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| 1 | Hepatitis C eradication with sofosbuvir leads to significant metabolic changes显示文摘AIM To assess the effect of sofosbuvir(SOF) based regimens on glycemic and lipid control.METHODS This is a retrospective analysis of hepatitis C virus(HCV)-infected patients treated and cured with a SOF regimen [SOF/ribavirin/interferon, SOF/simeprevir, or SOF/ledipasvir(LDV) ± ribavirin] from January 2014 to March 2015. Patients with hemoglobin A1C(HbA1C) and lipid panels within six months before and six months after therapy were identified and included in our study. Due to the known hemolytic effect of ribavirin, HbA1C was obtained a minimum of three months post-treatment for the patients treated with a ribavirin regimen. Medical history, demographics, HCV genotype, pre-therapy RNA, and liver biopsies were included in our analysis. The patients who started a new medication or had an adjustment of baseline medical management for hyper-lipidemia or diabetes mellitus(DM) were excluded from our analysis.RESULTS Two hundred and thirty-four patients were reviewed, of which 60 patients met inclusion criteria. Sixty-three point three percent were male, 26.7% were Caucasian, 41.7% were African American and 91.7% were infected with hepatitis C genotype 1. Mean age was 60.6 ± 6.7 years. Thirty-nine patients had HbA1C checked before and after treatment, of which 22 had the diagnosis of DM type 2. HbA1C significantly decreased with treatment of HCV(pretreatment 6.66% ± 0.95% vs posttreatment 6.14% ± 0.65%, P < 0.005). Those treated with SOF/LDV had a lower HbA1C response than those treated with other regimens(0.26% ± 0.53% vs 0.71% ± 0.83%, P = 0.070). Fifty-two patients had pre- and post-treatment lipid panels; there was a significant increase in low-density lipoprotein(LDL) and total cholesterol(TC) after treatment(LDL: 99.5 ± 28.9 mg/dL vs 128.3 ± 34.9 mg/dL, P < 0.001; TC: 171.6 ± 32.5 mg/dL vs 199.7 ± 40.0 mg/dL, P < 0.001). Pretreatment body-mass index(BMI) did not differ from post-treatment BMI(P = 0.684). CONCLUSION Eradication of HCV with a SOF regimen resulted in a significant drop in HbA1C and an increase in LDL and TC post therapy. | Amilcar L Morales Zachary Junga Manish B Singla Maria Sjogren Dawn Torres | 2016 | World Journal of Hepatology2016，8，35： | 2 |
| 2 | Rhodamine Hydrazone Derivatives Based Selective Fluorescent and Colorimetric Chemodosimeters for Hg2+ and Selective Colorimetric Chemosensor for Cu2+显示文摘 | Lee H Y Swamy K M K Junga J Y | 2013 | Sens Actuators B2013，182，6： | 1 |
| 3 | Mutation analysis of the MCM gene in Korean patients with MMA 显示文摘 | Junga JW Hwangb IT Parka JE | 2005 | Mol Genet Metab2005，84，4： | 1 |
| 4 | Myocardial ischemia in children with isolated ventricular noncompaction显示文摘 | Junga G Kneifel S Von Smekal A | 1999 | Eur Heart J1999，20，： | 1 |
| 5 | Comparison of Kjeldahl and Dumas Methods for Determining Protein Contents of Soybean Products显示文摘 | JUNGA S RICKERTA D A DEAKA N A | 2003 | JAOCS2003，80，12： | 1 |
| 6 | Hypoeholesterolemie Effects of Lactobaeillus plantarum KCT3928 by Increased Bile Acid Excretion in C57 BIM6 Mice 显示文摘 | JUNGAE J KIM S CHO S Y | 2009 | Nutrition2009，26，3： | 1 |
| 7 | Performance implications for the relationships among top management leadership, organ- izational culture, and appraisal practice: Testing two theory-based models of organizational learning theory in Japan 显示文摘 | Junga Y Takeuchi N | 2010 | International Journal of Human Resource Management2010，21，11： | 1 |
| 8 | Alteration in electrical and infrared switching properties of vanadium oxides due to proton irradiation显示文摘 | Anthony Leone Ann Marie Trione Frank Junga | 1990 | Transactions on Nuclear Science1990，37，： | 1 |
| 9 | Comparison of Kjeldahl and Dumas Methods for Determining Protein Contents of Soybean Products显示文摘 | S Junga D A Rickerta N A Deaka | 2003 | Journal of the American Oil Chemists''Society2003，80，20： | 1 |
| 10 | Experimental and cal- culated phases in two as-cast and annealed Mg-Zn-Y alloys显示文摘 | Farza dfara S A Sanjaria M Junga I H | 2012 | Ma- terials Characterization2012，63，： | 1 |
| 11 | A moment model for simulating raindrop scavenging of aerosols 显示文摘 | Chang H Junga Yong P lOmb K W Lee | 2003 | Aerosol Science2003，34，： | 1 |
| 12 | The effects of thermal annealing in NH3-ambient on the p-type ZnO films 显示文摘 | Eun Soo Junga Hong Seung Kima Hyung Koun Cho | 2007 | Superlattices and Microstructures2007，42，1： | 1 |
| 13 | Identification of a novel pathogen-induced gene encoding a leucine-rich repeat protein expressed in phloem cells of Capsicum annuum显示文摘 | Junga E H Junga H W Lee S C etal | 2004 | Biochim Biophys Acta2004，1676，： | 1 |
| 14 | Myocardial ischemia in children with isolated ventricular non-compaction显示文摘 | Junga G Kneifel S von Smekal A | | 0，，： | 1 |
| 15 | Activation of the phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis 显示文摘 | Yilmaz O Jungas T Verbeke P | 2004 | Infect Immun2004，72，7： | 1 |
| 16 | The analgesic and anti-inflammatory effect of WIN-34B,a new herbal formula for osteoarthritis composed of Lonieera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo显示文摘 | Moonkyu Kanga lnho Junga Jonghyun Hura | 2010 | Journal of Ethnopharmacology2010，131，： | 1 |
| 17 | Ownership structure and earnings informativeness:evidence from Korea显示文摘 | Junga K Kwon SY | 2002 | The International Journal of Accounting2002，37，3： | 1 |
| 18 | Hypocholesterolemic effects of Lactobacillus plant arum KCT3928by increased bile acid excretion in C57BL/6mice显示文摘 | Jungae J Kim S Cho sy | 2009 | Nutrition2009，26，3： | 1 |
| 19 | location of putative stem cells in dental epithelium and Their Association with notch and FGF Signaling显示文摘 | Haradaa H Kettunena P Junga HS | 1999 | J Cell Biol1999，147，1： | 1 |
| 20 | A Facile Solid -? Phase Synthesis of(+)-(S) - Clopidogrel 显示文摘 | Kiwon Junga Jae - Sun Kim Tae - Hyun Kimc | 2013 | Helvetica ChimicaActa2013，96，2： | 1 |
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