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| 1 | Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX显示文摘在 BCL-2 家庭蛋白质之间的相互作用决定房间的命运生活或死。他们怎么与对方一起交往调整 apoptosis,作为一个未解决的中央问题留下。到目前为止, antiapoptotic BCL-2 蛋白质被认为微弱地与 BAX 交往,但是这个相互作用的生理的意义是含糊的。此处,我们证明 recombinant BCL-2 和 BCL-w 与 3 包含域的肽从 BAX 导出的 BCL-2 相同(BH ) potently 交往,分别地展出 15 和 23 nM 的分离常数。为这个强壮的相互作用澄清基础,我们与跨越它的 BH3 领域的 BAX 肽决定了 BCL-2 的建筑群的三维的结构。它表明他们在正规 BH3 领域以外扩大并且包含了三 nonconserved 的相互作用控告了 BAX 的残余。新奇 BAX 变体,包含这三残余的丙氨酸替换,极大地为 BCL-2 和 BCL-w 损害了亲密关系,但是与野类型的 BAX 另外难区分。极其, BAX 变体的 apoptotic 活动不能被 BCL-2 和 BCL-w 制止,指观察紧密的相互作用为调整 BAX 激活是批评的。我们包括地也确定了与三 BCL-2 亚科蛋白质的有约束力的亲密关系。一起,数据表演由于为 BCL-2 , BCL-w 和 A1 的 BAX 的高亲密关系,并且为 BCL-XL , MCL-1 和 A1 的 BAK ,仅仅一个子集BH3仅仅蛋白质,通常包括的 BIM ,出价和美洲狮,能从 antiapoptotic BCL-2 蛋白质被期望到免费 BAX 或 BAK 得到 apoptosis 。 | Bonsu Ku Chengyu Liang Jae U Jung Byung-Ha Oh | 2011 | Cell Research2011，21，4： | 9 |
| 2 | Interim analysis of START: Study in asia of the combination of TACE (transcatheter arterial chemoembolization) with sorafenib in patients with hepatocellular carcinoma trial显示文摘 | Young‐Hwa Chung Guohong Han Jung‐Hwan Yoon Jijin Yang Jianhua Wang Guo‐Liang Shao Byung Ik Kim Teng‐Yu Lee Yee Chao | 2012 | Int J Cancer2012，，10： | 2 |
| 3 | Spectrum of toxic hepatitis following intentional paraquat ingestion: analysis of 187 cases显示文摘 | Chin‐Jung Yang Ja‐Liang Lin Dan‐Tzu Lin‐Tan Cheng‐Hao Weng Ching‐Wei Hsu Shen‐Yang Lee Shwu‐Hua Lee Chia‐Ming Chang Wey‐Ran Lin Tzung‐Hai Yen | 2012 | Liver Int2012，，9： | 1 |
| 4 | Chemokine (C-X-C Motif) Ligand 12 Is Associated with Gallbladder Carcinoma Progression and Is a Novel Independent Poor Prognostic Factor显示文摘 | Hyun Jung Lee Kyungmin Lee Dong Gwang Lee Kwang-Hee Bae Jang-Seong Kim Zhe Long Liang Song Mei Huang Yoon Suk Oh Ha Yon Kim Deog Yeon Jo Jeong-Ki Min Jin-Man Kim Hyo Jin Lee | 2012 | Clinical Cancer Research2012，，12： | 1 |
| 5 | High-performance programmable AC power source with low harmonic distortion using DSP-based repetitivecontrol technique 显示文摘 | Rong Shyang Ou Shih Liang Jung | 1997 | IEEE Trans Power Electronics1997，12，4： | 1 |
| 6 | Design and Implementation of a FPGA Based Control IC for AC Voltage Regulation 显示文摘 | Shih Liang Jung Meng Yueh Chang | 2009 | IEEE Transactions on Power Electronics2009，14，52： | 1 |
| 7 | Anti - in ammatory effects of Punica granatum Linne in vitro and in vivo显示文摘 | Chia- Jung Lee Lih -Geeng Chen Wen -Li Liang | 2010 | Food Chemistry2010，118，： | 1 |
| 8 | Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation 显示文摘 | Picard M Jung B Liang F | 2012 | Am J Respir Crit Care Med2012，186，11： | 1 |
| 9 | A macrophage subpopula- tion recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury 显示文摘 | Liang J Jung Y Tighe RM | 2012 | Am J Physiol Lung Cell Mol Physiol2012，302，9： | 1 |
| 10 | Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation 显示文摘 | Picard M Jung B Liang F | 2012 | Am J Respir Crit Care Med2012，186，11： | 1 |
| 11 | Potential of healing a tran- seeted anterior cruciate ligament with genetically modified extra- cellular matrix bioscaffolds in a goat model显示文摘 | Fisher MB Liang R Jung HJ | 2012 | Knee Surg Sports Traumatol Arthrosc2012，20，7： | 1 |
