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| 1 | Rheostatic Control of ABA Signaling through HOS15-Mediated OST1 Degradation显示文摘Dehydrating stresses trigger the accumulation of abscisic acid(ABA),a key plant stress-signaling hormone that activates Snf1-Related Kinases(SnRK2s)to mount adaptive responses.However,the regulatory circuits that terminate the SnRK2s signal relay after acclimation or post-stress conditions remain to be defined.Here,we show that the desensitization of the ABA signal is achieved by the regulation of OST1(SnRK2.6)protein stability via the E3-ubiquitin ligase HOS15.Upon ABA signal,HOS15-induced degradation of OST1 is inhibited and stabilized OST1 promotes the stress response.When the ABA signal terminates,protein phosphatases ABI1/2 promote rapid degradation of OST1 via HOS15.Notably,we found that even in the presence of ABA,OST1 levels are also depleted within hours of ABA signal onset.The unexpected dynamics of OST1 abundance are then resolved by systematic mathematical modeling,demonstrating a desensitizing feedback loop by which OST1-induced upregulation of ABI1/2 leads to the degradation of OST1.This model illustrates the complex rheostat dynamics underlying the ABA-induced stress response and desensitization. | Akhtar Ali Jae Kyoung Kim Masood Jan Haris Ali Khan Irfan Ullah Khan Mingzhe Shen Junghoon Park Chae Jin Lim Shah Hussain Dongwon Baek Kai Wang Woo Sik Chung Vicente Rubio Sang Yeol Lee Zhizhong Gong Woe Yeon Kim Ray ABressan Jose MPardo Dae-Jin Yun | 2019 | Molecular Plant2019，12，11： | 5 |
| 2 | 解决高度分割的车载自组网络连通性问题的路侧单元最优化调度方案显示文摘车载自组网络VANET是一种拥有高度动态拓扑结构的移动自组网络。为了解决其频繁的网络分割问题,最新研究提出使用一种特殊的称为路侧单元RSU的基础设施部署于道路两侧来提高VANET连通性。本文主要研究RSU调度中的节能降耗问题:给定一组路侧单元,我们的目标是寻找指定时段内打开或关闭RSU的最优调度,以确保RSU系统所消耗的总能量最小化,同时维持VANET系统网络连通性。我们将这一问题分解为两个子问题,即网络瞬像调度问题和网络瞬像选取问题。网络瞬像调度问题用于决定某时刻VANET网络瞬像中所需的连通状态RSU的最小值,而网络瞬像选取问题则用于决定系统需要在哪些时刻更新网络瞬像。通过对这两个子问题的研究,我们最终给出关于RSU调度问题的完全解,并通过理论分析与实验结果证明本文的算法可以在保持VANET连通性的同时明显地节能降耗。 | 邹凤 仲姣菲 伍伟丽 堵丁柱 Lee Junghoon | 2012 | 计算机工程与科学2012，34，1： | 4 |
| 3 | Effects of Lizhong Tang on gastrointestinal motility in mice显示文摘AIM To investigate the effects of Lizhong Tang,a traditional Chinese medicine formula,on gastrointestinal motility in mice.METHODS The in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates(ITRs) and gastric emptying(GE) values in normal mice and in mice with experimentally induced GI motility dysfunction(GMD).RESULTS In normal ICR mice,the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang(ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%,P < 0.01 with 0.1 g/kg Lizhong Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%,P < 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%,P < 0.05 with 0.1 g/kg Lizhong Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%,P < 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice,which were significantly and dose-dependently reversed by Lizhong Tang. Additionally,in loperamide- and cisplatin-induced models of GE delay,Lizhong Tang administration reversed the GE deficits.CONCLUSION These results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract. | Min Cheol Lee Wooram Ha Jinhyeong Park Junghoon Kim Yunjin Jung Byung Joo Kim | 2016 | World Journal of Gastroenterology2016，22，34： | 4 |
| 4 | Hybrid rapid prototyping system using machining and deposition显示文摘 | Hur Junghoon Lee Kunwoo Zhu Hu | 2002 | Computer- Aided Design2002，，34： | 1 |
| 5 | Hybrid rapid prototyping system using machining and deposition显示文摘 | Hur Junghoon Lee Kunwoo Jongwon Kim Zhu-hu | 2002 | Computer-Aided Design2002，34，10： | 1 |
| 6 | An Integrated Service- Device -Technology Roedmap for Smart City Development 显示文摘 | JungHoon Lee Robert Phaal Sang-Ho Lee | 2013 | Technological Forecasting and Social Change2013，80，2： | 1 |
| 7 | Reliable cloud storage system for mobile devices using personal computer显示文摘In recent years,the use of mobile devices such as smart phones,tablet PCs,etc.is rapidly increasing.In case of these mobile devices,the storage space is limited due to their characteristics.To make up for the limited space of storage in mobile devices,several methods are being researched.Of these,cloud storage service(CSS),one of cloud computing services,is an efficient solution to compensate such limited storage space.CSS is a service of storing files to the storage and thus getting access to stored files through networks(Internet)at anytime,anywhere.As for the existing CSS,users store their personally important files in the cloud storage,not in their own computers.It may cause security problems such as the leaking of information from private files or the damaging to the information.Thus,we propose a cloud storage system which can solve the security problem of CSS for mobile devices using the personal computer.Our system is deigned to store and manage files through the direct communication between mobile devices and personal computer storages by using the software as a service(SaaS),one of computing services,instead of directly storing files into cloud storages. | Sanggeun Song Junghoon Shin Sangjun Lee | 2012 | Journal of Measurement Science and Instrumentation2012，3，3： | 1 |
