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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Thompson CB: The B7 and CD28 receptor families显示文摘 | June C H Bluestone J A Nadler L M | 1994 | Immunol Today1994，15，7： | 1 |
| 3 | Considerations for the clinical applicationof chimeric antigen receptor T cells: observations froma recombinant DNA Advisory Committee Symposiumheld June 15,2010 显示文摘 | Ertl H C Zaia J? Rosenberg S A June C H Dotti G Kahn J | 2011 | Cancer Res2011，71，： | 1 |
| 4 | Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology显示文摘 | Kalos M June C H | 2013 | Immunity2013，39，1： | 1 |
| 5 | Engineering lympho- cyte subsets: tools, trials and tribulations显示文摘 | June C H Blazar B R Riley J L | 2009 | Nature Re- views Immunology2009，9，10： | 1 |
| 6 | Clinical perspec- tives for regulatory T cells in transplantation tolerance 显示文摘 | HIPPEN K L RILEY J L JUNE C H | 2011 | Semin Immunol2011，23，6： | 1 |
| 7 | Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology 显示文摘 | Kalos M June C H | 2013 | Immunity2013，39，1： | 1 |
| 8 | Clinical application of expanded CD4 + 25 + cells显示文摘 | June C H Blazar B R | 2006 | Semi Immunol2006，18，2： | 1 |
| 9 | Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia显示文摘 | Porter DL Levine BL June C H | 2011 | N Engl J Med2011，365，： | 1 |
| 10 | Regulated expression of telomerase activity in humanT lymphocyte development and activation显示文摘 | WENG N P LEVINE B L JUNE C H | 1996 | J Exp Med1996，183，6： | 1 |
| 11 | The B7 and CD28 receptor families显示文摘 | June C H Bluestone J A | 1994 | Immunol Today1994，15，7： | 1 |
| 12 | 4-1BB costimulation promotes human T cell adhesion to fibronectin显示文摘 | Kim Y J Mantel P L June C H | 1999 | Cellular Immunol1999，192，： | 1 |
| 13 | Principles of adoptive T cell cancer therapy 显示文摘 | C H June | 2007 | Journal of Clinical Investigation2007，117，5： | 1 |
| 14 | Pharyngeal and upper esophageal sphincter manometry in the evaluation of dysphagia 显示文摘 | Amine H June A C Donald O C | 2001 | J Clin Gastroenterol2001，33，5： | 1 |
| 15 | Synthesis of polyamine type flocculant and properties in potable water treatment 显示文摘 | LeeSP June H S Sang J C | 1998 | Journal of the Ko- rean Industrial and Engineering Chemistry1998，9，4： | 1 |
| 16 | Per- sistent calcium elevation correlates with the induction of surface immunoglobulin-mediated B cell DNA syn- thesis显示文摘 | YAMADA H JUNE C H FINKELMAN F | 1993 | J Exp Med1993，177，6： | 1 |
| 17 | Genetic therapies against HIV显示文摘 | JUNE C H KOHN D B | 2007 | Nat Biotechnol2007，25，12： | 1 |
| 18 | Examina tion of the inhibitory and stimulatory effects of IFN-alpha, beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens 显示文摘 | FRANCOIS D T KATONA I M JUNE C H | 1988 | Clin Immunol Immunopathol1988，48，3： | 1 |
| 19 | Predicting registered nurse job satisfaction and intent to leave 显示文摘 | Larrabee June H Janney Michelle A Ostrow C Lynne | 2003 | The Journal of nursing administration2003，33，5： | 1 |
| 20 | The B7 and CD28 receptor families显示文摘 | June C H Bluestone J A | 1994 | Immunol Today1994，15，7： | 1 |
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