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| 1 | Valproic acid reduces autophagy and promotes functional recovery after spinal cord injury in rats显示文摘Secondary damage is a critical determinant of the functional outcome in patients with spinal cord injury (SCI), and involves multiple mechanisms of which the most important is the loss of nerve cells mediated by multiple factors. Autophagy can result in cell death, and plays a key role in the development of SCI. It has been recognized that valproic acid (VPA) is neuroprotective in certain experimental animal models, however, the levels of autophagic changes in the process of neuroprotection by VPA treatment following SCI are still unknown. In the present study, we determined the extent of autophagy after VPA treatment in a rat model of SCI. We found that both the mRNA and protein levels of Beclin-1 and LC3 were significantly increased at 1, 2, and 6 h after SCI and peaked at 2 h; however, Western blot showed that autophagy was markedly decreased by VPA treatment at 2 h post-injury. Besides, post-SCI treatment with VPA improved the Basso-Beattie-Bresnahan scale, increased the number of ventral horn motoneurons, and reduced myelin sheath damage compared with vehicle-treated animals at 42 days after SCI. Together, our results demonstrated the characteristics of autophagy expression following SCI, and found that VPA reduced autophagy and enhanced motor function. | Hai-Hu Hao Li Wang Zhi-Jian Guo Lang Bai Rui-Ping Zhang Wei-Bing Shuang Yi-Jia Jia Jie Wang Xiao-Yu Li Qiang Liu | 2013 | Neuroscience Bulletin2013，29，4： | 19 |
| 2 | Characteristics of atmospheric single particles during haze periods in a typical urban area of Beijing:A case study in October,2014显示文摘To investigate the composition and possible sources of particles, especially during heavy haze pollution, a single particle aerosol mass spectrometer(SPAMS) was deployed to measure the changes of single particle species and sizes during October of 2014, in Beijing. A total of 2,871,431 particles with both positive and negative spectra were collected and characterized in combination with the adaptive resonance theory neural network algorithm(ART-2a). Eight types of particles were classified: dust particles(dust, 8.1%), elemental carbon(EC, 29.0%), organic carbon(OC, 18.0%), EC and OC combined particles(ECOC, 9.5%),Na-K containing particles(Na K, 7.9%), K-containing particles(K, 21.8%), organic nitrogen and potassium containing particles(KCN, 2.3%), and metal-containing particles(metal,3.6%). Three haze pollution events(P1, P2, P3) and one clean period(clean) were analyzed,based on the mass and number concentration of PM_(2.5)and the back trajectory results from the hybrid single particle Lagrangian integrated trajectory model(Hysplit-4 model). Results showed that EC, OC and K were the major components of single particles during the three haze pollution periods, which showed clearly increased ratios compared with those in the clean period. Results from the mixing state of secondary species of different types of particles showed that sulfate and nitrate were more readily mixed with carbon-containing particles during haze pollution episodes than in clean periods. | Lang Liu Yanli Wang Shiyong Du Wenjie Zhang Lujian Hou Sverre Vedal Bin Han Wen Yang Mindong Chen Zhipeng Bai | 2016 | Journal of Environmental Sciences2016，28，2： | 19 |
| 3 | An improved empirical wavelet transform method for rolling bearing fault diagnosis显示文摘Empirical wavelet transform(EWT)based on the scale space method has been widely used in rolling bearing fault diagnosis.However,using the scale space method to divide the frequency band,the redundant components can easily be separated,causing the band to rupture and making it difficult to extract rolling bearing fault characteristic frequency effectively.This paper develops a method for optimizing the frequency band region based on the frequency domain feature parameter set.The frequency domain feature parameter set includes two characteristic parameters:mean and variance.After adaptively dividing the frequency band by the scale space method,the mean and variance of each band are calculated.Sub-bands with mean and variance less than the main frequency band are combined with surrounding bands for subsequent analysis.An adaptive empirical wavelet filter on each frequency band is established to obtain the corresponding empirical mode.The margin factor sensitive to the shock pulse signal is introduced into the screening of empirical modes.The empirical mode with the largest margin factor is selected to envelope spectrum analysis.Simulation and experiment data show this method avoids over-segmentation and redundancy and can extract the fault characteristic frequency easier compared with only scale space methods. | HUANG HaiRun LI Ke SU WenSheng BAI JianYi XUE ZhiGang ZHOU Lang SU Lei PECHT Michael | 2020 | Science China(Technological Sciences)2020，63，11： | 10 |