| 12 | Application of two bicistron- ic systems involving 2A and IRES sequences to the biosynthesis of carotenoids in rice endosperm 显示文摘 | Ha SH Liang YS Jung H et ol | 2010 | Plant Biotechnol J2010，8，8： | 1 |
| 13 | Roles of RIG-I N-terminal tandem CARD and splice va- riant in TRIM25-mediated antiviral signal transduction 显示文摘 | Gack M U Kirchhofer A Shin Y C Inn KS Liang C CuiS Myong S Ha T Hopfner K P Jung J U | 2008 | Proc Natl Acad Sci USA2008，105，16： | 1 |
| 14 | Isolation and characterization of size sieved stem cells from human bone marrow显示文摘 | Nien Jung C Shie Liang H | 2002 | Stem Cells2002，20，： | 1 |
| 15 | Downregulation of autophagy by herpesvirus Bcl-2 homologs 显示文摘 | Liang CEX Jung JU | 2008 | Autophagy2008，4，3： | 1 |
| 16 | Engineering of hollow polymeric nanosphere-supported imidazolium-based ionic liquids with enhanced antimicrobial activities显示文摘The design of stable,efficient and processable bactericidal materials represents a significant challenge for combating multidrugresistant bacteria in a variety of engineering fields.Herein,we report a facile strategy for the preparation of hollow polymeric nanosphere(HPN)-supported imidazolium-based ionic liquids(denoted as HPN-ILs)with superior antimicrobial activities.HPNILs were tailored by moderate Friedel−Crafts polymerization followed by the sequential covalent bonding of imidazole and bromoalkene.The resultant HPN-ILs have uniform hollow spherical morphology,an adequate surface area,and excellent physicochemical stability.Furthermore,they are highly active against both Gram-positive and Gram-negative bacteria and exhibit typical time/dosage-dependent antibacterial activities.The rational combination of porous HPNs and antibacterial ILs to generate an all-in-one entity may open new avenues for the design and fabrication of efficient bacteriostatic agents.Moreover,HPN-ILs have good biocompatibility and can also be loaded onto diverse matrices,and thus could extend their practical bactericidal application in the potential biomedical-active field. | Yu Zhang Shuwei Li Yixin Xu Xinyun Shi Mingxin Zhang Yingning Huang Ying Liang Yaqiong Chen Wanli Ji Jung Rae Kim Wenliang Song Deng-Guang Yu Il Kim | 2022 | Nano Research2022，15，6： | 1 |
| 17 | Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation 显示文摘 | Heard M Jung B Liang F | 2012 | Am J Respir Cfit Care Med2012，186，11： | 1 |
| 18 | Formation of bandgap and subbands in graphene nanomeshes with sub-10nm ribbon width fabricated via nanoimprint lithography 显示文摘 | LIANG X G JUNG Y S WU SW etal | 2010 | Nano Letters2010，10，7： | 1 |
| 19 | Role of hyaluronan and hyalaronau- binding proteins in human asthma显示文摘 | Liang J Jiang D Jung Y | 2011 | J Allergy Clin lmmunol2011，128，2： | 1 |
| 20 | Multifunctional electrospun fabrics via layer-by-layer electrostatic assembly for chemical and biological protection 显示文摘 | LIANG Chen LEV Bromberg JUNG Ah Lee | 2010 | Chem Mater2010，22，4： | 1 |
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