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| 1 | Application of the sodium hyaluronate-CNTF scaffolds in repairing adult rat spinal cord injury and facilitating neural network formation显示文摘The present study aimed to explore the potential of the sodium hyaluronate-CNTF (ciliary neurotrophic factor) scaffold in activating endogenous neurogenesis and facilitating neural network re-formation after the adult rat spinal cord injury (SCI). After completely cutting and removing a 5-mm adult rat T8 segment, a sodium hyaluronate-CNTF scaffold was implanted into the lesion area. Dil tracing and immunofluorescence staining were used to observe the proliferation, differentiation and integration of neural stem cells (NSCs) after SCI. A planar multielectrode dish system (MED64) was used to test the electrophysiological characteristics of the regenerated neural network in the lesioned area. Electrophysiology and behavior evaluation were used to evaluate functional recovery of paraplegic rat hindlimbs. The Dil tracing and immunofluorescence results suggest that the sodium hyaluronate-CNTF scaffold could activate the NSCs originating from the spinal cord ependymal, and facilitate their migration to the lesion area and differentiation into mature neurons, which were capable of forming synaptic contact and receiving glutamatergic excitatory synaptic input. The MED64 results suggest that functional synapsis could be established among regenerated neurons as well as between regenerated neurons and the host tissue, which has been evidenced to be glutamatergic excitatory synapsis. The electrophysiology and behavior evaluation results indicate that the paraplegic rats’ sensory and motor functions were recovered in some degree. Collectively, this study may shed light on paraplegia treatment in clinics. | Yabin Xie Wei Song Wen Zhao Yudan Gao Junkui Shang Peng Hao Zhaoyang Yang Hongmei Duan Xiaoguang Li | 2018 | Science China(Life Sciences)2018，61，5： | 6 |
| 2 | Rapid qualitative and quantitative analysis of strong aroma base liquor based on SPME-MS combined with chemometrics显示文摘To objectively classify and evaluate the strong aroma base liquors(SABLs)of different grades,solid-phase microextraction-mass spectrometry(SPME-MS)combined with chemometrics were used.Results showed that SPME-MS combined with a back-propagation artificial neural network(BPANN)method yielded almost the same recognition performance compared to linear discriminant analysis(LDA)in distinguishing different grades of SABL,with 84%recognition rate for the test set.Partial least squares(PLS),successive projection algorithm partial least squares(SPA-PLS)model,and competitive adaptive reweighed samplingpartial least squares(CARS-PLS)were established for the prediction of the four esters in the SABL.CARS-PLS model showed a greater advantage in the quantitative analysis of ethyl acetate,ethyl butyrate,ethyl caproate,and ethyl lactate.These results corroborated the hypothesis that SPME-MS combined with chemometrics can effectively achieve an accurate determination of different grades of SABL and prediction performance of esters. | Zongbao Sun Junkui Li Jianfeng Wu Xiaobo Zou Chi-Tang Ho Liming Liang Xiaojing Yan Xuan Zhou | 2021 | Food Science and Human Wellness2021，10，3： | 3 |
| 3 | Disinfection byproduct formation from algal organic matters after ozonation or ozone combined with activated carbon treatment with subsequent chlorination显示文摘Algal organic matter(AOM),including extracellular organic matter(EOM)and intracellular organic matter(IOM)from algal blooms,is widely accepted as essential precursors of disinfection byproducts(DBPs).This study evaluated the effect of ozonation or ozone combined with activated carbon(O_(3)-AC)treatment on characteristic alternation and DBP formation with subsequent chlorination of Chlorella sp..The effects of p H and bromide concentration on DBP formation by ozonation or O_(3)-AC treatment were also investigated.Results showed that the potential formation of DBPs might be attributed to ozonation,but these DBP precursors could be further removed by activated carbon(AC)treatment.Moreover,the formation of target DBPs was controlled at acidic pH by alleviating the reactions between chlorine and AOM.Besides,the bromide substitution factor(BSF)value of trihalomethanes(THMs)from EOM and IOM remained constant after AC treatment.However,THM precursors could be significantly decreased by AC treatment.The above results indicated that O_(3)-AC was a feasible treatment method for algal-impacted water. | Qiufeng Lin Feilong Dong Cong Li Junkui Cui | 2021 | Journal of Environmental Sciences2021，33，6： | 2 |