| 8 | 显示文摘 | Lee Junghoon He Bo Patankar Neelesh A | 2005 | Journal of Micromechanics and Micromengineering2005，15，3： | 1 |
| 9 | An intelligent cache system with hardware prfetehing for high performance 显示文摘 | Lee Junghoon Jeong Shewoong | 2003 | IEEE Transactions on Computers2003，52，5： | 1 |
| 10 | Contact angle hysteresis on rough hydrophobic surfaces 显示文摘 | He Bo Lee Junghoon Patankar A N | 2004 | Colloids and Surfaces A2004，248，： | 1 |
| 11 | Multiple equilibrium droplet shapes and design criterion for rough hydrophobic surfaces 显示文摘 | He Bo Patankar Neelesh A Lee Junghoon | 2003 | Langmuir2003，19，： | 1 |
| 12 | Immersed finite element method and its applications to biological systems显示文摘 | Wing Kam Liu Yaling Liu David Farrell Lucy Zhang X. Sheldon Wang Yoshio Fukui Neelesh Patankar Yongjie Zhang Chandrajit Bajaj Junghoon Lee Juhee Hong Xinyu Chen Huayi Hsu | 2005 | Computer Methods in Applied Mechanics and Engineering2005，，13： | 1 |
| 13 | Multiple equilibrium droplet shapes and design criterion for rough hydrophobic surfaces 显示文摘 | He Bo Patankar Neelesh A Lee Junghoon | 2003 | Langmuir2003，12，19： | 1 |
| 14 | Electrowetting and electrowetting-on-dielectric for microscale liquid handling显示文摘 | Junghoon Lee Hyejin Moom Jesse Fowler | 2002 | Sersors and Actuasors A 952002，，： | 1 |
| 15 | Determination of optimal build orientation for hybrid rapid-prototyping显示文摘 | ZHU H LEE Kunwoo HUR Junghoon | 2002 | Journal of Materials Processing Technology2002，，： | 1 |
| 16 | Effect of Ar bubbling during plasma electrolytic oxidation of AZ31B magnesium alloy in silicate electrolyte显示文摘 | Junghoon Lee Yonghwan Kim Wonsub Chung | 2012 | Applied Surface Science2012，，： | 1 |
| 17 | The development of a CAD environment to determine the preferred build-up direction for layered manufacturing显示文摘 | Junghoon Hur Kunwoo Lee | 1998 | The International Journal of Advanced Manufacturing Technology1998，，4： | 1 |
| 18 | The effects of single versus combined therapy using LIM-kinase 2 inhibitor and type 5 phosphodiesterase inhibitor on erectile function in a rat model of cavernous nerve injury-induced erectile dysfunction显示文摘We aimed to determine whether combination of LIM-kinase 2 inhibitor(LIMK2i)and phosphodiesterase type-5 inhibitor(PDE5i)could restore erectile function through suppressing cavernous fibrosis and improving caver nous apoptosis in a rat model of cavernous nerve crush injury(CNCI).Seventy 12-week-old Sprague-Dawley rats were equally distributed into five groups as follows:(1)sham surgery(Group S),(2)CNCI(Group I),(3)CNCI treated with daily intraperitoneal administration of 10.0 mg kg^-1 LIMK2i(Group I+L),(4)daily oral administration of 20.0 mg kg-1 udenafil,PDE5i(Group I+U),and(5)combined administration of 10.0 mg kg^-1 LIMK2i and 20.0 mg kg^-1 udenafil(Group I+L+U).Rats in Groups I+L,I+U,and I+L+U were treated with respective regimens for 2 weeks after CNCI.At 2 weeks after surgery,erectile response was assessed using electrostimulation.Penile tissues were processed for histological studies and western blot.Group I showed lower intracavernous pressure(ICP)/mean arterial pressure(MAP),lower area under the curve(AUC)/MAP,decreased immunohistochemical staining for alpha-smooth muscle(SM)actin,higher apoptotic index,lower SM/collagen ratio,increased phospho-LIMK2-positive fibroblasts,decreased protein kinase B/endothelial nitric oxide synthase(Akt/eNOS)phosphorylation,increased LIMK2/cofilin phosphorylation,and increased protein expression of fibronectin,compared to Group S.In all three treatment groups,erectile responses,protein expression of fibronectin,and SM/collagen ratio were improved.Group I+L+U showed greater improvement in erectile response than Group I+L.SM content and apoptotic index in Groups I+U and I+L+U were improved compared to those in Group I.However,Group I+L did not show a significant improvement in SM content or apoptotic index.The number of phospho-LIMK2-positive fibroblasts was normalized in Groups I+L and I+L+U,but not in Group I+U.Akt/eNOS phosphorylation was improved in Groups I+U and I+L+U,but not in Group I+L.LIMK2/cofilin phosphorylation was improved in Groups I+L and I+L+U,but not in Group I+U.Our data indicate that combined treatment of LIMK2i and PDE5i immediate after CN injury could improve erectile function by improving cavernous apoptosis or eNOS phosphorylation and suppressing cavernous fibrosis.Rectification of Akt/eNOS and LIMK2/cofilin pathways appears to be involved in their improvement. | Min Chui Cho Junghoon Lee Juhyun Park Sohee Oh Ji Sun Chai Hwancheol Son Jae-Seung Paick Soo Woong Kim | 2019 | Asian Journal of Andrology2019，21，5： | 1 |
| 19 | Carrier frequency offset estimation usingESPRIT for interleaved OFDMA uplink systems 显示文摘 | Junghoon Lee Sungeun Lee Keuk - Joon Bang andSungkeun Cha | 2007 | IEEE Transactions on Vehicular Technology2007，56，5： | 1 |
| 20 | Hybrid rapid pro- totyping system using machining and deposition 显示文摘 | Junghoon Hur Kunwoo Lee Zhu Hu | 2002 | Comput- er-Aided Design2002，34，10： | 1 |
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