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您的检索式：作者名="June Hong Ahn"
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| 1 | Effects of trimetazidine in patients with acute myocardial infarction: data from the Korean Acute Myocardial Infarction Registry显示文摘 | Jeong Su Kim Chang Hoon Kim Kook Jin Chun June Hong Kim Yong Hyun Park Jun Kim Jin Hee Choi Sang Hyun Lee Eun Jung Kim Dae Gon Yu Eun Young Ahn Myung Ho Jeong | 2013 | Clinical Research in Cardiology2013，，： | 1 |
| 2 | GSK-LSD1,an LSD1 inhibitor,quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro显示文摘Dear Editor,Since the COVID-19 demonstrated a remarkable transmission speed and a high mortality risk,COVID-19 is currently declared as a pandemic by the World Health Organization.This is the first time that the WHO has declared a pandemic since H1N1 in 2009.As of 6 September 2020,the total number of COVID-19 patients is 26,763,217(876,616 deaths),and it continues to rise(http://gffzze7c39cdc9e894ca6s65x50kkpuoq965vv.ffgz.tsg.suse.edu.cn/).In spite of the urgent demand for the vaccines and therapeutics,global efforts are primarily focused on the utilization of the existing anti-viral drugs,such as remdesivir,hydroxychloroquine,and dexamethasone,to relieve the symptoms due to the limited development of renovative therapeutics. | Kyung Soo Hong June Hong Ahn Jong Geol Jang Jong Ho Lee Hong Nam Kim Dongha Kim Wonhwa Lee | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 3 | COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm显示文摘Sterol regulatory element binding protein-2(SREBP-2)is activated by cytokines or pathogen,such as virus or bacteria,but its association with diminished cholesterol levels in COVID-19 patients is unknown.Here,we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in COVID-19.Intriguingly,we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients’blood and propose SREBP-2 C-terminal fragment as an indicator for determining severity.We confirmed that SREBP-2-induced cholesterol biosynthesis was suppressed by Sestrin-1 and PCSK9 expression,while the SREBP-2-induced inflammatory responses was upregulated in COVID-19 ICU patients.Using an infectious disease mouse model,inhibitors of SREBP-2 and NF-κB suppressed cytokine storms caused by viral infection and prevented pulmonary damages.These results collectively suggest that SREBP-2 can serve as an indicator for severity diagnosis and therapeutic target for preventing cytokine storm and lung damage in severe COVID-19 patients. | Wonhwa Lee June Hong Ahn Hee Ho Park Hong Nam Kim Hyelim Kim Youngbum Yoo Hyosoo Shin Kyung Soo Hong Jong Geol Jang Chun Gwon Park Eun Young Choi Jong-Sup Bae Young-Kyo Seo | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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