| 4 | Young Yum pill inhibits inflammatory mediators and nuclear factor-kappa B signaling in lipopolysaccharide-stimulated RAW 264.7 macrophages显示文摘OBJECTIVE: To investigate the effect of Young Yum pill (YYP) on inflammatory mediators in cultured RAW 264.7 cells and elucidate the nuclear factor- kappa B (NF-κB)-related mechanism behind the action. METHODS: YYP was extracted with 95% ethanol Lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages were used to evaluate the effect of YYP on inflammatory mediators. Production of nitric oxide (NO) and prostaglandin E2 (PGE2) were measured by Griess test and enzyme-linked immunosorbent assay, respectively. The levels of genes and proteins involved in the generation of inflammatory mediators were examined using real-time polymerase chain reaction and Western blotting, respectively. RESULTS: YYP dose-dependently suppressed LPS-induced production of NO, PGE2 and tumor necrosis factor-α(TNF-α), and elevation of mRNA and protein levels of inducible NO synthase and cyclooxygenase- 2 in RAW 264.7 macrophages. These observations were associated with decreased NF-κB p65 phosphorylation and nuclear localization, enhanced Akt (protein kinase B) phosphorylation, as well as reduced inhibitor of κB (IκB)α degradation and IκB kinase α/β phosphorylation. CONCLUSION: The present study demonstrated an inhibitory effect of YYP on the NF-κB-regulated inflammatory mediators NO, PGE2 and TNF-α in LPS-stimulated RAW 264.7 macrophages, providing a pharmacological basis for the use of YYP in treating inflammatory disorders. | Yin Chengle Muhammad Jahangir Hossen Anfernee Kai-Wing Tse Su Tao Fu Xiuqiong Li Ting Guo Hui Zhu Peili Li Junkui Chou Jiyao Wang Yaping Yu Zhiling | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 5 | Experimental Study on Impingement and Film Overall Cooling Characteristics of Turbine Shroud显示文摘Based on the variable characteristics of the actual operating conditions of the turbine shroud and the purpose of improving the cooling effect of the turbine shroud,this paper builds a test system of the impingement-film cooling shroud with two gas inlet angles(90°,167°).The effects of film cooling hole arrangement,gas inlet angle,blowing ratio(0.7,1.0,1.5,2.0,2.5,3.0)and temperature ratio(1.2,1.3,1.4,1.5,1.6)on the cooling characteristics of the impingement-film cooling shroud were experimentally studied by infrared temperature measurement technology,especially the effects of gas inlet angle and temperature ratio.The results showed that the film covering effect of the film cooling hole vertical or the same direction of the high-temperature gas incoming flow is better than the film covering effect of the reverse direction with the incoming flow,and the optimal arrangement of film cooling holes can improve the cooling effectiveness of the shroud.Compared with 90°intake gas,the film coverage area on the shroud surface of the 167°intake gas is expanded,and the surface average overall cooling effectiveness is increased by 1.03%to 12.6%.The overall cooling effectiveness of turbine shroud increases with the increase of blowing ratio,which increases the flow rate and pressure of cooling gas,and the corresponding increase rate is between 1.04%and 9.96%.However,the increase in the temperature ratio increases the mainstream heating capacity,resulting in a decrease in the cooling effectiveness of the shroud,with a maximum reduction rate of 11.04%. | LI Ziqiang WANG Longfei MAO Junkui BI Shuai WANG Feilong | 2022 | Journal of Thermal Science2022，31，1： | 1 |
| 6 | Early Abandon to Accelerate Exact Dynamic Time Warping 显示文摘 | LI Junkui WANG Yuanzhen | 2009 | The International ArabJournal of Information Technology2009，6，2： | 1 |
| 7 | Radiation Safety Report of HIRFL in 2011显示文摘 | Su Youwu Li Zongqiang Li Wuyuan Xu Junkui Mao Wang Yan Weiwei Xu Chong | 2011 | IMP & HIRFL Annual Report2011，，1： | 1 |
| 8 | 6-43 Radiation Safety Report of HIRFL in 2016显示文摘The total operation time of HIRFL is 7 488 h in 2016,the user beam time is about 5 547.5 h(from 21 Dec.2015 to 21 Dec.2016).3 178 h for physics experiment,238.5 h for biological physics science research,2 023 h for irradiation effect research,and 108 h for machine research.There are 26 heavy ions beams were provided by HIRFL in 2016.The highest ions energy provided is 7.9 MeV/u,the maximum accumulated ion intensity is 1μA.Environment radiation level was measured with TLDs which were placed in the yard of the institute around HIRFL,15 sites of radiation level show no difference with environment background level of Gansu province[1]. | Su Youwu Xu Junkui Li Zongqiang Li Wuyuan Mao Wang Wang Lijun Xu Chong Yan Weiwei | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 9 | 6-44 Studying