| 4 | High value of controlled attenuation parameter predicts a poor antiviral response in patients with chronic hepatits B显示文摘BACKGROUND:Controlled attenuation parameter(CAP) is a non-invasive method for diagnosing hepatic steatosis based on vibration-controlled transient elastography.The objective of this study was to investigate the effect of high value of CAP on antiviral therapy in patients with chronic hepatitis B(CHB).METHODS:Patients with CHB receiving enticavir for initial antiviral therapy were studied;they were divided into the high CAP group and normal CAP group at baseline according to the CAP values.The effect of the antiviral therapy between the two groups were compared at week 12,24 and 48.Patients with high CAP value at baseline were divided into three subgroups,mild,moderate and severe elevation;the therapeutic response were compared among patients with normal CAP and subgroups of patients with elevated CAP.RESULTS:A total of 153 patients were enrolled.Among them,63 were in the high CAP group and 90 in the normal CAP group.Patients with high CAP had lower rates of ALT normalization and HBV DNA clearance in response to antiviral therapy compared with those with normal CAP at week 12,24 and 48.Further analysis showed that the rate of ALT normalization in patients with mildly and moderately elevated CAP were significant lower than those with normal CAP at week 12 and 24;while the difference was not significant between the patients with normal CAP and those with severely elevated CAP.The rate of HBV DNA clearance was significantly lower in patients with severely elevated CAP compared with those with normal CAP at week 12,24 and 48.CONCLUSION:CHB patients with high CAP had poor response to antiviral therapy. | Jing Chen Meng-Lan Wang Qin Long Lang Bai Hong Tang | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，4： | 9 |
| 5 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 7 |
| 6 | Preparation and application of monoclonal antibodies against hepatitis C virus nonstructural proteins显示文摘PreparationandapplicationofmonoclonalantibodiesagainsthepatitisCvirusnonstructuralproteinsGAOJianEn,TAOQiMin,GUOJianPin... | GAO Jian En, TAO Qi Min, GUO Jian Ping, JI He Ping, LANG Zheng Wei, JI Ying and FENG Bai Fang | 1997 | World Journal of Gastroenterology1997，3，2： | 6 |
| 7 | Prognostic analysis of transarterial chemoembolization combined with a traditional Chinese herbal medicine formula for treatment of unresectable hepatocellular carcinoma显示文摘 | YU Yang LANG Qing-bo CHEN Zhe LI Bai YU Chao-qin ZHU De-zeng HUANG Xue-qiang ZHAI Xiao-feng LING Chang-quan | 2009 | Chinese Medical Journal2009，，17： | 5 |
| 8 | The Genomes of the Allohexaploid Echinochloa crus-galli and Its Progenitors Provide Insights into Polyploidization-Driven Adaptation显示文摘The hexaploid species Echinochloa crus-galli is one of the most detrimental weeds in crop fields,especially in rice paddies.Its evolutionary history is similar to that of bread wheat,arising through polyploidization after hybridization between a tetraploid and a diploid species.In this study,we generated and analyzed high-quality genome sequences of diploid(E.haploclada),tetraploid(E.oryzicola),and hexaploid(E.crus-galli)Echinochloa species.Gene family analysis showed a significant loss of disease-resistance genes such as those encoding NB-ARC domain-containing proteins during Echinochloa polyploidization,contrary to their significant expansionduring wheat polyploidization,suggesting that natural selection might favor reduced investment in resistance in this weed to maximize its growth and reproduction.In contrast to the asymmetric patterns of genome evolution observed in wheat and other crops,no significant differences in selection pressure were detected between the subgenomes in E.oryzicola and E.crus-galli.In addition,distinctive differences in subgenome transcriptome dynamics during hexaploidization were observed between E.crus-galli and bread wheat.Collectively,our study documents genomic mechanisms underlying the adaptation of a major agricultural weed during polyploidization.The genomic and transcriptomic resources of three Echinochloa species and new insights into the polyploidization-driven adaptive evolution would be useful for future breeding cereal crops. | Chu-Yu Ye Dongya Wu Lingfeng Mao Lei Jia Jie Qiu Sangting Lao Meihong Chen Bowen Jiang Wei Tang Qiong Peng Lang Pan Lifeng Wang Xiaoxiao Feng Longbiao Guo Chulong Zhang Elizabeth A.Kellogg Kenneth M.Olsen Lianyang Bai Longjiang Fan | 2020 | Molecular Plant2020，13，9： | 4 |
