study of FRFT. In this paper, we present in detail the discretization method of the MPFRFT and define the discrete multiple-parameter fractional Fourier transform (DMPFRFT). Then, we utilize the tensor product to define two-dimensional multiple-parameter fractional Fourier transform (2D-MPFRFT) and the corresponding two-dimensional discrete multiple-parameter fractional Fourier transform (2D-DMPFRFT). Finally, as an application, a novel image encryption method based on 2D-DMPFRFT is proposed. Numerical simulations are performed to demonstrate that the proposed method is reliable and more robust to blind decryption than several existing methods. | LANG Jun, TAO Ran& WANG Yue Department of Electronic Engineering, Beijing Institute of Technology, Beijing 100081, China | 2010 | Science China(Information Sciences)2010，53，11： | 8 |
| 7 | Kinetic hydrate inhibitor performance of new copolymer poly(N-vinyl-2-pyrrolidone-co-2-vinyl pyridine)s with TBAB显示文摘In oil and gas field, the application of kinetic hydrate inhibitors (KHIs) independently has remained problematic in high subcooling and high water-cut situation. One feasible method to resolve this problem is the combined use of KHIs and some synergists, which would enhance KHIs’ inhibitory effect on both hydrate nucleation and hydrate crystal growth. In this study, a novel kind of KHI copolymer poly(N-vinyl-2-pyrrolidone-co-2-vinyl pyridine)s (HGs) is used in conjunction with TBAB to show its high performance on hydrate inhibition. The performance of HGs with different monomer ratios in structure II tetrahydrofuran (THF) hydrate is investigated using kinetic hydrate inhibitor evaluation apparatus by step-cooling method and isothermal cooling method. With the combined gas hydrate inhibitor at the concentration of 1.0 wt%, the induction time of 19 wt% THF solution could be prolonged to 8.5 h at a high subcooling of 6℃. Finally, the mechanism of HGs inhibiting the formation of gas hydrate is proposed. | Jun Hu Sijia Li Yanhong Wang Xuemei Lang Qingping Li Shuanshi Fan | 2012 | Journal of Natural Gas Chemistry2012，21，2： | 8 |
| 8 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 7 |
| 9 | Synthesis and application of a novel combined kinetic hydrate inhibitor显示文摘In oil and gas exploration and transportation,low dosage hydrate inhibitors(LDHIs) are more favorably utilized to inhibit the formation of hydrates than thermodynamic inhibitors(THs) as a trend. However,there are no industrial products of LDHIs available domestically,and the corresponding application experience is in urgent need. In this paper,a combined hydrate inhibitor(HY-1) was synthesized after a series of reaction condition optimization,and its performance on THF hydrate inhibition was investigated using kinetic hydrate inhibitor evaluation apparatus with 6 cells bathing in air. The results show that when the reaction temperature is 60°C,the reaction time is 6 h,and the monomer:solvent ratio is 1:2,the product has the best kinetic hydrate inhibitor performance on THF hydrate. On these bases,the scale-up production of this combined hydrate inhibitor was carried out. Although the scale-up product(HY-10) performs less effectively on the THF hydrate inhibition than HY-1,it functions better than a commercial product(Inhibex501) during in-house tests. HY-10 was successfully applied to the gas production process. Field trials in northern Shaanxi PetroChina Changqing Oilfield Company(PCOC) show that 2 wt% of HY-10 is effective on natural gas hydrate inhibition. It is found through economic analysis that the use of HY-10 has obvious economical advantage over methanol and Inhibex501. | HU Jun WANG YanHong LANG XueMei DU Juan LI QingPing FAN ShuanShi | 2011 | Science China(Technological Sciences)2011，54，12： | 6 |
| 10 | A Foodborne Bongkrekic Acid Poisoning Incident--Heilongjiang Province,2020显示文摘What is already known on this topic?Poisoning incidents caused by bongkrekic acid(BA),one of the metabolites of Burkholderia gladioli pathovar cocovenenans(B.cocovenenans),have been reported in Indonesia,Mozambique,and China.The reported case fatality rates averaged 60%,32%,and 26.5%,respectively.In China,B.cocovenenans is often called Pseudomonas cocovenenans subsp.farinofermentans.What is added by this report?In October 2020,9 persons in Jidong County,Heilongjiang Province died after consuming a homemade fermented corn flour product—sour soup—with a case fatality rate of 100%.BA was detected in both food samples and biological samples with a content of 330 mg/kg and 3 mg/L,respectively.The doses of BA consumed by the cases were approximately 22-33 times the lethal dose in human.What are the implications for public health practice?The consumption of fermented corn flour products,deteriorated fresh tremella,or black fungus and metamorphic starch products may cause BA poisoning.Health education should be strengthened so that homemade-starch-fermented food should be avoided and foods that have been kept for a long time should not be consumed.Meanwhile,training and emergency capacity building for primary healthcare workers should be strengthened to provide timely diagnosis and response. | Yuan Yuan Rui Gao Qiang Liang Li Song Jun Huang Nan Lang Jing Zhou | 2020 | China CDC weekly2020，2，51： | 5 |