of Residual Activity Induced by 300 MeV/u Carbon Ion in Copper Target显示文摘Activation of accelerator components due to beam losses is an important issue for a high-energy heavy ion accelerator.The induced components may become a main source of exposure to maintenance workers and a serious access-restriction for“hand-on”maintenance,and also have a certain radiation influence over the environment.In this work,experimental of residual activation induced by 300 MeV/u carbon ions was studied at the deep-therapy terminal of HIRFL. | Xu Junkui Su Youwu Li Wuyuan Pang Chengguo Yan Weiwei Xu Chong Mao Wang | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 10 | 6-42 Radiation Safety Report of HIRFL in 2015显示文摘The total operation time of HIRFL is 7 536 h in 2015; the user beam time is about 5 451.5 (from 21 Dec.2014 to 21 Dec. 2015); 4 836 h were used for experiments; 615.5 h were used for accelerator research. There are 26 heavy ions beams were provided by HIRFL in 2015. The highest ions energy provided is 464 MeV/u, the maximum accumulated ion intensity is 1 400 A for carbon ion. | Su Youwu Xu Junkui Li Zongqiang Mao Wang Li Wuyuan Xu Chong Yan Weiwei Pang Chengguo | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 11 | 6-43 Radiation Monitoring System for Wuwei Heavy Ion Medical Accelerator显示文摘To ensure the radiation safety of the accelerator staff, medical personnel, patients and surrounding residents,radiation monitoring system in the workplace was established at HIMM WuWei.The Radiation monitoring system is composed of monitoring, data acquisition unit and central control computer,the structure shown in Fig. 1. Inside and outside the accelerator radiation area 14 monitoring points were arranged(Fig. 2). A neutron detector and a -ray detector was installed at each monitoring point. | Li Zongqiang Mao Wang Li Wuyuan Xu Junkui Fu Xin Xu Chon Yan Weiwei Su Youwu | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 12 | Chronic spinal cord injury repair by NT3-chitosan only occurs after clearance of the lesion scar显示文摘Spinal cord injury(SCI)is a severe damage usually leading to limb dysesthesia,motor dysfunction,and other physiological disability.We have previously shown that NT3-chitosan could trigger an acute SCI repairment in rats and non-human primates.Due to the negative effect of inhibitory molecules in glial scar on axonal regeneration,however,the role of NT3-chitosan in the treatment of chronic SCI remains unclear.Compared with the fresh wound of acute SCI,how to handle the lesion core and glial scars is a major issue related to chronic-SCI repair.Here we report,in a chronic complete SCI rat model,establishment of magnetic resonancediffusion tensor imaging(MR-DTI)methods to monitor spatial and temporal changes of the lesion area,which matched well with anatomical analyses.Clearance of the lesion core via suction of cystic tissues and trimming of solid scar tissues before introducing NT3-chitosan using either a rigid tubular scaffold or a soft gel form led to robust neural regeneration,which interconnected the severed ascending and descending axons and accompanied with electrophysiological and motor functional recovery.In contrast,cystic tissue extraction without scar trimming followed by NT3-chitosan injection,resulted in little,if any regeneration.Taken together,after lesion core clearance,NT3-chitosan can be used to enable chronic-SCI repair and MR-DTI-based mapping of lesion area and monitoring of ongoing regeneration can potentially be implemented in clinical studies for subacute/chronic-SCI repair. | Can Zhao Jia-Sheng Rao Hongmei Duan Peng Hao Junkui Shang Yubo Fan Wen Zhao Yudan Gao Zhaoyang Yang Yi Eve Sun Xiaoguang Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 13 | 3-82 Study of Particle Fragments and Its Contribution in Carbon Ion Therapy显示文摘Carbon ions offer significant advantages for deep-seated local tumors therapy due to their physical and biologicalproperties, for heavy ions has a fixed range in the target matter, and characterized by a small entrance dose anda distinct maximum (Bragg peak) near the end of range. In 2006, IMP carried out some heavy ion cancer therapyexperiments. During the process of carbon ions cancer therapy, various kinds of secondary particle fragments arecreated from heavy ion reaction which will influence the treatment dose and healthy tissue of patient. Neutron isthe most abundant secondary particles in heavy ion reaction, which may influence largely patient body due to itsstrong penetrating power. Thus it is important to know the neutron contribution in heavy ion therapy to evaluatethe neutron impact and assess the patient safety. Particle fragments and its contribution from 430 MeV/u carbonions stopping in thick water target were calculated by Fluka Monte Carlo code[1]. | Xu Junkui Su Youwu Li Wuyuan Pang Chengguo | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 14 | Monte-Carlo Simulations of Neutron Radiation Field of Heavy Ion Cancer Therapy in IMP显示文摘 | Xu Junkui Su Youwu Li Wuyuan Li Zongqiang Mao Wang | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 15 | 6-22 Radiation Safety Report of HIRFL in 2014显示文摘The total operation time of HIRFL is 7 272 h in 2014, and the user beam time is about 4 964.5 h(from 21stDec.2013 to 21st Dec. 2014). 