| 9 | Effects of Blast Wave-induced Biomechanical Changes on Lung Injury in Rats显示文摘Objective To observe the dynamic impacts of shock waves on the severity of lung injury in rats with different injury distances.Methods Simulate open-field shock waves;detect the biomechanical effects of explosion sources at distances of 40,44,and 48 cm from rats;and examine the changes in the gross anatomy of the lungs,lung wet/dry weight ratio,hemoglobin concentration,blood gas analysis,and pathology.Results Biomechanical parameters such as the overpressure peak and impulse were gradually attenuated with an increase in the injury distance.The lung tissue hemorrhage,edema,oxygenation index,and pathology changed more significantly for the 40 cm group than for the 44 and 48 cm groups.The overpressure peak and impulse were significantly higher for the 40 cm group than for the 44 and 48 cm groups(P<0.05 or P<0.01).The animal mortality was significantly higher for the 40 cm group than for the other two groups(41.2%vs.17.8%and 10.0%,P<0.05).The healing time of injured lung tissues for the 40 cm group was longer than those for the 44 and 48 cm groups.Conclusions The effects of simulated open-field shock waves on the severity of lung injuries in rats were correlated with the injury distances,the peak overpressure,and the overpressure impulse. | LIU Wei CHAI Jia Ke QIN Bin HAN Shao Fang WANG Xiao Teng JIANG Shuai BAI Hai Liang LIU Ling Ying CHANG Yang YUE Xiao Tong WU Yu Shou ZHANG Zi Hao TANG Lang | 2020 | Biomedical and Environmental Sciences2020，33，5： | 2 |
| 10 | Interface Reversible Electric Field Regulated by Amphoteric Charged Protein-Based Coating Toward High-Rate and Robust Zn Anode显示文摘Metallic interface engineering is a promising strategy to stabilize Zn anode via promoting Zn^(2+) uniform deposition.However,strong interactions between the coating and Zn^(2+) and sluggish transport of Zn^(2+) lead to high anodic polarization.Here,we present a bio-inspired silk fibroin(SF)coating with amphoteric charges to construct an interface reversible electric field,which manipulates the transfer kinetics of Zn^(2+) and reduces anodic polarization.The alternating positively and negatively charged surface as a build-in driving force can expedite and homogenize Zn^(2+) flux via the inter-play between the charged coating and adsorbed ions,endowing the Zn-SF anode with low polarization voltage and stable plating/stripping.Experimental analyses with theo-retical calculations suggest that SF can facilitate the desolvation of[Zn(H_(2)O)_(6)]^(2+) and provide nucleation sites for uniform deposition.Consequently,the Zn-SF anode delivers a high-rate performance with low voltage polarization(83 mV at 20 mA cm^(−2)) and excellent stability(1500 h at 1 mA cm^(−2);500 h at 10 mA cm^(−2)),realizing exceptional cumulative capacity of 2.5 Ah cm^(−2).The full cell coupled with Zn_(x)V_(2)O_(5)·nH_(2)O(ZnVO)cathode achieves specific energy of~270.5/150.6 Wh kg^(−1)(at 0.5/10 A g^(−1))with-99.8% Coulombic efficiency and retains~80.3%(at 5.0 A g^(−1))after 3000 cycles. | Meihua Zhu Qing Ran Houhou Huang Yunfei Xie Mengxiao Zhong Geyu Lu Fu-Quan Bai Xing-You Lang Xiaoteng Jia Danming Chao | 2022 | Nano-Micro Letters2022，14，12： | 2 |
| 11 | Pattern characteristics in patients with primary liver cancer in different clinical stages显示文摘OBJECTIVE: To explore the characteristics of primary liver cancer in terms of Traditional Chinese Medicine(TCM) by analyzing the variations of the patterns along with the clinical stages.METHODS: The patients who were hospitalized in the Changhai Hospital of Traditional Chinese Medicine dated from March 1999 to December 2008 were included in this retrospective study. The patients were grouped according to their cancer stages, and their patterns were judged and quantified according to the 'Standard diagnosis and quantitative criteria of the common patterns in primary liv-er cancer' formulated by the Changhai Hospital of Traditional Chinese Medicine. Statistics methods included ANOVA and nonparametric test, among others.RESULTS: The data of the 398 newly diagnosed patients showed that Qi Stagnation, Blood Stasis, and Dampness patterns were more frequent than the other basic patterns with relatively high scores; patterns of Liver Qi Stagnation, Liver Blood Stasis, and Dampness Heat were more than the other complex patterns and scored relatively high. Scores of Dampness and Liver Qi Stagnation patterns varied among the groups at different stages and the differences were statistically significant(PDampness= 0.002,PLiver Qi Stagnation= 0.020). The highest scores of Dampness pattern and Liver Qi Stagnation pattern corresponded with Stage Ⅲb, and Stage equency wⅢ a, respectively. Dampness pattern fras higher(P =0.001) in the Stage Ⅲb group than in other groups.CONCLUSION: Pattern characteristics in patients with primary liver cancer of different clinical stages might manifest in the variations of the Dampness pattern along the process of the disease and the major pathogenic factor of primary liver cancer might be Dampness. | Qin Liping Meng Jing Lang Qingbo Liu Long Li Bai | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 2 |