| 11 | Design and performance of dual-band high temperature superconducting filter显示文摘In this paper,a dual-band high temperature superconducting (HTS) filter with 14-pole and 3 cross couplings is presented.The equivalent model,theoretical result,coupling matrix,and the simulated result of the filter are demonstrated.The desired filter is designed and fabricated using double-sided DyBa 2 Cu 3 O 7 thin films on MgO wafer 2 inches in diameter and 0.5 mm in thickness.The filter has two passbands with frequencies 1920-1940 MHz and 1960-1980 MHz respectively,and insertion loss less than 0.2 dB.The measurement results show that the response of practical filters is in good agreement with that of simulated results and theoretical analysis,with the group delay variation being less than ±20 ns over 90% of the filter bandwidth for the two passbands. | JI LaiYun MA Jie SUN Jun WANG Lang LI YanQi LIU Bin | 2012 | Science China(Information Sciences)2012，55，4： | 5 |
| 12 | Gene-lndexed Mutations in Maize显示文摘 | Xiaoduo Lu Jisheng Liu Wen Ren Qun Yang Zhenguang Chai Rumei Chen Lei Wang Jun Zhao Zhihong Lang Haiyang Wang Yunliu Fan Jiuran Zhao Chunyi Zhang | 2018 | Molecular Plant2018，11，3： | 4 |
| 13 | Technique of Anatomical Retroperitoneoscopic Adrenalectomy With Report of 800 Cases显示文摘 | Xu Zhang Bin Fu Bin Lang Jun Zhang Kai Xu Hong-Zhao Li Xin Ma Tao Zheng | 2007 | The Journal of Urology2007，，4： | 3 |
| 14 | Therapeutic effects of low-frequency phonophoresis with a Chinese herbal medicine versus sodium diclofenac for treatment of knee osteoarthritis: a double-blind, randomized, placebo-controlled clinical trial显示文摘OBJECTIVE: To evaluate the therapeutic effects of low-frequency phonophoresis with a Chinese herbal medicine(CHM) compared with sodium diclofenac(SD) for knee osteoarthritis(KOA).METHODS: In this double-blind, randomized, placebo-controlled trial, 100 KOA patients were assigned randomly to a placebo group, a CHM group,or SD group. Low-frequency phonophoresis was used to improve the efficiency of drug delivery.Pain at rest [using a visual analog scale(VAS)], pain on movement(VAS), and range of motion(degrees) in the three groups were evaluated using the Western Ontario and Mc Master Universities Osteoarthritis Index(WOMACAI) scores. Safety assessments comprised emergency adverse events, aswell as laboratory tests of blood biochemistry, creatinine, blood urea nitrogen, alanine aminotransferase and aspartate aminotransferase.RESULTS: Significant improvements were found after treatment in all outcome measures except stiffness and range of motion in patients in the CHMP group and SDP group(P < 0.05). No significant differences in all outcome measures were found between the CHMP group and SDP group.CONCLUSION: CHMP and SDP can show good therapeutic effects for KOA in terms of relieving pain and improving physical function. | Zhao Jun Wang Qingfu Wu Ji Shi Xinchao Qi Qingxue Zheng Haoyun Lang Song Yang Lili Zhang Dong | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 3 |
| 15 | Amperometric Determination of lndole-3-acetic Acid Based on Platinum Nanowires and Carbon Nanotubes显示文摘Platinum nanowire (PtNW) can be grown by electrodeposition in polycarbonate membrane, with the average diameter of the nanowires about 250 nm. The PtNW and multiwalled carbon nanotubes (CNT) are then dispersed into chitosan (CHIT) solution. The resulting PtNW-CNT-CHIT material brings new capabilities for electrochemical devices by using the synergistic action of the electrocatalytic activity of PtNW and CNT. By dropping the PtNW-CNT-CHIT film onto the glassy carbon (GC) electrode surface, and after evaporation an amperometric sensor for the determination of indole-3-acetic acid (IAA) was developed. The oxidation current of IAA increased significantly at the PtNW-CNT-CHIT film coated GC electrode, in contrast to that at the CNT-CHIT modified GC. The linear response of the sensor is from 50 ng/ml to 50 μg/ml with a detection limit of 25 ng/mL. | Ruo Zhong WANG Lang Tao XIAO Ming Hui YANG Jun Hui DING Feng Li QU Guo Li-SHEN | 2006 | Chinese Chemical Letters2006，17，12： | 3 |