3 749 h for physics experiment, 332 h for life science research, 883.5 h for materialscience and single particle effect research, and 235 h for machine research. There are 24 heavy ions beams wereprovided by HIRFL in 2014. The highest ions energy provided is 487 MeV/u, and the maximum accumulated ionintensity is 1 000 A. | Su Youwu Xu Junkui Li Zongqiang Mao Wang Li Wuyuan Xu Chong Yan Weiwei Pang Chengguo | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 16 | 5-8 Recent Progress of High Energy Electron Radiography Research Platform in Lanzhou显示文摘High Energy Electron Radiography(HEER)is a new method suitable for High Energy Density Physics(HEDP)research that uses a high energy electron beam as a probe for time resolved imaging measurements of high energy density processes in materials[1].A High Energy Electron Radiography Research Platform(HEERRP)based on a 50 MeV Electron Linac(e-Lianc)which was designed for experimental research of HEER has been proposed by Electron Accelerator Group in IMP.This e-Linac has two injection beam lines,one is a thermionic RF gun with Alpha Magnet and Quadrupole magnets,and the other is a photo-cathode RF gun with emittance compensation Solenoid,see the Fig.1,and parameters details see the Table 1. | Cao Shuchun Zhang Ziming Xu Junkui Liu Ming Shen Xiaokang Zong Yang Zhu Yunliang Zhou Youwei Wang Yanru Li Zhongping Zhao Quantang Xiao Rongqing Jing Yi Wei Gai | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 17 | HIRFL2017年辐射安全报告显示文摘The radiation safety and protection facilities of HIRFL mainly include area radiation monitoring system,environmental radiation monitoring system,safety interlock system and shielding bodies.The area radiation monitoring system consists of sixty-five fixed sites.The environmental radiation monitoring system is composed of three automatic monitoring stations and 15 fixed TLDs monitoring sites.The new safety interlock system was putinto operation in Dec.2017. | Su Youwu Xu Junkui Mao Wang Li Zongqiang Li Wuyuan Xu Chong Yan Weiwei Yang Yao | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 18 | HIAF的屏蔽设计显示文摘High intensity heavy-ion Accelerator Facility(HIAF)is designed by the Institute of Modern Physics,Chinese Academy of Sciences,which accelerate particles from proton up to uranium.To guarantee the radiation safety of HIAF during operation,the FLUKA code was adopted to calculate the shielding thickness.The calculations were based on carbon ion beam operation at the HIAF facility. | Xu Junkui Su Youwu Li Wuyuan Yang Yao | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 19 | 25 MeV质子直线加速器辐照监测系统显示文摘The 25 MeV proton linear accelerator radiation monitoring system was established and successfully applied to accelerator beam test in 2017.The radiation monitoring system includes radiation detector,data acquisition unit,central progress computer and radiation monitoring software.The structure of this radiation monitoring system is shown in Fig.1.There are 6 monitoring points distributed in the accelerator radiation area and each point is composed by one neutron and one gamma detector,to on-line monitor real time neutron and gamma dose rate level.The parameters of neutron and gamma detector such as measurement range,energy response and sensitivities can meet the requirement of proton linear accelerator radiation monitoring. | Li Zongqiang Mao Wang Liu Haitao Xu Junkui Li Wuyuan Su Youwu | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 20 | 验证FLIKA程序用于磁铁中能量沉积显示文摘The energy deposition in magnets is an important parameter for the magnets design,especially for those magnets working in a strong radiation environment.A new radioactive ion beam line named HFRS will be built in the HIAF,and RIBs are generated with the projectile fragmentation(PF)method.Secondary particles like neutrons,electrons,photons and other fission products can lead to heat load on the coils. | Yang Yao Li Wuyuan Xu Junkui Yan Weiwei Mao Wang Yang Bo Xu Chong Wang Lijun Su Youwu | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
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