| 12 | LncRNAs in ocular neovascularizations显示文摘The prevalence of eye diseases worldwide is dramatically increasing and represents a major concern in underdeveloped and developed regions. Ocular diseases, previously associated with a higher depression risk, also impose a substantial economic burden on affected families, thus early detection and/or accurate treatment in order to avoid and prevent blindness should be emphasized. Ocular neovascularization(NV), the leading cause of blindness in a variety of eye diseases, is a pathologic process characterized by the formation, proliferation and infiltration of anomalous, tiny and leaky fragile blood vessels within the eye. Genetics have been suspected to play an important role in the occurrence of eye diseases, with the detection of a numbers of specific gene mutations. Long non-coding RNA(lnc RNAs) are novel class of regulatory molecules previously associated with various biological processes and diseases, however the nature of the relation and pathways by which they might contribute to the development of corneal, choroidal and retinal NV have not yet been completely elucidated. In this review, we focus on the regulation and characteristics of lncR NAs, summarize results from ocular NV-related studies and discuss the implication of lncR NAs in ocular NV development. | Yacouba Cissé Lang Bai Min-Ting Chen | 2019 | International Journal of Ophthalmology(English edition)2019，12，12： | 1 |
| 13 | A facile way to rejuvenate Ag3PO4 as a recyclable highly efficient photocatalyst显示文摘 | WANG H BAI Y S YANG J T LANG X F LI J H GUO L | 2012 | Chemistry: A European Journal2012，18，18： | 1 |
| 14 | Distribution and risk assessment of polycyclic aromatic hy-drocarbons(PAHs)from Liaohe estuarine wetland soils显示文摘 | Yinhai Lang Nannan Wang Huiwang Gao Jie Bai | | 0，，： | 1 |
| 15 | 查看详情显示文摘 | Lu H Wang J Bai Y Lang J.W. Liu S. Lin Y.and Cheng J | | 0，，： | 1 |
| 16 | Cloning and characterization of a human LYPD7, a new memberof the Ly-6 superfamily 显示文摘 | Ni J Lang Q Y Bai M | 2009 | Molecular Biology Reports2009，36，4： | 1 |
| 17 | Efficacy of bilateral repetitive transcranial magnetic stimulation for nega- tive symptoms of schizophrenia: results of a multicenter doub- le-blind randomized controlled trial显示文摘 | Dlabac-de Lange JJ Bais L van Es FD | 2015 | Psyehol Med2015，45，6： | 1 |
| 18 | All-weather,natural silent speech recognition via machine-learning-assisted tattoo-like electronics显示文摘The internal availability of silent speech serves as a translator for people with aphasia and keeps human–machine/human interactions working under various disturbances.This paper develops a silent speech strategy to achieve all-weather,natural interactions.The strategy requires few usage specialized skills like sign language but accurately transfers high-capacity information in complicated and changeable daily environments.In the strategy,the tattoo-like electronics imperceptibly attached on facial skin record high-quality bio-data of various silent speech,and the machine-learning algorithm deployed on the cloud recognizes accurately the silent speech and reduces the weight of the wireless acquisition module.A series of experiments show that the silent speech recognition system(SSRS)can enduringly comply with large deformation(~45%)of faces by virtue of the electricitypreferred tattoo-like electrodes and recognize up to 110 words covering daily vocabularies with a high average accuracy of 92.64%simply by use of small-sample machine learning.We successfully apply the SSRS to 1-day routine life,including daily greeting,running,dining,manipulating industrial robots in deafening noise,and expressing in darkness,which shows great promotion in real-world applications. | Youhua Wang Tianyi Tang Yin Xu Yunzhao Bai Lang Yin Guang Li Hongmiao Zhang Huicong Liu YongAn Huang | 2021 | npj Flexible Electronics2021，5，1： | 1 |
| 19 | A small unmanned polar research aerial vehicle based on the composite control method显示文摘 | Xusheng Lei Lang Bai Yuhu Du Cunxiao Miao Yang Chen Tianmiao Wang | 2010 | Mechatronics2010，，5： | 1 |
| 20 | Thermal properties of Si(Al)/diamond composites pre- pared by in situ reactive sintering显示文摘 | Congxu Zhu Nangang Ma Ying Jin Hua Bai Yi Ma Jing Lang | 2012 | Materials and Design2012，41，： | 1 |
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