| 16 | Changes in dendritic cells and dendritic cell subpopulations in peripheral blood of recipients during acute rejection after kidney transplantation显示文摘 | Ma Linlin Liu Yong Wu Junjie Xu Xiuhong Liu Fen Feng Lang Xie Zelin Tang Yawang Sun Wen Guo Hongbo Zhang Lei Lin Jun Tian Ye | 2014 | Chinese Medical Journal2014，，8： | 3 |
| 17 | Source identification and ecological risk assessment of heavy metals in topsoil using environmental geochemical mapping: Typical urban renewal area in Beijing, China显示文摘 | Guo-Li Yuan Tian-He Sun Peng Han Jun Li Xin-Xin Lang | 2014 | Journal of Geochemical Exploration2014，，： | 2 |
| 18 | YWHAZ Binds to TRIM21 but Is Not Involved in TRIM21-stimulated Osteosarcoma Cell Proliferation显示文摘Objective Osteosarcoma is the most common type of malignant bone tumor in children and adolescents. The role of E3 ligases in tumorigenesis is currently a focus in tumor research. In the present study, we investigated the role of the E3 ligase tripartite motif 21(TRIM21) in osteosarcoma cell proliferation.Methods 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide(MTT) assays were used to assess osteosarcoma cell viability. U2-OS cells stably carrying a recombinant lentivirus expressing tetracycline-regulated TRIM21 were screened. Co-immunoprecipitation was coupled with LCMS/MS analysis to identify novel interacting partners of TRIM21. Co-immunoprecipitation and bimolecular fluorescence complementation(BIFC) were performed to validate the interactions between TRIM21 and its novel partner YWHAZ. A TRIM21-ΔRING construct was generated to test the effects of TRIM21 ligase activity on YWHAZ.Results TRIM21 positively regulated osteosarcoma cell proliferation. Overexpression of TRIM21 enhanced osteosarcoma cell tolerance toward various stresses. YWHAZ protein was identified as a novel interacting partner of TRIM21 and its expression levels were negatively regulated by TRIM21. The RING domain of TRIM21 was required for TRIM21 negative regulation of YWHAZ expression. However,overexpression of YWHAZ did not affect positive regulation of osteosarcoma cell proliferation by TRIM21.Conclusion Our results further clarify the molecular mechanisms underlying the pathogenesis of osteosarcoma. | ZENG Qing Zhong LIU Wan Ting LU Jun Lei LIU Xiao Hui ZHANG Yun Fang LIU Lang Xia GAO Xue Juan | 2018 | Biomedical and Environmental Sciences2018，31，3： | 2 |
| 19 | Sulfate sources constrained by sulfur and oxygen isotopic compositions in the upper reaches of the Xijiang River,China显示文摘While it is critical to accurately understand the sources and transformation of sulfate based on time-series analysis, there are limited studies on temporal variation of sulfate in rivers and on rock weathering by sulfuric acids.We conducted a monthly sampling campaign in the Beipan, Nanpan, and Hongshui Rivers over the course of one hydrological year. This study examined seasonal variations in riverine sulfate impacted by the monsoon climate in the upper reaches of the Xijiang River basin. In general, the SO_4^(2-) contents in these rivers dropped from relatively high levels to low values during the high-flow season, in response to increasing discharge. The sulfate was generally enriched in heavy isotopes during the low-flow season compared to the high-flow season. The calculated results indicate that the riverine sulfate was mainly derived from sulfide oxidation, but that evaporite dissolution could be an important source during the low-flow season, based on isotopic evidence. Mine drainage is likely an important source of sulfate to these rivers during the high-flow season due to contributions from fast surface flow, which responds to frequent heavy rain in monsoonal climate regions. Arelatively high proportion of HCO_3^- was found to be derived from rock weathering by sulfuric acid during the high-flow season when compared to that observed during the low-flow season. The results suggest that approximately one quarter of the HCO_3^- in the Hongshui River originated from carbonate weathering by sulfuric acid derived from the oxidation of sulfide. Such information on the specific dual isotopic characteristics of riverine sulfate throughout a hydrological year can provide unique evidence for understanding the temporal variability of sulfate concentrations and weathering processes in rivers. | Jing Liu Siliang Li Jun Zhong Xuetao Zhu Qingjun Guo Yunchao Lang Xiaokun Han | 2017 | Acta Geochimica2017，36，4： | 2 |
| 20 | Image encryption based on the multiple-parameter discrete fractional Fourier trans- form and chaos function显示文摘 | Lang Jun Tao Ran Wang Yue | 2010 | Opt Commun2010，283，10： | 1 |
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